The EMBO Journal Table of Contents for 15 June 2018; Vol. 37, No. 12

15 June 2018 | Volume 37, Number 12 Submit Table of Contents Commentary News & Views Review Articles Volume 37, Number 12 Commentary Algorithmically outsourcing the detection of statistical errors and other problems To err is human—and that includes scientific papers where statistical errors and wrong calculations can distort the message of the report. Algorithms to spot such erroneous calculations exist and could help to improve reproducibility and ease the burden on reviewers. Jonathan D Wren Published online 24.05.2018 News & Views How DNA vicinity controls SUMO E3 ligase activity Nse2/Mms21 activation by ssDNA binding to the SMC5‐6 complex exemplifies a mechanism by which protein group sumoylation can be triggered during DNA repair. Andrea Pichler Published online 24.05.2018 Review The assembly of lipid droplets and their roles in challenged cells This review offers a concise summary of our current view of how cytoplasmic lipid droplets respond to cellular stresses and pathogen invasion, and cross‐talk with other organelles in order to maintain energy balance and cellular physiology. W Mike Henne, Michael L Reese and Joel M Goodman Published online 22.05.2018 Articles LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages The Parkinson's disease‐associated kinase LRRK2 affects innate immune control of mycobacterial infections in vitro and in vivo via phagosome recruitment of class III PI3K and Rubicon. Anetta Härtlova, Susanne Herbst, Julien Peltier, Angela Rodgers, Orsolya Bilkei‐Gorzo, Antony Fearns, Brian D Dill, Heyne Lee, Rowan Flynn, Sally A Cowley, Paul Davies, Patrick A Lewis, Ian G Ganley, Jennifer Martinez, Dario R Alessi, Alastair D Reith, Matthias Trost and Maximiliano G Gutierrez Published online 22.05.2018 DNA activates the Nse2/Mms21 SUMO E3 ligase in the Smc5/6 complex A DNA sensor region in the Smc5/6 complex controls upregulation of sumoylation on chromatin and contributes to yeast cell survival after DNA damage. Nathalia Varejão, Eva Ibars, Jara Lascorz, Neus Colomina, Jordi Torres‐Rosell and David Reverter Published online 16.05.2018 Interplay of cell–cell contacts and RhoA/MRTF‐A signaling regulates cardiomyocyte identity Stable desmosomes prevent pathological myocyte‐to‐adipocyte conversion resulting from MRTF‐A mislocalization and subsequent PPAR activation. Tatjana Dorn, Jessica Kornherr, Elvira I Parrotta, Dorota Zawada, Harold Ayetey, Gianluca Santamaria, Laura Iop, Elisa Mastantuono, Daniel Sinnecker, Alexander Goedel, Ralf J Dirschinger, Ilaria My, Svenja Laue, Tarik Bozoglu, Christian Baarlink, Tilman Ziegler, Elisabeth Graf, Rabea Hinkel, Giovanni Cuda, Stefan Kääb, Andrew A Grace, Robert Grosse, Christian Kupatt, Thomas Meitinger, Austin G Smith, Karl‐Ludwig Laugwitz and Alessandra Moretti Published online 15.05.2018 FAM35A associates with REV7 and modulates DNA damage responses of normal and BRCA1‐defective cells Suppression of double strand break resection by 53BP1‐RIF1‐REV7 to allow non‐homologous end‐joining repair additionally requires FAM35A, an OB‐fold protein that may mediate interaction with single‐stranded DNA. Junya Tomida, Kei‐ichi Takata, Sarita Bhetawal, Maria D Person, Hsueh‐Ping Chao, Dean G Tang and Richard D Wood Published online 22.05.2018 α‐Synuclein stimulation of monoamine oxidase‐B and legumain protease mediates the pathology of Parkinson's disease Direct interaction between two Parkinson's disease‐associated proteins, α‐Synuclein and monoamine oxidase‐B (MAO‐B), regulates MAO‐B activity and neurotoxic cleavage of α‐Synuclein, resulting in dopaminergic neurodegeneration. Seong Su Kang, Eun Hee Ahn, Zhentao Zhang, Xia Liu, Fredric P Manfredsson, Ivette M Sandoval, Susov Dhakal, P Michael Iuvone, Xuebing Cao and Keqiang Ye Published online 16.05.2018 GTSF‐1 is required for formation of a functional RNA‐dependent RNA Polymerase complex in Caenorhabditis elegans The conserved zinc finger protein GTSF‐1 is needed for piRNA‐dependent transposon silencing in flies and mammals but dispensable in C. elegans, where it instead facilitates formation of a different class of small RNAs. Miguel Vasconcelos Almeida, Sabrina Dietz, Stefan Redl, Emil Karaulanov, Andrea Hildebrandt, Christian Renz, Helle D Ulrich, Julian König, Falk Butter and René F Ketting Published online 16.05.2018   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.