Nature Reviews Molecular Cell Biology contents August 2018 Volume 19 Number 8

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TABLE OF CONTENTS August 2018 Volume 19, Issue 8 Comment Research Highlights Reviews   Advertisement Nature Reviews Reader Survey At Nature Reviews we are continually looking for ways to ensure we meet our readers' needs. Your responses to this short survey will give us insight into how our content may be improved. Get started here. Comment   The challenges facing synthetic biology in eukaryotes    pp481 - 482 Francesca Ceroni & Tom Ellis doi:10.1038/s41580-018-0013-2 Stepping outside the comfort zone of membrane contact site research    pp483 - 484 Maria Bohnert & Maya Schuldiner doi:10.1038/s41580-018-0022-1 Cellular organelles extensively communicate with each other by close interactions, known as membrane contact sites. Schuldiner and Bohnert comment on the progress of this rapidly developing field, highlighting that the complexity of interactions at membrane contact sites is only now starting to emerge.   Research Highlights   Breakdancing on actin    p485 Paulina Strzyz doi:10.1038/s41580-018-0036-8 Two independent studies now show that polymerization of branched actin at DNA double-strand breaks (DSBs) mediates chromatin dynamics associated with homology-directed repair and is required for a robust and error-free DSB repair process.   Falling short to compete    pp486 - 487 Paulina Strzyz doi:10.1038/s41580-018-0032-z Increased shortening of RNA 3′ untranslated regions associated with tumorigenic transformation interferes with competing endogenous RNA (ceRNA) networks, which results in trans-repression of tumour suppressors through microRNA-mediated silencing.   Lipid droplets from the inside    pp486 - 487 Kim Baumann doi:10.1038/s41580-018-0037-7 The inner nuclear membrane is metabolically active and generates lipid droplets.   Parasitic interference    p487 Eytan Zlotorynski doi:10.1038/s41580-018-0035-9 MicroRNAs derived from a virus and teratocytes of a parasitic wasp are expressed in a host moth and delay its development by inhibiting the ecdysone receptor.   Nature Reviews Molecular Cell Biology JOBS of the week Bioinformatician Queen's University Belfast Postdoctoral position- Cell biology Sanofi Aventis R&D Research Scientist I, HIV Immunology Gilead Sciences Team Leader Antibody Engineering Glenmark pharmaceuticals SA Postdoctoral Scholar - Molecular and Cell Biology - He Lab University of California, Berkeley - The He Lab More Science jobs from Nature Reviews Molecular Cell Biology EVENT Metabolites as Signaling Molecules 09.12.18 Seattle, USA More science events from Advertisement Do you have a career question? The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.  Listen today!    Reviews   Dynamics and function of DNA methylation in plants    pp489 - 506 Huiming Zhang, Zhaobo Lang & Jian-Kang Zhu doi:10.1038/s41580-018-0016-z DNA methylation in plants mediates gene expression, transposon silencing, chromosome interactions and genome stability. It is therefore not surprising that the regulation of DNA methylation is important for plant development and for plant responses to biotic and abiotic stresses.   Designing cell function: assembly of synthetic gene circuits for cell biology applications    pp507 - 525 Mingqi Xie & Martin Fussenegger doi:10.1038/s41580-018-0024-z Taking advantage of genetic engineering, synthetic biology allows control and design of new cell functions. Recent advances in the development of genetic tools and the assembly of progressively more sophisticated gene circuits have made ‘designer cells’ a reality, with applications ranging from industry and biotechnology to medicine.   Roadblocks and resolutions in eukaryotic translation    pp526 - 541 Anthony P. Schuller & Rachel Green doi:10.1038/s41580-018-0011-4 Ribosomes encounter obstacles during translation elongation that cause their stalling and can have a profound impact on protein yield. Ribosome stalling depends on the genetic code, amino acid availability, regulatory elements and mRNA context and can be resolved by resumption of translation or by ribosome rescue and recycling.   Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. Click here to sign up.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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