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TABLE OF CONTENTS
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September 2018 Volume 19, Issue 9 |
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| Research Highlights Reviews | |
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Research Highlights | |
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Delivering gene therapy Darran Yates p515 | doi:10.1038/s41583-018-0051-y A study shows that, in a mouse model of neuronopathic Gaucher disease, delivery of a gene therapy into the brains of fetal animals prevents neurodegeneration, ameliorates associated neuroinflammation and promotes survival. PDF | Identity kit Sian Lewis pp516 - 517 | doi:10.1038/s41583-018-0046-8 Synapse formation and function at hippocampal CA1 synapses are shown to be regulated by three classes of leucine-rich repeat-containing adhesion molecules, which act in a modular manner to regulate spine density and synapse function. PDF | Unsilencing spared spinal neurons Natasha Bray pp516 - 517 | doi:10.1038/s41583-018-0047-7 Restoring function of the K+/Cl− co-transporter KCC2 in spinal inhibitory interneurons spared after spinal cord injury helps the recovery of hindlimb function in mice. PDF | Bringing back early memories Katherine Whalley p517 | doi:10.1038/s41583-018-0044-x In mice, 'lost' infant memories can be recovered through the optogenetic reactivation of silent engrams in the hippocampus. PDF | Hands of (cell) fate Sian Lewis p518 | doi:10.1038/s41583-018-0050-z Progressive hyperpolarization of ventricular zone progenitors regulates their sequential differentiation and migration in mouse primary sensory cortex. PDF | A narcotic–narcoleptic link Natasha Bray p518 | doi:10.1038/s41583-018-0043-y The brains of individuals who have been addicted to opiate drugs show an increase in the number of hypocretin-expressing neurons — the same neurons that are lost in individuals with narcolepsy. PDF | | | | |
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Reviews | |
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Decision-making in sensorimotor control Jason P. Gallivan, Craig S. Chapman, Daniel M. Wolpert & J. Randall Flanagan pp519 - 534 | doi:10.1038/s41583-018-0045-9 The planning and execution of goal-directed actions require numerous decisions to be made, from action selection to the continuous refinement of movement plans. Here, Gallivan et al. discuss these sensorimotor decision-making processes and their interactions with mechanisms of action planning and control. Full Text | PDF |
Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man Robert J. Fenster, Lauren A. M. Lebois, Kerry J. Ressler & Junghyup Suh pp535 - 551 | doi:10.1038/s41583-018-0039-7 Advanced techniques for the imaging and manipulation of neural circuits are increasingly being used to advance our understanding of psychiatric disorders. Ressler and colleagues describe our current understanding of the circuit dysfunction that underlies the symptoms of post-traumatic stress disorder. Full Text | PDF |
Enteric nervous system development: what could possibly go wrong? Meenakshi Rao & Michael D. Gershon pp552 - 565 | doi:10.1038/s41583-018-0041-0 The gastrointestinal tract is innervated by the enteric nervous system (ENS), and disruption of ENS development can result in various gastrointestinal disorders. Here, Rao and Gershon review the complex processes involved in ENS development, including cell migration, proliferation and organization. Full Text | PDF |
On the nature and use of models in network neuroscience Danielle S. Bassett, Perry Zurn & Joshua I. Gold pp566 - 578 | doi:10.1038/s41583-018-0038-8 Modern network neuroscience involves the use of various types of models to understand the brain. In this Review, Bassett, Zurn and Gold discuss the aims of this approach before examining how network models may be categorized and validated. Full Text | PDF |
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