| | Advertisement | | Advanced Imaging with Proven Optics Olympus is dedicated to your work, vision, and science. Through innovation and service, we seek to aide in your discoveries, advance your research, and inspire you to explore new possibilities. Our wide range of microscopes are built with the optical excellence and proven application expertise you can depend on. Your Science Matters™. > Learn more about Olympus microscopes | | | | | | | | | Advertisement | | AstraZeneca is in search of highly talented scientists to join the company's postdoc industrial programme. This is an excellent opportunity for early career scientists to make a significant impact in the world of science. Read more. *ad feature | | | | | Advertisement | | Submit your abstract for the RNA at the Bench and Bedside conference by July 30. This conference will cover the numerous roles of RNAs and the efforts to translate advances in the basic science into new therapies. It will address the opportunities, current status, and the future of this exciting field. View the draft program for more details. Remember to register before submitting your abstract. | | | | | | | Latest Comment | | | | | | | | Latest Articles | View all Articles | | | Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude OPEN | | Jacob S. Brenner, Daniel C. Pan, Jacob W. Myerson, Oscar A. Marcos-Contreras, Carlos H. Villa, Priyal Patel, Hugh Hekierski, Shampa Chatterjee, Jian-Qin Tao, Hamideh Parhiz, Kartik Bhamidipati, Thomas G. Uhler, Elizabeth D. Hood, Raisa Yu. Kiseleva, Vladimir S. Shuvaev, Tea Shuvaeva, Makan Khoshnejad, Ian Johnston, Jason V. Gregory, Joerg Lahann et al. | | | Unwanted uptake in the liver and limited accumulation in target organs is a major obstacle to targeted drug delivery. Here, the authors report on the hitchhiking of nanocarriers on red blood cells and the targeted upstream delivery to different target organs in mice, pigs and ex vivo human lungs. | | 11 July 2018 | doi: 10.1038/s41467-018-05079-7 | | Drug delivery Drug development Molecular medicine Nanoparticles | Graphene’s nonlinear-optical physics revealed through exponentially growing self-phase modulation OPEN | | Nathalie Vermeulen, David Castelló-Lurbe, Mulham Khoder, Iwona Pasternak, Aleksandra Krajewska, Tymoteusz Ciuk, Wlodek Strupinski, JinLuo Cheng, Hugo Thienpont & Jürgen Van Erps | | | Graphene enables extraordinary nonlinear-optical refraction, far exceeding predictions based on conventional nonlinear-susceptibility theory. Here, Vermeulen et al. show that rather than the nonlinear susceptibility, a complex saturable refraction process is central to graphene’s unusual behavior. | | 11 July 2018 | doi: 10.1038/s41467-018-05081-z | | Nonlinear optics Optical properties and devices | An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer’s disease OPEN | | Ming Jin, Brian O’Nuallain, Wei Hong, Justin Boyd, Valentina N. Lagomarsino, Tiernan T. O’Malley, Wen Liu, Charles R. Vanderburg, Matthew P. Frosch, Tracy Young-Pearse, Dennis J. Selkoe & Dominic M. Walsh | | | The optimal Aβ species to target for the potential treatment of Alzheimer’s disease has not yet been established. Here, the authors describe an in vitro assay that uses extracts from brain tissue from patients with Alzheimer’s disease, and application to human iPSC-derived neurons, to compare the neuroprotective potential of several anti-Aβ antibodies. | | 11 July 2018 | doi: 10.1038/s41467-018-05068-w | | Alzheimer's disease Antibody therapy | Large-scale gene losses underlie the genome evolution of parasitic plant Cuscuta australis OPEN | | Guiling Sun, Yuxing Xu, Hui Liu, Ting Sun, Jingxiong Zhang, Christian Hettenhausen, Guojing Shen, Jinfeng Qi, Yan Qin, Jing Li, Lei Wang, Wei Chang, Zhenhua Guo, Ian T. Baldwin & Jianqiang Wu | | | Dodders (Cuscuta spp., Convolvulaceae) are root- and leafless parasitic plants. Here, the authors sequence the genome of Cuscuta australis and find remarkable gene loss associated with parasitic lifestyle and large changes in body plan. | | 11 July 2018 | doi: 10.1038/s41467-018-04721-8 | | Comparative genomics Evolutionary developmental biology Plant evolution | A TFEB nuclear export signal integrates amino acid supply and glucose availability OPEN | | Linxin Li, Hans J. Friedrichsen, Sarah Andrews, Sarah Picaud, Laurent Volpon, Kaochin Ngeow, Georgina Berridge, Roman Fischer, Katherine L. B. Borden, Panagis Filippakopoulos & Colin R. Goding | | | On amino acid deprivation TFEB translocates from the cytoplasm to the nucleus. Here the authors identify a nuclear export signal in TFEB that requires dual phosphorylation at the S142 ERK/mTORC1 and S138 GSK3β sites, and further show glucose limitation drives nuclear accumulation of TFEB and inhibits GSK3β via an mTORC2-AKT dependent mechanism. | | 11 July 2018 | doi: 10.1038/s41467-018-04849-7 | | Cell biology Cell signalling | k-space imaging of anisotropic 2D electron gas in GaN/GaAlN high-electron-mobility transistor heterostructures OPEN | | L. L. Lev, I. O. Maiboroda, M.-A. Husanu, E. S. Grichuk, N. K. Chumakov, I. S. Ezubchenko, I. A. Chernykh, X. Wang, B. Tobler, T. Schmitt, M. L. Zanaveskin, V. G. Valeyev & V. N. Strocov | | | Semiconductor heterostructures hosting two-dimensional electron gases are widely used today in high-electron-mobility transistors. Here, the authors probe the electronic structure in GaN/AlGaN, heterostructures, discovering planar anisotropy of the electron Fermi surface, offering new insights into transport properties. | | 11 July 2018 | doi: 10.1038/s41467-018-04354-x | | Electronic devices Electronic properties and materials Surfaces, interfaces and thin films | Discovery of a drug candidate for GLIS3-associated diabetes OPEN | | Sadaf Amin, Brandoch Cook, Ting Zhou, Zaniar Ghazizadeh, Raphael Lis, Tuo Zhang, Mona Khalaj, Miguel Crespo, Manuradhi Perera, Jenny Zhaoying Xiang, Zengrong Zhu, Mark Tomishima, Chengyang Liu, Ali Naji, Todd Evans, Danwei Huangfu & Shuibing Chen | | | GLIS3 mutations are associated with type 1, type 2, and neonatal diabetes. Here, the authors generate mono-hormonal glucose-responding pancreatic β-like cells in vitro and through a screen identify a drug that rescues pancreatic β-like cell death in GLIS3 mutants by inhibiting the abnormally activated TGFβ pathway. | | 11 July 2018 | doi: 10.1038/s41467-018-04918-x | | Diabetes Disease model High-throughput screening | Patterns of genomic evolution in advanced melanoma OPEN | | E. Birkeland, S. Zhang, D. Poduval, J. Geisler, S. Nakken, D. Vodak, L. A. Meza-Zepeda, E. Hovig, O. Myklebost, S. Knappskog & P. E. Lønning | | | As melanoma progresses, it evolves. Here, in advanced melanoma the authors study genomic evolution, highlighting trunk mutations dominated by the ultraviolet damage signature, common late truncal whole-genome duplication events, as well as selective copy number gain of mutant BRAF. | | 10 July 2018 | doi: 10.1038/s41467-018-05063-1 | | Cancer Cancer genomics Medical genomics Melanoma | The nature of spin excitations in the one-third magnetization plateau phase of Ba3CoSb2O9 OPEN | | Y. Kamiya, L. Ge, Tao Hong, Y. Qiu, D. L. Quintero-Castro, Z. Lu, H. B. Cao, M. Matsuda, E. S. Choi, C. D. Batista, M. Mourigal, H. D. Zhou & J. Ma | | | Frustrated magnetic materials attract significant interest because their properties can become dominated by quantum fluctuations. Here the authors show that excitations in the plateau phase of a quantum magnet can be understood semiclassically even though the ground state involves strong quantum effects. | | 10 July 2018 | doi: 10.1038/s41467-018-04914-1 | | Magnetic properties and materials | A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA OPEN | | Sandhya Bangaru, Heng Zhang, Iuliia M. Gilchuk, Thomas G. Voss, Ryan P. Irving, Pavlo Gilchuk, Pranathi Matta, Xueyong Zhu, Shanshan Lang, Travis Nieusma, Juergen A. Richt, Randy A. Albrecht, Hillary A. Vanderven, Robin Bombardi, Stephen J. Kent, Andrew B. Ward, Ian A. Wilson & James E. Crowe Jr. | | | Broadly neutralizing antibodies are potential therapeutics and can aid rational vaccine development. Here, the authors show that the human monoclonal antibody H3v-47 recognizes a highly conserved epitope in HA of H3N2 viruses, inhibits virus replication by blocking egress and other mechanisms, and protects mice from disease. | | 10 July 2018 | doi: 10.1038/s41467-018-04704-9 | | Antibodies Influenza virus | A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model OPEN | | Naomi Tsuburaya, Kengo Homma, Tsunehiko Higuchi, Andrii Balia, Hiroyuki Yamakoshi, Norio Shibata, Seiichi Nakamura, Hidehiko Nakagawa, Shin-ichi Ikeda, Naoki Umezawa, Nobuki Kato, Satoshi Yokoshima, Masatoshi Shibuya, Manabu Shimonishi, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Isao Naguro, Keiko Imamura, Haruhisa Inoue et al. | | | Amyotrophic lateral sclerosis (ALS) is a neurological disease that leads to loss of voluntary muscle movement. Here, the authors screen for molecules that disrupt interaction between SOD1, a protein linked to ALS, and Derlin-1, and find an inhibitor that reduces pathology in an ALS mouse model. | | 10 July 2018 | doi: 10.1038/s41467-018-05127-2 | | Amyotrophic lateral sclerosis High-throughput screening Stress signalling | Integrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes OPEN | | Koichi Takahashi, Feng Wang, Kiyomi Morita, Yuanqing Yan, Peter Hu, Pei Zhao, Abdallah Abou Zhar, Chang Jiun Wu, Curtis Gumbs, Latasha Little, Samantha Tippen, Rebecca Thornton, Marcus Coyle, Marisela Mendoza, Erika Thompson, Jianhua Zhang, Courtney D. DiNardo, Nitin Jain, Farhad Ravandi, Jorge E. Cortes et al. | | | Mixed phenotype acute leukemia (MPAL) is a rare leukemia that presents both myeloid and lymphoid markers on blasts. Here the authors perform genomic analysis to show MPAL involves genetic and epigenetic heterogeneity and is genetically distinct from AML, B-ALL, and T-ALL. | | 10 July 2018 | doi: 10.1038/s41467-018-04924-z | | Acute myeloid leukaemia Cancer genomics | Collective molecular switching in hybrid superlattices for light-modulated two-dimensional electronics OPEN | | Marco Gobbi, Sara Bonacchi, Jian X. Lian, Alexandre Vercouter, Simone Bertolazzi, Björn Zyska, Melanie Timpel, Roberta Tatti, Yoann Olivier, Stefan Hecht, Marco V. Nardi, David Beljonne, Emanuele Orgiu & Paolo Samorì | | | Photochromic molecules offer the unique opportunity to demonstrate multifunctional devices with light-tunable electrical characteristics. Gobbi et al. build light-switchable electronic heterojunctions based on atomically precise, photo-reversible molecular superlattices on graphene and MoS2. | | 09 July 2018 | doi: 10.1038/s41467-018-04932-z | | Electronic devices Electronic properties and devices Electronic properties and materials Graphene Molecular self-assembly | Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts OPEN | | Daniel Torralba, Francesc Baixauli, Carolina Villarroya-Beltri, Irene Fernández-Delgado, Ana Latorre-Pellicer, Rebeca Acín-Pérez, Noa B Martín-Cófreces, Ángel Luis Jaso-Tamame, Salvador Iborra, Inmaculada Jorge, Gloria González-Aseguinolaza, Johan Garaude, Miguel Vicente-Manzanares, José Antonio Enríquez, María Mittelbrunn & Francisco Sánchez-Madrid | | | T cells are activated by antigen-bearing dendritic cells (DC), but how DCs receive reciprocal activating signals from T cells is still unclear. Here the authors show that mitochondrial DNA-containing extracellular vesicles from activated T cells can prime DCs for anti-viral immunity via the cGAS/STING DNA sensing pathways. | | 09 July 2018 | doi: 10.1038/s41467-018-05077-9 | | Dendritic cells Innate immunity Pattern recognition receptors T cells | AAVvector-mediated in vivo reprogramming into pluripotency OPEN | | Elena Senís, Lluc Mosteiro, Stefan Wilkening, Ellen Wiedtke, Ali Nowrouzi, Saira Afzal, Raffaele Fronza, Henrik Landerer, Maria Abad, Dominik Niopek, Manfred Schmidt, Manuel Serrano & Dirk Grimm | | | In vivo reprogramming of somatic cells is hampered by the need for vectors to express the OKSM factors in selected organs. Here the authors report new AAV-based vectors capable of in vivo reprogramming at low doses. | | 09 July 2018 | doi: 10.1038/s41467-018-05059-x | | Gene therapy Genetic vectors Regenerative medicine Reprogramming | TCR signal strength controls thymic differentiation of iNKT cell subsets OPEN | | Kathryn D. Tuttle, S. Harsha Krovi, Jingjing Zhang, Romain Bedel, Laura Harmacek, Lisa K. Peterson, Leonard L. Dragone, Adam Lefferts, Catherine Halluszczak, Kent Riemondy, Jay R. Hesselberth, Anjana Rao, Brian P. O’Connor, Philippa Marrack, James Scott-Browne & Laurent Gapin | | | Invariant natural killer T (iNKT) cells can be subsetted by their cytokine profiles, but how they develop in the thymus is unclear. Here the authors show, by analysing mice carrying mutant Zap70 genes, that T cell receptor signaling strength induces epigenetic changes of genes to modulate iNKT lineages. | | 09 July 2018 | doi: 10.1038/s41467-018-05026-6 | | Epigenetics in immune cells Lymphopoiesis NKT cells Signal transduction | Gut microbiota associations with common diseases and prescription medications in a population-based cohort OPEN | | Matthew A. Jackson, Serena Verdi, Maria-Emanuela Maxan, Cheol Min Shin, Jonas Zierer, Ruth C. E. Bowyer, Tiphaine Martin, Frances M. K. Williams, Cristina Menni, Jordana T. Bell, Tim D. Spector & Claire J. Steves | | | The human gut microbiome has been associated with many health factors, but variability between studies limits exploration of these effects. Here, Jackson et al. analyse gut microbiota associations for 38 common diseases and 51 medications within >2700 members of the TwinsUK cohort. | | 09 July 2018 | doi: 10.1038/s41467-018-05184-7 | | Health sciences Medical research Microbiome | Subclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates OPEN | | Philip Webster, Joanna C. Dawes, Hamlata Dewchand, Katalin Takacs, Barbara Iadarola, Bruce J. Bolt, Juan J. Caceres, Jakub Kaczor, Gopuraja Dharmalingam, Marian Dore, Laurence Game, Thomas Adejumo, James Elliott, Kikkeri Naresh, Mohammad Karimi, Katerina Rekopoulou, Ge Tan, Alberto Paccanaro & Anthony G. Uren | | | Evidence implicating cancer drivers can be sparse when limited to clonal events. Here, the authors present a retrovirus driven in vivo lymphomagenesis time course including hundreds of thousands of subclonal mutations and demonstrate the utility of these in mapping the selective forces affecting cancer gene loci, including negatively selected mutations. | | 09 July 2018 | doi: 10.1038/s41467-018-05069-9 | | Cancer Cancer genomics Cancer models | Assembly and activation of the Hippo signalome by FAT1 tumor suppressor OPEN | | Daniel Martin, Maria S. Degese, Lynn Vitale-Cross, Ramiro Iglesias-Bartolome, Juan Luis Callejas Valera, Zhiyong Wang, Xiaodong Feng, Huwate Yeerna, Vachan Vadmal, Toshiro Moroishi, Rick F. Thorne, Moraima Zaida, Bradford Siegele, Sok C. Cheong, Alfredo A. Molinolo, Yardena Samuels, Pablo Tamayo, Kun Liang Guan, Scott M. Lippman, J. Guy Lyons et al. | | | Dysregulation of the Hippo signaling is a frequent event in human malignancies, but the molecular mechanisms remain unclear. Here the authors show that in head and neck squamous carcinoma, FAT1 interacts with the Hippo signaling complex, resulting in the activation of core Hippo kinases and YAP1 inactivation. | | 09 July 2018 | doi: 10.1038/s41467-018-04590-1 | | Cancer genetics Cell signalling | An InP-based vortex beam emitter with monolithically integrated laser OPEN | | Juan Zhang, Changzheng Sun, Bing Xiong, Jian Wang, Zhibiao Hao, Lai Wang, Yanjun Han, Hongtao Li, Yi Luo, Yi Xiao, Chuanqing Yu, Takuo Tanemura, Yoshiaki Nakano, Shimao Li, Xinlun Cai & Siyuan Yu | | | Orbital-angular-momentum (OAM) beams have great potential for multiplexing signals in optical communication, but creating a compact source is challenging. The authors integrate a chip-scale optical vortex emitter and DFB laser into a single monolithic device for direct electrically pumped production of OAM beams. | | 09 July 2018 | doi: 10.1038/s41467-018-05170-z | | Integrated optics Optoelectronic devices and components Semiconductor lasers | Glycan recognition in globally dominant human rotaviruses OPEN | | Liya Hu, Banumathi Sankaran, Daniel R. Laucirica, Ketki Patil, Wilhelm Salmen, Allan Chris M Ferreon, Phoebe S. Tsoi, Yi Lasanajak, David F. Smith, Sasirekha Ramani, Robert L. Atmar, Mary K. Estes, Josephine C. Ferreon & B. V. Venkataram Prasad | | | Human rotaviruses (RV) bind to histo-blood group antigens (HBGA) for attachment, but how different viral genotypes interact with HBGA isn’t known. Here, Hu et al. report crystal structures of a prevalent and a neonate-specific RV in complex with HBGA and provide insights into glycan recognition and age-restricted tropism of RVs. | | 06 July 2018 | doi: 10.1038/s41467-018-05098-4 | | Carbohydrates Rotavirus Virus–host interactions X-ray crystallography | Evolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa OPEN | | Laura Bricio-Moreno, Victoria H. Sheridan, Ian Goodhead, Stuart Armstrong, Janet K.L. Wong, Elaine M. Waters, Joscelyn Sarsby, Stavros Panagiotou, James Dunn, Adrita Chakraborty, Yongliang Fang, Karl E. Griswold, Craig Winstanley, Joanne L. Fothergill, Aras Kadioglu & Daniel R. Neill | | | Mutations in gene pmrB are found in Pseudomonas aeruginosa isolates from cystic fibrosis patients. Here, Bricio-Moreno et al. show in a mouse model of respiratory infection that the mutations enhance bacterial adherence to epithelial cells and resistance to lysozyme, but also increase antibiotic susceptibility. | | 06 July 2018 | doi: 10.1038/s41467-018-04996-x | | Bacterial evolution Bacterial genes Bacterial host response Bacterial pathogenesis | Single-layer graphene membranes by crack-free transfer for gas mixture separation OPEN | | Shiqi Huang, Mostapha Dakhchoune, Wen Luo, Emad Oveisi, Guangwei He, Mojtaba Rezaei, Jing Zhao, Duncan T. L. Alexander, Andreas Züttel, Michael S. Strano & Kumar Varoon Agrawal | | | Graphene shows great promise for gas separation applications, but obtaining large membranes that are free of cracks and tears remains highly challenging. Here, the authors realize monolayer, crack-free, millimeter-scale graphene membranes that exhibit selective gas permeation solely thanks to their intrinsic defects | | 06 July 2018 | doi: 10.1038/s41467-018-04904-3 | | Chemical engineering Graphene Porous materials Synthesis and processing | miR-103 promotes endothelial maladaptation by targeting lncWDR59 OPEN | | Lucia Natarelli, Claudia Geißler, Gergely Csaba, Yuanyuan Wei, Mengyu Zhu, Andrea di Francesco, Petra Hartmann, Ralf Zimmer & Andreas Schober | | | MicroRNAs play important roles in endothelial cells injury, proliferation and maladaptation by negatively regulating posttranscriptional gene expression. Here the authors uncover the role of the long non coding RNA lncWDR59, target of miR-103, in endothelial maladaptation. | | 06 July 2018 | doi: 10.1038/s41467-018-05065-z | | Cardiovascular diseases Cell growth Double-strand DNA breaks Long non-coding RNAs miRNAs | Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish OPEN | | Shaoyang Zhao, Jianhong Xia, Xiuhua Wu, Leilei Zhang, Pengtao Wang, Haiyun Wang, Heying Li, Xiaoshan Wang, Yan Chen, Jean Agnetti, Yinxiong Li, Duanqing Pei & Xiaodong Shu | | | The functions of the class III PI3-kinase (PIK3C3) in gut homeostasis and innate immunity are poorly understood. Here the authors show that PIK3C3-deficient zebrafishes develop intestinal injury and inflammation due to mislocalization of cell junction proteins. | | 06 July 2018 | doi: 10.1038/s41467-018-05105-8 | | Development Disease model | A mosaic monoploid reference sequence for the highly complex genome of sugarcane OPEN | | Olivier Garsmeur, Gaetan Droc, Rudie Antonise, Jane Grimwood, Bernard Potier, Karen Aitken, Jerry Jenkins, Guillaume Martin, Carine Charron, Catherine Hervouet, Laurent Costet, Nabila Yahiaoui, Adam Healey, David Sims, Yesesri Cherukuri, Avinash Sreedasyam, Andrzej Kilian, Agnes Chan, Marie-Anne Van Sluys, Kankshita Swaminathan et al. | | | Sugarcane (Saccharum spp.) is a crop of major economic significance but has complex genome structure. Here, the authors generate a BAC-based monoploid sugarcane reference sequence. | | 06 July 2018 | doi: 10.1038/s41467-018-05051-5 | | Evolution Genome Plant genetics | A coronene-based semiconducting two-dimensional metal-organic framework with ferromagnetic behavior OPEN | | Renhao Dong, Zhitao Zhang, Diana C. Tranca, Shengqiang Zhou, Mingchao Wang, Peter Adler, Zhongquan Liao, Feng Liu, Yan Sun, Wujun Shi, Zhe Zhang, Ehrenfried Zschech, Stefan C. B. Mannsfeld, Claudia Felser & Xinliang Feng | | | Endowing metal–organic frameworks with both high electrical conductivity and magnetic ordering could make such materials useful for spintronics. Here the authors design a layer-stacking coronene-based 2D MOF that exhibits a semiconducting feature with an electrical conductivity of ~10 S cm−1 at 300 K, as well as ferromagnetism below ~20 K. | | 06 July 2018 | doi: 10.1038/s41467-018-05141-4 | | Electronic properties and materials Magnetic properties and materials Metal–organic frameworks | Genetic deficiency of NOD2 confers resistance to invasive aspergillosis OPEN | | Mark S. Gresnigt, Cristina Cunha, Martin Jaeger, Samuel M. Gonçalves, R. K. Subbarao Malireddi, Anne Ammerdorffer, Rosalie Lubbers, Marije Oosting, Orhan Rasid, Grégory Jouvion, Catherine Fitting, Dirk J. de Jong, João F. Lacerda, António Campos Jr., Willem J. G. Melchers, Katrien Lagrou, Johan Maertens, Thirumala-Devi Kanneganti, Agostinho Carvalho, Oumaima Ibrahim-Granet et al. | | | NOD2 has been shown to be crucial for immune recognition of Aspergillus infection. Here the authors show that a common NOD2 genetic variant associated with Crohn’s disease is associated with reduced risk of disease due to enhanced antifungal activates of monocytes and macrophages. | | 06 July 2018 | doi: 10.1038/s41467-018-04912-3 | | Disease genetics Fungal infection Immunopathogenesis NOD-like receptors | Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing OPEN | | Aamir Mir, Julia F. Alterman, Matthew R. Hassler, Alexandre J. Debacker, Edward Hudgens, Dimas Echeverria, Michael H. Brodsky, Anastasia Khvorova, Jonathan K. Watts & Erik J. Sontheimer | | | Resistance of gRNA to ubiquitous ribonucleases is required for CRISPR-Cas9-based therapeutics. Here, the authors explore chemical modifications at all positions of the crRNA guide and tracrRNA cofactor, and identify modified versions that are more potent and stable than their unmodified counterparts in editing human cells. | | 06 July 2018 | doi: 10.1038/s41467-018-05073-z | | CRISPR-Cas9 genome editing Molecular medicine Nucleic-acid therapeutics | Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses OPEN | | Fei Xiao, Denian Wang, Lingmiao Kong, Min Li, Zhongxue Feng, Bingxing Shuai, Lijun Wang, Yong’gang Wei, Hongyu Li, Sisi Wu, Chun Tan, Huan Zhao, Xuejiao Hu, Jin Liu, Yan Kang, Xuelian Liao, Yan Zhou & Wei Zhang | | | Sepsis is a life-threatening condition. Here, the authors show that intermedin alleviates organ injury and decreases mortality in septic mice by concurrently alleviating vascular leakage and inflammatory responses. Patients with high intermedin levels exhibit a low risk of shock, lower severity scores, and greatly improved survival outcomes. | | 06 July 2018 | doi: 10.1038/s41467-018-05062-2 | | Inflammation Molecular medicine Sepsis Translational immunology | Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70 OPEN | | Meng Zhao, Mattias N. D. Svensson, Koen Venken, Ashu Chawla, Shu Liang, Isaac Engel, Piotr Mydel, Jeremy Day, Dirk Elewaut, Nunzio Bottini & Mitchell Kronenberg | | | Invariant natural killer T (iNKT) cells can be subsetted based on their cytokine productions. Here the authors show, using Zap70 mutant mice, that interferon-γ secreting (IFN-γ) iNKT cells may be induced by hampered T cell receptor signallings to help ameliorate interleukin-17-mediated joint inflammation. | | 06 July 2018 | doi: 10.1038/s41467-018-05095-7 | | Interferons Lymphopoiesis NKT cells Signal transduction | Photonic crystal cavities from hexagonal boron nitride OPEN | | Sejeong Kim, Johannes E. Fröch, Joe Christian, Marcus Straw, James Bishop, Daniel Totonjian, Kenji Watanabe, Takashi Taniguchi, Milos Toth & Igor Aharonovich | | | Hexagonal boron nitride (hBN) is a layered van der Waals material showing promise for nanophotonics. Here, the authors design hBN photonic crystal cavities with quality factors exceeding 2000, and further demonstrate deterministic tuning of individual cavities by minimally-invasive electron beam induced etching. | | 05 July 2018 | doi: 10.1038/s41467-018-05117-4 | | Nanoscale devices Optics and photonics | ATR is a multifunctional regulator of male mouse meiosis OPEN | | Alexander Widger, Shantha K. Mahadevaiah, Julian Lange, Elias ElInati, Jasmin Zohren, Takayuki Hirota, Sarai Pacheco, Andros Maldonado-Linares, Marcello Stanzione, Obah Ojarikre, Valdone Maciulyte, Dirk G. de Rooij, Attila Tóth, Ignasi Roig, Scott Keeney & James M.A. Turner | | | ATR kinase is required for meiosis in non-mammalian model organisms. Here the authors demonstrate, using a tissue-specific knockout approach, that ATR is also essential for male meiosis in mouse, regulating meiotic recombination and synapsis. | | 05 July 2018 | doi: 10.1038/s41467-018-04850-0 | | Checkpoints Meiosis Spermatogenesis | Feeders facilitate telomere maintenance and chromosomal stability of embryonic stem cells OPEN | | Renpeng Guo, Xiaoying Ye, Jiao Yang, Zhongcheng Zhou, Chenglei Tian, Hua Wang, Haiying Wang, Haifeng Fu, Chun Liu, Ming Zeng, Jun Yang & Lin Liu | | | Feeder cells are widely used for the culture of embryonic stem cells (ESCs), but their specific effects are not well known. Here, the authors demonstrate that mouse ESCs exhibit telomere loss and chromosomal aberrations associated with reduced Zscan4 with increasing passages in the absence of feeders | | 05 July 2018 | doi: 10.1038/s41467-018-05038-2 | | Embryology Embryonic stem cells | Universal geometric frustration in pyrochlores OPEN | | B. A. Trump, S. M. Koohpayeh, K. J. T. Livi, J.-J. Wen, K. E. Arpino, Q. M. Ramasse, R. Brydson, M. Feygenson, H. Takeda, M. Takigawa, K. Kimura, S. Nakatsuji, C. L. Broholm & T. M. McQueen | | | The family of pyrochlore complex oxides includes many materials of fundamental or practical interest, such as spin ices and dielectrics. Trump et al. show that flexibility of the pyrochlores’ structure leads to local displacements that explain some of their unusual physical properties. | | 05 July 2018 | doi: 10.1038/s41467-018-05033-7 | | Condensed-matter physics Inorganic chemistry Materials chemistry Structure of solids and liquids | ATR is required to complete meiotic recombination in mice OPEN | | Sarai Pacheco, Andros Maldonado-Linares, Marina Marcet-Ortega, Cristina Rojas, Ana Martínez-Marchal, Judit Fuentes-Lazaro, Julian Lange, Maria Jasin, Scott Keeney, Oscar Fernández-Capetillo, Montserrat Garcia-Caldés & Ignasi Roig | | | ATR kinase is required for meiosis in non-mammalian model organisms. Here the authors demonstrate, using a hypomorphic Atr mutation and chemical inhibition, that ATR is also essential for male meiosis in mouse, regulating meiotic recombination and synapsis. | | 05 July 2018 | doi: 10.1038/s41467-018-04851-z | | Checkpoints Meiosis Spermatogenesis | A window of opportunity for cooperativity in the T Cell Receptor OPEN | | N. Martin-Blanco, R. Blanco, C. Alda-Catalinas, E. R. Bovolenta, C. L. Oeste, E. Palmer, W. W. Schamel, G. Lythe, C. Molina-París, M. Castro & B. Alarcon | | | T cells can be activated by a small, two-digit, number of antigen peptide molecules even though the receptor for antigen (TCR) is of low affinity. Here the authors present evidence that all TCRs within a nanocluster can become activated when only a subset is bound to antigen. | | 05 July 2018 | doi: 10.1038/s41467-018-05050-6 | | Lymphocyte activation Signal transduction T-cell receptor | | | | | | | | | Latest Author Corrections | | | | Author Correction: HuR regulates telomerase activity through TERC methylation OPEN | | Hao Tang , Hu Wang, Xiaolei Cheng, Xiuqin Fan, Fan Yang, Mengmeng Zhang, Yanlian Chen, Yuyang Tian, Cihang Liu, Dongxing Shao, Bin Jiang, Yali Dou, Yusheng Cong, Junyue Xing, Xiaotian Zhang, Xia Yi, Zhou Songyang, Wenbin Ma, Yong Zhao, Xian Wang et al. | | 10 July 2018 | doi: 10.1038/s41467-018-05213-5 | | Non-coding RNAs RNA-binding proteins RNA modification Telomeres | Author Correction: Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding OPEN | | Hou-Fu Guo, Chi-Lin Tsai, Masahiko Terajima, Xiaochao Tan, Priyam Banerjee, Mitchell D. Miller, Xin Liu, Jiang Yu, Jovita Byemerwa, Sarah Alvarado, Tamer S. Kaoud, Kevin N. Dalby, Neus Bota-Rabassedas, Yulong Chen, Mitsuo Yamauchi, John A. Tainer, George N. Phillips Jr. & Jonathan M. Kurie | | 10 July 2018 | doi: 10.1038/s41467-018-05295-1 | | Cancer microenvironment X-ray crystallography | | | | | Latest Publisher Correction | | | | | | | | Advertisement | | Communications Physics: Open for Submissions Communications Physics is a new open access journal that publishes high-quality primary research articles, reviews and commentary representing significant advances and new insights to the field of physics. The journal is now open for submissions. 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