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TABLE OF CONTENTS
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| September 2018 Volume 25, Issue 9 |
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 |  Correspondence
Meeting Reports
Review Articles
Articles
Technical Reports
Amendments & Corrections
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Review Articles | |
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| Structural basis of mitochondrial transcription pp754 - 765
Hauke S. Hillen, Dmitry Temiakov & Patrick Cramer
doi:10.1038/s41594-018-0122-9
Cramer and colleagues review and discuss how the structural elucidation of transcription factors and functional complexes of human mitochondrial RNA polymerase have informed emerging understanding of the mechanism of mitochondrial gene transcription. |
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Articles | |
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| Smchd1 regulates long-range chromatin interactions on the inactive X chromosome and at Hox clusters pp766 - 777
Natasha Jansz, Andrew Keniry, Marie Trussart, Heidi Bildsoe, Tamara Beck et al.
doi:10.1038/s41594-018-0111-z
In situ Hi-C and other genome-wide and imaging analyses in different mouse embryonic cell types reveal that the noncanonical SMC protein Smchd1 regulates long-range chromatin interactions and the developmental silencing of Hox genes. |
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| Terminal uridylyltransferases target RNA viruses as part of the innate immune system pp778 - 786
Jérémie Le Pen, Hongbing Jiang, Tomás Di Domenico, Emma Kneuss, Joanna Kosałka et al.
doi:10.1038/s41594-018-0106-9
A screen for C. elegans antiviral-defense genes identifies a homolog of the mammalian TUT4(7) terminal uridylyltransferase genes and leads to the discovery of 3′-terminal uridylation of viral RNAs as a conserved antiviral defense mechanism. |
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| Structural determinants of 5-HT2B receptor activation and biased agonism pp787 - 796
John D. McCorvy, Daniel Wacker, Sheng Wang, Bemnat Agegnehu, Jing Liu et al.
doi:10.1038/s41594-018-0116-7
Four crystal structures of the human serotonin receptor 5-HT2BR in complex with chemically and pharmacologically diverse drugs elucidate the structural bases for receptor activation, agonist-mediated biased signaling and β-arrestin2 translocation. |
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| Cryo-EM structures of the human volume-regulated anion channel LRRC8 pp797 - 804
Go Kasuya, Takanori Nakane, Takeshi Yokoyama, Yanyan Jia, Masato Inoue et al.
doi:10.1038/s41594-018-0109-6
Cryo-EM analyses of human LRRC8A show a homohexameric assembly that can adopt two conformations, compact or relaxed, indicating rigid-body motions that might be involved in channel gating. |
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| Structure and gating mechanism of the transient receptor potential channel TRPV3 pp805 - 813
Appu K. Singh, Luke L. McGoldrick & Alexander I. Sobolevsky
doi:10.1038/s41594-018-0108-7
The cryo-electron microscopy structures of the mouse TRPV3 channel, in the closed apo and agonist-bound open conformations, provide insights into the mechanism of activation. |
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| A dynamic three-step mechanism drives the HIV-1 pre-fusion reaction pp814 - 822
Maro Iliopoulou, Rory Nolan, Luis Alvarez, Yasunori Watanabe, Charles A. Coomer et al.
doi:10.1038/s41594-018-0113-x
The interactions between HIV-1 Env and host cell receptors CD4 and CCR5 or CXCR4 are examined using direct stochastic optical reconstruction microscopy and fluorescence fluctuation spectroscopy imaging, revealing a dynamic three-step process leading to formation of the pre-fusion complex. |
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| The nuclear actin-containing Arp8 module is a linker DNA sensor driving INO80 chromatin remodeling pp823 - 832
Kilian R. Knoll, Sebastian Eustermann, Vanessa Niebauer, Elisa Oberbeckmann, Gabriele Stoehr et al.
doi:10.1038/s41594-018-0115-8
X-ray crystal structures and mutational analysis of the Arp8 module of the yeast chromatin remodeler INO80 reveal its function as a linker DNA sensor required for nucleosome positioning. |
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| RNA polymerase II clustering through carboxy-terminal domain phase separation pp833 - 840
Marc Boehning, Claire Dugast-Darzacq, Marija Rankovic, Anders S. Hansen, Taekyung Yu et al.
doi:10.1038/s41594-018-0112-y
In vitro assays and high-resolution microscopy show that Pol II CTD undergoes length-dependent liquid phase separation and controls Pol II clustering and mobility in human cells. |
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| The ZZ domain of p300 mediates specificity of the adjacent HAT domain for histone H3 pp841 - 849
Yi Zhang, Yongming Xue, Jiejun Shi, JaeWoo Ahn, Wenyi Mi et al.
doi:10.1038/s41594-018-0114-9
Structural and biochemical analyses identify the ZZ domain of p300 as a novel histone H3–binding module that promotes p300 chromatin association and is required for selective acetylation of H3K18 and H3K27 in human cells. |
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| Structure of the mechanosensitive OSCA channels pp850 - 858
Mingfeng Zhang, Dali Wang, Yunlu Kang, Jing-Xiang Wu, Fuqiang Yao et al.
doi:10.1038/s41594-018-0117-6
Cryo-EM and electrophysiological studies of two mechanosensitive OSCA channels from Arabidopsis thaliana reveal their structural similarity to osmosensitive TMEM16 channels and suggest they are gated by force from lipid in response to osmotic stress. |
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| Architecture of Pol II(G) and molecular mechanism of transcription regulation by Gdown1 pp859 - 867
Miki Jishage, Xiaodi Yu, Yi Shi, Sai J. Ganesan, Wei-Yi Chen et al.
doi:10.1038/s41594-018-0118-5
Structural, biochemical, and modeling studies reveal how the non-canonical RNA Pol II subunit Gdown1 precludes general transcription factor interactions with Pol II(G) to repress transcriptional activity in the absence of Mediator. |
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| Reconstitution of anaphase DNA bridge recognition and disjunction pp868 - 876
Kata Sarlós, Andreas S. Biebricher, Anna H. Bizard, Julia A. M. Bakx, Anna G. Ferreté-Bonastre et al.
doi:10.1038/s41594-018-0123-8
Single-molecule and biochemistry approaches are used to investigate how ultra-fine DNA bridges, which form between sister chromatids during anaphase, are recognized and processed by cellular factors PICH, BLM, TopoIIIα and RPA. |
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| A single XLF dimer bridges DNA ends during nonhomologous end joining pp877 - 884
Thomas G. W. Graham, Sean M. Carney, Johannes C. Walter & Joseph J. Loparo
doi:10.1038/s41594-018-0120-y
Single-molecule imaging of nonhomologous end joining in Xenopus egg extract reveals that a single XLF dimer aligns broken DNA ends for ligation. |
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| Influenza virus infection causes global RNAPII termination defects pp885 - 893
Nan Zhao, Vittorio Sebastiano, Natasha Moshkina, Nacho Mena, Judd Hultquist et al.
doi:10.1038/s41594-018-0124-7
Influenza A virus (IAV) infection induces transcription termination defects in host cells, an effect modulated by SUMOylation of an intrinsically disordered region of the influenza NS1 protein expressed by the 1918 pandemic IAV strain. |
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Technical Reports | |
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| Genome-wide measurement of local nucleosome array regularity and spacing by nanopore sequencing pp894 - 901
Sandro Baldi, Stefan Krebs, Helmut Blum & Peter B. Becker
doi:10.1038/s41594-018-0110-0
A new approach to map nucleosome array regularity and spacing reveals modulation of array regularity and nucleosome repeat length depending on functional chromatin states. |
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Amendments & Corrections | |
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| Author Correction: Structural basis for the regulation of inositol trisphosphate receptors by Ca2+ and IP3 p902
Navid Paknejad & Richard K. Hite
doi:10.1038/s41594-018-0119-4 |
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