Wednesday, July 11, 2018

Nature Communications - 11 July 2018

Nature Communications


Advanced Imaging with Proven Optics

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11 July 2018 
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Focus on Autoimmune Disease from Nature Immunology

A series of Reviews specially commissioned by Nature Immunology discuss the genetic, environmental, microbial and cellular factors underpinning autoimmune disease as well as highlight avenues for therapeutic intervention. 

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Submit your abstract for the RNA at the Bench and Bedside conference by July 30.

This conference will cover the numerous roles of RNAs and the efforts to translate advances in the basic science into new therapies. It will address the opportunities, current status, and the future of this exciting field. View the draft program for more details.

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  Latest Comment    
Non-Hermitian photonics promises exceptional topology of light OPEN
Bikashkali Midya, Han Zhao & Liang Feng
10 July 2018 | doi: 10.1038/s41467-018-05175-8
Optical physics  Topological matter 
  Latest Articles View all Articles  

Tools for engineering coordinated system behaviour in synthetic microbial consortia OPEN
Nicolas Kylilis, Zoltan A. Tuza, Guy-Bart Stan & Karen M. Polizzi

The engineering of synthetic microbial communities necessitates the use of synthetic, orthogonal cell-to-cell communication channels. Here the authors present a library of characterised AHL-receiver devices and a software tool for the automatic identification of non-interfering chemical communication channels.

11 July 2018 | doi: 10.1038/s41467-018-05046-2
Microbial communities  Industrial microbiology  Synthetic biology 

Red blood cell-hitchhiking boosts delivery of nanocarriers to chosen organs by orders of magnitude OPEN
Jacob S. Brenner, Daniel C. Pan, Jacob W. Myerson, Oscar A. Marcos-Contreras, Carlos H. Villa, Priyal Patel, Hugh Hekierski, Shampa Chatterjee, Jian-Qin Tao, Hamideh Parhiz, Kartik Bhamidipati, Thomas G. Uhler, Elizabeth D. Hood, Raisa Yu. Kiseleva, Vladimir S. Shuvaev, Tea Shuvaeva, Makan Khoshnejad, Ian Johnston, Jason V. Gregory, Joerg Lahann et al.

Unwanted uptake in the liver and limited accumulation in target organs is a major obstacle to targeted drug delivery. Here, the authors report on the hitchhiking of nanocarriers on red blood cells and the targeted upstream delivery to different target organs in mice, pigs and ex vivo human lungs.

11 July 2018 | doi: 10.1038/s41467-018-05079-7
Drug delivery  Drug development  Molecular medicine  Nanoparticles 

Graphene’s nonlinear-optical physics revealed through exponentially growing self-phase modulation OPEN
Nathalie Vermeulen, David Castelló-Lurbe, Mulham Khoder, Iwona Pasternak, Aleksandra Krajewska, Tymoteusz Ciuk, Wlodek Strupinski, JinLuo Cheng, Hugo Thienpont & Jürgen Van Erps

Graphene enables extraordinary nonlinear-optical refraction, far exceeding predictions based on conventional nonlinear-susceptibility theory. Here, Vermeulen et al. show that rather than the nonlinear susceptibility, a complex saturable refraction process is central to graphene’s unusual behavior.

11 July 2018 | doi: 10.1038/s41467-018-05081-z
Nonlinear optics  Optical properties and devices 

An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer’s disease OPEN
Ming Jin, Brian O’Nuallain, Wei Hong, Justin Boyd, Valentina N. Lagomarsino, Tiernan T. O’Malley, Wen Liu, Charles R. Vanderburg, Matthew P. Frosch, Tracy Young-Pearse, Dennis J. Selkoe & Dominic M. Walsh

The optimal Aβ species to target for the potential treatment of Alzheimer’s disease has not yet been established. Here, the authors describe an in vitro assay that uses extracts from brain tissue from patients with Alzheimer’s disease, and application to human iPSC-derived neurons, to compare the neuroprotective potential of several anti-Aβ antibodies.

11 July 2018 | doi: 10.1038/s41467-018-05068-w
Alzheimer's disease  Antibody therapy 

Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe OPEN
Yasuhito Onodera, Jin-Min Nam, Mei Horikawa, Hiroki Shirato & Hisataka Sabe

Mitochondria subcellular localization is dynamically regulated during migration. Here, the authors show that Arf6–AMAP1 dependent ILK localization at focal adhesions reduces mitochondrial retrograde trafficking in migratory cells and prevents mitochondrial aggregation and detrimental ROS production.

11 July 2018 | doi: 10.1038/s41467-018-05087-7
Breast cancer  Cancer metabolism  Cancer therapeutic resistance  Cell invasion  Integrin signalling 

Large-scale gene losses underlie the genome evolution of parasitic plant Cuscuta australis OPEN
Guiling Sun, Yuxing Xu, Hui Liu, Ting Sun, Jingxiong Zhang, Christian Hettenhausen, Guojing Shen, Jinfeng Qi, Yan Qin, Jing Li, Lei Wang, Wei Chang, Zhenhua Guo, Ian T. Baldwin & Jianqiang Wu

Dodders (Cuscuta spp., Convolvulaceae) are root- and leafless parasitic plants. Here, the authors sequence the genome of Cuscuta australis and find remarkable gene loss associated with parasitic lifestyle and large changes in body plan.

11 July 2018 | doi: 10.1038/s41467-018-04721-8
Comparative genomics  Evolutionary developmental biology  Plant evolution 

Systemic control of immune cell development by integrated carbon dioxide and hypoxia chemosensation in Drosophila OPEN
Bumsik Cho, Carrie M. Spratford, Sunggyu Yoon, Nuri Cha, Utpal Banerjee & Jiwon Shim

In mammals, crosstalk between O2 and CO2 sensing central and peripheral chemoreceptors has been linked to functions of the hematopoietic system. Here, the authors show an evolutionarily relevant cascade involving multiple organs that links CO2- and O2-chemosensation to immune cell maturation in Drosophila.

11 July 2018 | doi: 10.1038/s41467-018-04990-3
Development  Haematopoiesis  Neuroimmunology 

A TFEB nuclear export signal integrates amino acid supply and glucose availability OPEN
Linxin Li, Hans J. Friedrichsen, Sarah Andrews, Sarah Picaud, Laurent Volpon, Kaochin Ngeow, Georgina Berridge, Roman Fischer, Katherine L. B. Borden, Panagis Filippakopoulos & Colin R. Goding

On amino acid deprivation TFEB translocates from the cytoplasm to the nucleus. Here the authors identify a nuclear export signal in TFEB that requires dual phosphorylation at the S142 ERK/mTORC1 and S138 GSK3β sites, and further show glucose limitation drives nuclear accumulation of TFEB and inhibits GSK3β via an mTORC2-AKT dependent mechanism.

11 July 2018 | doi: 10.1038/s41467-018-04849-7
Cell biology  Cell signalling 

k-space imaging of anisotropic 2D electron gas in GaN/GaAlN high-electron-mobility transistor heterostructures OPEN
L. L. Lev, I. O. Maiboroda, M.-A. Husanu, E. S. Grichuk, N. K. Chumakov, I. S. Ezubchenko, I. A. Chernykh, X. Wang, B. Tobler, T. Schmitt, M. L. Zanaveskin, V. G. Valeyev & V. N. Strocov

Semiconductor heterostructures hosting two-dimensional electron gases are widely used today in high-electron-mobility transistors. Here, the authors probe the electronic structure in GaN/AlGaN, heterostructures, discovering planar anisotropy of the electron Fermi surface, offering new insights into transport properties.

11 July 2018 | doi: 10.1038/s41467-018-04354-x
Electronic devices  Electronic properties and materials  Surfaces, interfaces and thin films 

A quantitative criterion for determining the order of magnetic phase transitions using the magnetocaloric effect OPEN
Jia Yan Law, Victorino Franco, Luis Miguel Moreno-Ramírez, Alejandro Conde, Dmitriy Y. Karpenkov, Iliya Radulov, Konstantin P. Skokov & Oliver Gutfleisch

Magnetocaloric materials often perform best when their magnetic transitions are at the boundary between first- and second-order behavior. Here the authors propose a simple criterion to determine the order of a transition, which may accelerate future magnetocaloric material searches.

11 July 2018 | doi: 10.1038/s41467-018-05111-w
Magnetic properties and materials  Phase transitions and critical phenomena 

Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance OPEN
Jone Michelena, Aleksandra Lezaja, Federico Teloni, Thomas Schmid, Ralph Imhof & Matthias Altmeyer

Methods to study anti-cancer drugs cytotoxicity are often low throughput and rely on population average. Here the authors present an automated image-based cytometry method to quantify multiple cytotoxicity parameters in single cells, and use it to study the effect of PARP inhibitors in cancer cells.

11 July 2018 | doi: 10.1038/s41467-018-05031-9
Cellular imaging  DNA damage and repair  DNA replication  Fluorescence imaging 

Discovery of a drug candidate for GLIS3-associated diabetes OPEN
Sadaf Amin, Brandoch Cook, Ting Zhou, Zaniar Ghazizadeh, Raphael Lis, Tuo Zhang, Mona Khalaj, Miguel Crespo, Manuradhi Perera, Jenny Zhaoying Xiang, Zengrong Zhu, Mark Tomishima, Chengyang Liu, Ali Naji, Todd Evans, Danwei Huangfu & Shuibing Chen

GLIS3 mutations are associated with type 1, type 2, and neonatal diabetes. Here, the authors generate mono-hormonal glucose-responding pancreatic β-like cells in vitro and through a screen identify a drug that rescues pancreatic β-like cell death in GLIS3 mutants by inhibiting the abnormally activated TGFβ pathway.

11 July 2018 | doi: 10.1038/s41467-018-04918-x
Diabetes  Disease model  High-throughput screening 

Catalyst-TiO(OH)2 could drastically reduce the energy consumption of CO2 capture OPEN
Qinghua Lai, Sam Toan, Mohammed A. Assiri, Huaigang Cheng, Armistead G. Russell, Hertanto Adidharma, Maciej Radosz & Maohong Fan

The notoriously slow kinetics in CO2 desorption hinders the development of efficient CO2 capture technologies. Here, the authors discover that nanostructured TiO(OH)2 as a catalyst is capable of dramatically increasing the rates of CO2 desorption from spent monoethanolamine.

10 July 2018 | doi: 10.1038/s41467-018-05145-0
Carbon capture and storage  Chemical engineering  Heterogeneous catalysis 

Ultrathin and multicolour optical cavities with embedded metasurfaces OPEN
Amr M. Shaltout, Jongbum Kim, Alexandra Boltasseva, Vladimir M. Shalaev & Alexander V. Kildishev

Achieving miniature and versatile nanophotonic devices with metasurfaces is of great interest. The authors embed a metasurface inside an optical cavity to reduce thickness and provide degrees of freedom for controlling resonant wavelengths, enabling multi-band filtering, structural colouration and spectral imaging.

10 July 2018 | doi: 10.1038/s41467-018-05034-6
Metamaterials  Nanocavities  Nanophotonics and plasmonics  Sub-wavelength optics 

Patterns of genomic evolution in advanced melanoma OPEN
E. Birkeland, S. Zhang, D. Poduval, J. Geisler, S. Nakken, D. Vodak, L. A. Meza-Zepeda, E. Hovig, O. Myklebost, S. Knappskog & P. E. Lønning

As melanoma progresses, it evolves. Here, in advanced melanoma the authors study genomic evolution, highlighting trunk mutations dominated by the ultraviolet damage signature, common late truncal whole-genome duplication events, as well as selective copy number gain of mutant BRAF.

10 July 2018 | doi: 10.1038/s41467-018-05063-1
Cancer  Cancer genomics  Medical genomics  Melanoma 

The nature of spin excitations in the one-third magnetization plateau phase of Ba3CoSb2O9 OPEN
Y. Kamiya, L. Ge, Tao Hong, Y. Qiu, D. L. Quintero-Castro, Z. Lu, H. B. Cao, M. Matsuda, E. S. Choi, C. D. Batista, M. Mourigal, H. D. Zhou & J. Ma

Frustrated magnetic materials attract significant interest because their properties can become dominated by quantum fluctuations. Here the authors show that excitations in the plateau phase of a quantum magnet can be understood semiclassically even though the ground state involves strong quantum effects.

10 July 2018 | doi: 10.1038/s41467-018-04914-1
Magnetic properties and materials 

A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA OPEN
Sandhya Bangaru, Heng Zhang, Iuliia M. Gilchuk, Thomas G. Voss, Ryan P. Irving, Pavlo Gilchuk, Pranathi Matta, Xueyong Zhu, Shanshan Lang, Travis Nieusma, Juergen A. Richt, Randy A. Albrecht, Hillary A. Vanderven, Robin Bombardi, Stephen J. Kent, Andrew B. Ward, Ian A. Wilson & James E. Crowe Jr.

Broadly neutralizing antibodies are potential therapeutics and can aid rational vaccine development. Here, the authors show that the human monoclonal antibody H3v-47 recognizes a highly conserved epitope in HA of H3N2 viruses, inhibits virus replication by blocking egress and other mechanisms, and protects mice from disease.

10 July 2018 | doi: 10.1038/s41467-018-04704-9
Antibodies  Influenza virus 

Positive and negative regulation of carbon nanotube catalysts through encapsulation within macrocycles OPEN
Matías Blanco, Belén Nieto-Ortega, Alberto de Juan, Mariano Vera-Hidalgo, Alejandro López-Moreno, Santiago Casado, Luisa R. González, Hidetaka Sawada, José M. González-Calbet & Emilio M. Pérez

Doping carbon nanomaterials with heteroatoms is the most common way to change their catalytic activity. Here, the authors show that the catalytic properties of single-walled carbon nanotubes can be modified by non-covalently encapsulating them within electron-accepting or electron-donating macrocycles to form rotaxane-like structures.

10 July 2018 | doi: 10.1038/s41467-018-05183-8
Carbon nanotubes and fullerenes  Interlocked molecules  Nanoscale materials 

A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model OPEN
Naomi Tsuburaya, Kengo Homma, Tsunehiko Higuchi, Andrii Balia, Hiroyuki Yamakoshi, Norio Shibata, Seiichi Nakamura, Hidehiko Nakagawa, Shin-ichi Ikeda, Naoki Umezawa, Nobuki Kato, Satoshi Yokoshima, Masatoshi Shibuya, Manabu Shimonishi, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Isao Naguro, Keiko Imamura, Haruhisa Inoue et al.

Amyotrophic lateral sclerosis (ALS) is a neurological disease that leads to loss of voluntary muscle movement. Here, the authors screen for molecules that disrupt interaction between SOD1, a protein linked to ALS, and Derlin-1, and find an inhibitor that reduces pathology in an ALS mouse model.

10 July 2018 | doi: 10.1038/s41467-018-05127-2
Amyotrophic lateral sclerosis  High-throughput screening  Stress signalling 

Integrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes OPEN
Koichi Takahashi, Feng Wang, Kiyomi Morita, Yuanqing Yan, Peter Hu, Pei Zhao, Abdallah Abou Zhar, Chang Jiun Wu, Curtis Gumbs, Latasha Little, Samantha Tippen, Rebecca Thornton, Marcus Coyle, Marisela Mendoza, Erika Thompson, Jianhua Zhang, Courtney D. DiNardo, Nitin Jain, Farhad Ravandi, Jorge E. Cortes et al.

Mixed phenotype acute leukemia (MPAL) is a rare leukemia that presents both myeloid and lymphoid markers on blasts. Here the authors perform genomic analysis to show MPAL involves genetic and epigenetic heterogeneity and is genetically distinct from AML, B-ALL, and T-ALL.

10 July 2018 | doi: 10.1038/s41467-018-04924-z
Acute myeloid leukaemia  Cancer genomics 

Efficient solar hydrogen generation in microgravity environment OPEN
Katharina Brinkert, Matthias H. Richter, Ömer Akay, Janine Liedtke, Michael Giersig, Katherine T. Fountaine & Hans-Joachim Lewerenz

While renewable energy production is a terrestrial concern, far less attention is devoted to solar-to-fuel conversion for long-term space missions. Here, the authors explore photoelectrochemical hydrogen generation in microgravity and overcome microgravity’s limitations by electrode nanostructuring.

10 July 2018 | doi: 10.1038/s41467-018-04844-y
Chemical engineering  Electrocatalysis  Nanoscale materials  Photocatalysis  Solar fuels 

Detection and removal of barcode swapping in single-cell RNA-seq data OPEN
Jonathan A. Griffiths, Arianne C. Richard, Karsten Bach, Aaron T. L. Lun & John C. Marioni

DNA barcode swapping results in mislabelling of sequencing reads between multiplexed samples. Here, the authors investigate the severity and consequences of barcode swapping for single-cell RNA-seq data, and develop a computational method to exclude swapped reads.

10 July 2018 | doi: 10.1038/s41467-018-05083-x
Data processing  Quality control 

Microtubule minus-end aster organization is driven by processive HSET-tubulin clusters OPEN
Stephen R. Norris, Seungyeon Jung, Prashant Singh, Claire E. Strothman, Amanda L. Erwin, Melanie D. Ohi, Marija Zanic & Ryoma Ohi

Microtubules (MT) form higher-order structures such as asters, but the molecular pathway underlying aster formation remains unclear. Here authors demonstrate that the kinesin-14, HSET, clusters with soluble (nonMT) tubulin via its N-terminal tail domain and thereby promotes MT aster formation.

09 July 2018 | doi: 10.1038/s41467-018-04991-2
Cytoskeleton  Kinesin  Microtubules  Mitotic spindle  Motor proteins 

Collective molecular switching in hybrid superlattices for light-modulated two-dimensional electronics OPEN
Marco Gobbi, Sara Bonacchi, Jian X. Lian, Alexandre Vercouter, Simone Bertolazzi, Björn Zyska, Melanie Timpel, Roberta Tatti, Yoann Olivier, Stefan Hecht, Marco V. Nardi, David Beljonne, Emanuele Orgiu & Paolo Samorì

Photochromic molecules offer the unique opportunity to demonstrate multifunctional devices with light-tunable electrical characteristics. Gobbi et al. build light-switchable electronic heterojunctions based on atomically precise, photo-reversible molecular superlattices on graphene and MoS2.

09 July 2018 | doi: 10.1038/s41467-018-04932-z
Electronic devices  Electronic properties and devices  Electronic properties and materials  Graphene  Molecular self-assembly 

Crystal and melt inclusion timescales reveal the evolution of magma migration before eruption OPEN
Dawn C. S. Ruth, Fidel Costa, Caroline Bouvet de Maisonneuve, Luis Franco, Joaquin A. Cortés & Eliza S. Calder

Volatile contents in melt inclusions can be used to unravel magma migration and degassing. Here, the authors use olivine chronometry and melt inclusion data from the 2008 Llaima eruption and find that magma intrusion occurred 4 years before the eruption and reached a depth of 3–4 km, 6 months before the eruption.

09 July 2018 | doi: 10.1038/s41467-018-05086-8
Geochemistry  Natural hazards  Petrology  Volcanology 

Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts OPEN
Daniel Torralba, Francesc Baixauli, Carolina Villarroya-Beltri, Irene Fernández-Delgado, Ana Latorre-Pellicer, Rebeca Acín-Pérez, Noa B Martín-Cófreces, Ángel Luis Jaso-Tamame, Salvador Iborra, Inmaculada Jorge, Gloria González-Aseguinolaza, Johan Garaude, Miguel Vicente-Manzanares, José Antonio Enríquez, María Mittelbrunn & Francisco Sánchez-Madrid

T cells are activated by antigen-bearing dendritic cells (DC), but how DCs receive reciprocal activating signals from T cells is still unclear. Here the authors show that mitochondrial DNA-containing extracellular vesicles from activated T cells can prime DCs for anti-viral immunity via the cGAS/STING DNA sensing pathways.

09 July 2018 | doi: 10.1038/s41467-018-05077-9
Dendritic cells  Innate immunity  Pattern recognition receptors  T cells 

Genome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development OPEN
Heather J. Painter, Neo Christopher Chung, Aswathy Sebastian, Istvan Albert, John D. Storey & Manuel Llinás

Transcriptomic analysis often doesn’t differentiate between newly synthesized and stabilized mRNAs. Using rapid 4-thiouracil incorporation, Painter et al. here define genome-wide active transcription throughout Plasmodium blood-stage developmental stages and identify associated regulatory DNA sequence motifs.

09 July 2018 | doi: 10.1038/s41467-018-04966-3
Gene expression analysis  Malaria  Parasite biology  Parasite development 

AAVvector-mediated in vivo reprogramming into pluripotency OPEN
Elena Senís, Lluc Mosteiro, Stefan Wilkening, Ellen Wiedtke, Ali Nowrouzi, Saira Afzal, Raffaele Fronza, Henrik Landerer, Maria Abad, Dominik Niopek, Manfred Schmidt, Manuel Serrano & Dirk Grimm

In vivo reprogramming of somatic cells is hampered by the need for vectors to express the OKSM factors in selected organs. Here the authors report new AAV-based vectors capable of in vivo reprogramming at low doses.

09 July 2018 | doi: 10.1038/s41467-018-05059-x
Gene therapy  Genetic vectors  Regenerative medicine  Reprogramming 

Heterogeneity in tumor chromatin-doxorubicin binding revealed by in vivo fluorescence lifetime imaging confocal endomicroscopy OPEN
Hugh Sparks, Hiroshi Kondo, Steven Hooper, Ian Munro, Gordon Kennedy, Christopher Dunsby, Paul French & Erik Sahai

The engagement of DNA-binding drugs to their target is difficult to study, particularly in vivo. Here the authors develop an in vivo fluorescence lifetime imaging confocal laparo/endomicroscope to show intra- and inter-tumor heterogeneity in doxorubicin binding to peritoneal metastases, which depends on the route of administration.

09 July 2018 | doi: 10.1038/s41467-018-04820-6
Cancer imaging  Confocal microscopy  Microendoscopy 

TCR signal strength controls thymic differentiation of iNKT cell subsets OPEN
Kathryn D. Tuttle, S. Harsha Krovi, Jingjing Zhang, Romain Bedel, Laura Harmacek, Lisa K. Peterson, Leonard L. Dragone, Adam Lefferts, Catherine Halluszczak, Kent Riemondy, Jay R. Hesselberth, Anjana Rao, Brian P. O’Connor, Philippa Marrack, James Scott-Browne & Laurent Gapin

Invariant natural killer T (iNKT) cells can be subsetted by their cytokine profiles, but how they develop in the thymus is unclear. Here the authors show, by analysing mice carrying mutant Zap70 genes, that T cell receptor signaling strength induces epigenetic changes of genes to modulate iNKT lineages.

09 July 2018 | doi: 10.1038/s41467-018-05026-6
Epigenetics in immune cells  Lymphopoiesis  NKT cells  Signal transduction 

Gut microbiota associations with common diseases and prescription medications in a population-based cohort OPEN
Matthew A. Jackson, Serena Verdi, Maria-Emanuela Maxan, Cheol Min Shin, Jonas Zierer, Ruth C. E. Bowyer, Tiphaine Martin, Frances M. K. Williams, Cristina Menni, Jordana T. Bell, Tim D. Spector & Claire J. Steves

The human gut microbiome has been associated with many health factors, but variability between studies limits exploration of these effects. Here, Jackson et al. analyse gut microbiota associations for 38 common diseases and 51 medications within >2700 members of the TwinsUK cohort.

09 July 2018 | doi: 10.1038/s41467-018-05184-7
Health sciences  Medical research  Microbiome 

Subclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates OPEN
Philip Webster, Joanna C. Dawes, Hamlata Dewchand, Katalin Takacs, Barbara Iadarola, Bruce J. Bolt, Juan J. Caceres, Jakub Kaczor, Gopuraja Dharmalingam, Marian Dore, Laurence Game, Thomas Adejumo, James Elliott, Kikkeri Naresh, Mohammad Karimi, Katerina Rekopoulou, Ge Tan, Alberto Paccanaro & Anthony G. Uren

Evidence implicating cancer drivers can be sparse when limited to clonal events. Here, the authors present a retrovirus driven in vivo lymphomagenesis time course including hundreds of thousands of subclonal mutations and demonstrate the utility of these in mapping the selective forces affecting cancer gene loci, including negatively selected mutations.

09 July 2018 | doi: 10.1038/s41467-018-05069-9
Cancer  Cancer genomics  Cancer models 

Assembly and activation of the Hippo signalome by FAT1 tumor suppressor OPEN
Daniel Martin, Maria S. Degese, Lynn Vitale-Cross, Ramiro Iglesias-Bartolome, Juan Luis Callejas Valera, Zhiyong Wang, Xiaodong Feng, Huwate Yeerna, Vachan Vadmal, Toshiro Moroishi, Rick F. Thorne, Moraima Zaida, Bradford Siegele, Sok C. Cheong, Alfredo A. Molinolo, Yardena Samuels, Pablo Tamayo, Kun Liang Guan, Scott M. Lippman, J. Guy Lyons et al.

Dysregulation of the Hippo signaling is a frequent event in human malignancies, but the molecular mechanisms remain unclear. Here the authors show that in head and neck squamous carcinoma, FAT1 interacts with the Hippo signaling complex, resulting in the activation of core Hippo kinases and YAP1 inactivation.

09 July 2018 | doi: 10.1038/s41467-018-04590-1
Cancer genetics  Cell signalling 

Attentional fluctuations induce shared variability in macaque primary visual cortex OPEN
George H. Denfield, Alexander S. Ecker, Tori J. Shinn, Matthias Bethge & Andreas S. Tolias

Attention reduces correlated variability in population activity, however the effect of fluctuations in attentional state has not been studied. Here, the authors report in a novel visual task that fluctuations in attentional allocation have a pronounced effect on correlated variability at longer timescales.

09 July 2018 | doi: 10.1038/s41467-018-05123-6
Attention  Striate cortex 

An InP-based vortex beam emitter with monolithically integrated laser OPEN
Juan Zhang, Changzheng Sun, Bing Xiong, Jian Wang, Zhibiao Hao, Lai Wang, Yanjun Han, Hongtao Li, Yi Luo, Yi Xiao, Chuanqing Yu, Takuo Tanemura, Yoshiaki Nakano, Shimao Li, Xinlun Cai & Siyuan Yu

Orbital-angular-momentum (OAM) beams have great potential for multiplexing signals in optical communication, but creating a compact source is challenging. The authors integrate a chip-scale optical vortex emitter and DFB laser into a single monolithic device for direct electrically pumped production of OAM beams.

09 July 2018 | doi: 10.1038/s41467-018-05170-z
Integrated optics  Optoelectronic devices and components  Semiconductor lasers 

Glycan recognition in globally dominant human rotaviruses OPEN
Liya Hu, Banumathi Sankaran, Daniel R. Laucirica, Ketki Patil, Wilhelm Salmen, Allan Chris M Ferreon, Phoebe S. Tsoi, Yi Lasanajak, David F. Smith, Sasirekha Ramani, Robert L. Atmar, Mary K. Estes, Josephine C. Ferreon & B. V. Venkataram Prasad

Human rotaviruses (RV) bind to histo-blood group antigens (HBGA) for attachment, but how different viral genotypes interact with HBGA isn’t known. Here, Hu et al. report crystal structures of a prevalent and a neonate-specific RV in complex with HBGA and provide insights into glycan recognition and age-restricted tropism of RVs.

06 July 2018 | doi: 10.1038/s41467-018-05098-4
Carbohydrates  Rotavirus  Virus–host interactions  X-ray crystallography 

Evolutionary trade-offs associated with loss of PmrB function in host-adapted Pseudomonas aeruginosa OPEN
Laura Bricio-Moreno, Victoria H. Sheridan, Ian Goodhead, Stuart Armstrong, Janet K.L. Wong, Elaine M. Waters, Joscelyn Sarsby, Stavros Panagiotou, James Dunn, Adrita Chakraborty, Yongliang Fang, Karl E. Griswold, Craig Winstanley, Joanne L. Fothergill, Aras Kadioglu & Daniel R. Neill

Mutations in gene pmrB are found in Pseudomonas aeruginosa isolates from cystic fibrosis patients. Here, Bricio-Moreno et al. show in a mouse model of respiratory infection that the mutations enhance bacterial adherence to epithelial cells and resistance to lysozyme, but also increase antibiotic susceptibility.

06 July 2018 | doi: 10.1038/s41467-018-04996-x
Bacterial evolution  Bacterial genes  Bacterial host response  Bacterial pathogenesis 

Single-layer graphene membranes by crack-free transfer for gas mixture separation OPEN
Shiqi Huang, Mostapha Dakhchoune, Wen Luo, Emad Oveisi, Guangwei He, Mojtaba Rezaei, Jing Zhao, Duncan T. L. Alexander, Andreas Züttel, Michael S. Strano & Kumar Varoon Agrawal

Graphene shows great promise for gas separation applications, but obtaining large membranes that are free of cracks and tears remains highly challenging. Here, the authors realize monolayer, crack-free, millimeter-scale graphene membranes that exhibit selective gas permeation solely thanks to their intrinsic defects

06 July 2018 | doi: 10.1038/s41467-018-04904-3
Chemical engineering  Graphene  Porous materials  Synthesis and processing 

Burden on hydropower units for short-term balancing of renewable power systems OPEN
Weijia Yang, Per Norrlund, Linn Saarinen, Adam Witt, Brennan Smith, Jiandong Yang & Urban Lundin

Quantifying burden on hydropower units for balancing variable renewable energy sources has been uncertain and difficult. Herein Yang et al. propose a framework and characterize the burden, performance and compensation of hydropower regulation of renewable power systems.

06 July 2018 | doi: 10.1038/s41467-018-05060-4
Electrical and electronic engineering  Energy economics  Energy infrastructure  Mechanical engineering  Renewable energy 

Self-assembly of multi-stranded perylene dye J-aggregates in columnar liquid-crystalline phases OPEN
Stefanie Herbst, Bartolome Soberats, Pawaret Leowanawat, Matthias Stolte, Matthias Lehmann & Frank Würthner

Perylene bisimides (PBI) exhibit interesting photophysical and self-assembly properties but detailed understanding of the correlation between packing motif and spectroscopic properties is lacking. Here the authors report on self-assembling of PBIs in liquid crystalline phases to give aggregates with J- and H-type coupling contribution between the chromophores.

06 July 2018 | doi: 10.1038/s41467-018-05018-6
Liquid crystals  Self-assembly 

miR-103 promotes endothelial maladaptation by targeting lncWDR59 OPEN
Lucia Natarelli, Claudia Geißler, Gergely Csaba, Yuanyuan Wei, Mengyu Zhu, Andrea di Francesco, Petra Hartmann, Ralf Zimmer & Andreas Schober

MicroRNAs play important roles in endothelial cells injury, proliferation and maladaptation by negatively regulating posttranscriptional gene expression. Here the authors uncover the role of the long non coding RNA lncWDR59, target of miR-103, in endothelial maladaptation.

06 July 2018 | doi: 10.1038/s41467-018-05065-z
Cardiovascular diseases  Cell growth  Double-strand DNA breaks  Long non-coding RNAs  miRNAs 

Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish OPEN
Shaoyang Zhao, Jianhong Xia, Xiuhua Wu, Leilei Zhang, Pengtao Wang, Haiyun Wang, Heying Li, Xiaoshan Wang, Yan Chen, Jean Agnetti, Yinxiong Li, Duanqing Pei & Xiaodong Shu

The functions of the class III PI3-kinase (PIK3C3) in gut homeostasis and innate immunity are poorly understood. Here the authors show that PIK3C3-deficient zebrafishes develop intestinal injury and inflammation due to mislocalization of cell junction proteins.

06 July 2018 | doi: 10.1038/s41467-018-05105-8
Development  Disease model 

Ternary complex of Kif2A-bound tandem tubulin heterodimers represents a kinesin-13-mediated microtubule depolymerization reaction intermediate OPEN
Daria Trofimova, Mohammadjavad Paydar, Anthony Zara, Lama Talje, Benjamin H. Kwok & John S. Allingham

The kinesin-13 family of microtubule (MT) depolymerases are major regulators of MT dynamics. Here the authors provide insights into the MT depolymerization mechanism by solving the crystal structure of a kinesin-13 monomer (Kif2A) in complex with two bent αβ-tubulin heterodimers.

06 July 2018 | doi: 10.1038/s41467-018-05025-7
Biochemistry  Cell biology  Cytoskeletal proteins  Structural biology  X-ray crystallography 

Engineering circular RNA for potent and stable translation in eukaryotic cells OPEN
R. Alexander Wesselhoeft, Piotr S. Kowalski & Daniel G. Anderson

Circular RNAs have recently been shown to have protein-coding potential. Here the authors design a self-splicing RNA that, when circularized, provides for stable high-yield protein production.

06 July 2018 | doi: 10.1038/s41467-018-05096-6
Molecular biology  Nucleic-acid therapeutics  Synthetic biology 

A mosaic monoploid reference sequence for the highly complex genome of sugarcane OPEN
Olivier Garsmeur, Gaetan Droc, Rudie Antonise, Jane Grimwood, Bernard Potier, Karen Aitken, Jerry Jenkins, Guillaume Martin, Carine Charron, Catherine Hervouet, Laurent Costet, Nabila Yahiaoui, Adam Healey, David Sims, Yesesri Cherukuri, Avinash Sreedasyam, Andrzej Kilian, Agnes Chan, Marie-Anne Van Sluys, Kankshita Swaminathan et al.

Sugarcane (Saccharum spp.) is a crop of major economic significance but has complex genome structure. Here, the authors generate a BAC-based monoploid sugarcane reference sequence.

06 July 2018 | doi: 10.1038/s41467-018-05051-5
Evolution  Genome  Plant genetics 

Observational constraint on cloud susceptibility weakened by aerosol retrieval limitations OPEN
Po-Lun Ma, Philip J. Rasch, Hélène Chepfer, David M. Winker & Steven J. Ghan

Cloud susceptibility to aerosols in models frequently exceeds satellite estimates. Here the authors show that the discrepancy can be explained by retrieval limitations especially in clean environments, suggesting that conventional comparison strategies may lead to misunderstanding.

06 July 2018 | doi: 10.1038/s41467-018-05028-4
Atmospheric chemistry  Atmospheric science  Climate and Earth system modelling  Climate sciences 

Metallization and molecular dissociation of dense fluid nitrogen OPEN
Shuqing Jiang, Nicholas Holtgrewe, Sergey S. Lobanov, Fuhai Su, Mohammad F. Mahmood, R. Stewart McWilliams & Alexander F. Goncharov

Nitrogen is a model system still presenting unknown behaviors at the pressures and temperatures typical of deep planets’ interiors. Here the authors explore, by pulsed laser heating in a diamond anvil cell and optical measurements, the metallization and non-molecular states of nitrogen in a previously unexplored domain above 1 Mbar and at 2000-7000K.

06 July 2018 | doi: 10.1038/s41467-018-05011-z
Chemical physics  Electronic properties and materials  Phase transitions and critical phenomena 

A coronene-based semiconducting two-dimensional metal-organic framework with ferromagnetic behavior OPEN
Renhao Dong, Zhitao Zhang, Diana C. Tranca, Shengqiang Zhou, Mingchao Wang, Peter Adler, Zhongquan Liao, Feng Liu, Yan Sun, Wujun Shi, Zhe Zhang, Ehrenfried Zschech, Stefan C. B. Mannsfeld, Claudia Felser & Xinliang Feng

Endowing metal–organic frameworks with both high electrical conductivity and magnetic ordering could make such materials useful for spintronics. Here the authors design a layer-stacking coronene-based 2D MOF that exhibits a semiconducting feature with an electrical conductivity of ~10 S cm−1 at 300 K, as well as ferromagnetism below ~20 K.

06 July 2018 | doi: 10.1038/s41467-018-05141-4
Electronic properties and materials  Magnetic properties and materials  Metal–organic frameworks 

Silver-catalyzed remote Csp3-H functionalization of aliphatic alcohols OPEN
Yuchao Zhu, Kaimeng Huang, Jun Pan, Xu Qiu, Xiao Luo, Qixue Qin, Jialiang Wei, Xiaojin Wen, Lizhi Zhang & Ning Jiao

Aliphatic alcohols usually require pre-activation for successful functionalization of their carbon chain. Here, the authors report a silver-catalyzed δ-selective functionalization of aliphatic alcohols via Csp3-H bond cleavage under mild conditions without the need of substrate pre-activation.

06 July 2018 | doi: 10.1038/s41467-018-05014-w
Catalysis  Organic chemistry  Chemical synthesis 

Genetic deficiency of NOD2 confers resistance to invasive aspergillosis OPEN
Mark S. Gresnigt, Cristina Cunha, Martin Jaeger, Samuel M. Gonçalves, R. K. Subbarao Malireddi, Anne Ammerdorffer, Rosalie Lubbers, Marije Oosting, Orhan Rasid, Grégory Jouvion, Catherine Fitting, Dirk J. de Jong, João F. Lacerda, António Campos Jr., Willem J. G. Melchers, Katrien Lagrou, Johan Maertens, Thirumala-Devi Kanneganti, Agostinho Carvalho, Oumaima Ibrahim-Granet et al.

NOD2 has been shown to be crucial for immune recognition of Aspergillus infection. Here the authors show that a common NOD2 genetic variant associated with Crohn’s disease is associated with reduced risk of disease due to enhanced antifungal activates of monocytes and macrophages.

06 July 2018 | doi: 10.1038/s41467-018-04912-3
Disease genetics  Fungal infection  Immunopathogenesis  NOD-like receptors 

Highly stretchable and transparent ionic conducting elastomers OPEN
Lei Shi, Tianxiang Zhu, Guoxin Gao, Xinyu Zhang, Wei Wei, Wenfeng Liu & Shujiang Ding

Conductive elastomers are often made of composite materials and realization of high transparency and high elasticity at the same time is therefore hard to achieve. Here the authors use a salt in polymer strategy to fabricate ionic conducting elastomers (ICE), which show good elasticity and transparency and simultaneously high conductivity.

06 July 2018 | doi: 10.1038/s41467-018-05165-w
Electronic devices  Polymers  Sensors and biosensors 

Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing OPEN
Aamir Mir, Julia F. Alterman, Matthew R. Hassler, Alexandre J. Debacker, Edward Hudgens, Dimas Echeverria, Michael H. Brodsky, Anastasia Khvorova, Jonathan K. Watts & Erik J. Sontheimer

Resistance of gRNA to ubiquitous ribonucleases is required for CRISPR-Cas9-based therapeutics. Here, the authors explore chemical modifications at all positions of the crRNA guide and tracrRNA cofactor, and identify modified versions that are more potent and stable than their unmodified counterparts in editing human cells.

06 July 2018 | doi: 10.1038/s41467-018-05073-z
CRISPR-Cas9 genome editing  Molecular medicine  Nucleic-acid therapeutics 

ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma OPEN
Peng Mao, Alexander J. Brown, Shingo Esaki, Svetlana Lockwood, Gregory M. K. Poon, Michael J. Smerdon, Steven A. Roberts & John J. Wyrick

Many factors contribute to mutation hotspots in cancer cells. Here the authors map UV damage at single-nucleotide resolution across the human genome and find that binding sites of ETS transcription factors are especially prone to forming UV lesions, leading to mutation hotspots in melanoma.

06 July 2018 | doi: 10.1038/s41467-018-05064-0
Biochemistry  Cancer  Genetics  Molecular biology 

Selective ensembles in supported palladium sulfide nanoparticles for alkyne semi-hydrogenation OPEN
Davide Albani, Masoud Shahrokhi, Zupeng Chen, Sharon Mitchell, Roland Hauert, Núria López & Javier Pérez-Ramírez

Developing robust catalysts for alkyne semi-hydrogenation remains a challenge. Here, the authors introduce a scalable protocol to prepare crystal phase and orientation controlled Pd3S nanoparticles supported on carbon nitride, exhibiting unparalleled semi-hydrogenation performance due to a high density of active and selective ensembles.

06 July 2018 | doi: 10.1038/s41467-018-05052-4
Catalytic mechanisms  Density functional theory  Heterogeneous catalysis 

Structures of DNA-bound human ligase IV catalytic core reveal insights into substrate binding and catalysis OPEN
Andrea M. Kaminski, Percy P. Tumbale, Matthew J. Schellenberg, R. Scott Williams, Jason G. Williams, Thomas A. Kunkel, Lars C. Pedersen & Katarzyna Bebenek

DNA Ligase IV (LigIV) catalyzes nick sealing of DNA double-strand break substrates during non-homologous end-joining. Here the authors present the crystal structures of two human LigIV DNA-bound catalytic states, which provide insights into its catalytic mechanism and the molecular basis of LIG4 syndrome causing disease mutations.

06 July 2018 | doi: 10.1038/s41467-018-05024-8
Non-homologous-end joining  X-ray crystallography 

Exploiting limited valence patchy particles to understand autocatalytic kinetics OPEN
Silvia Corezzi, Francesco Sciortino & Cristiano De Michele

Autocatalysis is common in chemistry, biophysics and material science, but existing approaches are unable to fully capture the physical mechanisms behind it. Here, the authors exploit a limited valence patchy particle model and reveal a novel kinetic effect crucially related to the presence of activation barriers.

06 July 2018 | doi: 10.1038/s41467-018-04977-0
Condensed-matter physics  Nanoscale materials  Soft materials  Theory and computation 

Intermedin protects against sepsis by concurrently re-establishing the endothelial barrier and alleviating inflammatory responses OPEN
Fei Xiao, Denian Wang, Lingmiao Kong, Min Li, Zhongxue Feng, Bingxing Shuai, Lijun Wang, Yong’gang Wei, Hongyu Li, Sisi Wu, Chun Tan, Huan Zhao, Xuejiao Hu, Jin Liu, Yan Kang, Xuelian Liao, Yan Zhou & Wei Zhang

Sepsis is a life-threatening condition. Here, the authors show that intermedin alleviates organ injury and decreases mortality in septic mice by concurrently alleviating vascular leakage and inflammatory responses. Patients with high intermedin levels exhibit a low risk of shock, lower severity scores, and greatly improved survival outcomes.

06 July 2018 | doi: 10.1038/s41467-018-05062-2
Inflammation  Molecular medicine  Sepsis  Translational immunology 

Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70 OPEN
Meng Zhao, Mattias N. D. Svensson, Koen Venken, Ashu Chawla, Shu Liang, Isaac Engel, Piotr Mydel, Jeremy Day, Dirk Elewaut, Nunzio Bottini & Mitchell Kronenberg

Invariant natural killer T (iNKT) cells can be subsetted based on their cytokine productions. Here the authors show, using Zap70 mutant mice, that interferon-γ secreting (IFN-γ) iNKT cells may be induced by hampered T cell receptor signallings to help ameliorate interleukin-17-mediated joint inflammation.

06 July 2018 | doi: 10.1038/s41467-018-05095-7
Interferons  Lymphopoiesis  NKT cells  Signal transduction 

Human pluripotent reprogramming with CRISPR activators OPEN
Jere Weltner, Diego Balboa, Shintaro Katayama, Maxim Bespalov, Kaarel Krjutškov, Eeva-Mari Jouhilahti, Ras Trokovic, Juha Kere & Timo Otonkoski

CRISPRa is an attractive tool for cellular reprogramming due to its multiplexing capacity and direct targeting of genomic loci. Here the authors demonstrate the reprogramming of human fibroblasts into iPSCs, which is enhanced by targeting a conserved Alu-motif.

06 July 2018 | doi: 10.1038/s41467-018-05067-x
CRISPR-Cas systems  Reprogramming  Stem-cell biotechnology  Transcriptional regulatory elements 

Photonic crystal cavities from hexagonal boron nitride OPEN
Sejeong Kim, Johannes E. Fröch, Joe Christian, Marcus Straw, James Bishop, Daniel Totonjian, Kenji Watanabe, Takashi Taniguchi, Milos Toth & Igor Aharonovich

Hexagonal boron nitride (hBN) is a layered van der Waals material showing promise for nanophotonics. Here, the authors design hBN photonic crystal cavities with quality factors exceeding 2000, and further demonstrate deterministic tuning of individual cavities by minimally-invasive electron beam induced etching.

05 July 2018 | doi: 10.1038/s41467-018-05117-4
Nanoscale devices  Optics and photonics 

ATR is a multifunctional regulator of male mouse meiosis OPEN
Alexander Widger, Shantha K. Mahadevaiah, Julian Lange, Elias ElInati, Jasmin Zohren, Takayuki Hirota, Sarai Pacheco, Andros Maldonado-Linares, Marcello Stanzione, Obah Ojarikre, Valdone Maciulyte, Dirk G. de Rooij, Attila Tóth, Ignasi Roig, Scott Keeney & James M.A. Turner

ATR kinase is required for meiosis in non-mammalian model organisms. Here the authors demonstrate, using a tissue-specific knockout approach, that ATR is also essential for male meiosis in mouse, regulating meiotic recombination and synapsis.

05 July 2018 | doi: 10.1038/s41467-018-04850-0
Checkpoints  Meiosis  Spermatogenesis 

A biomimetic chiral-driven ionic gate constructed by pillar[6]arene-based host–guest systems OPEN
Yue Sun, Fan Zhang, Jiaxin Quan, Fei Zhu, Wei Hong, Junkai Ma, Huan Pang, Yao Sun, Demei Tian & Haibing Li

Uptake and release of glucose is regulated by glucose-sensitive ion channels, but complexity of the system impedes investigation of the gating behavior under physiological conditions. Here the authors use a pillararene based artificial ion channel to mimic and investigate chirality driven switching of a glucose ion channel.

05 July 2018 | doi: 10.1038/s41467-018-05103-w
Molecular self-assembly  Self-assembly  Surface assembly 

Mouse MRI shows brain areas relatively larger in males emerge before those larger in females OPEN
Lily R. Qiu, Darren J. Fernandes, Kamila U. Szulc-Lerch, Jun Dazai, Brian J. Nieman, Daniel H. Turnbull, Jane A. Foster, Mark R. Palmert & Jason P. Lerch

Sex differences occur in various aspects of neurodevelopment. Here the authors use manganese-enhanced MRI at nine different postnatal stages to detail the development of structural sex differences in the mouse brain.

05 July 2018 | doi: 10.1038/s41467-018-04921-2
Neural circuits  Neuronal development 

Reconstructing the sediment concentration of a giant submarine gravity flow OPEN
Christopher John Stevenson, Peter Feldens, Aggeliki Georgiopoulou, Mischa Schӧnke, Sebastian Krastel, David J. W. Piper, Katja Lindhorst & David Mosher

Giant submarine gravity flows are a key mechanism in global sediment transport, yet their properties remain enigmatic. Here, the authors reconstruct the properties of a historic giant submarine gravity flow from deposits across the seafloor.

05 July 2018 | doi: 10.1038/s41467-018-05042-6
Geomorphology  Natural hazards 

Feeders facilitate telomere maintenance and chromosomal stability of embryonic stem cells OPEN
Renpeng Guo, Xiaoying Ye, Jiao Yang, Zhongcheng Zhou, Chenglei Tian, Hua Wang, Haiying Wang, Haifeng Fu, Chun Liu, Ming Zeng, Jun Yang & Lin Liu

Feeder cells are widely used for the culture of embryonic stem cells (ESCs), but their specific effects are not well known. Here, the authors demonstrate that mouse ESCs exhibit telomere loss and chromosomal aberrations associated with reduced Zscan4 with increasing passages in the absence of feeders

05 July 2018 | doi: 10.1038/s41467-018-05038-2
Embryology  Embryonic stem cells 

Universal geometric frustration in pyrochlores OPEN
B. A. Trump, S. M. Koohpayeh, K. J. T. Livi, J.-J. Wen, K. E. Arpino, Q. M. Ramasse, R. Brydson, M. Feygenson, H. Takeda, M. Takigawa, K. Kimura, S. Nakatsuji, C. L. Broholm & T. M. McQueen

The family of pyrochlore complex oxides includes many materials of fundamental or practical interest, such as spin ices and dielectrics. Trump et al. show that flexibility of the pyrochlores’ structure leads to local displacements that explain some of their unusual physical properties.

05 July 2018 | doi: 10.1038/s41467-018-05033-7
Condensed-matter physics  Inorganic chemistry  Materials chemistry  Structure of solids and liquids 

ATR is required to complete meiotic recombination in mice OPEN
Sarai Pacheco, Andros Maldonado-Linares, Marina Marcet-Ortega, Cristina Rojas, Ana Martínez-Marchal, Judit Fuentes-Lazaro, Julian Lange, Maria Jasin, Scott Keeney, Oscar Fernández-Capetillo, Montserrat Garcia-Caldés & Ignasi Roig

ATR kinase is required for meiosis in non-mammalian model organisms. Here the authors demonstrate, using a hypomorphic Atr mutation and chemical inhibition, that ATR is also essential for male meiosis in mouse, regulating meiotic recombination and synapsis.

05 July 2018 | doi: 10.1038/s41467-018-04851-z
Checkpoints  Meiosis  Spermatogenesis 

A window of opportunity for cooperativity in the T Cell Receptor OPEN
N. Martin-Blanco, R. Blanco, C. Alda-Catalinas, E. R. Bovolenta, C. L. Oeste, E. Palmer, W. W. Schamel, G. Lythe, C. Molina-París, M. Castro & B. Alarcon

T cells can be activated by a small, two-digit, number of antigen peptide molecules even though the receptor for antigen (TCR) is of low affinity. Here the authors present evidence that all TCRs within a nanocluster can become activated when only a subset is bound to antigen.

05 July 2018 | doi: 10.1038/s41467-018-05050-6
Lymphocyte activation  Signal transduction  T-cell receptor 
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Reply to ‘Inconclusive evidence for rapid adaptive evolution’ OPEN
Camilla Lo Cascio Sætre, Charles Coleiro, Martin Austad, Mark Gauci, Glenn-Peter Sætre, Kjetil Lysne Voje & Fabrice Eroukhmanoff
10 July 2018 | doi: 10.1038/s41467-018-05120-9
Evolutionary biology  Restoration ecology 

Inconclusive evidence for rapid adaptive evolution OPEN
Júlio Manuel Neto, Staffan Bensch, Lars Råberg & Bengt Hansson
10 July 2018 | doi: 10.1038/s41467-018-05119-2
Animal migration  Evolutionary biology  Restoration ecology 
  Latest Author Corrections    
Author Correction: Cryo-EM reveals the structural basis of microtubule depolymerization by kinesin-13s OPEN
Matthieu P. M. H. Benoit, Ana B. Asenjo & Hernando Sosa
11 July 2018 | doi: 10.1038/s41467-018-04858-6
Electron microscopy  Motor protein structure  Motor proteins  Structural biology 

Author Correction: HuR regulates telomerase activity through TERC methylation OPEN
Hao Tang , Hu Wang, Xiaolei Cheng, Xiuqin Fan, Fan Yang, Mengmeng Zhang, Yanlian Chen, Yuyang Tian, Cihang Liu, Dongxing Shao, Bin Jiang, Yali Dou, Yusheng Cong, Junyue Xing, Xiaotian Zhang, Xia Yi, Zhou Songyang, Wenbin Ma, Yong Zhao, Xian Wang et al.
10 July 2018 | doi: 10.1038/s41467-018-05213-5
Non-coding RNAs  RNA-binding proteins  RNA modification  Telomeres 

Author Correction: Next generation histology methods for three-dimensional imaging of fresh and archival human brain tissues OPEN
Hei Ming Lai, Alan King Lun Liu, Harry Ho Man Ng, Marc H. Goldfinger, Tsz Wing Chau, John DeFelice, Bension S. Tilley, Wai Man Wong, Wutian Wu & Steve M. Gentleman
10 July 2018 | doi: 10.1038/s41467-018-05089-5
Immunohistochemistry  Neurology  Neuroscience  Optical imaging 

Author Correction: Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding OPEN
Hou-Fu Guo, Chi-Lin Tsai, Masahiko Terajima, Xiaochao Tan, Priyam Banerjee, Mitchell D. Miller, Xin Liu, Jiang Yu, Jovita Byemerwa, Sarah Alvarado, Tamer S. Kaoud, Kevin N. Dalby, Neus Bota-Rabassedas, Yulong Chen, Mitsuo Yamauchi, John A. Tainer, George N. Phillips Jr. & Jonathan M. Kurie
10 July 2018 | doi: 10.1038/s41467-018-05295-1
Cancer microenvironment  X-ray crystallography 
  Latest Publisher Correction    
Publisher Correction: Spatio-temporal variability of processes across Antarctic ice-bed–ocean interfaces OPEN
Florence Colleoni, Laura De Santis, Christine S. Siddoway, Andrea Bergamasco, Nicholas R. Golledge, Gerrit Lohmann, Sandra Passchier & Martin J. Siegert
11 July 2018 | doi: 10.1038/s41467-018-05206-4
Cryospheric science  Geodynamics  Palaeoceanography  Palaeoclimate 

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