Nature Communications - 12 September 2018

Advertisement Asia Pacific Vascular Biology Organization Conference, May 9-12, 2019, Guangzhou, China. Register Now.  More than thirty-four international renowned top speakers. Zhongshan Ophthalmic Center (ZOC), the largest eye hospital in China; the State Key Laboratory of Ophthalmology (SKLO), the only one of its kind in China; and the Asia Pacific Vascular Biology Organization (APVBO).     Weekly Content Alert Nature Communications is fully open access. Read more. 12 September 2018  Latest content: Editorial Comment Articles Author Corrections Publisher Corrections Advertisement   Advanced Imaging with Proven Optics Olympus is dedicated to your work, vision, and science. Through innovation and service, we seek to aide in your discoveries, advance your research, and inspire you to explore new possibilities. Our wide range of microscopes are built with the optical excellence and proven application expertise you can depend on. Your Science Matters™. > Learn more about Olympus microscopes Journal homepage Recommend to library Web feed   Advertisement Communications Physics: Open for Submissions Communications Physics is a new open access journal that publishes high-quality primary research articles, reviews and commentary representing significant advances and new insights to the field of physics. The journal is now open for submissions. Find out more >>     Latest Editorial       Reproducibility: let’s get it right from the start OPEN 12 September 2018 | doi: 10.1038/s41467-018-06012-8     Latest Comment       Europe’s renewable energy directive poised to harm global forests OPEN Timothy D. Searchinger, Tim Beringer, Bjart Holtsmark, Daniel M. Kammen, Eric F. Lambin, Wolfgang Lucht, Peter Raven & Jean-Pascal van Ypersele 12 September 2018 | doi: 10.1038/s41467-018-06175-4 Carbon cycle  Climate sciences  Environmental sciences  Forest ecology      Latest Articles View all Articles     Bioinspired 3D structures with programmable morphologies and motions OPEN Amirali Nojoomi, Hakan Arslan, Kwan Lee & Kyungsuk Yum Spatially controlled expansion and contraction of soft tissues to achieve complex three dimensional morphologies remains challenging in man-made materials. Here the authors demonstrate encoding of 2D hydrogels with spatially and temporally controlled growth to create dynamic 3D structures. 12 September 2018 | doi: 10.1038/s41467-018-05569-8 Bioinspired materials  Gels and hydrogels  Mechanical engineering  Superconducting metamaterials for waveguide quantum electrodynamics OPEN Mohammad Mirhosseini, Eunjong Kim, Vinicius S. Ferreira, Mahmoud Kalaee, Alp Sipahigil, Andrew J. Keller & Oskar Painter Metamaterials remain relatively unexplored in quantum optics. Here, the authors couple a transmon qubit to a superconducting metamaterial with a deep sub-wavelength lattice constant and probe the coherent and dissipative dynamics of the system by measuring the Lamb shift and radiative lifetime of the qubit. 12 September 2018 | doi: 10.1038/s41467-018-06142-z Metamaterials  Qubits  Superconducting devices  Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer OPEN Liwei Cao, Matthias Pauthner, Raiees Andrabi, Kimmo Rantalainen, Zachary Berndsen, Jolene K. Diedrich, Sergey Menis, Devin Sok, Raiza Bastidas, Sung-Kyu Robin Park, Claire M. Delahunty, Lin He, Javier Guenaga, Richard T. Wyatt, William R. Schief, Andrew B. Ward, John R. Yates III, Dennis R. Burton & James C. Paulson HIV envelope (Env) is a potential vaccine antigen and its N-glycans are part of the epitope of broadly neutralizing antibodies. Here, the authors show that glycosylation of Env from infectious virus closely matches Env from recombinant membrane-bound trimers, while it differs significantly from recombinant soluble, cleaved Env trimers. 12 September 2018 | doi: 10.1038/s41467-018-06121-4 Glycobiology  HIV infections  Vaccines  Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes OPEN Brett M. Stevens, Nabilah Khan, Angelo D’Alessandro, Travis Nemkov, Amanda Winters, Courtney L. Jones, Wei Zhang, Daniel A. Pollyea & Craig T. Jordan Myelodysplastic syndrome (MDS) arises from mutations in hematopoietic stem cells (HSCs). Here, the authors demonstrate that HSCs in higher-risk MDS express the surface marker CD123 and are characterized by activation of protein synthesis machinery and increased oxidative phosphorylation. 12 September 2018 | doi: 10.1038/s41467-018-05984-x Cell biology  Diseases  Medical research  Molecular biology  Stem cells  Evolution of the quantum Hall bulk spectrum into chiral edge states OPEN T. Patlatiuk, C. P. Scheller, D. Hill, Y. Tserkovnyak, G. Barak, A. Yacoby, L. N. Pfeiffer, K. W. West & D. M. Zumbühl The evolution of the quantum Hall state from bulk spectrum to edge state remains obscure. Here, Patlatiuk and Scheller et al. observe magnetic compression against a hard edge followed by motion into the bulk and depopulation of the integer quantum Hall edge states, in agreement with the bulk-to-edge correspondence. 12 September 2018 | doi: 10.1038/s41467-018-06025-3 Electronic and spintronic devices  Electronic devices  Quantum Hall  Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses OPEN Kate M. Smith, Sofiya Tsimbalyuk, Megan R. Edwards, Emily M. Cross, Jyoti Batra, Tatiana P. Soares da Costa, David Aragão, Christopher F. Basler & Jade K. Forwood Importin α isoforms regulate the nuclear import of different cargo proteins but the mechanisms conferring isoform specificity are not fully understood. Here, the authors study the interactions of importin α1 and α3 with two viral cargos, elucidating the structural basis for isoform-specific cargo recognition. 12 September 2018 | doi: 10.1038/s41467-018-05928-5 Transport receptors  X-ray crystallography  STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas OPEN Yi-Ru Pan, Chih-Cheng Chen, Yu-Tien Chan, Hsiao-Jung Wang, Fan-Tso Chien, Yeng-Long Chen, Jing-Lan Liu & Muh-Hwa Yang The mechanism underlying the dissemination of diffuse large B-cell lymphoma (DLBCL) is unclear. Here, the authors show that STAT3 controls amoeboid migration in DLBCL via the transcriptional activation of RHOH, which then releases RhoA from RhoGDIγ-mediated suppression, or via regulating microtubule dynamics to activate RhoA. 12 September 2018 | doi: 10.1038/s41467-018-06134-z Cell migration  Lymphoma  Factors of the bone marrow microniche that support human plasma cell survival and immunoglobulin secretion OPEN Doan C. Nguyen, Swetha Garimalla, Haopeng Xiao, Shuya Kyu, Igor Albizua, Jacques Galipeau, Kuang-Yueh Chiang, Edmund K. Waller, Ronghu Wu, Greg Gibson, James Roberson, Frances E. Lund, Troy D. Randall, Iñaki Sanz & F. Eun-Hyung Lee Antibody-secreting cells (ASC) such as plasma cells must migrate to the bone marrow to survive, but microniche elements that promote survival are unknown. Here the authors define specific factors from the microniche that can maintain ASC in vitro for over 50 days, involving MSC secretome proteins, APRIL, and hypoxic conditions. 12 September 2018 | doi: 10.1038/s41467-018-05853-7 Antibodies  Immunological memory  Neuronal heterogeneity and stereotyped connectivity in the auditory afferent system OPEN Charles Petitpré, Haohao Wu, Anil Sharma, Anna Tokarska, Paula Fontanet, Yiqiao Wang, Françoise Helmbacher, Kevin Yackle, Gilad Silberberg, Saida Hadjab & François Lallemend Spiral ganglion neurons (SGNs) of the cochlea receive input from hair cells and project to the auditory brainstem. Here, the authors perform single-cell RNA sequencing to identify four SGN subclasses and characterize their molecular profile, electrophysiological properties and connectivity. 12 September 2018 | doi: 10.1038/s41467-018-06033-3 Cell biology  Cochlea  Computational biology and bioinformatics  Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing OPEN Muhammad Shoaib, David Walter, Peter J. Gillespie, Fanny Izard, Birthe Fahrenkrog, David Lleres, Mads Lerdrup, Jens Vilstrup Johansen, Klaus Hansen, Eric Julien, J. Julian Blow & Claus S. Sørensen Cell cycle and replication need to be tightly regulated to ensure genome stability in mammalian cells. Here the authors provide a link between chromatin structure and DNA replication regulation by showing that chromatin compaction limits replication licensing thereby promoting genome integrity. 12 September 2018 | doi: 10.1038/s41467-018-06066-8 Chromatin structure  Methylation  Speed dependent descending control of freezing behavior in Drosophila melanogaster OPEN Ricardo Zacarias, Shigehiro Namiki, Gwyneth M. Card, Maria Luisa Vasconcelos & Marta A. Moita Looming discs are perceived as an innate threat by flies and elicit a survival response. Here, the authors report that flies exhibit either an escape or freezing response depending on their walking speed and identify the involvement of a pair of neurons in mediating the behavior. 12 September 2018 | doi: 10.1038/s41467-018-05875-1 Behavioural genetics  Neuroscience  Recurrent circuits within medial entorhinal cortex superficial layers support grid cell firing OPEN Ipshita Zutshi, Maylin L. Fu, Varoth Lilascharoen, Jill K. Leutgeb, Byung Kook Lim & Stefan Leutgeb Medial entorhinal cortex (mEC) neurons encode various navigation parameters such as speed, head direction, as well as grid cells. Here, the authors demonstrate that brief disruption of the local activity in mEC specifically affects grid cell tuning. 12 September 2018 | doi: 10.1038/s41467-018-06104-5 Learning and memory  Neural circuits  Augmentation of vaccine-induced humoral and cellular immunity by a physical radiofrequency adjuvant OPEN Yan Cao, Xiaoyue Zhu, Md Nazir Hossen, Prateek Kakar, Yiwen Zhao & Xinyuan Chen Vaccine adjuvants ensure sufficient engagement of the immune system in vaccination, however safety issues can be associated with novel chemical adjuvants. Here, Cao et al. report a physical radiofrequency adjuvant to simultaneously augment vaccine-induced humoral and cellular immune responses without potentially harmful adverse reactions. 12 September 2018 | doi: 10.1038/s41467-018-06151-y Adjuvants  Biological physics  Preclinical research  Brain and psychological determinants of placebo pill response in chronic pain patients OPEN Etienne Vachon-Presseau, Sara E. Berger, Taha B. Abdullah, Lejian Huang, Guillermo A. Cecchi, James W. Griffith, Thomas J. Schnitzer & A. Vania Apkarian People vary in the extent to which they feel better after taking an inert, placebo, treatment, but the basis for individual placebo response is unclear. Here, the authors show how brain structural and functional variables, as well as personality traits, predict placebo response in those with chronic back pain. 12 September 2018 | doi: 10.1038/s41467-018-05859-1 Biomarkers  Cognitive neuroscience  Human behaviour  Pain  Dendritic defect-rich palladium–copper–cobalt nanoalloys as robust multifunctional non-platinum electrocatalysts for fuel cells OPEN Chaozhong Li, Qiang Yuan, Bing Ni, Ting He, Siming Zhang, Yong Long, Lin Gu & Xun Wang Fuel cells are promising for sustainable energy generation, but are limited by the performance of electrocatalysts. Here the authors synthesize dendritic palladium–copper–cobalt nanoalloys with electrocatalytic activity for oxygen reduction and formic acid oxidation as well as alcohol tolerance. 12 September 2018 | doi: 10.1038/s41467-018-06043-1 Electrocatalysis  Structural properties  Glutamic acid is a carrier for hydrazine during the biosyntheses of fosfazinomycin and kinamycin OPEN Kwo-Kwang A. Wang, Tai L. Ng, Peng Wang, Zedu Huang, Emily P. Balskus & Wilfred A. van der Donk The natural products fosfazinomycin A and kinamycin D are structurally distinct except for a nitrogen-nitrogen (N-N) bond. Here, the authors show that fosfazinomycin and kinamycin share a common pathway for N-N bond formation that is different from pathways found for other natural products. 11 September 2018 | doi: 10.1038/s41467-018-06083-7 Biocatalysis  Enzyme mechanisms  Inducing drop to bubble transformation via resonance in ultrasound OPEN Duyang Zang, Lin Li, Wenli Di, Zehui Zhang, Changlin Ding, Zhen Chen, Wei Shen, Bernard P. Binks & Xingguo Geng Bubbles tend to burst and retract into droplets. Here the authors show how a droplet can be turned into a bubble by levitating the droplets acoustically and exploiting their buckling to form gas bubbles. 11 September 2018 | doi: 10.1038/s41467-018-05949-0 Fluid dynamics  Fluids  Phosphoproteomic-based kinase profiling early in influenza virus infection identifies GRK2 as antiviral drug target OPEN Emilio Yángüez, Annika Hunziker, Maria Pamela Dobay, Soner Yildiz, Simon Schading, Elizaveta Elshina, Umut Karakus, Peter Gehrig, Jonas Grossmann, Ronald Dijkman, Mirco Schmolke & Silke Stertz Influenza A virus (IAV) causes annual epidemics and development of antivirals is needed. Here, the authors perform phosphoproteomics during IAV entry and identify GRK2 as drug target, inhibition of which decreases replication of seasonal and pandemic IAV in primary human cells and animal models. 11 September 2018 | doi: 10.1038/s41467-018-06119-y Antiviral agents  Influenza virus  Kinases  Proteomics  Reviving the Weizmann process for commercial n-butanol production OPEN Ngoc-Phuong-Thao Nguyen, Céline Raynaud, Isabelle Meynial-Salles & Philippe Soucaille Organic solvent n-butanol is produced mainly by petrochemical method. Here, the authors revive the historical Weizmann process by engineering Clostridium acetobutylicum strain and developing low pressure distillation and high cell density cultures for n-butanol continuous production at high-yield titer and productivity. 11 September 2018 | doi: 10.1038/s41467-018-05661-z Metabolic engineering  Size-dependent loss of aboveground animals differentially affects grassland ecosystem coupling and functions OPEN A. C. Risch, R. Ochoa-Hueso, W. H. van der Putten, J. K. Bump, M. D. Busse, B. Frey, D. J. Gwiazdowicz, D. S. Page-Dumroese, M. L. Vandegehuchte, S. Zimmermann & M. Schütz Defaunation can have impacts on ecosystem functioning that are currently little understood. Using an exclusion experiment, Risch et al. show the impacts of vertebrate and invertebrate losses on ecosystem coupling, particularly emphasising the role of invertebrates in ecosystem functioning. 11 September 2018 | doi: 10.1038/s41467-018-06105-4 Biodiversity  Ecological networks  Ecology  Ecosystem ecology  Grassland ecology  The Swr1 chromatin-remodeling complex prevents genome instability induced by replication fork progression defects OPEN Anjana Srivatsan, Bin-Zhong Li, Barnabas Szakal, Dana Branzei, Christopher D. Putnam & Richard D. Kolodner SWR-C and its substrate the histone variant Htz1 are considered important for genome maintenance. Here the authors reveal that SWR-C/Htz1 plays a critical role during replication stress caused by absence of the replication fork progression proteins Mrc1/Tof1/Csm3. 11 September 2018 | doi: 10.1038/s41467-018-06131-2 DNA damage checkpoints  Genomic instability  Stalled forks  Exome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations OPEN Jiang Chang, Jianbo Tian, Ying Zhu, Rong Zhong, Kan Zhai, Jiaoyuan Li, Juntao Ke, QiangQiang Han, Jiao Lou, Wei Chen, Beibei Zhu, Na Shen, Yi Zhang, Yajie Gong, Yang Yang, Danyi Zou, Xiating Peng, Zhi Zhang, Xuemei Zhang, Kun Huang et al. Pancreatic ductal adenocarcinoma is a lethal human cancer with a poor 5-year overall survival rate. Here the authors perform an exome-wide analysis in a cohort of PDAC patients to identify three novel missense variants in PKN1, DOK2, and APOB genes, that are associated with PDAC risk. 11 September 2018 | doi: 10.1038/s41467-018-06136-x Genome-wide association studies  Pancreatic cancer  Gravimetry through non-linear optomechanics OPEN Sofia Qvarfort, Alessio Serafini, P. F. Barker & Sougato Bose Precise gravimetric measurements are an important but challenging task. Here, Qvarfort et al. theoretically show that, in an optomechanical cavity, only the phase of the optical output needs to be measured to obtain a precise value for the gravitational acceleration with high sensitivity. 11 September 2018 | doi: 10.1038/s41467-018-06037-z Optical metrology  Optomechanics  Quantum metrology  Critical Southern Ocean climate model biases traced to atmospheric model cloud errors OPEN Patrick Hyder, John M. Edwards, Richard P. Allan, Helene T. Hewitt, Thomas J. Bracegirdle, Jonathan M. Gregory, Richard A. Wood, Andrew J. S. Meijers, Jane Mulcahy, Paul Field, Kalli Furtado, Alejandro Bodas-Salcedo, Keith D. Williams, Dan Copsey, Simon A. Josey, Chunlei Liu, Chris D. Roberts, Claudio Sanchez, Jeff Ridley, Livia Thorpe et al. The Southern Ocean is critically important for global climate yet poorly represented by climate models. Here the authors trace sea surface temperature biases in this region to cloud-related errors in atmospheric-model simulated surface heat fluxes and provide a pathway to improve the models. 11 September 2018 | doi: 10.1038/s41467-018-05634-2 Atmospheric dynamics  Physical oceanography  Projection and prediction  GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation OPEN Steven Offenbacher, Yizu Jiao, Steven J. Kim, Julie Marchesan, Kevin L. Moss, Li Jing, Kimon Divaris, Sompop Bencharit, Cary S. Agler, Thiago Morelli, Shaoping Zhang, Lu Sun, William T. Seaman, Dale Cowley, Silvana P. Barros, James D. Beck, Matthias Munz, Arne S. Schaefer & Kari E. North IL-1β in gingival crevicular fluid (GCF) is a marker of inflammation in periodontal disease. Here, Offenbacher et al. identify genetic variants in the IL37 locus associated with GCF-IL-1β and show that the IL-1β-increasing allele at rs3811046 leads to an enhanced inflammatory response in vitro and in vivo. 11 September 2018 | doi: 10.1038/s41467-018-05940-9 Genome-wide association studies  Interleukins  Periodontitis  Risk factors  GraphDDP: a graph-embedding approach to detect differentiation pathways in single-cell-data using prior class knowledge OPEN Fabrizio Costa, Dominic Grün & Rolf Backofen Inference and representation of differentiation trajectories from single cell RNA-seq data remains a challenge. Here, the authors offer a visualization approach that captures both continuous differentiation trajectories and discrete clusters representing metastable states along the trajectories. 11 September 2018 | doi: 10.1038/s41467-018-05988-7 Computational models  Data processing  High-throughput screening  Large intrinsic anomalous Hall effect in half-metallic ferromagnet Co3Sn2S2 with magnetic Weyl fermions OPEN Qi Wang, Yuanfeng Xu, Rui Lou, Zhonghao Liu, Man Li, Yaobo Huang, Dawei Shen, Hongming Weng, Shancai Wang & Hechang Lei The large intrinsic anomalous Hall effect (AHE) in magnetic Weyl semimetals is expected but rarely verified experimentally. Here, Wang et al. report large intrinsic AHE with linear dependence on magnetization in a half-metallic ferromagnet Co3Sn2S2 single crystal with Kagome lattice of Co atoms, arising dominantly from the Weyl fermions. 11 September 2018 | doi: 10.1038/s41467-018-06088-2 Electronic properties and materials  Ferromagnetism  Topological insulators  Understanding 6th-century barbarian social organization and migration through paleogenomics OPEN Carlos Eduardo G. Amorim, Stefania Vai, Cosimo Posth, Alessandra Modi, István Koncz, Susanne Hakenbeck, Maria Cristina La Rocca, Balazs Mende, Dean Bobo, Walter Pohl, Luisella Pejrani Baricco, Elena Bedini, Paolo Francalacci, Caterina Giostra, Tivadar Vida, Daniel Winger, Uta von Freeden, Silvia Ghirotto, Martina Lari, Guido Barbujani et al. The Longobards invaded and conquered much of Italy after the fall of the Western Roman Empire. Here, the authors sequence and analyze ancient genomic DNA from 63 samples from two cemeteries associated with the Longobards and identify kinship networks and two distinct genetic and cultural groups in each. 11 September 2018 | doi: 10.1038/s41467-018-06024-4 Archaeology  History  Interdisciplinary studies  Population genetics  Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis OPEN Haibo Wang, Wenting Guo, Joy Mitra, Pavana M. Hegde, Tijs Vandoorne, Bradley J. Eckelmann, Sankar Mitra, Alan E. Tomkinson, Ludo Van Den Bosch & Muralidhar L. Hegde Impairment of DNA repair has been associated with neurodegeneration. Here the authors investigate the mechanisms of defects in repair caused by mutations in the RNA/DNA binding protein FUS in amyotrophic lateral sclerosis and elucidate its role in the DNA ligation during DNA single-strand break repair of oxidative breaks. 11 September 2018 | doi: 10.1038/s41467-018-06111-6 Cell death in the nervous system  DNA damage and repair  Molecular neuroscience  Neuroscience  Microbial metabolite sensor GPR43 controls severity of experimental GVHD OPEN Hideaki Fujiwara, Melissa D. Docampo, Mary Riwes, Daniel Peltier, Tomomi Toubai, Israel Henig, S. Julia Wu, Stephanie Kim, Austin Taylor, Stuart Brabbs, Chen Liu, Cynthia Zajac, Katherine Oravecz-Wilson, Yaping Sun, Gabriel Núñez, John E. Levine, Marcel R.M. van den Brink, James L. M. Ferrara & Pavan Reddy The microbial metabolite sensor GPR43 has been previously shown to be a crucial modulator of immune responses. Here the authors show GPR43 is required for controlling disease pathology severity in the context of experimental models of GVHD. 10 September 2018 | doi: 10.1038/s41467-018-06048-w Bone marrow transplantation  Graft-versus-host disease  Translational immunology  Transplant immunology  The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature OPEN Gareth J. Inman, Jun Wang, Ai Nagano, Ludmil B. Alexandrov, Karin J. Purdie, Richard G. Taylor, Victoria Sherwood, Jason Thomson, Sarah Hogan, Lindsay C. Spender, Andrew P. South, Michael Stratton, Claude Chelala, Catherine A. Harwood, Charlotte M. Proby & Irene M. Leigh It is known cutaneous squamous cell carcinoma (cSCC) involves a high tumour mutation burden. Here the authors identify common cSCC mutated genes, copy number changes, altered pathways and report the presence of a novel mutation signature associated with chronic exposure to the immunosuppressive drug azathioprine. 10 September 2018 | doi: 10.1038/s41467-018-06027-1 Cancer genomics  Squamous cell carcinoma  Entanglement and teleportation between polarization and wave-like encodings of an optical qubit OPEN Demid V. Sychev, Alexander E. Ulanov, Egor S. Tiunov, Anastasia A. Pushkina, A. Kuzhamuratov, Valery Novikov & A. I. Lvovsky Interfacing quantum information between discrete and continuous would allow exploiting the best of both worlds, but it has been shown only for single-rail encoding. Here, the authors extend this to the more practical dual-rail encoding, realizing teleportation between a polarization qubit and a CV qubit. 10 September 2018 | doi: 10.1038/s41467-018-06055-x Quantum information  Quantum optics  Qubits  Single photons and quantum effects  Different patterns of clonal evolution among different sarcoma subtypes followed for up to 25 years OPEN Jakob Hofvander, Björn Viklund, Anders Isaksson, Otte Brosjö, Fredrik Vult von Steyern, Pehr Rissler, Nils Mandahl & Fredrik Mertens Hofvander and colleagues compare the patterns of clonal evolution in different pathogenetic subgroups of sarcoma. They show that sarcomas driven by gene fusion or amplification display few additional changes over time, whereas sarcomas with complex karyotypes show a gradual increase of nucleotide- and chromosome-level mutations. 10 September 2018 | doi: 10.1038/s41467-018-06098-0 Cancer  Genetics  Molecular biology  Oncology  Sarcoma  AIP1 and cofilin ensure a resistance to tissue tension and promote directional cell rearrangement OPEN Keisuke Ikawa & Kaoru Sugimura Cells must resist or release tension/compression when proliferating and moving during development. Here the authors show that AIP1, together with cofilin, promotes local actin turnover to regulate linkage between actomyosin and cell junctions and resist mechanical load imposed by tissue stretching. 10 September 2018 | doi: 10.1038/s41467-018-05605-7 Cytoskeleton  Morphogenesis  ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes OPEN HRD1 is an E3 ligase known to play a role in targeting degradation of misfolded proteins in the ER. Here the authors show that HRD1 interacts with metabolic enzymes and its liver specific deficiency results in lower body weight, blood glucose and plasma lipids during high fat diet in mice. 10 September 2018 | doi: 10.1038/s41467-018-06091-7 Obesity  Ubiquitin ligases  Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD OPEN Mark L. Schultz, Kelsey L. Krus, Susmita Kaushik, Derek Dang, Ravi Chopra, Ling Qi, Vikram G. Shakkottai, Ana Maria Cuervo & Andrew P. Lieberman Niemann-Pick type C1 disease is most commonly caused by the allele NPC1 I1061T, which is misfolded in the ER and rapidly degraded by the ubiquitin proteasome system. Here the authors show that the I1061T mutant is also degraded by ER-phagy. 10 September 2018 | doi: 10.1038/s41467-018-06115-2 Autophagy  Lipid-storage diseases  Mechanisms of disease  Conserved collateral antibiotic susceptibility networks in diverse clinical strains of Escherichia coli OPEN Nicole L. Podnecky, Elizabeth G. A. Fredheim, Julia Kloos, Vidar Sørum, Raul Primicerio, Adam P. Roberts, Daniel E. Rozen, Ørjan Samuelsen & Pål J. Johnsen Resistance to one antibiotic can in some cases increase susceptibility to other antibiotics. Here, Podnecky et al. study these collateral responses in E. coli clinical isolates and show that efflux-related resistance mechanisms and relative fitness of the strains are principal contributors to this phenomenon. 10 September 2018 | doi: 10.1038/s41467-018-06143-y Antimicrobial resistance  Bacteriology  Microbiology  Dynamics of cellular states of fibro-adipogenic progenitors during myogenesis and muscular dystrophy OPEN Barbora Malecova, Sole Gatto, Usue Etxaniz, Magda Passafaro, Amy Cortez, Chiara Nicoletti, Lorenzo Giordani, Alessio Torcinaro, Marco De Bardi, Silvio Bicciato, Francesca De Santa, Luca Madaro & Pier Lorenzo Puri Fibro-adipogenic progenitors (FAPs) resident in skeletal muscle are involved in both regeneration and maladaptive processes. Here, the authors identify subpopulations of FAPs with biological activities implicated in physiological muscle repair that are altered in pathological conditions such as muscular dystrophies. 10 September 2018 | doi: 10.1038/s41467-018-06068-6 Cell biology  Skeletal muscle  Transcriptomics  Gut fungal dysbiosis correlates with reduced efficacy of fecal microbiota transplantation in Clostridium difficile infection OPEN Tao Zuo, Sunny H. Wong, Chun Pan Cheung, Kelvin Lam, Rashid Lui, Kitty Cheung, Fen Zhang, Whitney Tang, Jessica Y. L. Ching, Justin C. Y. Wu, Paul K. S. Chan, Joseph J. Y. Sung, Jun Yu, Francis K. L. Chan & Siew C. Ng Fecal microbiota transplantation (FMT) is effective in treating recurrent Clostridium difficile infection (CDI). Here, the authors show that the composition of the gut fungal microbiota of donors and recipients, and especially the abundance of Candida, correlates with FMT outcome in CDI patients. 10 September 2018 | doi: 10.1038/s41467-018-06103-6 Dysbiosis  Fungal host response  Translational research  CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury OPEN Injuries in the embryonal kidney can be repaired by a cell migratory response but how this is regulated at a molecular level is unclear. Here, the authors show in mice that deletion of Cxcl12 and Myc delays pronephros injury repair by changing mitochondrial metabolism and glycolysis. 10 September 2018 | doi: 10.1038/s41467-018-06094-4 Developmental biology  Nephrons  SMRT-Cappable-seq reveals complex operon variants in bacteria OPEN Bo Yan, Matthew Boitano, Tyson A. Clark & Laurence Ettwiller Fragmentation of transcripts can hide operon complexity in genome-wide transcriptome sequencing. Here the authors sequenced a prokaryotic transcriptome using PacBio and provide insights into operon structure and read-through at termination sites. 10 September 2018 | doi: 10.1038/s41467-018-05997-6 Bacterial transcription  Gene expression  A fully protected hydrogenase/polymer-based bioanode for high-performance hydrogen/glucose biofuel cells OPEN Adrian Ruff, Julian Szczesny, Nikola Marković, Felipe Conzuelo, Sónia Zacarias, Inês A. C. Pereira, Wolfgang Lubitz & Wolfgang Schuhmann Hydrogenases are promising alternatives to noble metal-based catalysts for hydrogen oxidation. Here the authors fully protect air-sensitive hydrogenases from high potential and oxygen damage using a polymer multilayer bioanode in a biofuel cell that delivers a benchmark open circuit voltage. 10 September 2018 | doi: 10.1038/s41467-018-06106-3 Biocatalysis  Energy  Fuel cells  A PECTIN METHYLESTERASE gene at the maize Ga1 locus confers male function in unilateral cross-incompatibility OPEN Zhaogui Zhang, Baocai Zhang, Zhibin Chen, Dongmei Zhang, Huairen Zhang, Hang Wang, Yu’e Zhang, Darun Cai, Juan Liu, Senlin Xiao, Yanqing Huo, Jie Liu, Lanjun Zhang, Mingming Wang, Xu Liu, Yongbiao Xue, Li Zhao, Yihua Zhou & Huabang Chen Unilateral cross-incompatibility between certain varieties of maize prevents cross-fertilization and can facilitate hybrid breeding. Here the authors show that a PECTIN METHYLESTERASE gene is able to overcome this reproductive barrier and confer fertility when expressed in pollen of the male parent. 10 September 2018 | doi: 10.1038/s41467-018-06139-8 Agricultural genetics  Fertilization  Plant breeding  Structure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component OPEN Jialing Wang, Shuai Yuan, Dongjie Zhu, Hao Tang, Nan Wang, Wenyuan Chen, Qiang Gao, Yuhua Li, Junzhi Wang, Hongrong Liu, Xinzheng Zhang, Zihe Rao & Xiangxi Wang Herpes simplex virus type-2 (HSV-2) belongs to the α-herpesvirinae subfamily and is a sexually transmitted virus that causes genital ulcer disease. Here the authors present the 3.75 Å cryo-EM structure of the HSV-2 C-capsid with capsid-vertex-specific component and describe α-herpesvirus-specific structural features. 10 September 2018 | doi: 10.1038/s41467-018-06078-4 Cryoelectron microscopy  Herpes virus  PoreDesigner for tuning solute selectivity in a robust and highly permeable outer membrane pore OPEN Ratul Chowdhury, Tingwei Ren, Manish Shankla, Karl Decker, Matthew Grisewood, Jeevan Prabhakar, Carol Baker, John H. Golbeck, Aleksei Aksimentiev, Manish Kumar & Costas D. Maranas Monodisperse angstrom-sized membrane proteins, found in biological membranes, are difficult to implement in synthetic industrial membranes. Here authors present a pore design procedure, to redesign the robust beta-barrel Outer Membrane Protein F (OmpF) with specific solute selectivity. 10 September 2018 | doi: 10.1038/s41467-018-06097-1 Computational biology and bioinformatics  Membrane proteins  Protein design  Contribution of allelic imbalance to colorectal cancer OPEN Kimmo Palin, Esa Pitkänen, Mikko Turunen, Biswajyoti Sahu, Päivi Pihlajamaa, Teemu Kivioja, Eevi Kaasinen, Niko Välimäki, Ulrika A. Hänninen, Tatiana Cajuso, Mervi Aavikko, Sari Tuupanen, Outi Kilpivaara, Linda van den Berg, Johanna Kondelin, Tomas Tanskanen, Riku Katainen, Marta Grau, Heli Rauanheimo, Roosa-Maria Plaketti et al. In this study the authors examine the allelic imbalance (AI) landscape of colorectal cancer, reporting loss of TP53 as a driver of AI. They use CRISPR-Cas9 screens to identify 79 genes (within AI regions) regulating cell growth and identify a network of transcription factors that may contribute to colorectal tumorigenesis. 10 September 2018 | doi: 10.1038/s41467-018-06132-1 Cancer genetics  Cancer genomics  Colorectal cancer  Molecular basis for disassembly of an importin:ribosomal protein complex by the escortin Tsr2 OPEN Sabina Schütz, Erich Michel, Fred F. Damberger, Michaela Oplová, Cohue Peña, Alexander Leitner, Ruedi Aebersold, Frederic H.-T. Allain & Vikram Govind Panse Ribosomal proteins are transported to the nucleus with the help of importins, from which they are released prior to incorporation into the nascent ribosome. Here the authors report the NMR structure of the ribosomal protein eS26 in complex with the escortin Tsr2 and shed light on the mechanism of eS26 release from importin. 10 September 2018 | doi: 10.1038/s41467-018-06160-x NMR spectroscopy  Ribosomal proteins  RNA  RNA-binding proteins  Deglacial mobilization of pre-aged terrestrial carbon from degrading permafrost OPEN Maria Winterfeld, Gesine Mollenhauer, Wolf Dummann, Peter Köhler, Lester Lembke-Jene, Vera D. Meyer, Jens Hefter, Cameron McIntyre, Lukas Wacker, Ulla Kokfelt & Ralf Tiedemann Permafrost-derived carbon (C) may have been an additional source of greenhouse gases during the last glacial-interglacial transition. Here the authors show that ancient C from degrading permafrost was mobilised during phases of rapid sea-level rise, partially explaining changes in atmospheric CO2 and ∆14C. 10 September 2018 | doi: 10.1038/s41467-018-06080-w Carbon cycle  Cryospheric science  Coordinated collective migration and asymmetric cell division in confluent human keratinocytes without wounding OPEN Emma Lång, Anna Połeć, Anna Lång, Marijke Valk, Pernille Blicher, Alexander D. Rowe, Kim A. Tønseth, Catherine J. Jackson, Tor P. Utheim, Liesbeth M. C. Janssen, Jens Eriksson & Stig Ove Bøe Epithelial sheet migration requires polarized and coordinated cell movement. Here, the authors demonstrate serum-activated collective migration followed by polarized asymmetric cell divisions in otherwise quiescent human keratinocyte monolayers in the absence of wound edges. 10 September 2018 | doi: 10.1038/s41467-018-05578-7 Collective cell migration  Mitosis  Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology OPEN Cai Zhang, Joonbae Seo, Kazutoshi Murakami, Esam S. B. Salem, Elise Bernhard, Vishnupriya J. Borra, Kwangmin Choi, Celvie L. Yuan, Calvin C. Chan, Xiaoting Chen, Taosheng Huang, Matthew T. Weirauch, Senad Divanovic, Nathan R. Qi, Hala Einakat Thomas, Carol A. Mercer, Haruhiko Siomi & Takahisa Nakamura The RNA-induced silencing complex (RISC) represses gene expression via micro-RNA guided mRNA silencing. Here, the authors show that RISC component Argonaute 2 in the liver regulates energy metabolism by inducing microRNAs that cause metabolic disruption and by suppressing protein translation linked to AMPK activation. 10 September 2018 | doi: 10.1038/s41467-018-05870-6 Metabolic syndrome  miRNAs  Tropical peatland carbon storage linked to global latitudinal trends in peat recalcitrance OPEN Suzanne B. Hodgkins, Curtis J. Richardson, René Dommain, Hongjun Wang, Paul H. Glaser, Brittany Verbeke, B. Rose Winkler, Alexander R. Cobb, Virginia I. Rich, Malak Missilmani, Neal Flanagan, Mengchi Ho, Alison M. Hoyt, Charles F. Harvey, S. Rose Vining, Moira A. Hough, Tim R. Moore, Pierre J. H. Richard, Florentino B. De La Cruz, Joumana Toufaily et al. Large peatlands exist at high latitudes because flooded conditions and cold temperatures slow decomposition, so the presence of (sub)tropical peat is enigmatic. Here the authors show that low-latitude peat is preserved due to lower carbohydrate and greater aromatic content resulting in chemical recalcitrance. 07 September 2018 | doi: 10.1038/s41467-018-06050-2 Carbon cycle  Infrared spectroscopy  Wetlands ecology  Boosting potassium-ion batteries by few-layered composite anodes prepared via solution-triggered one-step shear exfoliation OPEN Yajie Liu, Zhixin Tai, Jian Zhang, Wei Kong Pang, Qing Zhang, Haifeng Feng, Konstantin Konstantinov, Zaiping Guo & Hua Kun Liu Developing high-performance potassium-ion batteries remains a challenge. Here, the authors show that few-layered Sb2S3/carbon composite anode synthesized via simple exfoliation minimizes the volume changes during (de)intercalation of K+ ions with boosted rate performance and cyclability. 07 September 2018 | doi: 10.1038/s41467-018-05786-1 Electrochemistry  Energy  A rationally designed JAZ subtype-selective agonist of jasmonate perception OPEN Yousuke Takaoka, Mana Iwahashi, Andrea Chini, Hiroaki Saito, Yasuhiro Ishimaru, Syusuke Egoshi, Nobuki Kato, Maho Tanaka, Khurram Bashir, Motoaki Seki, Roberto Solano & Minoru Ueda The phytohormone JA-Ile can promote plant resistance against herbivores and fungal pathogens but also inhibits growth, limiting its potential use in agriculture. Here, the authors design a stereoisomer of JA-Ile analog and demonstrate that it can promote defense while having minimal impact on growth. 07 September 2018 | doi: 10.1038/s41467-018-06135-y Biotic  Jasmonic acid  Natural products  Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells OPEN Claudia Isabelle Keller Valsecchi, M. Felicia Basilicata, Giuseppe Semplicio, Plamen Georgiev, Noel Marie Gutierrez & Asifa Akhtar In Drosophila the Male-Specific Lethal complex (MSLc) mediates upregulation of the single male X chromosome. Here the authors provide evidence that MSL2 also targets autosomal genes required for proper development and that MSL2 binds and similarly regulates mouse orthologues. 07 September 2018 | doi: 10.1038/s41467-018-05642-2 Chromatin immunoprecipitation  Developmental biology  Dosage compensation  Genome-wide analysis of gene expression  T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells OPEN Hye-Ran Kim, YeVin Mun, Kyung-Sik Lee, Yoo-Jin Park, Jeong-Su Park, Jin-Hwa Park, Bu-Nam Jeon, Chang-Hyun Kim, Youngsoo Jun, Young-Min Hyun, Minsoo Kim, Sang-Myeong Lee, Chul-Seung Park, Sin-Hyeog Im & Chang-Duk Jun Microvilli can participate in adhesion or migration of T cells, but whether they are involved in function regulation is unclear. Here the authors show that T cell microvilli form budding vesicles containing T cell signalling components for deposition onto antigen presenting cells (APC) and modulation of APC functions. 07 September 2018 | doi: 10.1038/s41467-018-06090-8 Dendritic cells  Imaging the immune system  Protein transport  T cells  Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits OPEN Thorunn Rafnar, Bjarni Gunnarsson, Olafur A. Stefansson, Patrick Sulem, Andres Ingason, Michael L. Frigge, Lilja Stefansdottir, Jon K. Sigurdsson, Vinicius Tragante, Valgerdur Steinthorsdottir, Unnur Styrkarsdottir, Simon N. Stacey, Julius Gudmundsson, Gudny A. Arnadottir, Asmundur Oddsson, Florian Zink, Gisli Halldorsson, Gardar Sveinbjornsson, Ragnar P. Kristjansson, Olafur B. Davidsson et al. Uterine leiomyomas are common benign tumors. Here, a meta-analysis of two European leiomyoma GWAS uncovers 21 leiomyoma risk variants at 16 loci, providing evidence of genetic overlap between leiomyoma and various benign and malignant tumors and highlighting the role of estrogen in tumor growth. 07 September 2018 | doi: 10.1038/s41467-018-05428-6 Cancer genetics  Genetics research  Genome-wide association studies  A global meta-analysis of yield stability in organic and conservation agriculture OPEN Samuel Knapp & Marcel G. A. van der Heijden Yields vary between different cropping systems, though their temporal stability has not been quantified. Here, Knapp and van der Heijden present a meta-analysis showing that yields in organic agriculture have, per unit food produced, a lower temporal stability. 07 September 2018 | doi: 10.1038/s41467-018-05956-1 Agroecology  Agriculture  Environmental sciences  Staufen1 links RNA stress granules and autophagy in a model of neurodegeneration OPEN Sharan Paul, Warunee Dansithong, Karla P. Figueroa, Daniel R. Scoles & Stefan M. Pulst Spinocerebellar ataxia type 2 (SCA2) is caused by polyglutamine repeats in the ATXN2 protein. Here the authors demonstrate that Staufen1, known to be an RNA-binding protein, interacts with ATXN2 and contributes to pathology in a mouse model of SCA2. 07 September 2018 | doi: 10.1038/s41467-018-06041-3 RNA decay  Spinocerebellar ataxia  Correlative microscopy approach for biology using X-ray holography, X-ray scanning diffraction and STED microscopy OPEN M. Bernhardt, J.-D. Nicolas, M. Osterhoff, H. Mittelstädt, M. Reuss, B. Harke, A. Wittmeier, M. Sprung, S. Köster & T. Salditt X-ray techniques benefit from correlative imaging approaches, but combination with super-resolution microscopy has not been explored. Here the authors image the cardiomyocyte cytoskeleton by combining holographic X-ray imaging, X-ray scanning diffraction and STED in the same synchrotron endstation. 07 September 2018 | doi: 10.1038/s41467-018-05885-z Biological techniques  Optical techniques  Optics and photonics  SAXS  Structure determination  Liquid-state quantitative SERS analyzer on self-ordered metal liquid-like plasmonic arrays OPEN Li Tian, Mengke Su, Fanfan Yu, Yue Xu, Xiaoyun Li, Lei Li, Honglin Liu & Weihong Tan The design and application of a liquid interfacial plasmonic platform promises for practical applications of surface-enhanced Raman scattering (SERS). Here, the authors report a reversible chloroform/water encasing strategy to self-assemble metal liquid-like 3D gold nanorod arrays with attractive SERS capability. 07 September 2018 | doi: 10.1038/s41467-018-05920-z Bioanalytical chemistry  Characterization and analytical techniques  Sensors  Trojan Horse nanotheranostics with dual transformability and multifunctionality for highly effective cancer treatment OPEN Xiangdong Xue, Yee Huang, Ruonan Bo, Bei Jia, Hao Wu, Ye Yuan, Zhongling Wang, Zhao Ma, Di Jing, Xiaobao Xu, Weimin Yu, Tzu-yin Lin & Yuanpei Li Size and charge can significantly affect delivery of therapeutic agents to tumours. Here, the authors report on nanoparticles optimised for delivery to the tumour which release smaller particles and change charge in the tumour microenvironment to optimise tumour penetration and cellular uptake. 07 September 2018 | doi: 10.1038/s41467-018-06093-5 Biomaterials  Drug delivery  Decisions are expedited through multiple neural adjustments spanning the sensorimotor hierarchy OPEN Natalie A. Steinemann, Redmond G. O’Connell & Simon P. Kelly When needed, we can speed up our decisions at the expense of accuracy. Here, the authors employ a novel human electrophysiology paradigm to show that hastened decisions are implemented through multiple, fundamentally distinct neural process adjustments across the sensorimotor hierarchy. 07 September 2018 | doi: 10.1038/s41467-018-06117-0 Decision  Refined efficacy estimates of the Sanofi Pasteur dengue vaccine CYD-TDV using machine learning OPEN I. Dorigatti, C. A. Donnelly, D. J. Laydon, R. Small, N. Jackson, L. Coudeville & N. M. Ferguson Clinical trials for the CYD-TDV dengue vaccine showed that vaccine efficacy varies with prior dengue exposure, but baseline serostatus is only known for 12% of subjects. Here, Dorigatti et al. use machine learning to impute baseline serostatus and determine vaccine efficacy by baseline serostatus, age and dengue serotype. 07 September 2018 | doi: 10.1038/s41467-018-06006-6 Clinical trials  Dengue virus  Live attenuated vaccines  Machine learning  Compartmentalised RNA catalysis in membrane-free coacervate protocells OPEN Björn Drobot, Juan M. Iglesias-Artola, Kristian Le Vay, Viktoria Mayr, Mrityunjoy Kar, Moritz Kreysing, Hannes Mutschler & T-Y Dora Tang Phase separation of mixtures of oppositely charged polymers provides a simple and direct route to compartmentalisation via coacervation. Here authors demonstrate that a coacervate microenvironment supports RNA catalysis whilst selectively sequestering RNA based on length. 07 September 2018 | doi: 10.1038/s41467-018-06072-w Biophysics  Chemistry  Materials science  Solubility-mediated sustained release enabling nitrate additive in carbonate electrolytes for stable lithium metal anode OPEN Yayuan Liu, Dingchang Lin, Yuzhang Li, Guangxu Chen, Allen Pei, Oliver Nix, Yanbin Li & Yi Cui The solid-electrolyte interphase (SEI) is one of the governing factors for the reversibility of Li metal anode. Here, the authors reveal the impact of nitrate additive on the SEI in carbonate electrolytes, and demonstrate a method to overcome the solubility limitation of nitrate. 07 September 2018 | doi: 10.1038/s41467-018-06077-5 Batteries  Electrochemistry  Energy  Highly efficient genome editing by CRISPR-Cpf1 using CRISPR RNA with a uridinylate-rich 3′-overhang OPEN Su Bin Moon, Jeong Mi Lee, Jeong Gu Kang, Nan-Ee Lee, Dae-In Ha, Do Yon Kim, Sun Hee Kim, Kwangsun Yoo, Daesik Kim, Jeong-Heon Ko & Yong-Sam Kim Cpf1 is a promising alternative to Cas9 though indel generation efficiency is target dependent. Here the authors show that the addition of a polyU 3′ overhang can improve the efficiency of low efficiency guide RNAs. 07 September 2018 | doi: 10.1038/s41467-018-06129-w CRISPR-Cas9 genome editing  Gene targeting  Targeted gene repair  Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability OPEN Hema Adhikari & Christopher M. Counter RAS isoforms are frequently mutated in cancer but their inhibition remains challenging. By comparing the protein interactomes of the highly similar isoforms HRAS, NRAS and KRAS, the authors here identify PIP5K1A as a KRAS-specific interactor and a target to inhibit KRAS-driven cell growth. 07 September 2018 | doi: 10.1038/s41467-018-05692-6 Cancer  Cell signalling  Oncogene proteins  Protein–protein interaction networks  Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor OPEN Sanja Mikulovic, Carlos Ernesto Restrepo, Samer Siwani, Pavol Bauer, Stefano Pupe, Adriano B. L. Tort, Klas Kullander & Richardson N. Leão There are two subtypes of hippocampal theta oscillations that differ in frequency range, pharmacology, and behavioural correlates. Here, the authors report that activity of OLM interneurons in the ventral hippocampus mediates type 2 theta, associated with increased risk-taking in the presence of predator threat. 07 September 2018 | doi: 10.1038/s41467-018-05907-w Cellular neuroscience  Neural circuits  Correct determination of charge transfer state energy from luminescence spectra in organic solar cells OPEN Mathias List, Tanmoy Sarkar, Pavlo Perkhun, Jörg Ackermann, Chieh Luo & Uli Würfel The charge transfer state is the key to understand the open circuit voltage of organic solar cells and is commonly accessed by electroluminescence spectra. Here List et al. show that the reliable spectra can only be obtained by a correction of the device-specific out-coupling effect. 07 September 2018 | doi: 10.1038/s41467-018-05987-8 Electronics, photonics and device physics  Solar energy and photovoltaic technology  Optical spectroscopy  Stereoselective oxidative glycosylation of anomeric nucleophiles with alcohols and carboxylic acids OPEN Tianyi Yang, Feng Zhu & Maciej A. Walczak Glycosylation of partially protected sugars is usually limited by suboptimal regio- and stereo-selectivities. Here, the authors show a general oxidative glycosylation between anomeric stannanes with a nonprotected hydroxyl group and oxygen nucleophiles, additionally providing mechanistic insights into the origin of selectivity. 07 September 2018 | doi: 10.1038/s41467-018-06016-4 Carbohydrate chemistry  Synthetic chemistry methodology  Natural product synthesis  Stereochemistry  Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia OPEN Yusuke Shiozawa, Luca Malcovati, Anna Gallì, Aiko Sato-Otsubo, Keisuke Kataoka, Yusuke Sato, Yosaku Watatani, Hiromichi Suzuki, Tetsuichi Yoshizato, Kenichi Yoshida, Masashi Sanada, Hideki Makishima, Yuichi Shiraishi, Kenichi Chiba, Eva Hellström-Lindberg, Satoru Miyano, Seishi Ogawa & Mario Cazzola Mutations to the splicing machinery may have an important role in myelodysplasia. Here, the authors describe splicing factor gene mutations in myelodysplasia and report tumor suppressor, epigenetic, iron metabolism and heme biosynthesis genes as their targets. 07 September 2018 | doi: 10.1038/s41467-018-06063-x Myelodysplastic syndrome  RNA splicing  Antagonistic chemical coupling in self-reconfigurable host–guest protocells OPEN Nicolas Martin, Jean-Paul Douliez, Yan Qiao, Richard Booth, Mei Li & Stephen Mann Multi-compartmentalised soft micro-systems are used as models of synthetic protocells. Here, the authors developed nested host–guest protocell constructs capable of self-reconfiguration in response to changes in pH generated by antagonistic modes of enzyme-mediated coupling. 07 September 2018 | doi: 10.1038/s41467-018-06087-3 Biomaterials – cells  Self-assembly  Focused clamping of a single neuronal SNARE complex by complexin under high mechanical tension OPEN Min Ju Shon, Haesoo Kim & Tae-Young Yoon The SNARE complex enables the fusion of synaptic vesicles with presynaptic membrane via a zippering process that is modulated by the protein complexin, though the precise mechanism remains unclear. Here, the authors used magnetic tweezers to show how complexin prepares a SNARE complex for fusion under mechanical tension. 07 September 2018 | doi: 10.1038/s41467-018-06122-3 Magnetic tweezers  Molecular conformation  Molecular neuroscience  Single-molecule biophysics  Synaptic vesicle exocytosis  Passive sensing around the corner using spatial coherence OPEN M. Batarseh, S. Sukhov, Z. Shen, H. Gemar, R. Rezvani & A. Dogariu Non-line-of-sight sensing requires purposely controlling some of the properties of light during the measurement process. Here, the authors show that reflection from a diffusive surface preserves some coherence properties and the shape and the distance to an incoherently illuminated object can be measured using the spatial coherence function. 07 September 2018 | doi: 10.1038/s41467-018-05985-w Imaging and sensing  Optical physics  Selective sorting of polymers with different terminal groups using metal-organic frameworks OPEN Benjamin Le Ouay, Chikara Watanabe, Shuto Mochizuki, Masayoshi Takayanagi, Masataka Nagaoka, Takashi Kitao & Takashi Uemura The separation of high molecular weight polymers composed of the same number of monomeric units remains highly challenging. Here, the authors show that efficient separation and purification of mixtures of polymers that differ only by their terminal groups can be achieved through polymer threading in metal-organic framework channels. 07 September 2018 | doi: 10.1038/s41467-018-06099-z Metal–organic frameworks  Polymers  Manipulating and visualizing the dynamic aggregation-induced emission within a confined quartz nanopore OPEN Yi-Lun Ying, Yuan-Jie Li, Ju Mei, Rui Gao, Yong-Xu Hu, Yi-Tao Long & He Tian The difficulty in recovering the aggregation-induced emission fluorogens (AIEgens) to the initial dispersed state upon illuminating has limited their applications. Here, the authors employ the confined space in the quartz nanopore to achieve a nanopore-size dependent restriction of AIEgens. 07 September 2018 | doi: 10.1038/s41467-018-05832-y Bioanalytical chemistry  Chemical modification  Fluorescent probes  Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes OPEN Gabriel B. Ferguson, Ben Van Handel, Maxwell Bay, Petko Fiziev, Tonis Org, Siyoung Lee, Ruzanna Shkhyan, Nicholas W. Banks, Mila Scheinberg, Ling Wu, Biagio Saitta, Joseph Elphingstone, A. Noelle Larson, Scott M. Riester, April D. Pyle, Nicholas M. Bernthal, Hanna KA Mikkola, Jason Ernst, Andre J. van Wijnen, Michael Bonaguidi et al. Human development provides a roadmap for advancing pluripotent stem cell-based regenerative therapies. Here the authors mapped human skeletogenesis using RNA sequencing on 5 cell types from a single foetal stage as well as chondrocytes at 4 stages in vivo and 2 stages during in vitro differentiation. 07 September 2018 | doi: 10.1038/s41467-018-05573-y Cartilage development  Transcriptomics  Conservation of epigenetic regulation by the MLL3/4 tumour suppressor in planarian pluripotent stem cells OPEN Yuliana Mihaylova, Prasad Abnave, Damian Kao, Samantha Hughes, Alvina Lai, Farah Jaber-Hijazi, Nobuyoshi Kosaka & A. Aziz Aboobaker The Mll3/4 histone methyltransferases can act as tumour suppressors in humans. Here, the authors identify three orthologs of mammalian MLL3/4 in the planarian Schmidtea mediterranea and show that knockdown causes outgrowths in regenerating animals, suggesting that the tumour suppressive function of these genes is deeply conserved. 07 September 2018 | doi: 10.1038/s41467-018-06092-6 Adult stem cells  Cancer stem cells  Epigenetics  Evolutionary developmental biology  Modular engineering to increase intracellular NAD(H/+) promotes rate of extracellular electron transfer of Shewanella oneidensis OPEN Feng Li, Yuan-Xiu Li, Ying-Xiu Cao, Lei Wang, Chen-Guang Liu, Liang Shi & Hao Song A bottleneck for the application of bioelectrochemical systems is the slow rate of extracellular electron transfer. Here the authors use a synthetic biology approach to redirect metabolic flux to NAD+ biosynthesis, which enhances the intracellular electron flux and the extracellular electron transfer rate. 07 September 2018 | doi: 10.1038/s41467-018-05995-8 Electrophysiology  Genetic engineering  Metabolic engineering  High-throughput chromatin accessibility profiling at single-cell resolution OPEN Anja Mezger, Sandy Klemm, Ishminder Mann, Kara Brower, Alain Mir, Magnolia Bostick, Andrew Farmer, Polly Fordyce, Sten Linnarsson & William Greenleaf Single-cell chromatin accessibility is a promising means to identify regulatory programs in mixtures of cells. Here the authors describe µ-ATAC-seq, a low-cost method that can generate thousands of accessibility profiles per day. 07 September 2018 | doi: 10.1038/s41467-018-05887-x Epigenetics analysis  Epigenomics  Sequencing  Necroptosis mediates myofibre death in dystrophin-deficient mice OPEN Jennifer E. Morgan, Alexandre Prola, Virginie Mariot, Veronica Pini, Jinhong Meng, Christophe Hourde, Julie Dumonceaux, Francesco Conti, Frederic Relaix, Francois-Jerôme Authier, Laurent Tiret, Francesco Muntoni & Maximilien Bencze Muscular dystrophies are characterised by extensive myofibre cell death. Here Morgan et al. show that RIPK3-mediated necroptosis contributes to myofibre cell death in Duchenne muscular dystrophy, and that RIPK3 deletion protects dystrophic mice against myofibre degeneration. 07 September 2018 | doi: 10.1038/s41467-018-06057-9 Necroptosis  Skeletal muscle  Sub-2 Å Ewald curvature corrected structure of an AAV2 capsid variant OPEN Yong Zi Tan, Sriram Aiyer, Mario Mietzsch, Joshua A. Hull, Robert McKenna, Joshua Grieger, R. Jude Samulski, Timothy S. Baker, Mavis Agbandje-McKenna & Dmitry Lyumkis Single-particle cryo-EM is a powerful method for macromolecular structure determination. Here the authors demonstrate that Ewald sphere curvature correction, sub-Angstrom pixilation and per-particle CTF refinement can improve map quality and resolution and present the 1.86 Å cryo-EM structure of an adeno-associated virus serotype 2 variant. 07 September 2018 | doi: 10.1038/s41467-018-06076-6 Cryoelectron microscopy  Genetic vectors  Molecular modelling  Imaging the nanoscale phase separation in vanadium dioxide thin films at terahertz frequencies OPEN H. T. Stinson, A. Sternbach, O. Najera, R. Jing, A. S. Mcleod, T. V. Slusar, A. Mueller, L. Anderegg, H. T. Kim, M. Rozenberg & D. N. Basov The insulator-to-metal transition in vanadium dioxide still has many unexplored properties. Here the authors use multi-modal THz and mid-IR nano-imaging to examine the phase transition in VO2 thin films, and discuss the unexpectedly smooth transition at THz frequencies in the context of a dimer Hubbard model. 06 September 2018 | doi: 10.1038/s41467-018-05998-5 Electronic properties and materials  Phase transitions and critical phenomena  Scanning probe microscopy  Terahertz optics  Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses OPEN Qiuhui Li, Qu Deng, Hsueh-Ping Chao, Xin Liu, Yue Lu, Kevin Lin, Bigang Liu, Gregory W. Tang, Dingxiao Zhang, Amanda Tracz, Collene Jeter, Kiera Rycaj, Tammy Calhoun-Davis, Jiaoti Huang, Mark A. Rubin, Himisha Beltran, Jianjun Shen, Gurkamal Chatta, Igor Puzanov, James L. Mohler et al. The functional significance of the observed heterogeneity of androgen receptor (AR) expression in prostate cancer is unknown. Here the authors show AR expression heterogeneity is associated with distinct castration/enzalutamide responses and identify BCL-2 as a potential therapeutic target in castration-resistant prostate cancer. 06 September 2018 | doi: 10.1038/s41467-018-06067-7 Cancer stem cells  Prostate cancer  Tumour heterogeneity  Urological cancer  Jungle Express is a versatile repressor system for tight transcriptional control OPEN Thomas L. Ruegg, Jose H. Pereira, Joseph C. Chen, Andy DeGiovanni, Pavel Novichkov, Vivek K. Mutalik, Giovani P. Tomaleri, Steven W. Singer, Nathan J. Hillson, Blake A. Simmons, Paul D. Adams & Michael P. Thelen Tightly regulated promoters with strong inducibility and scalability are highly desirable for biological applications. Here the authors describe ‘Jungle Express’, a EilR repressor-based broad host system activated by cationic dyes. 06 September 2018 | doi: 10.1038/s41467-018-05857-3 Applied microbiology  Synthetic biology  Transcriptional regulatory elements  microCLIP super learning framework uncovers functional transcriptome-wide miRNA interactions OPEN Maria D. Paraskevopoulou, Dimitra Karagkouni, Ioannis S. Vlachos, Spyros Tastsoglou & Artemis G. Hatzigeorgiou AGO-PAR-CLIP is widely used for high-throughput miRNA target characterization. Here, the authors show that the previously neglected non-T-to-C clusters denote functional miRNA binding events, and develop microCLIP, a super learning framework that accurately detects miRNA interactions. 06 September 2018 | doi: 10.1038/s41467-018-06046-y Computational models  Gene expression analysis  Machine learning  miRNAs  Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression OPEN Yuan Jiang, Yan-Yi Jiang, Jian-Jun Xie, Anand Mayakonda, Masaharu Hazawa, Li Chen, Jin-Fen Xiao, Chun-Quan Li, Mo-Li Huang, Ling-Wen Ding, Qiao-Yang Sun, Liang Xu, Deepika Kanojia, Maya Jeitany, Jian-Wen Deng, Lian-Di Liao, Harmik J. Soukiasian, Benjamin P. Berman, Jia-Jie Hao, Li-Yan Xu et al. Master regulator transcription factors TP63 and SOX2 have been reported to overlap in genomic occupancy in squamous cell carcinomas (SCCs). Here, the authors demonstrate that TP63 and SOX2 promote co-operatively long non-coding RNA CCAT1 expression through activating its super-enhancer, and CCAT1 forms a complex with TP63 and SOX2, which regulates EGFR super-enhancers and enhances both the MEK/ERK1/2 and PI3K/AKT signaling pathways in SCC. 06 September 2018 | doi: 10.1038/s41467-018-06081-9 Cancer  Gastrointestinal cancer  Head and neck cancer  Lung cancer  Oncogenes  Printing two-dimensional gallium phosphate out of liquid metal OPEN Nitu Syed, Ali Zavabeti, Jian Zhen Ou, Md Mohiuddin, Naresh Pillai, Benjamin J. Carey, Bao Yue Zhang, Robi S. Datta, Azmira Jannat, Farjana Haque, Kibret A. Messalea, Chenglong Xu, Salvy P. Russo, Chris F. McConville, Torben Daeneke & Kourosh Kalantar-Zadeh Two-dimensional piezoelectric materials hold promise for nano-electromechanical technologies, yet it is challenging to prepare them in large areas with high sample homogeneity. Syed et al. surface print GaPO4 sheets with unit cell thickness over centimetres using a liquid metal-based synthesis process. 06 September 2018 | doi: 10.1038/s41467-018-06124-1 Soft materials  Two-dimensional materials  Realization of vertical metal semiconductor heterostructures via solution phase epitaxy OPEN Xiaoshan Wang, Zhiwei Wang, Jindong Zhang, Xiang Wang, Zhipeng Zhang, Jialiang Wang, Zhaohua Zhu, Zhuoyao Li, Yao Liu, Xuefeng Hu, Junwen Qiu, Guohua Hu, Bo Chen, Ning Wang, Qiyuan He, Junze Chen, Jiaxu Yan, Wei Zhang, Tawfique Hasan, Shaozhou Li et al. Controlling the composition and crystal phase of layered heterostructures is important. Here, the authors report the liquid-phase epitaxial growth of Sn0.5W0.5S2 nanosheets with 83% metallic phase on SnS2 nanoplates, which are used as 100 ppb level chemiresistive gas sensors at room temperature. 06 September 2018 | doi: 10.1038/s41467-018-06053-z Sensors and biosensors  Solid-phase synthesis  Two-dimensional materials  Unexpected stability of aqueous dispersions of raspberry-like colloids OPEN Yang Lan, Alessio Caciagli, Giulia Guidetti, Ziyi Yu, Ji Liu, Villads E. Johansen, Marlous Kamp, Chris Abell, Silvia Vignolini, Oren A. Scherman & Erika Eiser The ability to stabilise colloidal suspensions in solution against salt-induced aggregation is critical to many industrial applications, but it remains challenging at high salt concentration. To overcome this problem, Lan et al. introduce a raspberry-like colloidal particle with controllable morphology. 06 September 2018 | doi: 10.1038/s41467-018-05560-3 Chemical physics  Colloids  Materials science  Soft materials  Drought reduces blue-water fluxes more strongly than green-water fluxes in Europe OPEN René Orth & Georgia Destouni The partitioning of drought-induced water deficits into blue-water runoff and green-water evapotranspiration is critical, as the respective anomalies threaten different societal sectors. Here the authors show that drought reduces runoff much faster and stronger than it reduces evapotranspiration across European climates. 06 September 2018 | doi: 10.1038/s41467-018-06013-7 Climate sciences  Hydrology  Nucleolar fibrillarin is an evolutionarily conserved regulator of bacterial pathogen resistance OPEN Varnesh Tiku, Chun Kew, Parul Mehrotra, Raja Ganesan, Nirmal Robinson & Adam Antebi Innate immunity is critical in the response to bacterial infection. Here the authors show a role for the nucleolar-associated protein fibrillarin in regulating the innate response to infection. 06 September 2018 | doi: 10.1038/s41467-018-06051-1 Cell biology  Genetics  Infection  Pattern recognition receptors  Biomimetic coating-free surfaces for long-term entrapment of air under wetting liquids OPEN Eddy M. Domingues, Sankara Arunachalam, Jamilya Nauruzbayeva & Himanshu Mishra Trapping air at the solid-liquid interface is a promising strategy for reducing frictional drag but could not be realized without perfluorinated coatings so-far. Here the authors demonstrate a biomimetic coating-free approach for entrapping air for long periods upon immersion in liquids. 06 September 2018 | doi: 10.1038/s41467-018-05895-x Bioinspired materials  Design, synthesis and processing  Structural properties  Nuclear Nestin deficiency drives tumor senescence via lamin A/C-dependent nuclear deformation OPEN Nestin can be localised in the nucleus of cancer cells, but its nuclear role in tumorigenesis is unclear. Here, the authors show that nuclear Nestin prevents senescence in tumor cells by stabilising lamin A/C from proteasomal degradation to maintain nuclear integrity. 06 September 2018 | doi: 10.1038/s41467-018-05808-y Cancer  Intermediate filaments  Senescence  Dynamic capillary assembly of colloids at interfaces with 10,000g accelerations OPEN Axel Huerre, Marco De Corato & Valeria Garbin The deformation of soft materials under high rates remains challenging to be probed directly and thus understood. Huerre et al. examine the self-assembly of colloids confined at a fluid interface driven by ultrasound and show the formation of string-like microstructures caused by dynamic capillarity. 06 September 2018 | doi: 10.1038/s41467-018-06049-9 Colloids  Fluid dynamics  Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis OPEN Xiaohong Ruby Xu, Yiming Wang, Reheman Adili, Lining Ju, Christopher M. Spring, Joseph Wuxun Jin, Hong Yang, Miguel A. D. Neves, Pingguo Chen, Yan Yang, Xi Lei, Yunfeng Chen, Reid C. Gallant, Miao Xu, Hailong Zhang, Jina Song, Peifeng Ke, Dan Zhang, Naadiya Carrim, Si-Yang Yu et al. Activation of integrin αIIbβ3 at the surface of platelets is required for their aggregation and for thrombus formation. Here Xu et al. identify apolipoprotein A-IV as a novel ligand for platelet αIIbβ3 integrin, and find it inhibits platelet aggregation and thrombosis. 06 September 2018 | doi: 10.1038/s41467-018-05806-0 Platelets  Thrombosis  Quantum nondemolition measurement of mechanical motion quanta OPEN Luca Dellantonio, Oleksandr Kyriienko, Florian Marquardt & Anders S. Sørensen Although electro-and optomechanics has recently moved towards the quantum regime, the quantized energy spectrum of a mechanical oscillator has not been directly observed. Here Dellantonio et al. propose an electromechanical setup with a membrane resonator that could enable phonon number measurements. 06 September 2018 | doi: 10.1038/s41467-018-06070-y Optomechanics  Quantum mechanics  Single photons and quantum effects  Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin OPEN Deshun Gong, Ximin Chi, Kang Ren, Gaoxingyu Huang, Gewei Zhou, Nieng Yan, Jianlin Lei & Qiang Zhou The plasma membrane Ca2+ ATPase (PMCA) is essential for maintaining Ca2+ homeostasis in eukaryotic cells, and neuroplastin (NPTN) was recently identified as an obligatory subunit of PMCA. Here the authors present the cryo-EM structure of NPTN bound to human PMCA1, which reveals that the NPTN transmembrane (TM) helix interacts with TM10 and the TM8-9-linker of PMCA1. 06 September 2018 | doi: 10.1038/s41467-018-06075-7 Cryoelectron microscopy  Membrane proteins  Water chemistry reveals a significant decline in coral calcification rates in the southern Red Sea OPEN Zvi Steiner, Alexandra V. Turchyn, Eyal Harpaz & Jacob Silverman Ocean acidification and warming threaten coral reefs globally. Here, the authors show that the net contribution of corals to the CaCO3 budget of the tropical Red Sea declined dramatically between 1998 and 2015 and remained low between 2015 and 2018. 06 September 2018 | doi: 10.1038/s41467-018-06030-6 Biogeochemistry  Carbon cycle  Coral reefs  Environmental sciences  Ocean sciences  Reflection of near-infrared light confers thermal protection in birds OPEN Iliana Medina, Elizabeth Newton, Michael R. Kearney, Raoul A. Mulder, Warren P. Porter & Devi Stuart-Fox More than half of solar radiation is at near-infrared (NIR) wavelengths. Here, Medina et al. show that among Australian birds NIR reflectivity is higher in species from hot, arid environments and their biophysical modelling further shows that this can reduce water loss from evaporative cooling. 06 September 2018 | doi: 10.1038/s41467-018-05898-8 Animal physiology  Evolutionary ecology  Phylogenetics  LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat OPEN Elena Schmidt, Ines Dhaouadi, Isabella Gaziano, Matteo Oliverio, Paul Klemm, Motoharu Awazawa, Gerfried Mitterer, Eduardo Fernandez-Rebollo, Marta Pradas-Juni, Wolfgang Wagner, Philipp Hammerschmidt, Rute Loureiro, Christoph Kiefer, Nils R. Hansmeier, Sajjad Khani, Matteo Bergami, Markus Heine, Evgenia Ntini, Peter Frommolt, Peter Zentis et al. Brown adipose tissue (BAT) thermogenesis counteracts obesity and promotes metabolic health. The role of long non-coding RNAs (lncRNAs) in the regulation of this process is not well understood. Here the authors identify a maternally expressed lncRNA, H19, that increases BAT oxidative metabolism and energy expenditure. 06 September 2018 | doi: 10.1038/s41467-018-05933-8 Fat metabolism  Imprinting  Long non-coding RNAs  Role of dimensional crossover on spin-orbit torque efficiency in magnetic insulator thin films OPEN Qiming Shao, Chi Tang, Guoqiang Yu, Aryan Navabi, Hao Wu, Congli He, Junxue Li, Pramey Upadhyaya, Peng Zhang, Seyed Armin Razavi, Qing Lin He, Yawen Liu, Pei Yang, Se Kwon Kim, Cheng Zheng, Yizhou Liu, Lei Pan, Roger K. Lake, Xiufeng Han, Yaroslav Tserkovnyak et al. The spin-orbit torque (SOT) induced magnetic switching makes metal/magnetic insulators bilayers preferred in the energy efficient spintronic applications. Here the authors show SOT switching in W/TmIG bilayers and reveal the dimension crossover of SOT as a function of TmIG thickness. 06 September 2018 | doi: 10.1038/s41467-018-06059-7 Electronic and spintronic devices  Magnetic properties and materials  Spintronics  Surfaces, interfaces and thin films  Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel OPEN Binsen Li, Peng Ge, Kevin A. Murray, Phorum Sheth, Meng Zhang, Gayatri Nair, Michael R. Sawaya, Woo Shik Shin, David R. Boyer, Shulin Ye, David S. Eisenberg, Z. Hong Zhou & Lin Jiang The intrinsically disordered protein alpha-synuclein (aSyn) forms polymorphic fibrils. Here the authors provide molecular insights into aSyn fibril polymorphism and present the cryo-EM structures of the two predominant species, a rod and a twister both determined at 3.7 Å resolution. 06 September 2018 | doi: 10.1038/s41467-018-05971-2 Cryoelectron microscopy  Neurodegeneration  Protein aggregation  Utilization of rare codon-rich markers for screening amino acid overproducers OPEN Bo Zheng, Xiaoyan Ma, Ning Wang, Tingting Ding, Liwei Guo, Xiaorong Zhang, Yu Yang, Chun Li & Yi-Xin Huo Current toxic analogues-based amino acid overproducer screening method cannot provide accuracy, sensitivity and high throughput simultaneously. Here, the authors use rare codon rich marker for the selection of overproducers of multiple amino acids from random mutation libraries of E. coli and C. glutamicum. 06 September 2018 | doi: 10.1038/s41467-018-05830-0 Applied microbiology  Bacterial techniques and applications  High-throughput screening  Metabolic engineering  Tree rings reveal globally coherent signature of cosmogenic radiocarbon events in 774 and 993 CE OPEN Ulf Büntgen, Lukas Wacker, J. Diego Galván, Stephanie Arnold, Dominique Arseneault, Michael Baillie, Jürg Beer, Mauro Bernabei, Niels Bleicher, Gretel Boswijk, Achim Bräuning, Marco Carrer, Fredrik Charpentier Ljungqvist, Paolo Cherubini, Marcus Christl, Duncan A. Christie, Peter W. Clark, Edward R. Cook, Rosanne D’Arrigo, Nicole Davi et al. Despite their extensive use, the absolute dating of tree-ring chronologies has not hitherto been independently validated at the global scale. Here, the identification of distinct 14C excursions in 484 individual tree rings, enable the authors to confirm the dating of 44 dendrochronologies from five continents. 06 September 2018 | doi: 10.1038/s41467-018-06036-0 Atmospheric chemistry  Atmospheric science  Palaeoclimate  LY6E mediates an evolutionarily conserved enhancement of virus infection by targeting a late entry step OPEN Katrina B. Mar, Nicholas R. Rinkenberger, Ian N. Boys, Jennifer L. Eitson, Matthew B. McDougal, R. Blake Richardson & John W. Schoggins The interferon-induced gene LY6E increases virus infection, but the underlying mechanism is poorly understood. Here, Mar et al. show that LY6E enhances uncoating of influenza A virus after endosomal escape and that viral enhancement by LY6E is conserved across evolution. 06 September 2018 | doi: 10.1038/s41467-018-06000-y Influenza virus  Interferons  Viral infection  Virus–host interactions    Nature Communications JOBS of the week Research Scientist (f / m) In Vitro Pharmacology Evotec International GmbH Postdoctoral Fellowship / Research Scientist Boston University School of Medicine, BUMC Tenure-Track / Tenured Faculty Position Washington University in St. Louis Senior Scientific Officer Cancer Research UK Beatson Institute Postdoctoral fellow - Experimental Cancer Genetics Wellcome Sanger Institute Faculty Position in Immunology National University of Singapore, Dept of Microbiology and Immunology Postdoctoral Fellow or Staff Scientist f / m in Cancer Genetics and Oncogenic Signalling Klinikum rechts der Isar der Technischen Universität München - DKFZ Postdoctoral Research Fellow Columbia University’s Department of Medicine Postdoctoral Research Fellowship Genentech, Inc. Research Leader (Listeria - Microbes in the Food Chain) Quadram Institute Bioscience More Science jobs from Nature Communications EVENT NanoTox 2018 - 9th International Conference on Nanotoxicology 18.09.18 Neuss, Germany More science events from     Latest Author Corrections       Author Correction: TRPS1 shapes YAP/TEAD-dependent transcription in breast cancer cells OPEN Dana Elster, Marie Tollot, Karin Schlegelmilch, Alessandro Ori, Andreas Rosenwald, Erik Sahai & Björn von Eyss 12 September 2018 | doi: 10.1038/s41467-018-06266-2 Breast cancer  Mechanisms of disease  Transcriptomics  Author Correction: Origin of large plasticity and multiscale effects in iron-based metallic glasses OPEN Baran Sarac, Yurii P. Ivanov, Andrey Chuvilin, Thomas Schöberl, Mihai Stoica, Zaoli Zhang & Jürgen Eckert 11 September 2018 | doi: 10.1038/s41467-018-06284-0 Glasses  Mechanical properties  Transmission electron microscopy  Author Correction: Yolk sac macrophage progenitors traffic to the embryo during defined stages of development OPEN C. Stremmel , R. Schuchert, F. Wagner, R. Thaler, T. Weinberger, R. Pick, E. Mass, H. C. Ishikawa-Ankerhold, A. Margraf, S. Hutter, R. Vagnozzi, S. Klapproth, J. Frampton, S. Yona, C. Scheiermann, J. D. Molkentin, U. Jeschke, M. Moser, M. Sperandio, S. Massberg et al. 07 September 2018 | doi: 10.1038/s41467-018-06065-9 Haematopoietic stem cells  Imaging the immune system  Innate immunity  Leukopoiesis  Author Correction: Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level OPEN Weiwu Ren, Robert Pengelly, Marco Farren-Dai, Saeideh Shamsi Kazem Abadi, Verena Oehler, Oluwafemi Akintola, Jason Draper, Michael Meanwell, Saswati Chakladar, Katarzyna Świderek, Vicent Moliner, Robert Britton, Tracey M. Gloster & Andrew J. Bennet 07 September 2018 | doi: 10.1038/s41467-018-06264-4 Carbohydrates  Enzyme mechanisms  Hydrolases  X-ray crystallography      Latest Publisher Corrections       Publisher Correction: Quantum coherence of multiple excitons governs absorption cross-sections of PbS/CdS core/shell nanocrystals OPEN Hirokazu Tahara, Masanori Sakamoto, Toshiharu Teranishi & Yoshihiko Kanemitsu 12 September 2018 | doi: 10.1038/s41467-018-06285-z Nanoparticles  Nanophotonics and plasmonics  Publisher Correction: Collective molecular switching in hybrid superlattices for light-modulated two-dimensional electronics OPEN Marco Gobbi, Sara Bonacchi, Jian X. Lian, Alexandre Vercouter, Simone Bertolazzi, Björn Zyska, Melanie Timpel, Roberta Tatti, Yoann Olivier, Stefan Hecht, Marco V. Nardi, David Beljonne, Emanuele Orgiu & Paolo Samorì 06 September 2018 | doi: 10.1038/s41467-018-05541-6     Advertisement ========================================== Register for the latest nature.com webcast========================================== Distinct Metabolic Profiling of Invading PANC-1 Pancreatic Cancer Cells During this webcast Dr. Mayumi Fujita of the National Institutes for Quantum and Radiological Science and Technology in Japan will address the method of real-time imaging of invading cancer cells and describe how this model could be useful for other studies. Register for FREE today Sponsored by IncuCyte     Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. Click here to sign up.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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