Monday, August 13, 2018

Leukemia - Table of Contents alert Volume 32 Issue 8

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Volume 32, Issue 8

In this issue
Review Article
Brief Communication
Also new
Now Enrolling - Clinical studies for oral pracinostat in Acute Myeloid Leukemia (AML) Patients Unfit for Induction Chemotherapy and in Myelodysplastic Syndromes (MDS) trials

Pracinostat is an investigational agent not approved for commercial use by the FDA or any other regulatory agency worldwide


Review Article

Molecular remission as a therapeutic objective in acute promyelocytic leukemia

Laura Cicconi, Pierre Fenaux, Hagop Kantarjian, Martin Tallman, Miguel A. Sanz et al.

Leukemia 2018 32 :1671 - 1678; July 19, 2018; 10.1038/s41375-018-0219-5


Abstract | Full Text

Diagnostic algorithm for lower-risk myelodysplastic syndromes

Ghulam J. Mufti, Donal P. McLornan, Arjan A. van de Loosdrecht, Ulrich Germing & Robert P. Hasserjian

Leukemia 2018 32 :1679 - 1696; June 26, 2018; 10.1038/s41375-018-0173-2


Abstract | Full Text

Patient-centered practice in elderly myeloma patients: an overview and consensus from the European Myeloma Network (EMN)

Alessandra Larocca, Sandra Maria Dold, Sonja Zweegman, Evangelos Terpos, Ralph Wäsch et al.

Leukemia 2018 32 :1697 - 1712; April 25, 2018; 10.1038/s41375-018-0142-9


Abstract | Full Text

Implications of STAT3 and STAT5 signaling on gene regulation and chromatin remodeling in hematopoietic cancer

Bettina Wingelhofer, Heidi A. Neubauer, Peter Valent, Xiaonan Han, Stefan N. Constantinescu et al.

Leukemia 2018 32 :1713 - 1726; March 27, 2018; 10.1038/s41375-018-0117-x


Abstract | Full Text


Characterisation of immunoparesis in newly diagnosed myeloma and its impact on progression-free and overall survival in both old and recent myeloma trials

Jennifer L. J. Heaney, John P. Campbell, Gulnaz Iqbal, David Cairns, Alex Richter et al.

Leukemia 2018 32 :1727 - 1738; June 20, 2018; 10.1038/s41375-018-0163-4


Abstract | Full Text

Inhibition of microRNA-138 enhances bone formation in multiple myeloma bone marrow niche

Shokichi Tsukamoto, Marianne B. Løvendorf, Jihye Park, Karma Z. Salem, Michaela R. Reagan et al.

Leukemia 2018 32 :1739 - 1750; June 20, 2018; 10.1038/s41375-018-0161-6


Abstract | Full Text

Consequences of mutant TET2 on clonality and subclonal hierarchy

Cassandra M. Hirsch, Aziz Nazha, Kassy Kneen, Mohamed E. Abazeed, Manja Meggendorfer et al.

Leukemia 2018 32 :1751 - 1761; May 24, 2018; 10.1038/s41375-018-0150-9


Abstract | Full Text

Recurrent somatic mutations are rare in patients with cryptic dyskeratosis congenita

Martin Kirschner, Angela Maurer, Marcin W. Wlodarski, Monica S. Ventura Ferreira, Anne-Sophie Bouillon et al.

Leukemia 2018 32 :1762 - 1767; April 02, 2018; 10.1038/s41375-018-0125-x


Abstract | Full Text

Moxetumomab pasudotox in relapsed/refractory hairy cell leukemia

Robert J. Kreitman, Claire Dearden, Pier Luigi Zinzani, Julio Delgado, Lionel Karlin et al.

Leukemia 2018 32 :1768 - 1777; July 20, 2018; 10.1038/s41375-018-0210-1


Abstract | Full Text

Obinutuzumab plus bendamustine in previously untreated patients with CLL: a subgroup analysis of the GREEN study

Stephan Stilgenbauer, Veronique Leblond, Robin Foà, Sebastian Böttcher, Osman Ilhan et al.

Leukemia 2018 32 :1778 - 1786; April 27, 2018; 10.1038/s41375-018-0146-5


Abstract | Full Text

The impact of individual comorbidities on non-relapse mortality following allogeneic hematopoietic stem cell transplantation

Joshua A. Fein, Avichai Shimoni, Myriam Labopin, Noga Shem-Tov, Ronit Yerushalmi et al.

Leukemia 2018 32 :1787 - 1794; June 27, 2018; 10.1038/s41375-018-0185-y


Abstract | Full Text

Brief Communication

Mutant IL-7Rα and mutant NRas are sufficient to induce murine T cell acute lymphoblastic leukemia

Sarah D. Cramer, Julie A. Hixon, Caroline Andrews, Ross J. Porter, Gisele O. L. Rodrigues et al.

Leukemia 2018 32 :1795 - 1882; February 15, 2018; 10.1038/s41375-017-0001-0


Abstract | Full Text

Ibrutinib versus temsirolimus: 3-year follow-up of patients with previously treated mantle cell lymphoma from the phase 3, international, randomized, open-label RAY study

S Rule, W Jurczak, M Jerkeman, C Rusconi, M Trneny et al.

Leukemia 2018 32 :1799 - 1803; February 02, 2018; 10.1038/s41375-018-0023-2


Abstract | Full Text

Once-weekly carfilzomib, pomalidomide, and low-dose dexamethasone for relapsed/refractory myeloma: a phase I/II study

Sara Bringhen, Roberto Mina, Anna Maria Cafro, Anna Marina Liberati, Stefano Spada et al.

Leukemia 2018 32 :1803 - 1807; January 30, 2018; 10.1038/s41375-018-0024-1


Abstract | Full Text

High PIM1 expression is a biomarker of T-cell acute lymphoblastic leukemia with JAK/STAT activation or t(6;7)(p21;q34)/TRB@-PIM1 rearrangement

Roberta La Starza, Monica Messina, Valentina Gianfelici, Valentina Pierini, Caterina Matteucci et al.

Leukemia 2018 32 :1807 - 1810; February 02, 2018; 10.1038/s41375-018-0031-2


Abstract | Full Text

Prognostic significance of interphase FISH in monoclonal gammopathy of undetermined significance

Arjun Lakshman, Shilpa Paul, S. Vincent Rajkumar, Rhett P. Ketterling, Patricia T. Greipp et al.

Leukemia 2018 32 :1811 - 1815; January 30, 2018; 10.1038/s41375-018-0030-3


Abstract | Full Text

Diagnostic thresholds for free light chains in multiple myeloma depend on the assay used

Xavier Bossuyt, Michel Delforge, Martin Reynders, Doreen Dillaerts, Ben Sprangers et al.

Leukemia 2018 32 :1815 - 1818; April 20, 2018; 10.1038/s41375-018-0041-0


Abstract | Full Text

Proteomic and genomic integration identifies kinase and differentiation determinants of kinase inhibitor sensitivity in leukemia cells

Pedro Casado, Edmund H. Wilkes, Farideh Miraki-Moud, Marym Mohammad Hadi, Ana Rio-Machin et al.

Leukemia 2018 32 :1818 - 1822; April 07, 2018; 10.1038/s41375-018-0032-1


Abstract | Full Text

Whole-exome sequencing reveals acquisition of mutations leading to the onset of donor cell leukemia after hematopoietic transplantation: a model of leukemogenesis

Julia Suárez-González, Carolina Martínez-Laperche, Nerea Martínez, Gabriela Rodríguez-Macías, Mi Kwon et al.

Leukemia 2018 32 :1822 - 1826; February 05, 2018; 10.1038/s41375-018-0042-z


Abstract | Full Text

MicroRNA-101 expression is associated with JAK2V617F activity and regulates JAK2/STAT5 signaling

Francesca Pagano, Federico Comoglio, Jacob Grinfeld, Juan Li, Anna Godfrey et al.

Leukemia 2018 32 :1826 - 1830; February 27, 2018; 10.1038/s41375-018-0053-9


Abstract | Full Text

Pegylated interferon Alfa-2a and hydroxyurea in polycythemia vera and essential thrombocythemia: differential cellular and molecular responses

Tsewang Tashi, Sabina Swierczek, Soo Jin Kim, Mohamed E. Salama, Jihyun Song et al.

Leukemia 2018 32 :1830 - 1833; February 28, 2018; 10.1038/s41375-018-0080-6


Abstract | Full Text

Reduced BAP1 activity prevents ASXL1 truncation-driven myeloid malignancy in vivo

Ying Guo, Hui Yang, Shi Chen, Peng Zhang, Rong Li et al.

Leukemia 2018 32 :1834 - 1837; April 02, 2018; 10.1038/s41375-018-0126-9


Abstract | Full Text

Genomic discovery and clonal tracking in multiple myeloma by cell-free DNA sequencing

Guangwu Guo, Noopur S. Raje, Charles Seifer, Jake Kloeber, Randi Isenhart et al.

Leukemia 2018 32 :1838 - 1841; March 27, 2018; 10.1038/s41375-018-0115-z


Abstract | Full Text

JAK/MAP kinase pathway activation and TP53 mutations in acute leukemia with megakaryocytic and erythroid differentiation

Wenbin Xiao, Raajit Rampal, Yanming Zhang, Robert Cimera, Achim A. Jungbluth et al.

Leukemia 2018 32 :1842 - 1845; April 24, 2018; 10.1038/s41375-018-0145-6


Abstract | Full Text

An MDS-derived cell line and a series of its sublines serve as an in vitro model for the leukemic evolution of MDS

Jun-ichiro Kida, Takayuki Tsujioka, Shin-ichiro Suemori, Shuichiro Okamoto, Kanae Sakakibara et al.

Leukemia 2018 32 :1846 - 1850; June 28, 2018; 10.1038/s41375-018-0189-7


Abstract | Full Text

A comparison of clinical and molecular characteristics of patients with systemic mastocytosis with chronic myelomonocytic leukemia to CMML alone

Mrinal M. Patnaik, Rangit Vallapureddy, Terra L. Lasho, Katherine P. Hoversten, Christy M. Finke et al.

Leukemia 2018 32 :1850 - 1856; April 02, 2018; 10.1038/s41375-018-0121-1


Abstract | Full Text

Granulomonocytic progenitors are key target cells of azacytidine in higher risk myelodysplastic syndromes and acute myeloid leukemia

Ashfaq Ali, Justine Penneroux, Reinaldo Dal Bello Jr, Aline Massé, Samuel Quentin et al.

Leukemia 2018 32 :1856 - 1860; February 26, 2018; 10.1038/s41375-018-0076-2


Abstract | Full Text

Cell of origin dictates aggression and stem cell number in acute lymphoblastic leukemia

Elaine G. Garcia, Sowmya Iyer, Sara P. Garcia, Siebe Loontiens, Ruslan I. Sadreyev et al.

Leukemia 2018 32 :1860 - 1865; April 18, 2018; 10.1038/s41375-018-0130-0


Abstract | Full Text

Nucleolin promotes execution of the hematopoietic stem cell gene expression program

Csaba Mahotka, Sanil Bhatia, Jutta Kollet & Edgar Grinstein

Leukemia 2018 32 :1865 - 1868; March 08, 2018; 10.1038/s41375-018-0090-4


Abstract | Full Text

Validation of a biological score to predict response in chronic lymphocytic leukemia patients treated front-line with bendamustine and rituximab

Massimo Gentile, Tait D. Shanafelt, Gianluigi Reda, Francesca Romana Mauro, Katja Zirlik et al.

Leukemia 2018 32 :1869 - 1873; March 20, 2018; 10.1038/s41375-018-0100-6


Abstract | Full Text

Discriminating a common somatic ASXL1 mutation (c.1934dup; p.G646Wfs*12) from artifact in myeloid malignancies using NGS

Michael O. Alberti, Sridhar Nonavinkere Srivatsan, Jin Shao, Samantha N. McNulty, Gue Su Chang et al.

Leukemia 2018 32 :1874 - 1878; June 29, 2018; 10.1038/s41375-018-0193-y


Abstract | Full Text

Polycomb repressive complex 2 haploinsufficiency identifies a high-risk subgroup of pediatric acute myeloid leukemia

Jonathan Bond, Elise Labis, Alice Marceau-Renaut, Nicolas Duployez, Myriam Labopin et al.

Leukemia 2018 32 :1878 - 1882; June 27, 2018; 10.1038/s41375-018-0187-9


Abstract | Full Text

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