Nature Reviews Cancer contents September 2018 Volume 18 Number 9

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Advertisement Nature Conference on Inflammation and Cancer  This meeting will bring together a diverse group of researchers from the many interconnected areas of immunology and cancer to discuss how inflammation affects tumour development and metastasis. Presentations will focus on the most recent findings on the tumour-promoting and -suppressing effects of inflammation, the immune tumour environment, and therapeutic approaches. October 23-25, 2018 | Beijing, China REGISTER NOW >> TABLE OF CONTENTS September 2018 Volume 18, Issue 9 Comment Research Highlights Reviews Perspectives   Advertisement Now accepting applications! Lung Cancer Innovation QuickFire Challenge Up to $750,000 in total grants will be awarded to up to three innovators with the best ideas, technologies, or solutions that address the complete spectrum of lung health - related to preventing, intercepting or curing lung cancer. Learn more about this challenge and apply here by September 14, 2018.   Advertisement Register for the latest nature.com webcast Tissue-based profiling for confident decisions in immuno-oncology Learn how standardizing tissue profiling in drug development and trial designs in immuno-oncology will improve decision making.  Thursday 12th September 2018 Sponsored by Definiens   Advertisement 2018 longlist - see the full line up The nominations for the 2018 Nature Research Awards for Inspiring Science and Innovating Science are in. See who's been long listed here > In partnership with The Estée Lauder Companies.   Advertisement Communications Biology: Open for Submissions Communications Biology is a new open access journal that publishes high-quality primary research articles, reviews and commentary representing significant advances and new insights to the field of biology. The journal is now open for submissions. Find out more >>   Comment   Clinical tumour sequencing for precision oncology: time for a universal strategy    Michael L. Cheng, Michael F. Berger, David M. Hyman & David B. Solit pp527 - 528 | doi:10.1038/s41568-018-0043-2 Comprehensive genomic characterization of patient tumours has the potential to advance therapies and inform basic cancer research. In this Comment, David B. Solit and colleagues provide their personal perspective on the implementation of an enterprise-wide, prospective clinical sequencing strategy and make a call for a universal approach to next-generation sequencing-based tumour profiling. Full Text | PDF   Research Highlights   How to predict the future Anna Dart p529 | doi:10.1038/s41568-018-0046-z Two groups have used targeted sequencing to identify features of clonal haematopoiesis in healthy individuals including the number of somatic mutations, the presence of specific mutations and clonal size, which predict risk of developing acute myeloid leukaemia years before diagnosis. PDF   The sugar loop Ulrike Harjes pp530 - 531 | doi:10.1038/s41568-018-0049-9 PI3K inhibition in solid cancers driven by PI3K catalytic subunit-α has shown limited clinical benefit. This might be due to activation of a glucose–insulin feedback loop, which can be interrupted by dietary or pharmaceutical approaches, thereby improving therapy outcome. PDF   Subclones work together Sarah Seton-Rogers pp530 - 531 | doi:10.1038/s41568-018-0047-y Vinci et al. provide evidence for subclonal cooperation driving the maintenance of tumour heterogeneity in paediatric high-grade gliomas. PDF   Second chances Anna Dart p531 | doi:10.1038/s41568-018-0044-1 Mutant KRAS has so far proven to be an undruggable target for lung adenocarcinoma and a widely held assumption is that KRAS mutations confer independence from upstream signalling. Two groups have now independently shown this might not be the case and suggest pan-ERBB inhibitors could be used to treat patients with KRAS-driven lung cancer PDF   Nature Reviews Cancer JOBS of the week Cancer Genetics / Genomics Post-doctoral Positions University of Pennsylvania, Department of Genetics Molecular Mechanisms and Translational Research in Kidney Cancer UT Southwestern Medical Center Faculty Position in Cancer Biology / Genetics Life Sciences Institute (LSI) - University of Michigan Research Fellow Mayo Clinic Research Fellow Dana-Farber Cancer Institute (DFCI) More Science jobs from Nature Reviews Cancer EVENT 2nd International Conference on Oncology and Radiology 17.09.18 Rome, Italy More science events from Advertisement Searching for a new career?  At Nature Research we frequently recruit talented individuals to join our editorial and publishing teams. If you have a PhD and a passion for science this may be the perfect career for you. Visit our research editorial and publishing careers website to discover more about what we do.   Reviews   Every step of the way: integrins in cancer progression and metastasis    Hellyeh Hamidi & Johanna Ivaska pp533 - 548 | doi:10.1038/s41568-018-0038-z In this Review, Hamidi and Ivaska discuss the contribution of integrins to the different steps of cancer progression, highlighting some of the recently identified unconventional roles of integrins and novel opportunities to target integrin signalling. Full Text | PDF Collection: Cancer at Nature Research   Deciphering the cells of origin of squamous cell carcinomas    Adriana Sánchez-Danés & Cédric Blanpain pp549 - 561 | doi:10.1038/s41568-018-0024-5 This Review discusses the origins of squamous cell carcinoma (SCC), with a focus on skin, lung, oesophageal and head and neck cancer, and describes how oncogenic mutations and the cell of origin cooperate in determining the rise of SCC. Full Text | PDF Collection: Cancer origins   Advertisement Nature Reviews Reader Survey At Nature Reviews we are continually looking for ways to ensure we meet our readers' needs. Your responses to this short survey will give us insight into how our content may be improved. Get started here.     Perspectives   Adapting to stress — chaperome networks in cancer    Suhasini Joshi, Tai Wang, Thaís L. S. Araujo, Sahil Sharma, Jeffrey L. Brodsky et al. pp562 - 575 | doi:10.1038/s41568-018-0020-9 In this Opinion, Joshi et al. argue that in cancer cells, a state of chaperome hyperconnectivity is obtained by increasing the interaction strength among chaperome machinery members. These chaperome scaffolding platforms act to increase the functional diversity of oncogenic processes and have implications for the development of chaperome inhibitors. Full Text | PDF   Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flow    Robert J. Gillies, Joel S. Brown, Alexander R. A. Anderson & Robert A. Gatenby pp576 - 585 | doi:10.1038/s41568-018-0030-7 This Opinion proposes that temporal variations in intratumoural blood flow are the result of eco-evolutionary dynamics. It describes adaptive strategies to stochastically varying environments that may strongly affect observed cancer phenotypes and clinical outcomes including formation of metastases and response to treatment. Full Text | PDF Collection: Cancer at Nature Research   Targeting ATR in cancer    Emilio Lecona & Oscar Fernandez-Capetillo pp586 - 595 | doi:10.1038/s41568-018-0034-3 This Opinion provides insight into the potential of targeting the replication stress response in cancer and discusses the strategy of inhibiting ataxia telangiectasia and Rad3-related protein (ATR) and the need for reliable biomarkers to enable patient stratification. Full Text | PDF Collection: Cancer at Nature Research   Advertisement Register for the latest nature.com webcast: Discover how fluorescent imaging is providing new insights into immune processes. Dr. Garry Nolan of Stanford University will present evidence of deep internal order in immune functionality demonstrating that differentiation and immune activities have evolved with a definable "shape".  Register for FREE today   Sponsored by Akoya Bio   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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