Monday, July 30, 2018

Nature Immunology Contents: August 2018 Volume 19 Issue 8

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August 2018 Volume 19, Issue 8

Research Highlights
News & Views
Review Articles
Amendments & Corrections

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Research Highlights


Symbionts and metabolites    p787
Ioana Visan

Modeling AD    p787
Ioana Visan

Triggering myelopoiesis    p787
Laurie A. Dempsey

Autophagy & MDSCs    p787
Laurie A. Dempsey

A harmful pairing    p787
Zoltan Fehervari

TILs show the way    p787
Zoltan Fehervari

JOBS of the week
Senior Bioinformatics Scientist
Armauer Hansen Research Institute
Postdoctoral Fellow
University of California - San Francisco
Faculty Positions at Institut Pasteur of Shanghai, Chinese Academy of Sciences, China
Institute Pasteur of Shanghai, Chinese Academy of Sciences, China
Postdoctoral Fellow (m / f) in the Rinkevich Lab
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Postdoctoral Fellow
The University of Texas MD Anderson Cancer Center
More Science jobs from
Cancer Immunotherapy: Recent Progress and Future Challenges
Palermo, Italy
More science events from



Comment on: Evidence of innate lymphoid cell redundancy in humans    pp788 - 789
Jordan S. Orange, Emily M. Mace, Anthony R. French, Wayne M. Yokoyama, Todd A. Fehniger et al.

Reply to ‘Comment on: Evidence of innate lymphoid cell redundancy in humans’    pp789 - 790
Eric Vivier, Fréderic Vély & Alain Fischer

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News & Views


B cells race the clock to get a second wind    pp791 - 793
Tri Giang Phan & Stuart G. Tangye

Co-stimulatory second signals delivered through TLRs or CD40 rescue antigen-stimulated B cells from metabolic dysfunction and apoptosis. This identifies a critical time-limited window during which B cells integrate sequential signals to successfully initiate humoral immunity.


γδ T cells and IgE team up to prevent tumors    pp793 - 795
J. Michael McGraw & Wendy L. Havran

In response to epithelial DNA damage, tissue-resident γδ T cells initiate and shape a tumor-protective IgE response that requires CD4+ T cells and immune effector cells expressing the high-affinity IgE receptor FcεRI.


An RNA checkpoint that keeps immunological memory at bay    pp795 - 797
Dimitris L. Kontoyiannis

What keeps memory T cells functionally silent in the absence of infection is unclear. New data reveal the existence of a deterministic halt in the protein-synthesis machinery of memory T cells and expose the discriminatory functions of a family of RNA-binding proteins.


CD8+ T cells have commitment issues    pp797 - 799
Renu Balyan, Joanna Brzostek & Nicholas R. J. Gascoigne

T cell activation is 'digital': exhaustive single-cell analysis shows that only the proportion of cells that cross the activation threshold is reduced when the affinity of the TCR for its ligand is reduced.


Review Articles


Natural killer cell specificity for viral infections    pp800 - 808
Quirin Hammer, Timo Rückert & Chiara Romagnani

Romagnani and colleagues discuss the specific recognition of viral antigens and peptides by NK cells and its implications for the composition of the NK cell repertoire and the selection of viral variants.




The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity    pp809 - 820
Wilson Castro, Sonia T. Chelbi, Charlène Niogret, Cristina Ramon-Barros, Suzanne P. M. Welten et al.

Regulatory factor X (RFX) is a transcription factor family comprising seven known members, yet the functional roles of RFX7 remain unknown. Guarda and colleagues show that RFX7 regulates natural killer (NK) cell survival and activity by limiting their cellular metabolism.


TCRs are randomly distributed on the plasma membrane of resting antigen-experienced T cells    pp821 - 827
Benedikt Rossboth, Andreas M. Arnold, Haisen Ta, René Platzer, Florian Kellner et al.

TCRs are often thought to be pre-clustered before T cell activation. Rossboth et al. use super-resolution microscopy and statistical image analysis to demonstrate that TCRs are in fact randomly distributed on resting T cells.


Translational repression of pre-formed cytokine-encoding mRNA prevents chronic activation of memory T cells    pp828 - 837
Fiamma Salerno, Sander Engels, Maartje van den Biggelaar, Floris P. J. van Alphen, Aurelie Guislain et al.

Wolkers and colleagues show that the RNA-binding protein ZFP36L2 represses the translation of pre-formed cytokine-encoding mRNAs in memory T cells.


Maintenance of CD4 T cell fitness through regulation of Foxo1    pp838 - 848
Ryan H. Newton, Sharad Shrestha, Jenna M. Sullivan, Kathleen B. Yates, Ewoud B. Compeer et al.

Foxo proteins are required for maintaining T cell quiescence. Turka and colleagues use a constitutively active Foxo1 in Treg cells to show that its downregulation is essential for maintaining their fitness in a competitive environment.


T cell cytolytic capacity is independent of initial stimulation strength    pp849 - 858
Arianne C. Richard, Aaron T. L. Lun, Winnie W. Y. Lau, Berthold Göttgens, John C. Marioni et al.

Lymphocytes interpret antigenic signals into a functional response. Richard et al. demonstrate that the overall qualitative response by CTLs is independent of TCR ligand strength; instead, ligands determine the rate and uniformity at which CTLs respond.


Epithelial damage and tissue γδ T cells promote a unique tumor-protective IgE response    pp859 - 870
Greg Crawford, Mark David Hayes, Rocio Castro Seoane, Sophie Ward, Tim Dalessandri et al.

Evidence of protective and homeostatic roles for IgE is relatively limited. Strid and colleagues demonstrate that γδ T cells induce switching to IgE that provides protection against experimentally induced epithelial cancer.


Second signals rescue B cells from activation-induced mitochondrial dysfunction and death    pp871 - 884
Munir Akkaya, Javier Traba, Alexander S. Roesler, Pietro Miozzo, Billur Akkaya et al.

B cells need at least two signals to terminally differentiate into antibody-secreting cells. Pierce and colleagues show that persistent exposure to antigen in the absence of T cell help or ‘pathogen pattern motifs’ leads to B cell death via a calcium-dependent ‘metabolic timer’.




Adjustment of dendritic cells to the breast-cancer microenvironment is subset specific    pp885 - 897
Paula Michea, Floriane Noël, Eve Zakine, Urszula Czerwinska, Philémon Sirven et al.

Soumelis and colleagues use RNA-based sequencing to define the transcriptional signatures of DC subsets and monocytes-macrophages in human primary breast cancer.


Amendments & Corrections


Author Correction: T-bet-dependent NKp46+ innate lymphoid cells regulate the onset of TH17-induced neuroinflammation    p898
Brandon Kwong, Rejane Rua, Yuanyuan Gao, John Flickinger Jr, Yan Wang et al.

Publisher Correction: Macrophages: damage control    p898
Zoltan Fehervari

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