Nature Cell Biology contents: July 2018 Volume 20 Number 7

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Advertisement Do you have a career question?  The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud. Listen today! TABLE OF CONTENTS July 2018 Volume 20, Issue 7 Editorial News & Views Review Articles Letters Articles Resources   Advertisement nature.com webcasts Nature Research Custom Media presents a webcast on: Combining scRNA-seq and Flow Analyses Date: Tuesday, July 24, 2018 Join our webcast to learn how fluorescence intensity information from flow parameters can be merged into a single-cell RNA expression matrix and analysed. This webcast has been produced on behalf of the sponsor who retains sole responsibility for content  Register for FREE  Sponsored by: SeqGeq      Advertisement Nature Spotlight on Hong Kong: Building science innovation  Hong Kong is maximising major scientific innovation and commercial benefits through its proximity to the research and development hubs in mainland China. Yet barriers to collaboration remain.  Access the full supplement for more >>    Advertisement Scientific Reports Top 100 in Plant Science This collection presents the top 100 most highly accessed plant science articles published in Scientific Reports in 2017. Access the collection >>>   Editorial   Focusing on mitochondrial form and function    p735 doi:10.1038/s41556-018-0139-7 News & Views   Pro-tumorigenic AMPK in glioblastoma    pp736 - 737 Nektaria Maria Leli & Constantinos Koumenis doi:10.1038/s41556-018-0129-9 Grasping for aspartate in tumour metabolism    pp738 - 739 Accalia Fu & Nika N. Danial doi:10.1038/s41556-018-0137-9 GNAS shifts metabolism in pancreatic cancer    pp740 - 741 Pablo E. Hollstein & Reuben J. Shaw doi:10.1038/s41556-018-0120-5 A single-cell chromatin map of human embryos    pp742 - 744 Raquel Pérez-Palacios & Deborah Bourc'his doi:10.1038/s41556-018-0134-z Nature Cell Biology JOBS of the week Post Doctoral Researcher The Ohio State University Wexner Medical Center Faculty position Sabanci University Postdoctoral Fellow - Translational Cancer Research University of Pennsylvania Research Associate / PhD Position TU Dresden Postdoctoral Research Associate University of Leicester More Science jobs from Nature Cell Biology EVENT 10th International Congress on Structural Biolog 18.10.18 Helsinki, Finland More science events from Review Articles   The multifaceted contributions of mitochondria to cellular metabolism    pp745 - 754 Jessica B. Spinelli & Marcia C. Haigis doi:10.1038/s41556-018-0124-1 Mitochondrial dynamics in adaptive and maladaptive cellular stress responses    pp755 - 765 Verónica Eisner, Martin Picard & György Hajnóczky doi:10.1038/s41556-018-0133-0 Mitochondria sense and respond to many stressors and can support cell survival or death through energy production and signalling pathways. Mitochondrial responses depend on fusion–fission dynamics that dilute and segregate damaged mitochondria. Mitochondrial motility and inter-organellar interactions, such as with the endoplasmic reticulum, also function in cellular adaptation to stress. In this Review, we discuss how stressors influence these components, and how they contribute to the complex adaptive and pathological responses that lead to disease.   Mechanisms and impact of altered tumour mechanics    pp766 - 774 Hamid Mohammadi & Erik Sahai doi:10.1038/s41556-018-0131-2 Tumours are often more stiff than normal tissue. In this Review, Mohammadi and Sahai discuss recent insights into how such altered tumour mechanics arise and how this affects tumorigenesis.   Advertisement Calls for nominations:  2018 John Maddox Prize for Standing up for Science Recognising the work of individuals who promote science in the face of hostility.   Letters   Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours    pp775 - 781 Javier Garcia-Bermudez, Lou Baudrier, Konnor La, Xiphias Ge Zhu, Justine Fidelin et al. doi:10.1038/s41556-018-0118-z Garcia-Bermudez et al. and Sullivan et al. show that endogenous aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours, and that metformin depletes aspartate to limit tumour growth.   Aspartate is an endogenous metabolic limitation for tumour growth    pp782 - 788 Lucas B. Sullivan, Alba Luengo, Laura V. Danai, Lauren N. Bush, Frances F. Diehl et al. doi:10.1038/s41556-018-0125-0 Garcia-Bermudez et al. and Sullivan et al. show that endogenous aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours, and that metformin depletes aspartate to limit tumour growth.   Articles   Senescence-associated ribosome biogenesis defects contributes to cell cycle arrest through the Rb pathway    pp789 - 799 Frédéric Lessard, Sebastian Igelmann, Christian Trahan, Geneviève Huot, Emmanuelle Saint-Germain et al. doi:10.1038/s41556-018-0127-y Lassard et al. demonstrate a relationship between cellular senescence and perturbed ribosome biogenesis and find that the ribosomal protein S14 is an inhibitor of CDK4, inducing an Rb-dependent cell cycle arrest.   Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis    pp800 - 810 Carlos Sacristan, Misbha Ud Din Ahmad, Jenny Keller, Job Fermie, Vincent Groenewold et al. doi:10.1038/s41556-018-0130-3 Sacristan et al. show that the dynein adaptor Spindly facilitates oligomerisation of the RZZ complex to expand the kinetochore, after which Spindly-associated dynein compacts the kinetochore to allow for faithful chromosome segregation.   Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism    pp811 - 822 Krushna C. Patra, Yasutaka Kato, Yusuke Mizukami, Sebastian Widholz, Myriam Boukhali et al. doi:10.1038/s41556-018-0122-3 Bardeesy and colleagues show that mutant GNAS suppresses salt-inducible kinases by activating PKA, leading to lipid remodelling and pancreatic tumourigenesis   AMP kinase promotes glioblastoma bioenergetics and tumour growth    pp823 - 835 Rishi Raj Chhipa, Qiang Fan, Jane Anderson, Ranjithmenon Muraleedharan, Yan Huang et al. doi:10.1038/s41556-018-0126-z Signalling by the energy sensor kinase AMPK is generally tumour suppressive, but Chhipa et al. show that AMPK is upregulated in glioblastoma, where it phosphorylates CREB1 to enhance HIF1a and GABPA transcription and to support tumour bioenergetics.   Resources   Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis    pp836 - 846 Amir Giladi, Franziska Paul, Yoni Herzog, Yaniv Lubling, Assaf Weiner et al. doi:10.1038/s41556-018-0121-4 Using a multi-tier scRNA-seq and CRISP-seq approach, Giladi et al. define a transcriptional signature for the naive haematopoietic stem cell state, and follow progenitor plasticity and fate commitment under the influence of cytokines and growth factors.   Single-cell multi-omics sequencing of human early embryos    pp847 - 858 Lin Li, Fan Guo, Yun Gao, Yixin Ren, Peng Yuan et al. doi:10.1038/s41556-018-0123-2 Using scCOOL-seq, Li et al. simultaneously characterize the DNA methylation and chromatin accessibility of the same cell during human preimplantation development.   Advertisement nature.com webcasts Nature Research Custom Media presents a webcast on: Practical Considerations for T Cell Receptor (TCR) Therapies Targeting Solid Tumors Date: Tuesday, July 17, 2018 Join the webcast to learn about the advantages of automated cell cloning and methods for rapid cloning and validation of functional TCRs. This webcast has been produced on behalf of the sponsor who retains sole responsibility for content  Register for FREE  Sponsored by: Berkeley Lights Inc    Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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