Monday, June 25, 2018

Nature Reviews Cancer contents July 2018 Volume 18 Number 7

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Nature Reviews Cancer

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TABLE OF CONTENTS

July 2018 Volume 18, Issue 7

Editorial
Research Highlights
Reviews
Perspectives
 
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Nature Research Custom Media presents a webcast on: Rspondin3 from stromal myofibroblasts orchestrates gastric epithelial stem cells2

Date: Wednesday, July 11, 2018 Join our webcast to learn how the RNAscope® Dual ISH technology was utilized to thoroughly characterize the gastric antral gland stem cell niche.

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Editorial

 

Early detection: a long road ahead    p401
doi:10.1038/s41568-018-0021-8

Research Highlights

 

Lethally high ROS levels thwart resistance    p403
Sarah Seton-Rogers
doi:10.1038/s41568-018-0031-6

Wang, Leite de Oliveira et al. show that BRAFV600E-mutant melanomas that are resistant to BRAF and MEK inhibitors are vulnerable to increased levels of reactive oxygen species and that this can be exploited therapeutically using a histone deacetylase inhibitor.

 

On the cutting edge    pp404 - 405
Ulrike Harjes
doi:10.1038/s41568-018-0017-4

A recent study published in Science Translational Medicine generated a mouse model to study the link between surgical wounding and distant tumour growth, showing that the systemic wound healing response induced by surgery can promote tumour growth.

 

Organoid diversity    pp404 - 405
Anna Dart
doi:10.1038/s41568-018-0018-3

Roerink et al. have used organoids derived from multiple single cells of colorectal cancers from three patients as well as from normal colorectal epithelium of the same patients to comprehensively study intratumoural heterogeneity.

 

Inverted architecture    p405
Sarah Seton-Rogers
doi:10.1038/s41568-018-0025-4

Single-cell RNA sequencing analysis in paediatric diffuse midline gliomas with histone H3 lysine 27 to methionine mutations indicates that these aggressive tumours contain many stem-like cells and that lineage-based therapeutic targeting might be beneficial.

 

Nature Reviews Cancer
JOBS of the week
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Postdoctoral Fellowships in Experimental Genetics, Epigenetics and Functional Screens
The University of Texas MD Anderson Cancer Center
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Reviews

 

Organoids in cancer research    pp407 - 418
Jarno Drost & Hans Clevers
doi:10.1038/s41568-018-0007-6

In this Review, Drost and Clevers discuss the recent advances in organoid models of cancer and how they can be exploited to drive the translation of basic cancer research into novel patient-specific treatment regimens in the clinic.

 

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Nature Research Custom Media presents a webcast on: Rapid discovery of glioma-specific TCRs using Digital Cell Biology

Date: Tuesday, July 17, 2018

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Perspectives

 

Oncolytic viruses as engineering platforms for combination immunotherapy    pp419 - 432

doi:10.1038/s41568-018-0009-4

In this Opinion article, Twumasi-Boateng et al. discuss the use of oncolytic viruses as multiplexed immune-modulating platforms with the potential to improve the effectiveness of immunotherapies through novel synergistic mechanisms promoting antitumour immune activity.

 

Mechanisms of cancer resistance in long-lived mammals    pp433 - 441
Andrei Seluanov, Vadim N. Gladyshev, Jan Vijg & Vera Gorbunova
doi:10.1038/s41568-018-0004-9

In this Opinion article, Seluanov et al. discuss the diverse mechanisms of cancer resistance found in long-lived mammals and argue that studies of unconventional long-lived and cancer-resistant animal species could provide breakthroughs in cancer therapy and prevention.

 

Non-canonical functions of the RB protein in cancer    pp442 - 451
Frederick A. Dick, David W. Goodrich, Julien Sage & Nicholas J. Dyson
doi:10.1038/s41568-018-0008-5

This Opinion discusses studies indicating a direct role of RB in chromatin regulation and DNA repair. The authors propose that a non-canonical RB pathway exists, which is independent of the function of RB in cell cycle regulation and which contributes to cancer progression.

 

Revisiting the role of ABC transporters in multidrug-resistant cancer    pp452 - 464
Robert W. Robey, Kristen M. Pluchino, Matthew D. Hall, Antonio T. Fojo, Susan E. Bates et al.
doi:10.1038/s41568-018-0005-8

This Opinion argues for a new look at the role of ABC transporters in cancer multidrug resistance to push forward their clinical application as biomarkers and as targets in combination therapies in order to improve anticancer drug efficiency.

 

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