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Nature Reviews Genetics Contents August 2018 Volume 19 Number 8

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TABLE OF CONTENTS

August 2018 Volume 19, Issue 8

Research Highlights
Reviews
 
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Research Highlights

 

Breakdancing on actin    p469
Paulina Strzyz
doi:10.1038/s41576-018-0033-y

Two independent studies now show that polymerization of branched actin at DNA double-strand breaks (DSBs) mediates chromatin dynamics associated with homology-directed repair and is required for a robust and error-free DSB repair process.

 

Chromosome interaction hubs around nuclear bodies    pp470 - 471
Linda Koch
doi:10.1038/s41576-018-0026-x

A paper in Cell presents split–pool recognition of interactions by tag extension (SPRITE), a method that enables the identification of multiple, simultaneously occurring DNA and RNA interactions genome-wide within the nucleus.

 

Refining the splice region    pp470 - 471
Rebecca Furlong
doi:10.1038/s41576-018-0028-8

A study in Genome Research reports the impact of genetic variation near splice sites on human disease and may help prioritize and functionally interpret newly identified variants.

 

Prospecting for pluripotency    p471
Dorothy Clyde
doi:10.1038/s41576-018-0030-1

Unlike most organisms, planaria maintain pluripotent stem cells (PSCs) beyond embryogenesis. A new study reports the prospective identification and isolation of a neoblast subpopulation containing adult PSCs, characterization of which should help uncover the mechanisms underlying pluripotency and tissue regeneration.

 

All eyes on rapid adaptive evolution    p472
Linda Koch
doi:10.1038/s41576-018-0027-9

A new study reveals that DNA methylation-mediated repression of gene expression regulates early eye development in blind cave morphs of Astyanax mexicanus.

 

What makes us human?    p472
Linda Koch
doi:10.1038/s41576-018-0029-7

A publication in Science reports the sequencing, assembly and comparative analysis of new and improved great ape genomes and provides a stepping stone for the identification of genetic variation specific to humans.

 

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Reviews

 

A-to-I RNA editing — immune protector and transcriptome diversifier    pp473 - 490
Eli Eisenberg & Erez Y. Levanon
doi:10.1038/s41576-018-0006-1

Next-generation sequencing technologies have enabled the comparison of editomes from multiple individuals and from multiple species. The results have changed our understanding of the extent and distribution of A-to-I editing and its role in evolution and disease.

 

From genome-wide associations to candidate causal variants by statistical fine-mapping    pp491 - 504
Daniel J. Schaid, Wenan Chen & Nicholas B. Larson
doi:10.1038/s41576-018-0016-z

Fine-mapping is the process by which a trait-associated region from a genome-wide association study (GWAS) is analysed to identify the particular genetic variants that are likely to causally influence the examined trait. This Review discusses the diverse statistical approaches to fine-mapping and their foundations, strengths and limitations, including integration of trans-ethnic human population data and functional annotations.

 

The rice genome revolution: from an ancient grain to Green Super Rice    pp505 - 517
Rod A. Wing, Michael D. Purugganan & Qifa Zhang
doi:10.1038/s41576-018-0024-z

Genomic technologies are helping researchers to understand the natural genetic variation that exists in wild and cultivated rice populations. Harnessing this genetic variation will be key to developing Green Super Rice varieties with high yield and low environmental costs.

 

Controlling nuclear RNA levels    pp518 - 529
Manfred Schmid & Torben Heick Jensen
doi:10.1038/s41576-018-0013-2

RNA is controlled at various stages of transcription and processing to achieve appropriate gene regulation. Whereas much research has focused on the cytoplasmic control of RNA levels, this Review discusses our emerging appreciation of the importance of nuclear RNA regulation, including the molecular machinery involved in nuclear RNA decay, how functional RNAs bypass degradation and roles for nuclear RNA decay in physiology and disease.

 

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