| Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13 Structural analysis demonstrates how TRIP13 and p31comet disassemble the mitotic checkpoint complex. Claudio Alfieri, Leifu Chang, David Barford | Targeting STING with covalent small-molecule inhibitors The discovery and characterization of small-molecule antagonists that inhibit the stimulator of interferon genes (STING) protein may help to develop therapies for the treatment of autoinflammatory disease. Simone M. Haag, Muhammet F. Gulen, Luc Reymond et al. | Coronary artery development, one cell at a time An analysis of gene-expression patterns in single cells provides detailed insights into the developmental processes that lead to maturation of the coronary arteries. Arndt F. Siekmann | Structure of the origin recognition complex bound to DNA replication origin The cryo-EM structure of the yeast origin recognition complex (ORC) bound to a 72-base-pair origin DNA sequence provides insights into the basis of the origin selection mechanism. Ningning Li, Wai Hei Lam, Yuanliang Zhai et al. | Species-specific activity of antibacterial drug combinations Screening pairwise combinations of antibiotics and other drugs against three bacterial pathogens reveals that antagonistic and synergistic drug–drug interactions are specific to microbial species and strains. Ana Rita Brochado, Anja Telzerow, Jacob Bobonis et al. | Evolution of cooperation in stochastic games Cooperation is more likely to evolve in a public-goods-distribution game when payoffs can change between rounds so that the stakes increase when players cooperate and decrease when players defect. Christian Hilbe, Štěpán Šimsa, Krishnendu Chatterjee et al. | Suppression of insulin feedback enhances the efficacy of PI3K inhibitors Benjamin D. Hopkins, Chantal Pauli, Xing Du et al. | CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions Mutations in all three genes encoding ribonuclease H2 sensitize cells to poly(ADP–ribose) polymerase inhibitors by compromising ribonucleotide excision repair. Michal Zimmermann, Olga Murina, Martin A. M. Reijns et al. | The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells Activation of P2RX7 receptors by extracellular ATP is required for the generation, maintenance and function of central and tissue-resident CD8+ memory T cells. Henrique Borges da Silva, Lalit K. Beura, Haiguang Wang et al. | Single-cell analysis of early progenitor cells that build coronary arteries During development, new arteries can arise from pre-existing veins; the cell fate switch involved occurs gradually and before the onset of blood flow in mouse embryo hearts. Tianying Su, Geoff Stanley, Rahul Sinha et al. | Speciation far from the madding crowd New species of marine fishes are found to emerge at a faster rate in high-latitude oceans, which have lower densities of species, than in the species-rich tropics. Are the tropics too crowded for new species to take hold? Arne O. Mooers, Dan A. Greenberg | An inverse latitudinal gradient in speciation rate for marine fishes Contrary to previous hypotheses, high-latitude fish lineages form new species at much faster rates than their tropical counterparts especially in geographical regions that are characterized by low surface temperatures and high endemism. Daniel L. Rabosky, Jonathan Chang, Pascal O. Title et al. | Kinase-controlled phase transition of membraneless organelles in mitosis The dual-specificity kinase DYRK3 acts as a central ‘dissolvase’, mediating the phase transitions of several types of membraneless organelles during mitosis. Arpan Kumar Rai, Jia-Xuan Chen, Matthias Selbach et al. | Scaling up molecular pattern recognition with DNA-based winner-take-all neural networks DNA-strand-displacement reactions are used to implement a neural network that can distinguish complex and noisy molecular patterns from a set of nine possibilities—an improvement on previous demonstrations that distinguished only four simple patterns. Kevin M. Cherry, Lulu Qian | Self-organizing multicellular structures designed using synthetic biology Synthetic genetic circuits can induce cells to form simple 3D structures reminiscent of those generated during early embryonic development. This advance will help engineers build tissues that have desirable structures. Jesse Tordoff, Ron Weiss | Synchronous tropical and polar temperature evolution in the Eocene A 26-million-year record of equatorial sea surface temperatures reveals synchronous changes of tropical and polar temperatures during the Eocene epoch forced by variations in concentrations of atmospheric carbon dioxide, with a constant degree of polar amplification. Margot J. Cramwinckel, Matthew Huber, Ilja J. Kocken et al. | | | Structure of a human synaptic GABAA receptor The cryo-electron microscopy structure of the type A GABA receptor bound to GABA and the benzodiazepine site antagonist flumazenil reveals structural mechanisms that underlie intersubunit interactions and ligand selectivity of the receptor. Shaotong Zhu, Colleen M. Noviello, Jinfeng Teng et al. | | | OTULIN limits cell death and inflammation by deubiquitinating LUBAC OTULIN, which removes ubiquitin chains deposited by LUBAC, promotes LUBAC activity by preventing its auto-ubiquitination, thereby supporting normal mouse embryo development and preventing pro-inflammatory cell death in adult mice. Klaus Heger, Katherine E. Wickliffe, Ada Ndoja et al. | | Cryo-EM structure of an essential Plasmodium vivax invasion complex Structural studies show that conserved residues in Plasmodium vivax reticulocyte-binding protein 2b determine interactions with transferrin receptor 1 that are essential for host invasion, suggesting avenues for designing vaccines that work across P. vivax strains. Jakub Gruszczyk, Rick K. Huang, Li-Jin Chan et al. | | | | | |
No comments:
Post a Comment