Wednesday, July 25, 2018

Nature Reviews Cancer contents August 2018 Volume 18 Number 8

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Nature Reviews Cancer

Visualize and Quantify Cellular Interactions in the Tumor Microenvironment

What would it mean to your research if you could accurately quantify cellular interactions in the tumor microenvironment? Download the eBook to learn how scientists are using the Phenoptics research solution to visualize, analyze, quantify and phenotype immune cells in situ, in FFPE tissue sections and TMAs. Download eBook

August 2018 Volume 18, Issue 8

Research Highlights
Amendments & Corrections

Lower Your QNS Rate with this Novel FFPE Extraction Method

Extracting high quality DNA and RNA from FFPE samples can be extremely challenging due to variability among samples and nucleic acid damage during the fixation process. The extraction process is also time-consuming and labor intensive. The Covaris truXTRAC ® FFPE kits provide a novel solution to these challenges by utilizing Adaptive Focused Acoustics ® (AFA ®) to physically remove paraffin from FFPE samples, improving nucleic acid extraction.
Learn more about this process and how truXTRAC FFPE can dramatically improve your FFPE extraction.


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Join us November 2-5, 2018 in New Orleans, LA to advance the understanding of, and ultimately help to eliminate, the disparities along the cancer continuum that represent a major public health problem in our country. Learn more
Scientific Reports Editor's choice collection: Tumour Microenvironment Researchers are unravelling the dynamics of tumour microenvironments to understand how to model, define and fight tumours using multidisciplinary approaches. This collection presents a selection of articles from a variety of fields outlining some of the work being done within this growing research topic. Access the collection >>>

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Research Highlights


Success stories    p465
Ulrike Harjes

Analyses of clinical trial patients with exceptional responses show that adoptive T cell therapy can be optimised to improve effectiveness in patients of chronic lymphocytic leukaemia and breast cancer.


It’s all Greek to me    pp466 - 467
Anna Dart

Tumour-associated neutrophils can inhibit the proliferation of pro-tumoural interleukin-17 (IL-17)+ γδ T cells via production of reactive oxygen species.


Falling short to compete    pp466 - 467
Paulina Strzyz

Increased shortening of RNA 3′ untranslated regions associated with tumorigenic transformation interferes with competing endogenous RNA (eRNA) networks, which results in trans-repression of tumour suppressors through microRNA-mediated silencing.


From rock ‘n’ roll to heavy metal    p467
Ulrike Harjes

Three studies published in Developmental Cell, Nature and Nature Medicine shed new light on mechanisms of cancer-associated cachexia in early and advanced disease.


Tumours trigger systemic disruption    pp468 - 469
Sarah Seton-Rogers

Breast tumours in mice promote metabolic changes in the liver and sleep disruption through increasing activity of hypocretin (also known as orexin) neurons (HO neurons).


STAT3 on the brain    pp468 - 469
Sarah Seton-Rogers

Priego et al. show that a subpopulation of reactive astrocytes expressing signal transducer and activator of transcription 3 (STAT3) is crucial for the development of brain metastases and report positive initial clinical data that inhibiting STAT3 can reduce metastasis.


Metabolizing microbes in control    p469
Anna Dart

The gut microbiota can metabolize bile acids to affect immunosurveillance in the liver of mice and indirectly control the growth of primary liver tumours and liver metastases.


Nature Reviews Cancer
JOBS of the week
Postdoctoral Fellow – Cancer Innate Immunity
Johnson & Johnson Pharmaceutical Research & Development
Group Leader in Immuno-Oncology
Gustave Roussy Cancer Campus
Postdoc position – Liver Cancer Translational Research: Barcelona
IDIBAPS (August Pi i Sunyer Biomedical Research Institute)
Endowed Chair In Cancer Research
University of Iowa Health Care, Department of Pathology
German Cancer Research Center (DKFZ).
More Science jobs from
Nature Reviews Cancer
Frontiers in Cancer Research
Heidelberg, Germany
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A causal mechanism for childhood acute lymphoblastic leukaemia    pp471 - 484
Mel Greaves

In this Review, Greaves describes the evidence supporting the model that infections early in life reduce the risk of childhood common B cell precursor acute lymphoblastic leukaemia (BCP-ALL) development. Given this evidence, paediatric BCP-ALL may be a preventable cancer.


Inflammatory breast cancer biology: the tumour microenvironment is key    pp485 - 499
Bora Lim, Wendy A. Woodward, Xiaoping Wang, James M. Reuben & Naoto T. Ueno

Although the aggressive underlying biology of inflammatory breast cancer (IBC) remains largely undefined, the tumour microenvironment (TME) has emerged as a key contributor. This Review discusses intrinsic characteristics of IBC, extrinsic features of the TME and intrinsic–extrinsic communication.



Do you have a career question?

The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud. 

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Artificial intelligence in radiology    pp500 - 510
Ahmed Hosny, Chintan Parmar, John Quackenbush, Lawrence H. Schwartz & Hugo J. W. L. Aerts

In this Opinion article, Hosny et al. discuss the application of artificial intelligence to image-based tasks in the field of radiology and consider the advantages and challenges of its clinical implementation.


Ciliary signalling in cancer    pp511 - 524
Hanqing Liu, Anna A. Kiseleva & Erica A. Golemis

This Opinion discusses the role of the primary cilium as a platform for pathways implicated in cancer and how changes in the ciliation of cells in the tumour microenvironment can affect cancer progression.


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Insights on cancer resistance in vertebrates: reptiles as a parallel system to mammals    p525
Ylenia Chiari, Scott Glaberman & Vincent J. Lynch

Amendments & Corrections


Publisher Correction: Oncolytic viruses as engineering platforms for combination immunotherapy    p526
Kwame Twumasi-Boateng, Jessica L. Pettigrew, Y. Y. Eunice Kwok, John C. Bell & Brad H. Nelson

Author Correction: Inflammatory breast cancer biology: the tumour microenvironment is key    p526
Bora Lim, Wendy A. Woodward, Xiaoping Wang, James M. Reuben & Naoto T. Ueno

Author Correction: A causal mechanism for childhood acute lymphoblastic leukaemia    p526
Mel Greaves

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