| | | | | | Advertisement | | Professor Mark Ferguson, Director-General of Science Foundation Ireland explains why he's looking to attract researchers to work in Ireland. With access to funding from the Irish Government and industry, it's a great time to think about moving. Read more. *ad feature | | | | | | | Latest Articles | View all Articles | | | Slow thermal equilibration in methylammonium lead iodide revealed by transient mid-infrared spectroscopy OPEN | | Peijun Guo, Jue Gong, Sridhar Sadasivam, Yi Xia, Tze-Bin Song, Benjamin T. Diroll, Constantinos C. Stoumpos, John B. Ketterson, Mercouri G. Kanatzidis, Maria K. Y. Chan, Pierre Darancet, Tao Xu & Richard D. Schaller | | | Hybrid organic-inorganic perovskites are emerging materials for efficient photovoltaics; however understanding how charge/heat dissipates inside the material remains a challenge. Here, the authors use a spectroscopic approach to observe unusually slow thermal equilibration between the organic and inorganic components. | | 18 July 2018 | doi: 10.1038/s41467-018-05015-9 | | Atomistic models Condensed-matter physics Materials for energy and catalysis Optical spectroscopy | Bilophila wadsworthia aggravates high fat diet induced metabolic dysfunctions in mice OPEN | | Jane M. Natividad, Bruno Lamas, Hang Phuong Pham, Marie-Laure Michel, Dominique Rainteau, Chantal Bridonneau, Gregory da Costa, Johan van Hylckama Vlieg, Bruno Sovran, Celia Chamignon, Julien Planchais, Mathias L. Richard, Philippe Langella, Patrick Veiga & Harry Sokol | | | Lipid intake is known to promote Bilophila wadsworthia growth. Here the authors show that B. wadsworthia aggravates high fat diet induced metabolic dysfunctions and its suppression, both pharmacologically or mediated by Lactobacillus rhamnosus, limits the severity of metabolic impairment. | | 18 July 2018 | doi: 10.1038/s41467-018-05249-7 | | Metabolic syndrome Microbiome | Using controlled disorder to probe the interplay between charge order and superconductivity in NbSe2 OPEN | | Kyuil Cho, M. Kończykowski, S. Teknowijoyo, M. A. Tanatar, J. Guss, P. B. Gartin, J. M. Wilde, A. Kreyssig, R. J. McQueeney, A. I. Goldman, V. Mishra, P. J. Hirschfeld & R. Prozorov | | | The interplay between superconductivity and charge density wave (CDW) in 2H-NbSe2 is still not fully understood. Here, Cho et al. use controlled disorder to probe the interplay between these two phases in 2H-NbSe2 and find that superconductivity initially competes with CDW but eventually long-range CDW order assists superconductivity. | | 18 July 2018 | doi: 10.1038/s41467-018-05153-0 | | Electronic properties and materials Superconducting properties and materials | A complex of C9ORF72 and p62 uses arginine methylation to eliminate stress granules by autophagy OPEN | | Maneka Chitiprolu, Chantal Jagow, Veronique Tremblay, Emma Bondy-Chorney, Geneviève Paris, Alexandre Savard, Gareth Palidwor, Francesca A. Barry, Lorne Zinman, Julia Keith, Ekaterina Rogaeva, Janice Robertson, Mathieu Lavallée-Adam, John Woulfe, Jean-François Couture, Jocelyn Côté & Derrick Gibbings | | | Many Amyotrophic Lateral Sclerosis (ALS)-linked mutations cause accumulation of stress granules, and most ALS cases are caused by repeat expansions in C9ORF72. Here the authors show that C9ORF72 and the autophagy receptor p62 interact to associate with proteins symmetrically dimethylated on arginines such as FUS, to eliminate stress granules by autophagy. | | 18 July 2018 | doi: 10.1038/s41467-018-05273-7 | | Amyotrophic lateral sclerosis Macroautophagy Methylation | p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis OPEN | | Talha Anwar, Caroline Arellano-Garcia, James Ropa, Yu-Chih Chen, Hong Sun Kim, Euisik Yoon, Sierrah Grigsby, Venkatesha Basrur, Alexey I. Nesvizhskii, Andrew Muntean, Maria E. Gonzalez, Kelley M. Kidwell, Zaneta Nikolovska-Coleska & Celina G. Kleer | | | Polycomb group protein EZH2 is overexpressed in ER- breast cancer, promoting metastasis. Here, the authors show that independent of the polycomb group, phosphorylation of EZH2 at T367 by p38 promotes cytoplasmic localization of EZH2, binding to vinculin and other regulators of cell migration and invasion. | | 18 July 2018 | doi: 10.1038/s41467-018-05078-8 | | Metastasis Oncogenes Phosphorylation | TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival OPEN | | Lele Zhu, Xiaoping Xie, Lingyun Zhang, Hui Wang, Zuliang Jie, Xiaofei Zhou, Jianhong Shi, Shuli Zhao, Boxiang Zhang, Xuhong Cheng & Shao-Cong Sun | | | Interleukin-15 (IL-15) regulates the homeostasis of many immune cell types, including natural killer T (NKT) cells, but the underlying mechanism is not completely clear. Here the authors analyse Tbkbp1-deficient mice and show that IL-15 induces Tbkbp1-dependent autophagy to modulate NKT survival. | | 18 July 2018 | doi: 10.1038/s41467-018-05097-5 | | Autophagy Interleukins NKT cells Signal transduction | Manipulation of facet orientation in hybrid perovskite polycrystalline films by cation cascade OPEN | | Guanhaojie Zheng, Cheng Zhu, Jingyuan Ma, Xiaonan Zhang, Gang Tang, Runguang Li, Yihua Chen, Liang Li, Jinsong Hu, Jiawang Hong, Qi Chen, Xingyu Gao & Huanping Zhou | | | Crystal facet orientations of the polycrystalline hybrid lead halide perovskite thin films play a crucial role in determining the device performance. Here Zheng et al. demonstrate effective control of the crystal stacking mode by cation cascade doping, which promotes the charge transport in the photovoltaic device. | | 18 July 2018 | doi: 10.1038/s41467-018-05076-w | | Devices for energy harvesting Solar cells | Unveiling the bosonic nature of an ultrashort few-electron pulse OPEN | | Gregoire Roussely, Everton Arrighi, Giorgos Georgiou, Shintaro Takada, Martin Schalk, Matias Urdampilleta, Arne Ludwig, Andreas D. Wieck, Pacome Armagnat, Thomas Kloss, Xavier Waintal, Tristan Meunier & Christopher Bäuerle | | | Electronic excitations in low-dimensional quantum nanoelectronic devices are collective waves that are strongly affected by the Coulomb interaction. Here, the authors demonstrate that they are able to prepare these collective excitations down to the single electron level and control their propagation. | | 18 July 2018 | doi: 10.1038/s41467-018-05203-7 | | Electronic devices Electronic properties and materials Semiconductors | Large ice loss variability at Nioghalvfjerdsfjorden Glacier, Northeast-Greenland OPEN | | Christoph Mayer, Janin Schaffer, Tore Hattermann, Dana Floricioiu, Lukas Krieger, Paul A. Dodd, Torsten Kanzow, Carlo Licciulli & Clemens Schannwell | | | The Greenland Ice Sheet has increasingly lost mass over the past few decades, yet the contribution from glaciers in Northeast Greenland is difficult to quantify. Here, the authors show that the floating part of 79 North Glacier has continuously lost mass since at least 2001, with a very high annual variability. | | 17 July 2018 | doi: 10.1038/s41467-018-05180-x | | Climate-change impacts Cryospheric science Physical oceanography | Exchange-biasing topological charges by antiferromagnetism OPEN | | Qing Lin He, Gen Yin, Alexander J. Grutter, Lei Pan, Xiaoyu Che, Guoqiang Yu, Dustin A. Gilbert, Steven M. Disseler, Yizhou Liu, Padraic Shafer, Bin Zhang, Yingying Wu, Brian J. Kirby, Elke Arenholz, Roger K. Lake, Xiaodong Han & Kang L. Wang | | | Spin-polarized carriers could show an extra Hall component when moving through certain real-space topological spin textures. Here, He et al. report an exchange bias experienced by the topological spin textures living at the interface between a topological insulator and an adjacent antiferromagnet, suggesting a chiral spin texture is induced. | | 17 July 2018 | doi: 10.1038/s41467-018-05166-9 | | Magnetic properties and materials Topological insulators | Cold deep subduction recorded by remnants of a Paleoproterozoic carbonated slab OPEN | | Cheng Xu, Jindřich Kynický, Wenlei Song, Renbiao Tao, Zeng Lü, Yunxiu Li, Yueheng Yang, Miroslav Pohanka, Michaela V. Galiova, Lifei Zhang & Yingwei Fei | | | The onset of modern-style plate tectonics remains under debate. Here, Xu et al. report a cold thermal-gradient recorded in an eclogite xenolith in Paleoproterozoic carbonatite from orogen, and propose that modern-style subduction has operated since at least the Paleoproterozoic. | | 17 July 2018 | doi: 10.1038/s41467-018-05140-5 | | Geology Petrology | Downregulated NDR1 protein kinase inhibits innate immune response by initiating an miR146a-STAT1 feedback loop OPEN | | Zhiyong Liu, Qiang Qin, Cheng Wu, Hui Li, Jia’nan Shou, Yuting Yang, Meidi Gu, Chunmei Ma, Wenlong Lin, Yan Zou, Yuanyuan Zhang, Feng Ma, Jihong Sun & Xiaojian Wang | | | The authors show that NDR1 promotion of STAT1 translation is an important event for IFN-dependent antiviral immune response. These data suggest that NDR1 has an important role in controlling viral infections. | | 17 July 2018 | doi: 10.1038/s41467-018-05176-7 | | Antimicrobial responses Innate immunity Signal transduction | Stromal PTEN determines mammary epithelial response to radiotherapy OPEN | | Gina M. Sizemore, Subhasree Balakrishnan, Katie A. Thies, Anisha M. Hammer, Steven T. Sizemore, Anthony J. Trimboli, Maria C. Cuitiño, Sarah A. Steck, Gary Tozbikian, Raleigh D. Kladney, Neelam Shinde, Manjusri Das, Dongju Park, Sarmila Majumder, Shiva Krishnan, Lianbo Yu, Soledad A. Fernandez, Arnab Chakravarti, Peter G. Shields, Julia R. White et al. | | | The tumor microenvironment influences tumor progression. Here the authors show that lack of stromal PTEN phosphatase induces DNA repair defects in the neighboring mammary gland epithelial cells via hyperactivation of EGF-receptor signaling, resulting in higher radiation-induced DNA damage and hyperplasia. | | 17 July 2018 | doi: 10.1038/s41467-018-05266-6 | | Breast cancer Cancer microenvironment DNA damage and repair Radiotherapy | Direct observation of DNA target searching and cleavage by CRISPR-Cas12a OPEN | | Yongmoon Jeon, You Hee Choi, Yunsu Jang, Jihyeon Yu, Jiyoung Goo, Gyejun Lee, You Kyeong Jeong, Seung Hwan Lee, In-San Kim, Jin-Soo Kim, Cherlhyun Jeong, Sanghwa Lee & Sangsu Bae | | | Cas12a is a RNA-guided DNA endonuclease whose detailed mechanisms of target searching and DNA cleavage remained unclear. Here authors use single-molecule fluorescence assays to show that Cas12a searches for their on-target site. | | 17 July 2018 | doi: 10.1038/s41467-018-05245-x | | Biophysical chemistry CRISPR-Cas9 genome editing Single-molecule biophysics | Integrated genetic and epigenetic analysis of myxofibrosarcoma OPEN | | Koichi Ogura, Fumie Hosoda, Yasuhito Arai, Hiromi Nakamura, Natsuko Hama, Yasushi Totoki, Akihiko Yoshida, Momoko Nagai, Mamoru Kato, Erika Arakawa, Wakako Mukai, Hirofumi Rokutan, Akira Kawai, Sakae Tanaka & Tatsuhiro Shibata | | | Myxofibrosarcoma occurs in adults and is associated with high local relapse. Here, based on exome/transcriptome sequencing and DNA methylation analysis, the authors identify driver genes and methylation clusters associated with unique combinations of mutations, outcomes, and immune cell compositions. | | 17 July 2018 | doi: 10.1038/s41467-018-03891-9 | | Cancer genomics Sarcoma | The replication initiation determinant protein (RepID) modulates replication by recruiting CUL4 to chromatin OPEN | | Sang-Min Jang, Ya Zhang, Koichi Utani, Haiqing Fu, Christophe E. Redon, Anna B. Marks, Owen K. Smith, Catherine J. Redmond, Adrian M. Baris, Danielle A. Tulchinsky & Mirit I. Aladjem | | | RepID has previously been shown to promote origin firing. Here the authors reveal that RepID regulates replication origins via the recruitment of the CRL4 complex, and prevents re-initiation and unscheduled DNA replication. | | 17 July 2018 | doi: 10.1038/s41467-018-05177-6 | | Cancer therapy DNA replication Origin firing Protein–protein interaction networks Ubiquitylation | An intercross population study reveals genes associated with body size and plumage color in ducks OPEN | | Zhengkui Zhou, Ming Li, Hong Cheng, Wenlei Fan, Zhengrong Yuan, Qiang Gao, Yaxi Xu, Zhanbao Guo, Yunsheng Zhang, Jian Hu, Hehe Liu, Dapeng Liu, Weihuang Chen, Zhuqing Zheng, Yong Jiang, Zhiguo Wen, Yongming Liu, Hua Chen, Ming Xie, Qi Zhang et al. | | | Ducks, one of the most common domestic fowls, originated from mallards. Here, the authors perform whole-genome sequencing of mallards, indigenous-breed ducks, and Pekin ducks, as well as 1026 ducks from a population generated by wild × domestic crosses to identify selection signals and map variants associated with body size and plumage color. | | 17 July 2018 | doi: 10.1038/s41467-018-04868-4 | | Animal breeding Genome evolution Population genetics | Thresholds of lake and reservoir connectivity in river networks control nitrogen removal OPEN | | Noah M. Schmadel, Judson W. Harvey, Richard B. Alexander, Gregory E. Schwarz, Richard B. Moore, Ken Eng, Jesus D. Gomez-Velez, Elizabeth W. Boyer & Durelle Scott | | | Lakes, reservoirs, and other ponded waters are common in large river basins yet their influence on nitrogen budgets is often indistinct. Here, the authors show how a ponded waters’ relative size, shape, and degree of connectivity to the river network control nitrogen removal. | | 17 July 2018 | doi: 10.1038/s41467-018-05156-x | | Element cycles Environmental sciences Hydrology | Squamate reptiles challenge paradigms of genomic repeat element evolution set by birds and mammals OPEN | | Giulia I. M. Pasquesi, Richard H. Adams, Daren C. Card, Drew R. Schield, Andrew B. Corbin, Blair W. Perry, Jacobo Reyes-Velasco, Robert P. Ruggiero, Michael W. Vandewege, Jonathan A. Shortt & Todd A. Castoe | | | Large-scale patterns of genomic repeat element evolution have been studied mainly in birds and mammals. Here, the authors analyze the genomes of over 60 squamate reptiles and show high variation in repeat elements compared to mammals and birds, and particularly high microsatellite seeding in snakes. | | 17 July 2018 | doi: 10.1038/s41467-018-05279-1 | | Comparative genomics Genome evolution Mobile elements Molecular evolution | A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling OPEN | | Kislay Parvatiyar, Jose Pindado, Anurupa Dev, Saba Roghiyh Aliyari, Shivam A. Zaver, Hoda Gerami, Maxime Chapon, Amir A. Ghaffari, Anant Dhingra & Genhong Cheng | | | The innate immunity system detects viral pathogens by sensing viral DNA or RNA via distinct pathways, but whether these pathways cross-regulate is unclear. Here the authors show that TRAF3, a known regulator of the RNA-sensing pathway, modulates an NF-κB activator NIK to control DNA-sensing by the adaptor STING in immune cells. | | 17 July 2018 | doi: 10.1038/s41467-018-05168-7 | | Infection NF-kappaB Pattern recognition receptors RIG-I-like receptors | CD32 expression is associated to T-cell activation and is not a marker of the HIV-1 reservoir OPEN | | Roger Badia, Ester Ballana, Marc Castellví, Edurne García-Vidal, Maria Pujantell, Bonaventura Clotet, Julia G. Prado, Jordi Puig, Miguel A. Martínez, Eva Riveira-Muñoz & José A. Esté | | | CD32 has been previously shown to be expressed preferentially by CD4 T cells latently harbouring HIV-1. Here the authors show that CD32 expression in CD4 T cells is associated with T cell activation, is up-regulated by HIV-1 infection and importantly does not appear to represent an enriched cellular niche for latent HIV-1. | | 16 July 2018 | doi: 10.1038/s41467-018-05157-w | | CD4-positive T cells HIV infections Retrovirus | In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer OPEN | | Caitlin L. Grzeskowiak, Samrat T. Kundu, Xiulei Mo, Andrei A. Ivanov, Oksana Zagorodna, Hengyu Lu, Richard H. Chapple, Yiu Huen Tsang, Daniela Moreno, Maribel Mosqueda, Karina Eterovic, Jared J. Fradette, Sumreen Ahmad, Fengju Chen, Zechen Chong, Ken Chen, Chad J. Creighton, Haian Fu, Gordon B. Mills, Don L. Gibbons et al. | | | KRAS-driven lung cancers represent an aggressive form of NSCLC. In this study the authors perform an in vivo functional screening and identify GATAD2B as a driver of tumor growth and metastasis in KRAS-driven lung cancer. | | 16 July 2018 | doi: 10.1038/s41467-018-04572-3 | | Cancer Cancer genetics | Fe-N system at high pressure reveals a compound featuring polymeric nitrogen chains OPEN | | M. Bykov, E. Bykova, G. Aprilis, K. Glazyrin, E. Koemets, I. Chuvashova, I. Kupenko, C. McCammon, M. Mezouar, V. Prakapenka, H.-P. Liermann, F. Tasnádi, A. V. Ponomareva, I. A. Abrikosov, N. Dubrovinskaia & L. Dubrovinsky | | | Owing to the energetic nature of N–N bonds, poly-nitrogen compounds are considered promising high energy density materials. Here, the authors synthesize three iron–nitrogen compounds at high pressure, including FeN4, which features polymeric nitrogen chains of [N42−]n units. | | 16 July 2018 | doi: 10.1038/s41467-018-05143-2 | | Chemical bonding Solid-phase synthesis Solid-state chemistry | Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission OPEN | | Shinya Tasaki, Katsuya Suzuki, Yoshiaki Kassai, Masaru Takeshita, Atsuko Murota, Yasushi Kondo, Tatsuya Ando, Yusuke Nakayama, Yuumi Okuzono, Maiko Takiguchi, Rina Kurisu, Takahiro Miyazaki, Keiko Yoshimoto, Hidekata Yasuoka, Kunihiro Yamaoka, Rimpei Morita, Akihiko Yoshimura, Hiroyoshi Toyoshiba & Tsutomu Takeuchi | | | Little information is available on molecular changes in response to treatment of rheumatoid arthritis (RA). Here the authors report a multi-omics study collecting patients' transcriptome, proteome, and immunophenotype data to help understand the impact of drug treatments on RA molecular phenotypes. | | 16 July 2018 | doi: 10.1038/s41467-018-05044-4 | | Biomarkers Predictive medicine Rheumatoid arthritis | Root exudate metabolites drive plant-soil feedbacks on growth and defense by shaping the rhizosphere microbiota OPEN | | Lingfei Hu, Christelle A. M. Robert, Selma Cadot, Xi Zhang, Meng Ye, Beibei Li, Daniele Manzo, Noemie Chervet, Thomas Steinger, Marcel G. A. van der Heijden, Klaus Schlaeppi & Matthias Erb | | | Plants can modify soil microbiota through root exudation, but how this process influences plant health in turn is often unclear. Here, Hu et al. show that maize benzoxazinoids released into the soil modify root-associated microbiota and thereby increase leaf defenses of the next plant generation. | | 16 July 2018 | doi: 10.1038/s41467-018-05122-7 | | Biotic Microbiome Secondary metabolism | Self-hydrogenated shell promoting photocatalytic H2 evolution on anatase TiO2 OPEN | | Yue Lu, Wen-Jin Yin, Kai-Lin Peng, Kuan Wang, Qi Hu, Annabella Selloni, Fu-Rong Chen, Li-Min Liu & Man-Ling Sui | | | Photocatalytic water splitting on TiO2 is a promising route to H2 fuel production, but the mechanistic pathway at the water–TiO2 interface remains poorly understood. Here, using liquid environmental TEM and first-principles calculations, the authors unveil the formation of a self-hydrogenated shell on the TiO2 surface that further promotes H2 production. | | 16 July 2018 | doi: 10.1038/s41467-018-05144-1 | | Characterization and analytical techniques Nanoparticles Photocatalysis | Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b OPEN | | Sunglim Cho, Hyang-Mi Lee, I-Shing Yu, Youn Soo Choi, Hsi-Yuan Huang, Somaye Sadat Hashemifar, Ling-Li Lin, Mei-Chi Chen, Nikita D. Afanasiev, Aly Azeem Khan, Shu-Wha Lin, Alexander Y. Rudensky, Shane Crotty & Li-Fan Lu | | | In the germinal center (GC), B and T cells interact to induce the production of protective antibodies against threats. Here the authors show that microRNA miR-146a modulates CD40 signaling in GC B cells, while both miR-146a and miR-146b synergize to control GC T cell responses, thereby implicating intricate controls of GC response by miR-146. | | 16 July 2018 | doi: 10.1038/s41467-018-05196-3 | | Gene regulation in immune cells Germinal centres Humoral immunity miRNA in immune cells | Act1 is a negative regulator in T and B cells via direct inhibition of STAT3 OPEN | | Cun-Jin Zhang, Chenhui Wang, Meiling Jiang, Chunfang Gu, Jianxin Xiao, Xing Chen, Bradley N. Martin, Fangqiang Tang, Erin Yamamoto, Yibo Xian, Han Wang, Fengling Li, R. Balfour Sartor, Howard Smith, M. Elaine Husni, Fu-Dong Shi, Ji Gao, Julie Carman, Ashok Dongre, Susan C. McKarns et al. | | | Adaptor for IL-17 receptors (Act1) is known to be crucial for IL-17-mediated immune responses. Here the authors show that Act1 also functions as a negative regulator of T and B cells by direct inhibition of STAT3. | | 16 July 2018 | doi: 10.1038/s41467-018-04974-3 | | Autoimmunity B cells Lupus nephritis T cells | ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage OPEN | | Somaira Nowsheen, Khaled Aziz, Kuntian Luo, Min Deng, Bo Qin, Jian Yuan, Karthik B. Jeganathan, Jia Yu, Henan Zhang, Wei Ding, Jan M. van Deursen & Zhenkun Lou | | | Following double-strand break a cascade of events leads to the recruitment of repair factors to damaged sites. Here the authors identify ZNF506 as a key factor that mediates post-translational modification changes in H2AX affecting the DNA damage response. | | 16 July 2018 | doi: 10.1038/s41467-018-05161-0 | | DNA damage response Double-strand DNA breaks Histone post-translational modifications Phosphorylation Radiotherapy | A diuranium carbide cluster stabilized inside a C80 fullerene cage OPEN | | Xingxing Zhang, Wanlu Li, Lai Feng, Xin Chen, Andreas Hansen, Stefan Grimme, Skye Fortier, Dumitru-Claudiu Sergentu, Thomas J. Duignan, Jochen Autschbach, Shuao Wang, Yaofeng Wang, Giorgios Velkos, Alexey A. Popov, Nabi Aghdassi, Steffen Duhm, Xiaohong Li, Jun Li, Luis Echegoyen, W. H. Eugen Schwarz et al. | | | While metal–carbon double bonds are common in transition metal chemistry and catalysis, unsupported uranium–carbon double bonds remain highly challenging to prepare. Here, the authors stabilize and characterize a U=C=U cluster containing unusually short, unsupported double bonds inside an Ih(7)-C80 fullerene cage. | | 16 July 2018 | doi: 10.1038/s41467-018-05210-8 | | Carbon nanotubes and fullerenes Chemical bonding Nuclear chemistry | Population genomics of hypervirulent Klebsiella pneumoniae clonal-group 23 reveals early emergence and rapid global dissemination OPEN | | Margaret M. C. Lam, Kelly L. Wyres, Sebastian Duchêne, Ryan R. Wick, Louise M. Judd, Yunn-Hwen Gan, Chu-Han Hoh, Sophia Archuleta, James S. Molton, Shirin Kalimuddin, Tse Hsien Koh, Virginie Passet, Sylvain Brisse & Kathryn E. Holt | | | Since the 1980s, hypervirulent clonal-group CG23 serotype K1 Klebsiella pneumoniae has been recognised as a prominent cause of community-acquired liver abscess and other severe infections. Here, the authors investigate the genomic evolutionary history of CG23 and suggest a new reference strain for CG23. | | 13 July 2018 | doi: 10.1038/s41467-018-05114-7 | | Bacterial evolution Bacterial genetics Bacterial genomics Genetic variation Pathogens | KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development OPEN | | Anqi Geng, Runxiang Qiu, Kiyohito Murai, Jiancheng Liu, Xiwei Wu, Heying Zhang, Henry Farhoodi, Nam Duong, Meisheng Jiang, Jiing-kuan Yee, Walter Tsark & Qiang Lu | | | The division of neural progenitors is closely regulated but how is unclear. Here, the authors show that mitotic kinesin KIF20A/MKLP2 interacts with a regulator of G protein signaling RGS3 in neural progenitor cells, dislodging it from the intercellular bridge of dividing cortical cells. | | 13 July 2018 | doi: 10.1038/s41467-018-05152-1 | | Developmental neurogenesis Neural stem cells | Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors OPEN | | Thomas Duhen, Rebekka Duhen, Ryan Montler, Jake Moses, Tarsem Moudgil, Noel F. de Miranda, Cheri P. Goodall, Tiffany C. Blair, Bernard A. Fox, Jason E. McDermott, Shu-Ching Chang, Gary Grunkemeier, Rom Leidner, Richard Bryan Bell & Andrew D. Weinberg | | | Identifying and enumerating tumor-specific CD8 T cells are important for assessing cancer prognosis and therapy efficacy. Here the authors show that CD39 and CD103 mark a subset of tumor-infiltrating CD8 T cells that are tumor-reactive and exhibit characteristics of exhausted or tissue-resident memory T cells. | | 13 July 2018 | doi: 10.1038/s41467-018-05072-0 | | CD8-positive T cells Immunological memory Immunotherapy Tumour immunology | Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection OPEN | | Alvaro Baeza Garcia, Edwin Siu, Tiffany Sun, Valerie Exler, Luis Brito, Armin Hekele, Gib Otten, Kevin Augustijn, Chris J. Janse, Jeffrey B. Ulmer, Jürgen Bernhagen, Erol Fikrig, Andrew Geall & Richard Bucala | | | Plasmodium species produce an ortholog of the cytokine macrophage migration inhibitory factor, PMIF, which modulates the host inflammatory response to malaria. Here, the authors show that inhibition of PMIF may have translational benefits for managing malaria infections. | | 13 July 2018 | doi: 10.1038/s41467-018-05041-7 | | Immunology Infectious diseases Malaria Vaccines | Reactive astrocytic S1P3 signaling modulates the blood–tumor barrier in brain metastases OPEN | | Brunilde Gril, Anurag N. Paranjape, Stephan Woditschka, Emily Hua, Emma L. Dolan, Jeffrey Hanson, Xiaolin Wu, Wojciech Kloc, Ewa Izycka-Swieszewska, Renata Duchnowska, Rafał Pęksa, Wojciech Biernat, Jacek Jassem, Naema Nayyar, Priscilla K. Brastianos, O. Morgan Hall, Cody J. Peer, William D. Figg, Gary T. Pauly, Christina Robinson et al. | | | When brain metastases form, the blood–brain barrier morphs into the blood–tumor barrier (BTB), surrounded by neuroinflammatory response. Here, the authors show that S1P3 is upregulated in neuroinflammatory response in highly BTB permeable lesions, and modulation of S1P3 could impact BTB permeability. | | 13 July 2018 | doi: 10.1038/s41467-018-05030-w | | Blood–brain barrier Breast cancer Metastasis | Nonstimulatory peptide–MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling OPEN | | Xiang Zhao, Shvetha Sankaran, Jiawei Yap, Chien Tei Too, Zi Zong Ho, Garry Dolton, Mateusz Legut, Ee Chee Ren, Andrew K. Sewell, Antonio Bertoletti, Paul A. MacAry, Joanna Brzostek & Nicholas R. J. Gascoigne | | | Coagonism, the ability of nonstimulatory antigens to promote T-cell activation, has been reported in mice. Here the authors show that coagonism also occurs in human CD8 T cells, in which a nonstimulatory HIV GAG peptide enhances a specific T-cell response to a hepatitis B virus epitope by amplifying T-cell receptor signals. | | 13 July 2018 | doi: 10.1038/s41467-018-05288-0 | | Adaptive immunity Lymphocyte activation MHC T-cell receptor | Modulation of anti-tumor immunity by the brain’s reward system OPEN | | Tamar L Ben-Shaanan, Maya Schiller, Hilla Azulay-Debby, Ben Korin, Nadia Boshnak, Tamar Koren, Maria Krot, Jivan Shakya, Michal A. Rahat, Fahed Hakim & Asya Rolls | | | Neural activation can have wide ranging effects beyond central and peripheral nervous system. This work shows that chemogenetic activation of the brain’s reward system ventral tegmental area (VTA) can boost mice’s immune function, confer anti-tumor immunity, and reduce tumor mass in experimental rodent models of lung carcinoma and melanoma. | | 13 July 2018 | doi: 10.1038/s41467-018-05283-5 | | Neuroimmunology Tumour immunology | HHEX is a transcriptional regulator of the VEGFC/FLT4/PROX1 signaling axis during vascular development OPEN | | Sébastien Gauvrit, Alethia Villasenor, Boris Strilic, Philip Kitchen, Michelle M. Collins, Rubén Marín-Juez, Stefan Guenther, Hans-Martin Maischein, Nana Fukuda, Maurice A. Canham, Joshua M. Brickman, Clifford W. Bogue, Padma-Sheela Jayaraman & Didier Y. R. Stainier | | | VEGFC, its receptor FLT4, and transcriptional effector PROX1 control formation of the lymphatic system but how is unclear. Here, the authors show that the transcription factor hematopoietically expressed homeobox (HHEX) regulates VEGFC, FLT4 and PROX1 in fish and mammals during angiogenic sprouting and lymphatic formation. | | 13 July 2018 | doi: 10.1038/s41467-018-05039-1 | | Development Growth factor signalling Lymphangiogenesis | Anomalous mechanical behavior of nanocrystalline binary alloys under extreme conditions OPEN | | S. A. Turnage, M. Rajagopalan, K. A. Darling, P. Garg, C. Kale, B. G. Bazehhour, I. Adlakha, B. C. Hornbuckle, C. L. Williams, P. Peralta & K. N. Solanki | | | Metals deformed at very high rates experience a rapid increase in flow stress due to dislocation drag. Here, the authors stabilise a nanocrystalline microstructure to suppress dislocation velocity and limit drag effects, conserving low strain-rate deformation mechanisms up to higher strain rates and temperatures. | | 12 July 2018 | doi: 10.1038/s41467-018-05027-5 | | Metals and alloys Nanoscale materials Structural properties | A molecular neuromorphic network device consisting of single-walled carbon nanotubes complexed with polyoxometalate OPEN | | Hirofumi Tanaka, Megumi Akai-Kasaya, Amin TermehYousefi, Liu Hong, Lingxiang Fu, Hakaru Tamukoh, Daisuke Tanaka, Tetsuya Asai & Takuji Ogawa | | | Neuromorphic hardware is based on principles of neuroscience, and has the potential to provide higher-level brain functions. Here, the authors develop a neuromorphic network device, constructed from single-walled carbon nanotubes and polyoxometalate, that mimics nerve impulse generation. | | 12 July 2018 | doi: 10.1038/s41467-018-04886-2 | | Carbon nanotubes and fullerenes Computer science Electronic properties and materials Materials for devices | | | | | | | | Latest Addendum | | | | | | | | Latest Author Corrections | | | | Author Correction: Generation and characterization of ultrathin free-flowing liquid sheets OPEN | | Jake D. Koralek, Jongjin B. Kim, Petr Brůža, Chandra B. Curry, Zhijiang Chen, Hans A. Bechtel, Amy A. Cordones, Philipp Sperling, Sven Toleikis, Jan F. Kern, Stefan P. Moeller, Siegfried H. Glenzer & Daniel P. DePonte | | 17 July 2018 | doi: 10.1038/s41467-018-05365-4 | | Infrared spectroscopy Microfluidics Microscopy Physics | Author Correction: A novel atypical sperm centriole is functional during human fertilization OPEN | | Emily L. Fishman, Kyoung Jo, Quynh P. H. Nguyen, Dong Kong, Rachel Royfman, Anthony R. Cekic, Sushil Khanal, Ann L. Miller, Calvin Simerly, Gerald Schatten, Jadranka Loncarek, Vito Mennella & Tomer Avidor-Reiss | | 13 July 2018 | doi: 10.1038/s41467-018-05324-z | | Centrosome Spermatogenesis | | | | | Latest Publisher Corrections | | | | Publisher Correction: FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells OPEN | | Minh Binh Nguyen, Idan Cohen, Vinod Kumar, Zijian Xu, Carmit Bar, Katherine L. Dauber-Decker, Pai-Chi Tsai, Pauline Marangoni, Ophir D. Klein, Ya-Chieh Hsu, Ting Chen, Marja L. Mikkola & Elena Ezhkova | | 17 July 2018 | doi: 10.1038/s41467-018-05361-8 | | Differentiation Skin stem cells Stem-cell differentiation | | | | | Advertisement | | Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. 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