| | | | An abstract drawing from the 73,000-year-old levels at Blombos Cave, South Africa
A silcrete flake with a 73,000-year-old cross-hatched ochre drawing, from Blombos Cave, South Africa, demonstrates that early Homo sapiens used a range of media and techniques to produce graphic representations.
Christopher S. Henshilwood, Francesco d'Errico, Karen L. van Niekerk et al. | Necroptosis microenvironment directs lineage commitment in liver cancer
The tumour microenvironment determines which type of liver cancer develops, with transformed hepatocytes giving rise to intrahepatic cholangiocarcinoma or hepatocellular carcinoma depending on whether they are surrounded by cells undergoing necroptosis or apoptosis.
Marco Seehawer, Florian Heinzmann, Luana D'Artista et al. | Giant and anisotropic many-body spin–orbit tunability in a strongly correlated kagome magnet
The topological magnet Fe3Sn2 exhibits a giant nematic energy shift of a many-body electronic state, demonstrating anisotropic spin–orbit tunability.
Jia-Xin Yin, Songtian S. Zhang, Hang Li et al. | Gene editing reveals the effect of thousands of variants in a key cancer gene
Gene editing has now been used to introduce every possible single-nucleotide mutation into key protein-coding regions in the cancer-predisposition gene BRCA1, to identify the variants that are linked to cancer risk.
Stephen J. Chanock | The electrifying energy of gut microbes
Some bacteria make energy in a process that is accompanied by transfer of electrons to a mineral. A previously unknown electron-transfer pathway now reveals an energy-generation system used by bacteria in the human gut.
Laty A. Cahoon, Nancy E. Freitag | In vivo CRISPR editing with no detectable genome-wide off-target mutations
A strategy developed to define off-target effects of gene-editing nucleases in whole organisms is validated and leveraged to show that CRISPR–Cas9 nucleases can be used effectively in vivo without inducing detectable off-target mutations.
Pinar Akcakaya, Maggie L. Bobbin, Jimmy A. Guo et al. | Touch and tactile neuropathic pain sensitivity are set by corticospinal projections
Somatosensory corticospinal neurons facilitate touch sensitivity and touch-evoked neuropathic pain in mice.
Yuanyuan Liu, Alban Latremoliere, Xinjian Li et al. | Designer proteins activate fluorescent molecules
A computational method has been devised that allows a structural motif found in proteins, known as a β-barrel, to be designed to bind specifically to any small molecule, opening the door to biotechnological applications.
Roberto A. Chica | Accurate classification of BRCA1 variants with saturation genome editing
Germline BRCA1 loss-of-function variants are associated with predisposition to early-onset breast and ovarian cancer; here the authors use CRISPR/Cas9 genome editing to functionally assess thousands of BRCA1 variants in order to facilitate the clinical interpretation of these variants.
Gregory M. Findlay, Riza M. Daza, Beth Martin et al. | A flavin-based extracellular electron transfer mechanism in diverse Gram-positive bacteria
The Gram-positive Listeria monocytogenes pathogen possesses a distinctive extracellular electron transfer mechanism, which is probably present in numerous ecologically diverse species of the Firmcutes phylum.
Samuel H. Light, Lin Su, Rafael Rivera-Lugo et al. | De novo design of a fluorescence-activating β-barrel
The elucidation of general principles for designing β-barrels enables the de novo creation of fluorescent proteins.
Jiayi Dou, Anastassia A. Vorobieva, William Sheffler et al. | A cortical filter that learns to suppress the acoustic consequences of movement
Training of mice to associate a particular sound frequency with locomotion results in selective suppression of cortical responses to that frequency during movement, consistent with a motor-dependent form of auditory cortical plasticity.
David M. Schneider, Janani Sundararajan, Richard Mooney | Neighbourhood deaths cause a switch in cancer subtype
How the same type of cell can form different kinds of tumour isn't always clear. The discovery that cancer subtype in mice is influenced by the type of cell death occurring in the microenvironment provides some insight.
Eli Pikarsky | The genetic basis and cell of origin of mixed phenotype acute leukaemia
A large-scale genomics study shows that the cell of origin and founding mutations determine disease subtype and lead to the expression of multiple haematopoietic lineage-defining antigens in mixed phenotype acute leukaemia.
Thomas B. Alexander, Zhaohui Gu, Ilaria Iacobucci et al. | Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor
The structure of a complex containing calcitonin gene-related peptide, the human calcitonin gene-related peptide receptor and the Gs heterotrimer, determined using Volta phase-plate cryo-electron microscopy, provides structural insight into the regulation of G-protein-coupled receptors by receptor activity modifying protein 1.
Yi-Lynn Liang, Maryam Khoshouei, Giuseppe Deganutti et al. | From the archive
What Nature was saying 50 and 100 years ago.
| A topological source of quantum light
Topologically protected edge states realized in a square array of ring resonators are used to demonstrate a robust source of heralded single photons produced by spontaneous four-wave mixing.
Sunil Mittal, Elizabeth A. Goldschmidt, Mohammad Hafezi | Tracing HIV-1 strains that imprint broadly neutralizing antibody responses
Similarity of antibody responses in HIV-1 transmission pairs reveals a significant impact of the virus genome on imprinting antibody responses.
Roger D. Kouyos, Peter Rusert, Claus Kadelka et al. | Extremely efficient terahertz high-harmonic generation in graphene by hot Dirac fermions
Efficient terahertz harmonic generation—challenging but important for ultrahigh-speed optoelectronic technologies—is demonstrated in graphene through a nonlinear process that could potentially be generalized to other materials.
Hassan A. Hafez, Sergey Kovalev, Jan-Christoph Deinert et al. | Experimental and computational framework for a dynamic protein atlas of human cell division
Quantitative live-cell imaging provides a dynamic protein atlas of mitosis.
Yin Cai, M. Julius Hossain, Jean-Karim Hériché et al. | Coherent encoding of subjective spatial position in visual cortex and hippocampus
When running through a virtual reality corridor, a mouse's position is represented in both the hippocampus (as expected) and the primary visual cortex, for places that are visually identical.
Aman B. Saleem, E. Mika Diamanti, Julien Fournier et al. | | | | | | | | Brief Communications Arising | | | | | Optimized arylomycins are a new class of Gram-negative antibiotics
Chemical optimization of arylomycins results in an inhibitor of bacterial type I signal peptidase that shows activity both against multidrug-resistant clinical isolates of Gram-negative bacteria in vitro and in several in vivo infection models.
Peter A. Smith, Michael F. T. Koehler, Hany S. Girgis et al. | | | Future response of global coastal wetlands to sea-level rise
A global modelling approach shows that in response to rises in global sea level, gains of up to 60% in coastal wetland areas are possible, if appropriate coastal management solutions are developed to help support wetland resilience.
Mark Schuerch, Tom Spencer, Stijn Temmerman et al. | | Stepwise and independent origins of roots among land plants
Meristems of the rooting axes of Asteroxylon mackiei preserved in 407-million-year-old Rhynie chert lack root caps, which demonstrates that the evolution of the root systems of modern vascular plants occurred in a stepwise fashion.
Alexander J. Hetherington, Liam Dolan | | | | | |
No comments:
Post a Comment