| | A homing system targets therapeutic T cells to brain cancer
Therapeutic T cells bearing ligands engineered to optimize adhesion and transmigration through the blood–brain barrier can be targeted to brain tumours.
Heba Samaha, Antonella Pignata, Kristen Fousek et al. | Coupling of bone resorption and formation by RANKL reverse signalling
Osteoclasts secrete small extracellular vesicles that stimulate osteoblasts, promoting bone formation via receptor activator of nuclear factor-kappa B ligand (RANKL), thereby linking bone formation and resorption.
Yuki Ikebuchi, Shigeki Aoki, Masashi Honma et al. | Population dynamics of normal human blood inferred from somatic mutations
Analysis of blood from a healthy human show that haematopoietic stem cells increase rapidly in numbers through early life, reaching a stable plateau in adulthood, and contribute to myeloid and B lymphocyte populations throughout life.
Henry Lee-Six, Nina Friesgaard Øbro, Mairi S. Shepherd et al. | Receptor becomes a ligand to control bone remodelling
The protein RANKL is released by bone-forming cells called osteoblasts, and binds to its receptor, RANK, on osteoclast cells to trigger bone removal. It emerges that the pathway can act in reverse to stimulate bone formation.
Mone Zaidi, Christopher P. Cardozo | Extensive sex differences at the initiation of genetic recombination
Differential DNA methylation and the long-range effects of chromatin organization lead to pronounced differences in recombination landscape between males and females.
Kevin Brick, Sarah Thibault-Sennett, Fatima Smagulova et al. | T cells engineered to home in on brain cancer
Immunotherapies activate T cells to destroy tumours, but the approach has failed in some brain cancers. A strategy to improve migration of T cells across the blood–brain barrier could overcome this limitation.
Michael Platten | A fluid-to-solid jamming transition underlies vertebrate body axis elongation
Cell collectives in embryonic tissues undergo a fluid-to-solid jamming transition, similar to those that occur in soft materials such as foams, emulsions and colloidal suspensions, to physically sculpt the vertebrate body axis.
Alessandro Mongera, Payam Rowghanian, Hannah J. Gustafson et al. | Deterministic teleportation of a quantum gate between two logical qubits
A teleported controlled-NOT gate is realized experimentally between two logical qubits implemented as superconducting cavity quantum memories, thus demonstrating an important tool for universal computation in a quantum modular architecture.
Kevin S. Chou, Jacob Z. Blumoff, Christopher S. Wang et al. | Superluminal motion of a relativistic jet in the neutron-star merger GW170817
Emission from the radio counterpart of the gravitation-wave event GW170817 was powered by a wide-angle outflow at early times, but probably dominated by a narrowly collimated jet at later times.
K. P. Mooley, A. T. Deller, O. Gottlieb et al. | Tissue ‘melting’ sculpts embryo
Collections of cells in the tails of zebrafish embryos have now been found to transition between behaving as solids and fluids. This transition is responsible for the head-to-tail elongation of the embryo.
Pierre-François Lenne, Vikas Trivedi | In vivo reprogramming of wound-resident cells generates skin epithelial tissue
Four transcription factors that specify keratinocyte cell fate, facilitate in vivo reprogramming of wound-resident mesenchymal cells, epithealization and regeneration of skin epithelial tissues in mice.
Masakazu Kurita, Toshikazu Araoka, Tomoaki Hishida et al. | Hundred-fold enhancement in far-field radiative heat transfer over the blackbody limit
Rates of radiative heat transfer between sub-wavelength planar membranes are experimentally and theoretically shown to exceed the blackbody limit in the far field by more than two orders of magnitude.
Dakotah Thompson, Linxiao Zhu, Rohith Mittapally et al. | Precancerous neoplastic cells can move through the pancreatic ductal system
Comparison of multiple lesions from individual pancreases sheds light on how ancestral clones can spread through the ductal system and give rise to precursor lesions, with acquisition of further mutations leading to pancreatic cancer.
Alvin P. Makohon-Moore, Karen Matsukuma, Ming Zhang et al. | An orthogonal proteomic survey uncovers novel Zika virus host factors
Integrative analyses identify host proteins that are modulated by Zika virus at multiple levels and provide a comprehensive framework for the understanding of Zika virus-induced changes to cellular pathways.
Pietro Scaturro, Alexey Stukalov, Darya A. Haas et al. | Phosphocode-dependent functional dichotomy of a common co-receptor in plant signalling
The plant receptor kinase co-receptor BAK1 contains phosphosites that are required for immune function but not for brassinosteroid-regulated growth in Arabidopsis thaliana; an additional tyrosine phosphosite may be required for the function of many Arabidopsis receptor kinases.
Artemis Perraki, Thomas A. DeFalco, Paul Derbyshire et al. | | | | | | 
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Linda Partridge, Joris Deelen, P. Eline Slagboom | | | Malaria parasite translocon structure and mechanism of effector export
Cryo-electron microscopy analysis of the purified Plasmodium translocon of exported proteins (PTEX) reveals two distinct resolved states, suggesting a mechanism by which Plasmodium falciparum exports malarial effector proteins into erythrocytes.
Chi-Min Ho, Josh R. Beck, Mason Lai et al. | | | All-inorganic perovskite nanocrystal scintillators
All-inorganic perovskite nanocrystals containing caesium and lead provide low-cost, flexible and solution-processable scintillators that are highly sensitive to X-ray irradiation and emit radioluminescence that is colour-tunable across the visible spectrum.
Qiushui Chen, Jing Wu, Xiangyu Ou et al. | | Sulfoxaflor exposure reduces bumblebee reproductive success
Chronic exposure to sulfoxaflor (a sulfoximine-based insecticide) has severe sub-lethal effects on bumblebee (Bombus terrestris) colonies; exposed colonies produced fewer workers and fewer reproductive offspring than unexposed control colonies.
Harry Siviter, Mark J. F. Brown, Ellouise Leadbeater | | | | | |
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