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Identification of Exo1-Msh2 interaction motifs in DNA mismatch repair and new Msh2-binding partners pp650 - 659 Eva M. Goellner, Christopher D. Putnam, William J. Graham V, Christine M. Rahal, Bin-Zhong Li et al. doi:10.1038/s41594-018-0092-y A pair of SHIP box motifs identified within the Exo1 nuclease mediate interactions with Msh2 during DNA mismatch repair and define potential new Msh2-binding partners in yeast and human cells. |
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Structural basis for the regulation of inositol trisphosphate receptors by Ca2+ and IP3 pp660 - 668 Navid Paknejad & Richard K. Hite doi:10.1038/s41594-018-0089-6 Cryo-EM analyses of human IP3 receptor in different ligand states (apo, with Ca2+ and/or IP3) reveal conformational changes in the cytoplasmic domain and how Ca2+ can regulate channel function. |
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Mechanisms of genetic instability caused by (CGG)n repeats in an experimental mammalian system pp669 - 676 Artem V. Kononenko, Thomas Ebersole, Karen M. Vasquez & Sergei M. Mirkin doi:10.1038/s41594-018-0094-9 A new system to analyze the instability of fragile X (CGG)n repeats in mammalian cells suggests that long repeats cause replication fork stalling, resulting in repeat length changes and mutation at a distance via break-induced replication. |
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Analyses of mRNA structure dynamics identify embryonic gene regulatory programs pp677 - 686 Jean-Denis Beaudoin, Eva Maria Novoa, Charles E. Vejnar, Valeria Yartseva, Carter M. Takacs et al. doi:10.1038/s41594-018-0091-z Characterization of mRNA structure during the zebrafish maternal-to-zygotic transition identifies the ribosome as a major RNA structure remodeler in vivo and reveals that structural dynamics can affect gene expression, partly by modulating miRNA activity. |
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RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation pp687 - 697 Homa Rahnamoun, Jihoon Lee, Zhengxi Sun, Hanbin Lu, Kristen M. Ramsey et al. doi:10.1038/s41594-018-0102-0 Cell-based and in vitro analyses reveal that BRD4 functionally associates with eRNAs and that BRD4 bromodomains, through eRNA interactions, promote BRD4 binding at mutant p53-targeted enhancers to augment enhancer activation and tumor promoting gene expression. |
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Cryo-EM structure of the αvβ8 integrin reveals a mechanism for stabilizing integrin extension pp698 - 704 Anthony Cormier, Melody G. Campbell, Saburo Ito, Shenping Wu, Jianlong Lou et al. doi:10.1038/s41594-018-0093-x The cryo-EM structure of human αvβ8 integrin in the extended-closed conformation shows the headpiece rotating about a flexible αv-knee, suggesting a ligand surveillance mechanism for integrins. |
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Atomic insights into the genesis of cellular filaments by globular proteins pp705 - 714 Laura McPartland, Danielle M. Heller, David S. Eisenberg, Ann Hochschild & Michael R. Sawaya doi:10.1038/s41594-018-0096-7 A set of GFP fusions with as few as 12 residues appended to the C terminus is shown to assemble into filaments in E. coli. Crystal structures reveal a mechanism termed ‘runaway domain coupling’ and illustrate how protein filament formation can evolve. |
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Cation trafficking propels RNA hydrolysis pp715 - 721 Nadine L. Samara & Wei Yang doi:10.1038/s41594-018-0099-4 Time-resolved X-ray crystal structures of RNA hydrolysis by RNase H1 reveal that cations in addition to the two canonical Mg2+ ions position the reactants in the active site and enable catalysis. |
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Structure of a mitochondrial fission dynamin in the closed conformation pp722 - 731 Olga Bohuszewicz & Harry H. Low doi:10.1038/s41594-018-0097-6 The mitochondrial fission dynamin (Dnm1) from an algae is captured in a closed conformation, with the GTPase domain compacted against the stalk. This work indicates that formation of the closed conformation may contribute to membrane fission. |
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DNA melting initiates the RAG catalytic pathway pp732 - 742 Heng Ru, Wei Mi, Pengfei Zhang, Frederick W. Alt, David G. Schatz et al. doi:10.1038/s41594-018-0098-5 Cryo-EM structures of the RAG endonuclease in complex with intact DNA substrates reveal that DNA melting is the first step in V(D)J recombination, a mechanism potentially conserved in retroviral integration and DNA transposition. |
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Author Correction: H3K64 trimethylation marks heterochromatin and is dynamically remodeled during developmental reprogramming p743 Sylvain Daujat, Thomas Weiss, Fabio Mohn, Ulrike C Lange, Céline Ziegler-Birling et al. doi:10.1038/s41594-018-0090-0 |
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Author Correction: Structure of the core of the type III secretion system export apparatus p743 Lucas Kuhlen, Patrizia Abrusci, Steven Johnson, Joseph Gault, Justin Deme et al. doi:10.1038/s41594-018-0095-8 |
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Publisher Correction: Mechanism of parkin activation by phosphorylation p744 Véronique Sauvé, George Sung, Naoto Soya, Guennadi Kozlov, Nina Blaimschein et al. doi:10.1038/s41594-018-0105-x |
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