Nature Reviews Cancer contents August 2018 Volume 18 Number 8

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Advertisement Visualize and Quantify Cellular Interactions in the Tumor Microenvironment What would it mean to your research if you could accurately quantify cellular interactions in the tumor microenvironment? Download the eBook to learn how scientists are using the Phenoptics™ research solution to visualize, analyze, quantify and phenotype immune cells in situ, in FFPE tissue sections and TMAs. Download eBook TABLE OF CONTENTS August 2018 Volume 18, Issue 8 Research Highlights Reviews Perspectives Correspondence Amendments & Corrections   Advertisement   Lower Your QNS Rate with this Novel FFPE Extraction Method Extracting high quality DNA and RNA from FFPE samples can be extremely challenging due to variability among samples and nucleic acid damage during the fixation process. The extraction process is also time-consuming and labor intensive. The Covaris truXTRAC ® FFPE kits provide a novel solution to these challenges by utilizing Adaptive Focused Acoustics ® (AFA ®) to physically remove paraffin from FFPE samples, improving nucleic acid extraction.   Learn more about this process and how truXTRAC FFPE can dramatically improve your FFPE extraction.   Advertisement 11th AACR Conference on The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved  Join us November 2-5, 2018 in New Orleans, LA to advance the understanding of, and ultimately help to eliminate, the disparities along the cancer continuum that represent a major public health problem in our country. Learn more   Advertisement Scientific Reports Editor's choice collection: Tumour Microenvironment Researchers are unravelling the dynamics of tumour microenvironments to understand how to model, define and fight tumours using multidisciplinary approaches. This collection presents a selection of articles from a variety of fields outlining some of the work being done within this growing research topic. Access the collection >>>   Advertisement Are you a talented researcher ready for a new leadership role?  Indiana University's Precision Health Initiative has an ambitious plan to find a cure or an effective treatment for cancer, and your skills could help achieve that goal.  Find out more. *ad feature   Research Highlights   Success stories    p465 Ulrike Harjes doi:10.1038/s41568-018-0039-y Analyses of clinical trial patients with exceptional responses show that adoptive T cell therapy can be optimised to improve effectiveness in patients of chronic lymphocytic leukaemia and breast cancer.   It’s all Greek to me    pp466 - 467 Anna Dart doi:10.1038/s41568-018-0032-5 Tumour-associated neutrophils can inhibit the proliferation of pro-tumoural interleukin-17 (IL-17)+ γδ T cells via production of reactive oxygen species.   Falling short to compete    pp466 - 467 Paulina Strzyz doi:10.1038/s41568-018-0036-1 Increased shortening of RNA 3′ untranslated regions associated with tumorigenic transformation interferes with competing endogenous RNA (eRNA) networks, which results in trans-repression of tumour suppressors through microRNA-mediated silencing.   From rock ‘n’ roll to heavy metal    p467 Ulrike Harjes doi:10.1038/s41568-018-0041-4 Three studies published in Developmental Cell, Nature and Nature Medicine shed new light on mechanisms of cancer-associated cachexia in early and advanced disease.   Tumours trigger systemic disruption    pp468 - 469 Sarah Seton-Rogers doi:10.1038/s41568-018-0040-5 Breast tumours in mice promote metabolic changes in the liver and sleep disruption through increasing activity of hypocretin (also known as orexin) neurons (HO neurons).   STAT3 on the brain    pp468 - 469 Sarah Seton-Rogers doi:10.1038/s41568-018-0042-3 Priego et al. show that a subpopulation of reactive astrocytes expressing signal transducer and activator of transcription 3 (STAT3) is crucial for the development of brain metastases and report positive initial clinical data that inhibiting STAT3 can reduce metastasis.   Metabolizing microbes in control    p469 Anna Dart doi:10.1038/s41568-018-0035-2 The gut microbiota can metabolize bile acids to affect immunosurveillance in the liver of mice and indirectly control the growth of primary liver tumours and liver metastases.   Nature Reviews Cancer JOBS of the week Postdoctoral Fellow – Cancer Innate Immunity Johnson & Johnson Pharmaceutical Research & Development Group Leader in Immuno-Oncology Gustave Roussy Cancer Campus Postdoc position – Liver Cancer Translational Research: Barcelona IDIBAPS (August Pi i Sunyer Biomedical Research Institute) Endowed Chair In Cancer Research University of Iowa Health Care, Department of Pathology Postdoc German Cancer Research Center (DKFZ). More Science jobs from Nature Reviews Cancer EVENT Frontiers in Cancer Research 09.10.18 Heidelberg, Germany More science events from Reviews   A causal mechanism for childhood acute lymphoblastic leukaemia    pp471 - 484 Mel Greaves doi:10.1038/s41568-018-0015-6 In this Review, Greaves describes the evidence supporting the model that infections early in life reduce the risk of childhood common B cell precursor acute lymphoblastic leukaemia (BCP-ALL) development. Given this evidence, paediatric BCP-ALL may be a preventable cancer.   Inflammatory breast cancer biology: the tumour microenvironment is key    pp485 - 499 Bora Lim, Wendy A. Woodward, Xiaoping Wang, James M. Reuben & Naoto T. Ueno doi:10.1038/s41568-018-0010-y Although the aggressive underlying biology of inflammatory breast cancer (IBC) remains largely undefined, the tumour microenvironment (TME) has emerged as a key contributor. This Review discusses intrinsic characteristics of IBC, extrinsic features of the TME and intrinsic–extrinsic communication.   Advertisement   Do you have a career question? The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.  Listen today!   Perspectives   Artificial intelligence in radiology    pp500 - 510 Ahmed Hosny, Chintan Parmar, John Quackenbush, Lawrence H. Schwartz & Hugo J. W. L. Aerts doi:10.1038/s41568-018-0016-5 In this Opinion article, Hosny et al. discuss the application of artificial intelligence to image-based tasks in the field of radiology and consider the advantages and challenges of its clinical implementation.   Ciliary signalling in cancer    pp511 - 524 Hanqing Liu, Anna A. Kiseleva & Erica A. Golemis doi:10.1038/s41568-018-0023-6 This Opinion discusses the role of the primary cilium as a platform for pathways implicated in cancer and how changes in the ciliation of cells in the tumour microenvironment can affect cancer progression.   Advertisement Nature Reviews Reader Survey At Nature Reviews we are continually looking for ways to ensure we meet our readers' needs. Your responses to this short survey will give us insight into how our content may be improved. Get started here.     Correspondence   Insights on cancer resistance in vertebrates: reptiles as a parallel system to mammals    p525 Ylenia Chiari, Scott Glaberman & Vincent J. Lynch doi:10.1038/s41568-018-0033-4 Amendments & Corrections   Publisher Correction: Oncolytic viruses as engineering platforms for combination immunotherapy    p526 Kwame Twumasi-Boateng, Jessica L. Pettigrew, Y. Y. Eunice Kwok, John C. Bell & Brad H. Nelson doi:10.1038/s41568-018-0019-2 Author Correction: Inflammatory breast cancer biology: the tumour microenvironment is key    p526 Bora Lim, Wendy A. Woodward, Xiaoping Wang, James M. Reuben & Naoto T. Ueno doi:10.1038/s41568-018-0022-7 Author Correction: A causal mechanism for childhood acute lymphoblastic leukaemia    p526 Mel Greaves doi:10.1038/s41568-018-0029-0 Advertisement nature.com webcasts Nature Research Custom presents a webcast on: Molecular imaging reveals ONC201 antitumor efficacy and immune stimulation in cancer models Date: Wednesday, August 15, 2018 Join our live webcast to learn about the benefits of cell culture, xenograft tissue sections and mouse models coupled with imaging in preclinical immuno-oncology trials. This webcast has been produced on behalf of the sponsor who retains sole responsibility for content Register for FREE  Sponsored by: Perkin Elmer      Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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