Nature Reviews Genetics Contents September 2018 Volume 19 Number 9

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Advertisement When your sequencing results matter, don't sell yourself short. Only PacBio long-read sequencing provides complete and accurate views of all types of genomic variation, revealing SNPs/SNVs, structural variants, mobile elements, haplotypes, and fully intact genes. Discover more with whole genome sequencing  TABLE OF CONTENTS September 2018 Volume 19, Issue 9 Research Highlights Reviews   Advertisement   Register for the latest nature.com webcast Simultaneous gene expression and epitope analysis of immune cells from astronauts - Thursday, 6th September, 2018 Listen to Dr Christopher Mason from Weil Cornell Medical College discuss his plan for the survival of the human species on Earth, in space and on other planets.  Register for FREE today Sponsored by BD   Advertisement Nature Reviews Reader Survey At Nature Reviews we are continually looking for ways to ensure we meet our readers' needs. Your responses to this short survey will give us insight into how our content may be improved. Get started here.     Research Highlights   How to predict the future Anna Dart p531 | doi:10.1038/s41576-018-0041-y Two studies use targeted sequencing to identify features of clonal haematopoiesis that may predict the risk of developing acute myeloid leukaemia years before diagnosis. PDF   The genetics of loneliness Dorothy Clyde pp532 - 533 | doi:10.1038/s41576-018-0036-8 One in four UK adults over the age of 65 suffers from loneliness. An analysis of UK Biobank data has identified 15 genomic loci associated with loneliness and reports a possible causal link between obesity and loneliness and depression. PDF   Gold rush to gene-editing in the brain Michelle Trenkmann pp532 - 533 | doi:10.1038/s41576-018-0038-6 A study in Nature Biomedical Engineering reports improvements in neurological symptoms in a mouse model of fragile X syndrome after non-viral delivery of Cas9 ribonucleoproteins to the brain. PDF   Koala genome insights Darren J. Burgess p533 | doi:10.1038/s41576-018-0039-5 A paper in Nature Genetics reports a high-quality reference genome for the koala, with insights into its specialized lifestyle, and potential applications in vaccine development and conservation strategies. PDF   Concentrating on intrinsic disorder Paulina Strzyz p534 | doi:10.1038/s41576-018-0037-7 Many eukaryotic proteins, including key transcription regulators, contain intrinsically disordered regions (IDRs), which serve as flexible interaction platforms. The molecular understanding of IDR-based interactions is now emerging, providing new insights into how IDRs promote protein compartmentalization and/or phase separation and how these processes regulate gene expression. PDF   Advertisement Searching for a new career? At Nature Research we frequently recruit talented individuals to join our editorial and publishing teams. If you have a PhD and a passion for science this may be the perfect career for you. Visit our research editorial and publishing careers website to discover more about what we do Reviews   Towards a complete map of the human long non-coding RNA transcriptome    Barbara Uszczynska-Ratajczak, Julien Lagarde, Adam Frankish, Roderic Guigó & Rory Johnson pp535 - 548 | doi:10.1038/s41576-018-0017-y Virtually all studies depend on annotations, maps of the genome that catalogue gene loci and the sequences of their transcripts. This Review discusses the state of currently available long non-coding RNA annotations and the impact of emerging technologies such as long-read sequencing. Full Text | PDF Collection: Non-coding RNA   Population genomics of bacterial host adaptation    Samuel K. Sheppard, David S. Guttman & J. Ross Fitzgerald pp549 - 565 | doi:10.1038/s41576-018-0032-z High-throughput sequencing technologies have enabled comparative analysis of large numbers of diverse bacterial genomes. Such studies are providing insights into the genomic changes that accompany changes in host specificity, with possible implications for controlling transmission of pathogenic bacteria. Full Text | PDF   Using genetic data to strengthen causal inference in observational research    Jean-Baptiste Pingault, Paul F. O’Reilly, Tabea Schoeler, George B. Ploubidis, Frühling Rijsdijk et al. pp566 - 580 | doi:10.1038/s41576-018-0020-3 Various types of observational studies can provide statistical associations between factors, such as between an environmental exposure and a disease state. This Review discusses the various genetics-focused statistical methodologies that can move beyond mere associations to identify (or refute) various mechanisms of causality, with implications for responsibly managing risk factors in health care and the behavioural and social sciences. Full Text | PDF Collection: Study designs   The personal and clinical utility of polygenic risk scores    Ali Torkamani, Nathan E. Wineinger & Eric J. Topol pp581 - 590 | doi:10.1038/s41576-018-0018-x Polygenic risk profiling can lead to actionable outcomes for individuals at high risk of developing a subset of common adult-onset polygenic diseases. The authors review recent studies that have demonstrated the utility of polygenic risk scores for disease risk stratification and their potential impact on early disease detection, prevention, therapeutic intervention and life planning. Full Text | PDF Collection: Translational genetics   Advertisement Communications Biology: Open for Submissions Communications Biology is a new open access journal that publishes high-quality primary research articles, reviews and commentary representing significant advances and new insights to the field of biology. The journal is now open for submissions. Find out more >>   Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. Click here to sign up.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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