The EMBO Journal Table of Contents for 3 September 2018; Vol. 37, No. 17

3 September 2018 | Volume 37, Number 17 Submit Table of Contents News & Views Articles Volume 37, Number 17 News & Views MIM through MOM: the awakening of Bax and Bak pores A new study shows that Bax/Bak pores on the mitochondrial outer membrane allow the extrusion and permeabilization of the mitochondrial inner membrane to release mtDNA independently of caspases. Katia Cosentino and Ana J García‐Sáez Published online 22.08.2018 Hip to the Game: YAP/TAZ is required for nonmelanoma skin cancers Two recent studies show that initiation of mammalian epidermal malignancies depends on aberrant Hippo signaling and downstream YAP/TAZ nuclear regulators. Matilde M Miranda and William E Lowry Published online 23.07.2018 Articles Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis The formation of BAX/BAK pores in apoptotic cells triggers extrusion of mitochondrial DNA through the inner mitochondria membrane, thereby activating cytosolic cGAS/STING signalling. Joel S Riley, Giovanni Quarato, Catherine Cloix, Jonathan Lopez, Jim O'Prey, Matthew Pearson, James Chapman, Hiromi Sesaki, Leo M Carlin, João F Passos, Ann P Wheeler, Andrew Oberst, Kevin M Ryan and Stephen WG Tait Published online 26.07.2018 YAP‐TEAD signaling promotes basal cell carcinoma development via a c‐JUN/AP1 axis Hippo signaling regulator YAP is dispensable for normal skin homeostasis but required for epidermal transformation and tumor cell invasion. Dejan Maglic, Karin Schlegelmilch, Antonella FM Dost, Riccardo Panero, Michael T Dill, Raffaele A Calogero and Fernando D Camargo Published online 23.07.2018 Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling A new class of RIPK2 inhibitors dampen inflammatory signalling in a kinase‐independent manner by blocking RIPK2‐XIAP binding and RIPK2 ubiquitination. Matous Hrdinka, Lisa Schlicher, Bing Dai, Daniel M Pinkas, Joshua C Bufton, Sarah Picaud, Jennifer A Ward, Catherine Rogers, Chalada Suebsuwong, Sameer Nikhar, Gregory D Cuny, Kilian VM Huber, Panagis Filippakopoulos, Alex N Bullock, Alexei Degterev and Mads Gyrd‐Hansen Published online 19.07.2018 Seipin regulates lipid homeostasis by ensuring calcium‐dependent mitochondrial metabolism Loss of SERCA‐interactor Seipin disrupts mitochondrial Ca2+ homeostasis and metabolism, leading to defective lipogenesis in flies and lipodystrophy in patients. Long Ding, Xiao Yang, He Tian, Jingjing Liang, Fengxia Zhang, Guodong Wang, Yingchun Wang, Mei Ding, Guanghou Shui and Xun Huang Published online 26.07.2018 ER‐to‐lysosome‐associated degradation of proteasome‐resistant ATZ polymers occurs via receptor‐mediated vesicular transport Clearance of proteasome‐resistant protein aggregates from the endoplasmic reticulum requires components of the LC3 lipidation machinery but occurs independently of autophagosome formation. Ilaria Fregno, Elisa Fasana, Timothy J Bergmann, Andrea Raimondi, Marisa Loi, Tatiana Soldà, Carmela Galli, Rocco D'Antuono, Diego Morone, Alberto Danieli, Paolo Paganetti, Eelco van Anken and Maurizio Molinari Published online 03.08.2018 Staphylococcus aureus virulence attenuation and immune clearance mediated by a phage lysin‐derived protein The recombinant phage lysin‐derived protein, V12CBD, blocks Staphylococcus aureus virulence and enhances host innate immunity by activating macrophages via the NF‐KB pathway, providing a potential therapeutic candidate for anti‐virulence therapy. Hang Yang, Jingjing Xu, Wuyou Li, Shujuan Wang, Junhua Li, Junping Yu, Yuhong Li and Hongping Wei Published online 23.07.2018 Luteinizing hormone signaling restricts hematopoietic stem cell expansion during puberty Increased expression of the luteinizing hormone receptor in the adult bone marrow ensures normal hematopoiesis and prevents leukemogenesis. Yi Jacky Peng, Hua Yu, Xiaoxin Hao, Wenjie Dong, Xiujuan Yin, Minghui Lin, Junke Zheng and Bo O Zhou Published online 23.07.2018 Atypical APC/C‐dependent degradation of Mcl‐1 provides an apoptotic timer during mitotic arrest By acting in a slow, Cdc20‐independent manner, APC/C‐degradation of apoptotic regulator Mcl‐1 serves as a timer that distinguishes a prolonged mitotic delay from normal mitosis. Lindsey A Allan, Agnieszka Skowyra, Katie I Rogers, Désirée Zeller and Paul R Clarke Published online 09.07.2018 Rtt105 functions as a chaperone for replication protein A to preserve genome stability RPA loading at yeast replication forks is facilitated by Rtt105, which mediates RPA nuclear import and modulates its single‐stranded DNA binding mode. Shuqi Li, Zhiyun Xu, Jiawei Xu, Linyu Zuo, Chuanhe Yu, Pu Zheng, Haiyun Gan, Xuezheng Wang, Longtu Li, Sushma Sharma, Andrei Chabes, Di Li, Sheng Wang, Sihao Zheng, Jinbao Li, Xuefeng Chen, Yujie Sun, Dongyi Xu, Junhong Han, Kuiming Chan, Zhi Qi, Jianxun Feng and Qing Li Published online 31.07.2018 KIF13A‐regulated RhoB plasma membrane localization governs membrane blebbing and blebby amoeboid cell migration Depletion of the kinesin KIF13A causes improper endosomal trafficking of RhoB to the plasma membrane, which in turn inhibits cancer cell 3D‐migration. Xiaowei Gong, Yuliia Didan, John G Lock and Staffan Strömblad Published online 26.07.2018 Neuregulin 3 promotes excitatory synapse formation on hippocampal interneurons Neuregulin 3 and its receptor the tyrosine kinase ErbB4 promote synaptic adhesion to facilitate synaptogenesis and synapse function. Thomas Müller, Stephanie Braud, René Jüttner, Birgit C Voigt, Katharina Paulick, Maria E Sheean, Constantin Klisch, Dilansu Gueneykaya, Fritz G Rathjen, Jörg RP Geiger, James FA Poulet and Carmen Birchmeier Published online 26.07.2018   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.