| | Advertisement | | Do you have a career question? The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud. Listen today! | | | | | | | | | | | Latest Editorial | | | | | | | | Latest Articles | View all Articles | | | Structural and topological nature of plasticity in sheared granular materials OPEN | | Yixin Cao, Jindong Li, Binquan Kou, Chengjie Xia, Zhifeng Li, Rongchang Chen, Honglan Xie, Tiqiao Xiao, Walter Kob, Liang Hong, Jie Zhang & Yujie Wang | | | It is a general consensus that the structural defects are the plasticity carriers in amorphous solids, but its microscopic view remains largely unknown. Cao et a. show that highly distorted coplanar tetrahedra act as defects in granular packings, which flip under shear to carry local plasticity. | | 25 July 2018 | doi: 10.1038/s41467-018-05329-8 | | Condensed-matter physics Glasses | A mosquito salivary gland protein partially inhibits Plasmodium sporozoite cell traversal and transmission OPEN | | Tyler R. Schleicher, Jing Yang, Marianna Freudzon, Alison Rembisz, Samuel Craft, Madeleine Hamilton, Morven Graham, Godfree Mlambo, Abhai K. Tripathi, Yue Li, Peter Cresswell, Photini Sinnis, George Dimopoulos & Erol Fikrig | | | Mosquito saliva can affect transmission of Plasmodium to mammalian hosts, but active saliva components or mechanisms are poorly understood. Here, the authors identify a mosquito saliva protein that binds Plasmodium sporozoites and inhibits cell traversal in vitro and sporozoite speed in mice. | | 25 July 2018 | doi: 10.1038/s41467-018-05374-3 | | Malaria Parasite biology Pathogens | PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity OPEN | | Jessica van Setten, Jennifer A. Brody, Yalda Jamshidi, Brenton R. Swenson, Anne M. Butler, Harry Campbell, Fabiola M. Del Greco, Daniel S. Evans, Quince Gibson, Daniel F. Gudbjartsson, Kathleen F. Kerr, Bouwe P. Krijthe, Leo-Pekka Lyytikäinen, Christian Müller, Martina Müller-Nurasyid, Ilja M. Nolte, Sandosh Padmanabhan, Marylyn D. Ritchie, Antonietta Robino, Albert V. Smith et al. | | | Abnormal PR interval duration is associated with risk for atrial fibrillation and heart block. Here, van Setten et al. identify 44 PR interval loci in a genome-wide association study of over 92,000 individuals and find genetic overlap with QRS duration, heart rate and atrial fibrillation. | | 25 July 2018 | doi: 10.1038/s41467-018-04766-9 | | Atrial fibrillation Cardiovascular genetics Genetic association study | Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins OPEN | | Alexander P. Hynes, Geneviève M. Rousseau, Daniel Agudelo, Adeline Goulet, Beatrice Amigues, Jeremy Loehr, Dennis A. Romero, Christophe Fremaux, Philippe Horvath, Yannick Doyon, Christian Cambillau & Sylvain Moineau | | | Some phages carry genes coding for anti-CRISPR (Acr) proteins that interfere with the activity of bacterial CRISPR-Cas systems. Here, Hynes et al. characterize a new Acr family from streptococcal phages and investigate its potential in genome-editing applications. | | 25 July 2018 | doi: 10.1038/s41467-018-05092-w | | CRISPR-Cas9 genome editing Phage biology | Enhancer histone-QTLs are enriched on autoimmune risk haplotypes and influence gene expression within chromatin networks OPEN | | Richard C. Pelikan, Jennifer A. Kelly, Yao Fu, Caleb A. Lareau, Kandice L. Tessneer, Graham B. Wiley, Mandi M. Wiley, Stuart B. Glenn, John B. Harley, Joel M. Guthridge, Judith A. James, Martin J. Aryee, Courtney Montgomery & Patrick M. Gaffney | | | Disease risk variants can exert their influence on phenotypes by altering epigenome function. Here, Pelikan et al. show that variants inducing allelic imbalance in histone marks in lymphoblastoid cell lines from lupus patients are enriched in autoimmune disease haplotypes and influence gene expression. | | 25 July 2018 | doi: 10.1038/s41467-018-05328-9 | | Autoimmune diseases Chromatin structure Epigenomics Quantitative trait loci | Suppression of atom motion and metal deposition in mixed ionic electronic conductors OPEN | | Pengfei Qiu, Matthias T. Agne, Yongying Liu, Yaqin Zhu, Hongyi Chen, Tao Mao, Jiong Yang, Wenqing Zhang, Sossina M. Haile, Wolfgang G. Zeier, Jürgen Janek, Ctirad Uher, Xun Shi, Lidong Chen & G. Jeffrey Snyder | | | Mixed ionic–electronic conductors are limited by material decomposition. Here the authors reveal the mechanism for atom migration and deposition in Cu2–δ(S,Se) materials based on a critical chemical potential difference and propose electronically conducting, ion-blocking interfaces to enhance stability. | | 25 July 2018 | doi: 10.1038/s41467-018-05248-8 | | Electrochemistry Thermodynamics Thermoelectric devices and materials Thermoelectrics | Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer OPEN | | Aurélie S. Cazet, Mun N. Hui, Benjamin L. Elsworth, Sunny Z. Wu, Daniel Roden, Chia-Ling Chan, Joanna N. Skhinas, Raphaël Collot, Jessica Yang, Kate Harvey, M. Zahied Johan, Caroline Cooper, Radhika Nair, David Herrmann, Andrea McFarland, Niantao Deng, Manuel Ruiz-Borrego, Federico Rojo, José M. Trigo, Susana Bezares et al. | | | Stromal cell recruitment, activation and crosstalk with cancer cells is poorly understood. Here, the authors demonstrate that cancer cell-derived Hedgehog ligand triggers stromal remodeling that in turn induces a cancer-stem-cell like, drug-resistant phenotype of nearby cancer cells while treatment with smoothened inhibitors reverses these phenotypes. | | 24 July 2018 | doi: 10.1038/s41467-018-05220-6 | | Breast cancer Cancer microenvironment Cancer stem cells | Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens OPEN | | Giulia Escobar, Luigi Barbarossa, Giulia Barbiera, Margherita Norelli, Marco Genua, Anna Ranghetti, Tiziana Plati, Barbara Camisa, Chiara Brombin, Davide Cittaro, Andrea Annoni, Attilio Bondanza, Renato Ostuni, Bernhard Gentner & Luigi Naldini | | | An immune suppressive tumor microenvironment (TME) is a limitation for immunotherapy. Here the authors show that, in a B cell acute lymphoblastic leukemia mouse model, gene-based delivery of IFNα reprograms the leukemia-induced immunosuppressive TME into immunostimulatory and enhances T-cell responses. | | 24 July 2018 | doi: 10.1038/s41467-018-05315-0 | | Cancer immunotherapy Cancer microenvironment Tumour immunology | In-orbit operation of an atomic clock based on laser-cooled 87Rb atoms OPEN | | Liang Liu, De-Sheng Lü, Wei-Biao Chen, Tang Li, Qiu-Zhi Qu, Bin Wang, Lin Li, Wei Ren, Zuo-Ren Dong, Jian-Bo Zhao, Wen-Bing Xia, Xin Zhao, Jing-Wei Ji, Mei-Feng Ye, Yan-Guang Sun, Yuan-Yuan Yao, Dan Song, Zhao-Gang Liang, Shan-Jiang Hu, Dun-He Yu et al. | | | Cold atom clocks are among the most precise measuring devices and play key roles in everyday life and scientific explorations. Here the authors demonstrate the first in-orbit atomic clock using cold Rb atoms operating in microgravity and opening possibilities of space surveys and tests of fundamental physics. | | 24 July 2018 | doi: 10.1038/s41467-018-05219-z | | Atomic and molecular interactions with photons Quantum metrology Quantum optics | Femtosecond formation dynamics of the spin Seebeck effect revealed by terahertz spectroscopy OPEN | | Tom S. Seifert, Samridh Jaiswal, Joseph Barker, Sebastian T. Weber, Ilya Razdolski, Joel Cramer, Oliver Gueckstock, Sebastian F. Maehrlein, Lukas Nadvornik, Shun Watanabe, Chiara Ciccarelli, Alexey Melnikov, Gerhard Jakob, Markus Münzenberg, Sebastian T. B. Goennenwein, Georg Woltersdorf, Baerbel Rethfeld, Piet W. Brouwer, Martin Wolf, Mathias Kläui et al. | | | Probing spin-transfer in THz regime facilities new understanding of magnon control and applications. Here the authors show that spin Seebeck current arises as fast as metal electron thermalization by femtosecond laser pulse in YIG/Pt, which reveals its critical dependence on carrier dynamics after excitation. | | 24 July 2018 | doi: 10.1038/s41467-018-05135-2 | | Spintronics Terahertz optics | Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID OPEN | | Hiroki Sasaguri, Kenichi Nagata, Misaki Sekiguchi, Ryo Fujioka, Yukio Matsuba, Shoko Hashimoto, Kaori Sato, Deepika Kurup, Takanori Yokota & Takaomi C. Saido | | | CRISPR-guided cytidine deaminases, including BE3 (Base Editor 3) and Target-AID (activation-induced cytidine deaminase), can covert C:G base pairs to T:A at target site. Here, the authors generate missense mutations of mouse Psen1 gene and find BE3 has higher editing efficiency than Target-AID. | | 24 July 2018 | doi: 10.1038/s41467-018-05262-w | | Alzheimer's disease CRISPR-Cas9 genome editing Diseases Neurochemistry | Prioritizing phylogenetic diversity captures functional diversity unreliably OPEN | | Florent Mazel, Matthew W. Pennell, Marc W. Cadotte, Sandra Diaz, Giulio Valentino Dalla Riva, Richard Grenyer, Fabien Leprieur, Arne O. Mooers, David Mouillot, Caroline M. Tucker & William D. Pearse | | | An ongoing conservation question is if we can maintain functional diversity by optimizing for preservation of phylogenetic diversity. Here, Mazel et al. show that functional diversity increases with phylogenetic diversity in some clades but not others, and thus could be a risky conservation strategy. | | 23 July 2018 | doi: 10.1038/s41467-018-05126-3 | | Biodiversity Conservation biology | Discovery of a silicate rock-boring organism and macrobioerosion in fresh water OPEN | | Ivan N. Bolotov, Olga V. Aksenova, Torkild Bakken, Christopher J. Glasby, Mikhail Yu. Gofarov, Alexander V. Kondakov, Ekaterina S. Konopleva, Manuel Lopes-Lima, Artyom A. Lyubas, Yu Wang, Andrey Yu. Bychkov, Agniya M. Sokolova, Kitti Tanmuangpak, Sakboworn Tumpeesuwan, Ilya V. Vikhrev, J. Bruce H. Shyu, Than Win & Oleg S. Pokrovsky | | | Macrobioerosion, the boring of rock and other hard substrates by living organisms, is used as a marker of marine paleo-environments. Here, Bolotov et al. describe a rock-boring mussel and its associated community from freshwater in Myanmar, demonstrating that macrobioerosion is a wider phenomenon. | | 23 July 2018 | doi: 10.1038/s41467-018-05133-4 | | Biodiversity Biogeography Freshwater ecology Palaeoecology | Microbial biogeography of 925 geothermal springs in New Zealand OPEN | | Jean F. Power, Carlo R. Carere, Charles K. Lee, Georgia L. J. Wakerley, David W. Evans, Mathew Button, Duncan White, Melissa D. Climo, Annika M. Hinze, Xochitl C. Morgan, Ian R. McDonald, S. Craig Cary & Matthew B. Stott | | | Power et al. catalogue the microbial biodiversity and physicochemistry of around 1000 hotsprings across New Zealand, providing insights into the ecological conditions that drive community assembly in these ecosystems. | | 23 July 2018 | doi: 10.1038/s41467-018-05020-y | | Biogeography Environmental microbiology Microbial ecology | Lithography for robust and editable atomic-scale silicon devices and memories OPEN | | Roshan Achal, Mohammad Rashidi, Jeremiah Croshaw, David Churchill, Marco Taucer, Taleana Huff, Martin Cloutier, Jason Pitters & Robert A. Wolkow | | | Manipulation at the atomic scale comes with a trade-off between simplicity and thermal stability. Here, Achal et al. demonstrate improved automated hydrogen lithography and repassivation, enabling error-corrected atomic writing of large-scale structures/memories that are stable at room temperature. | | 23 July 2018 | doi: 10.1038/s41467-018-05171-y | | Electronics, photonics and device physics Semiconductors Surface patterning | A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer OPEN | | Tomoko Saito, Atsushi Niida, Ryutaro Uchi, Hidenari Hirata, Hisateru Komatsu, Shotaro Sakimura, Shuto Hayashi, Sho Nambara, Yosuke Kuroda, Shuhei Ito, Hidetoshi Eguchi, Takaaki Masuda, Keishi Sugimachi, Taro Tobo, Haruto Nishida, Tsutomu Daa, Kenichi Chiba, Yuichi Shiraishi, Tetsuichi Yoshizato, Masaaki Kodama et al. | | | Advanced colorectal cancers are characterised by intra-tumour heterogeneity dictated by neutral evolution. Here the authors analyse early colorectal tumours by whole-exome sequencing and find that Darwinian evolution determines the fate of early lesions in colorectal adenoma and carcinoma in situ. | | 23 July 2018 | doi: 10.1038/s41467-018-05226-0 | | Colorectal cancer Tumour heterogeneity | Atomic-level insight into super-efficient electrocatalytic oxygen evolution on iron and vanadium co-doped nickel (oxy)hydroxide OPEN | | Jian Jiang, Fanfei Sun, Si Zhou, Wei Hu, Hao Zhang, Jinchao Dong, Zheng Jiang, Jijun Zhao, Jianfeng Li, Wensheng Yan & Mei Wang | | | While splitting water could provide a renewable way to produce fuel, highly active catalysts are needed to overcome water oxidation’s sluggish kinetics. Here, authors gain atomic-level insight on metal ion synergetic interactions that boost water oxidation performances in co-doped nickel hydroxide. | | 23 July 2018 | doi: 10.1038/s41467-018-05341-y | | Characterization and analytical techniques Electrocatalysis Solid-state chemistry | Signatures of transient Wannier-Stark localization in bulk gallium arsenide OPEN | | C. Schmidt, J. Bühler, A.-C. Heinrich, J. Allerbeck, R. Podzimski, D. Berghoff, T. Meier, W. G. Schmidt, C. Reichl, W. Wegscheider, D. Brida & A. Leitenstorfer | | | In strong enough electric fields the non-linear response of electrons in crystals is expected to lead to spatial localization but so far this has only been seen in artificial structures. Schmidt et al. present evidence of this Wannier-Stark localization effect in bulk GaAs driven by intense mid-infrared pulses. | | 23 July 2018 | doi: 10.1038/s41467-018-05229-x | | Electronic properties and materials Semiconductors Terahertz optics | Metaproteomics reveals associations between microbiome and intestinal extracellular vesicle proteins in pediatric inflammatory bowel disease OPEN | | Xu Zhang, Shelley A. Deeke, Zhibin Ning, Amanda E. Starr, James Butcher, Jennifer Li, Janice Mayne, Kai Cheng, Bo Liao, Leyuan Li, Ruth Singleton, David Mack, Alain Stintzi & Daniel Figeys | | | Gut microbial dysbiosis has been implicated in the pathogenesis of inflammatory bowel disease. Here, the authors examine host-microbiota protein interactions that occur in inflammatory bowel disease; they show an upregulation in proteins related to antimicrobial activities, and alterations in intestinal extracellular vesicles that are associated with aberrant microbiota-interactions. | | 20 July 2018 | doi: 10.1038/s41467-018-05357-4 | | Gastrointestinal diseases Microbiome Paediatric research Proteomics | Direct reprogramming of fibroblasts into neural stem cells by single non-neural progenitor transcription factor Ptf1a OPEN | | Dongchang Xiao, Xiaoning Liu, Min Zhang, Min Zou, Qinqin Deng, Dayu Sun, Xuting Bian, Yulong Cai, Yanan Guo, Shuting Liu, Shengguo Li, Evelyn Shiang, Hongyu Zhong, Lin Cheng, Haiwei Xu, Kangxin Jin & Mengqing Xiang | | | Fibroblasts can be reprogrammed into induced neural stem cells (iNSCs) using transcription factors expressed in neural progenitors. Here the authors show that Ptf1a, which is normally expressed in postmitotic neurons, can reprogram fibroblasts to iNSCs through Notch independent interaction with Rbpj. | | 20 July 2018 | doi: 10.1038/s41467-018-05209-1 | | Alzheimer's disease Neural stem cells | Collective magnetism in an artificial 2D XY spin system OPEN | | Naëmi Leo, Stefan Holenstein, Dominik Schildknecht, Oles Sendetskyi, Hubertus Luetkens, Peter M. Derlet, Valerio Scagnoli, Diane Lançon, José R. L. Mardegan, Thomas Prokscha, Andreas Suter, Zaher Salman, Stephen Lee & Laura J. Heyderman | | | Magnetic metamaterials can be designed to provide models of frustrated systems that allow theoretical predictions to be experimentally tested. Here the authors realise a 2D XY model with dipolar interactions and find behaviour consistent with predictions of a low-temperature ordered state. | | 20 July 2018 | doi: 10.1038/s41467-018-05216-2 | | Magnetic properties and materials Phase transitions and critical phenomena Statistical physics, thermodynamics and nonlinear dynamics | Co-transmission of acetylcholine and GABA regulates hippocampal states OPEN | | Virág T. Takács, Csaba Cserép, Dániel Schlingloff, Balázs Pósfai, András Szőnyi, Katalin E. Sos, Zsuzsanna Környei, Ádám Dénes, Attila I. Gulyás, Tamás F. Freund & Gábor Nyiri | | | Acetylcholine (ACh) release in the central nervous system is thought to be unitary and mediated non-synaptically in volume transmission. Here, Takács and colleagues show cholinergic terminals juxtapose GABAergic synapses anatomically and functionally, and GABA and ACh molecules are co-transmitted. | | 20 July 2018 | doi: 10.1038/s41467-018-05136-1 | | Cellular neuroscience Neurotransmitters | Abnormal RNA stability in amyotrophic lateral sclerosis OPEN | | E. M. Tank, C. Figueroa-Romero, L. M. Hinder, K. Bedi, H. C. Archbold, X. Li, K. Weskamp, N. Safren, X. Paez-Colasante, C. Pacut, S. Thumma, M. T. Paulsen, K. Guo, J. Hur, M. Ljungman, E. L. Feldman & S. J. Barmada | | | RNA instability may be a contributing factor in amyotrophic lateral sclerosis (ALS). Here the authors carry out genome-wide assessment of RNA synthesis and stability in cells derived from patients with C9orf72 ALS, sporadic ALS and healthy controls. | | 20 July 2018 | doi: 10.1038/s41467-018-05049-z | | Amyotrophic lateral sclerosis RNA | An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure OPEN | | Yoshinori Takahashi, Haiyan He, Zhenyuan Tang, Tatsuya Hattori, Ying Liu, Megan M. Young, Jacob M. Serfass, Longgui Chen, Melat Gebru, Chong Chen, Carson A. Wills, Jennifer M. Atkinson, Han Chen, Thomas Abraham & Hong-Gang Wang | | | During autophagy, phagophores elongate to form double-membrane vesicles but the mechanism behind their closure is unknown. Here, the authors develop an autophagy assay and find a role for the endosomal sorting complexes required for transport component CHMP2A as a phagophore closure regulator. | | 20 July 2018 | doi: 10.1038/s41467-018-05254-w | | ESCRT Macroautophagy Molecular biology | TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity OPEN | | Paloma Riquelme, Jan Haarer, Anja Kammler, Lisa Walter, Stefan Tomiuk, Norbert Ahrens, Anja K. Wege, Ivan Goecze, Daniel Zecher, Bernhard Banas, Rainer Spang, Fred Fändrich, Manfred B. Lutz, Birgit Sawitzki, Hans J. Schlitt, Jordi Ochando, Edward K. Geissler & James A. Hutchinson | | | Regulatory macrophages (Mreg) can directly suppress T effector cell responses. Here the authors show that human Mreg also elicit TIGIT+ regulatory T cells by integrating multiple differentiation signals, and that donor Mreg-induced recipient Tregs may promote kidney transplant acceptance in patients. | | 20 July 2018 | doi: 10.1038/s41467-018-05167-8 | | Allotransplantation Immunosuppression Monocytes and macrophages Regulatory T cells | Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma OPEN | | Matija Snuderl, Kasthuri Kannan, Elke Pfaff, Shiyang Wang, James M. Stafford, Jonathan Serrano, Adriana Heguy, Karina Ray, Arline Faustin, Olga Aminova, Igor Dolgalev, Stacie L. Stapleton, David Zagzag, Luis Chiriboga, Sharon L. Gardner, Jeffrey H. Wisoff, John G. Golfinos, David Capper, Volker Hovestadt, Marc K. Rosenblum et al. | | | Pineoblastoma is a highly aggressive and rare childhood brain cancer, and the genetic drivers of sporadic pineoblastoma are unknown. Here, the authors genomically interrogated pediatric and adult pineoblastomas and found novel variants including recurrent homozygous deletions of DROSHA. | | 20 July 2018 | doi: 10.1038/s41467-018-05029-3 | | Cancer epigenetics Cancer genomics CNS cancer Paediatric cancer | High-throughput discovery of organic cages and catenanes using computational screening fused with robotic synthesis OPEN | | R. L. Greenaway, V. Santolini, M. J. Bennison, B. M. Alston, C. J. Pugh, M. A. Little, M. Miklitz, E. G. B. Eden-Rump, R. Clowes, A. Shakil, H. J. Cuthbertson, H. Armstrong, M. E. Briggs, K. E. Jelfs & A. I. Cooper | | | Supramolecular assemblies remain of great importance to a variety of fields, yet their targeted design and synthesis remains highly challenging. Here, Cooper and colleagues combine computational screening with high-throughput robotic synthesis and discover 33 new organic cage molecules that form cleanly in one-pot syntheses. | | 20 July 2018 | doi: 10.1038/s41467-018-05271-9 | | Computational chemistry Interlocked molecules Molecular capsules Self-assembly | Abrupt high-latitude climate events and decoupled seasonal trends during the Eemian OPEN | | J. Sakari Salonen, Karin F. Helmens, Jo Brendryen, Niina Kuosmanen, Minna Väliranta, Simon Goring, Mikko Korpela, Malin Kylander, Annemarie Philip, Anna Plikk, Hans Renssen & Miska Luoto | | | The Eemian period (120 ka) is considered a past analogue for future climatic warming, yet data from the high latitudes remains sparse. Here, the authors show that in Northern Europe, the Eemian saw dramatic climatic shifts, linked to changes in Earth’s orbit and North Atlantic oceanic circulation. | | 20 July 2018 | doi: 10.1038/s41467-018-05314-1 | | Climate change Palaeoclimate Palaeoecology | How nanoscale protein interactions determine the mesoscale dynamic organisation of bacterial outer membrane proteins OPEN | | Matthieu Chavent, Anna L. Duncan, Patrice Rassam, Oliver Birkholz, Jean Hélie, Tyler Reddy, Dmitry Beliaev, Ben Hambly, Jacob Piehler, Colin Kleanthous & Mark S. P. Sansom | | | In Escherichia coli, outer membrane protein (OMP) cluster and form islands, but the origin and behaviour of those clusters remains poorly understood. Here authors use coarse grained molecular dynamics simulation and show that their mesoscale simulations recapitulate the restricted diffusion characteristics of OMPs. | | 20 July 2018 | doi: 10.1038/s41467-018-05255-9 | | Biophysical chemistry Computational biophysics | FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence OPEN | | Joana Catarina Macedo, Sara Vaz, Bjorn Bakker, Rui Ribeiro, Petra Lammigje Bakker, Jose Miguel Escandell, Miguel Godinho Ferreira, René Medema, Floris Foijer & Elsa Logarinho | | | Evidence for mitotic decline in aged cells and for aneuploidy-driven progression into full senescence is limited. Here, the authors find that in aged cells, mitotic gene repression leads to increased chromosome mis-segregation and aneuploidy that triggers permanent cell cycle arrest and full senescence. | | 19 July 2018 | doi: 10.1038/s41467-018-05258-6 | | Aneuploidy Chromosome segregation Mechanisms of disease Senescence | HIV-1 targets L-selectin for adhesion and induces its shedding for viral release OPEN | | Joseph Kononchik, Joanna Ireland, Zhongcheng Zou, Jason Segura, Genevieve Holzapfel, Ashley Chastain, Ruipeng Wang, Matthew Spencer, Biao He, Nicole Stutzman, Daiji Kano, James Arthos, Elizabeth Fischer, Tae-Wook Chun, Susan Moir & Peter Sun | | | HIV binding is mediated via CD4 and chemokine co-receptors, but this does not explain the preferential infection of central memory CD4+ T cells. Here the authors show HIV targets L-selectin, induces shedding from the infected cell, and inhibition of L-selectin reduces HIV infection and release. | | 19 July 2018 | doi: 10.1038/s41467-018-05197-2 | | HIV infections | Genomic inference of the metabolism and evolution of the archaeal phylum Aigarchaeota OPEN | | Zheng-Shuang Hua, Yan-Ni Qu, Qiyun Zhu, En-Min Zhou, Yan-Ling Qi, Yi-Rui Yin, Yang-Zhi Rao, Ye Tian, Yu-Xian Li, Lan Liu, Cindy J. Castelle, Brian P. Hedlund, Wen-Sheng Shu, Rob Knight & Wen-Jun Li | | | The phylum of archaea Aigarchaeota is poorly characterized due to limited genomic sampling. Here, Hua and colleagues use genome-resolved metagenome sequencing to reconstruct six hot spring strains of Aigarchaeota and then infer their metabolism and evolutionary history. | | 19 July 2018 | doi: 10.1038/s41467-018-05284-4 | | Archaeal genomics Archaeal physiology Metagenomics Molecular evolution | Gate-controlled quantum dots and superconductivity in planar germanium OPEN | | N. W. Hendrickx, D. P. Franke, A. Sammak, M. Kouwenhoven, D. Sabbagh, L. Yeoh, R. Li, M. L. V. Tagliaferri, M. Virgilio, G. Capellini, G. Scappucci & M. Veldhorst | | | Superconductor–semiconductor hybrid systems can bring together physical properties that are promising for fast and coherent quantum technology. Here, Hendrickx et al. realize such a system in planar germanium heterostructures demonstrating excellent quantum dots and tunable Josephson supercurrents. | | 19 July 2018 | doi: 10.1038/s41467-018-05299-x | | Quantum dots Superconducting devices Superconducting properties and materials | Assessment of the impact of shared brain imaging data on the scientific literature OPEN | | Michael P. Milham, R. Cameron Craddock, Jake J. Son, Michael Fleischmann, Jon Clucas, Helen Xu, Bonhwang Koo, Anirudh Krishnakumar, Bharat B. Biswal, F. Xavier Castellanos, Stan Colcombe, Adriana Di Martino, Xi-Nian Zuo & Arno Klein | | | Data sharing is recognized as a way to promote scientific collaboration and reproducibility, but some are concerned over whether research based on shared data can achieve high impact. Here, the authors show that neuroimaging papers using shared data are no less likely to appear in top-ranked journals. | | 19 July 2018 | doi: 10.1038/s41467-018-04976-1 | | Cognitive neuroscience Databases Policy | Non-covalent control of spin-state in metal-organic complex by positioning on N-doped graphene OPEN | | Bruno de la Torre, Martin Švec, Prokop Hapala, Jesus Redondo, Ondřej Krejčí, Rabindranath Lo, Debashree Manna, Amrit Sarmah, Dana Nachtigallová, Jiří Tuček, Piotr Błoński, Michal Otyepka, Radek Zbořil, Pavel Hobza & Pavel Jelínek | | | Molecules can change their electronic properties when they are adsorbed on substrates, which can be useful for sensing and catalysis. Here, the authors use atomic force microscopy to show that the spin state of an iron complex can be changed upon displacing the molecule to different sites of a nitrogen-doped graphene | | 19 July 2018 | doi: 10.1038/s41467-018-05163-y | | Magnetic properties and materials Molecular electronics Scanning probe microscopy Two-dimensional materials | PRMT5-mediated regulation of developmental myelination OPEN | | Antonella Scaglione, Julia Patzig, Jialiang Liang, Rebecca Frawley, Jabez Bok, Angeliki Mela, Camila Yattah, Jingxian Zhang, Shun Xie Teo, Ting Zhou, Shuibing Chen, Emily Bernstein, Peter Canoll, Ernesto Guccione & Patrizia Casaccia | | | Myelin-forming cells derive from oligodendrocyte progenitors. Here the authors identify histone arginine methyl-transferase PRMT5 as critical for developmental myelination by modulating the cross-talk between histone arginine methylation and lysine acetylation, to favor differentiation. | | 19 July 2018 | doi: 10.1038/s41467-018-04863-9 | | Epigenetics Epigenetics in the nervous system Glial biology Histone post-translational modifications | Armadillo repeat containing 12 promotes neuroblastoma progression through interaction with retinoblastoma binding protein 4 OPEN | | Dan Li, Huajie Song, Hong Mei, Erhu Fang, Xiaojing Wang, Feng Yang, Huanhuan Li, Yajun Chen, Kai Huang, Liduan Zheng & Qiangsong Tong | | | Armadillo (ARM) family proteins can act as oncogenes or tumor suppressors. Here, the authors show that a new ARM protein (ARMC12) is upregulated in neuroblastoma, binds the PRC2 component RBBP4, and inhibits transcription of tumor suppressive genes. | | 19 July 2018 | doi: 10.1038/s41467-018-05286-2 | | Oncogenes Paediatric cancer | SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix OPEN | | Masatoshi Fukuda, Tatsuya Yoshizawa, Md. Fazlul Karim, Shihab U. Sobuz, Wataru Korogi, Daiki Kobayasi, Hiroki Okanishi, Masayoshi Tasaki, Katsuhiko Ono, Tomohiro Sawa, Yoshifumi Sato, Mami Chirifu, Takeshi Masuda, Teruya Nakamura, Hironori Tanoue, Kazuhisa Nakashima, Yoshihiro Kobashigawa, Hiroshi Morioka, Eva Bober, Sumio Ohtsuki et al. | | | SP7/Osterix is a transcription factor involved in osteoblast differentiation. Here, the authors show that Sirtuin 7 activates Osterix posttranslationally by regulating its lysine acylation, and that mice lacking Sirtuin 7 in osteoblasts show reduced bone formation. | | 19 July 2018 | doi: 10.1038/s41467-018-05187-4 | | Bone remodelling Post-translational modifications | The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis OPEN | | Wenguang Yin, Hyun-Taek Kim, ShengPeng Wang, Felix Gunawan, Lei Wang, Keishi Kishimoto, Hua Zhong, Dany Roman, Jens Preussner, Stefan Guenther, Viola Graef, Carmen Buettner, Beate Grohmann, Mario Looso, Mitsuru Morimoto, Graeme Mardon, Stefan Offermanns & Didier Y. R. Stainier | | | Tubulogenesis is required for the formation of many internal structures including the trachea. Here, the authors show that the potassium channel KCNJ13 regulates tracheal tube formation, with shorter tracheas forming in mutant mice due in part to changes in actin organization in tracheal smooth muscle cells. | | 19 July 2018 | doi: 10.1038/s41467-018-05043-5 | | Cytoskeleton Morphogenesis | | | | | | | | Latest Correspondence | | | | Reply to ‘Trace N-glycans including sulphated species may originate from various plasma glycoproteins and not necessarily IgG’ OPEN | | Jing-Rong Wang, Wei-Na Gao, Rudolf Grimm, Shibo Jiang, Yong Liang, Hua Ye, Zhan-Guo Li, Lee-Fong Yau, Hao Huang, Ju Liu, Min Jiang, Qiong Meng, Tian-Tian Tong, Hai-Hui Huang, Stephanie Lee, Xing Zeng, Liang Liu & Zhi-Hong Jiang | | 25 July 2018 | doi: 10.1038/s41467-018-05082-y | | Glycomics Rheumatoid arthritis | | | | | Latest Addendum | | | | | | | | Latest Publisher Corrections | | | | | | | | Advertisement | | Communications Chemistry: Open for Submissions Communications Chemistry is a new open access journal that publishes high-quality primary research articles, reviews and commentary representing significant advances and new insights to the field of chemistry. 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