| | | | | Table of ContentsOpinion News & Views Science & Society Scientific Reports Articles | Volume 19, Number 8 | Opinion | Recent studies support either X‐dampening or X‐inactivation as the mechanism of dosage compensation in human embryos. The data and possible underlying causes for these conflicting models are discussed here. Roni Saiba, Maniteja Arava and Srimonta Gayen Published online 23.07.2018 | | Digging up the graves of old ideas can be a fertile source of inspiration. Brooke Morriswood and Oliver Hoeller Published online 27.06.2018 | | The latest Facebook data breach highlights the need for guidelines for internet‐mediated big‐data research. Christophe Olivier Schneble, Bernice Simone Elger and David Shaw Published online 02.07.2018 | News & Views | Inhibition of the receptor tyrosine kinase AXL has been highlighted as promising therapeutic strategy in ovarian cancer. A study in this issue now identifies a novel mechanism to promote AXL dephosphorylation. Chiara Zurzolo Published online 02.07.2018 | | Charcot‐Marie‐Tooth neuropathy type 2A is thought to be caused by impaired mitochondrial fusion. A study in this issue now establishes a fly model to show that mainly increased mitochondrial fusion drives CMT2A. Eri Ueda and Naotada Ishihara Published online 20.07.2018 | Science & Society | Xenotransplantation using organs from human‐pig chimeras has great potential to alleviate the shortage of donor organs and benefit patients. However, scientific, ethical and financial issues need to be resolved before clinical testing can begin. John D Loike and Alan Kadish Published online 10.07.2018 | | Many promising vaccine candidates have not made it to the market, owing to economic rather than scientific factors. Market incentives, shared responsibility, and novel technologies could spur innovation to develop vaccines against a wider range of diseases. Adam Gristwood Published online 12.07.2018 | | A better understanding of the complex interplay between pathogens and the host immune system during co‐infection of different pathogens could help to develop more efficient therapies. Philip Hunter Published online 06.07.2018 | Scientific Reports | Functional compensation between individual stem and progenitor cells is critically important during disease progression and treatment. This study shows how individual HSC clones heterogeneously compensate for lymphopoietic deficiencies of other HSCs in vivo. Lisa Nguyen, Zheng Wang, Adnan Y Chowdhury, Elizabeth Chu, Jiya Eerdeng, Du Jiang and Rong Lu Published online 30.05.2018 | | The histone methyltransferase dMLL3/4 allows oocytes to acquire embryo fate at fertilization. dMLL3/4 promotes the expression of a coherent genetic program including a new oocyte‐to‐embryo transition gene, the IDGF4 glycoprotein. Pedro Prudêncio, Leonardo G Guilgur, João Sobral, Jörg D Becker, Rui Gonçalo Martinho and Paulo Navarro‐Costa Published online 23.07.2018 | Articles | In vivo expression in Drosophila motor neurons reveals that the two most prevalent forms of mitofusin alleles associated with CMT2A neuropathy (R94Q and R364W) have opposite effects on mitochondrial fusion. Najla El Fissi, Manuel Rojo, Aїcha Aouane, Esra Karatas, Gabriela Poliacikova, Claudine David, Julien Royet and Thomas Rival Published online 13.06.2018 | | Despite recent mass spectrometry‐based breakthroughs, accurate ADP‐ribose‐site localization remains challenging. Here the authors developed an unbiased, multistep ADP‐ribosylome data analysis workflow that identified tyrosine as a novel in vivo ADPr‐acceptor amino acid. Deena M Leslie Pedrioli, Mario Leutert, Vera Bilan, Kathrin Nowak, Kapila Gunasekera, Elena Ferrari, Ralph Imhof, Lars Malmström and Michael O Hottiger Published online 28.06.2018 | | Loss of 5‐hydroxymethylcytosine occurs frequently in a wide variety of tumours. This study provides proof of concept for an epigenetic differentiation therapy with vitamin C and its oxidation‐resistant derivative APM by induced 5hmC reprogramming. Guangzhe Ge, Ding Peng, Ziying Xu, Bao Guan, Zijuan Xin, Qun He, Yuanyuan Zhou, Xuesong Li, Liqun Zhou and Weimin Ci Published online 28.06.2018 | | MAP1B‐LC1 plays a pivotal role in the regulation of syntaxin 17 function. MAP1B‐LC1 provides a link between Stx17 and microtubules to prevent its association with Atg14L and autophagosome formation in fed cells. Kohei Arasaki, Haruki Nagashima, Yuri Kurosawa, Hana Kimura, Naoki Nishida, Naoshi Dohmae, Akitsugu Yamamoto, Shigeru Yanagi, Yuichi Wakana, Hiroki Inoue and Mitsuo Tagaya Published online 19.06.2018 | | S726‐phosphorylated adducin‐1 (ADD1) localizes to mitotic centrosomes and interacts with TPX2 to maintain spindle pole integrity. Wen‐Hsin Hsu, Won‐Jing Wang, Wan‐Yi Lin, Yu‐Min Huang, Chien‐Chen Lai, Jung‐Chi Liao and Hong‐Chen Chen | | MAPK/ERK signalling promotes ES cell differentiation. Negative feedback on ERK1/2 signalling influences the rate at which ES cells exit from naïve pluripotency. Interference with feedback regulator RSK increases the speed and homogeneity of transition to differentiation. Isabelle RE Nett, Carla Mulas, Laurent Gatto, Kathryn S Lilley and Austin Smith | | The GPI‐anchored tumour suppressor OPCML interacts with the oncogenic RTK AXL inducing its redistribution into cholesterol‐rich membrane domains. There, AXL is de‐phosphorylated by the resident phosphatase PTPRG, inhibiting AXL‐dependent signalling, motility and invasion. Jane Antony, Elisa Zanini, Zoe Kelly, Tuan Zea Tan, Evdoxia Karali, Mohammad Alomary, Youngrock Jung, Katherine Nixon, Paula Cunnea, Christina Fotopoulou, Andrew Paterson, Sushmita Roy‐Nawathe, Gordon B Mills, Ruby Yun‐Ju Huang, Jean Paul Thiery, Hani Gabra and Chiara Recchi Published online 15.06.2018 | | In C. elegans, caveolin‐1 expression and the formation of caveolae is positively regulated by the aging‐regulating insulin/IGF (IIS) cascade. The knockdown of cav‐1 extends lifespan and protects the worm from toxic protein aggregation, linking lipid assemblies to the regulation of aging. Noa Roitenberg, Michal Bejerano‐Sagie, Hana Boocholez, Lorna Moll, Filipa Carvalhal Marques, Ludmila Golodetzki, Yuval Nevo, Tayir Elami and Ehud Cohen Published online 26.06.2018 | | Synthetic hydrogels serve as microenvironments for the formation of micro‐capillaries by endothelial cells and mesenchymal stem cells. Perivascular MSCs change phenotype and extracellular matrix, a reversible switch also induced in Jagged1‐modified hydrogels. Ulrich Blache, Queralt Vallmajo‐Martin, Edward R Horton, Julien Guerrero, Valentin Djonov, Arnaud Scherberich, Janine T Erler, Ivan Martin, Jess G Snedeker, Vincent Milleret and Martin Ehrbar Published online 02.07.2018 | | Infection of human dendritic cells with a dengue RNA virus activates TLR9—known to recognize bacterial or viral DNA but not viral RNA—through inducing mitochondrial DNA release into the cytosol. Jenn‐Haung Lai, Mei‐Yi Wang, Chuan‐Yueh Huang, Chien‐Hsiang Wu, Li‐Feng Hung, Chia‐Ying Yang, Po‐Yuan Ke, Shue‐Fen Luo, Shih‐Jen Liu and Ling‐Jun Ho Published online 07.06.2018 | | | | Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation. | | | |
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