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TABLE OF CONTENTS
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July 2018 Volume 18, Issue 7 |
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| Editorial Research Highlights Reviews Perspectives | | Advertisement | | | | Do you have a career question? The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud. Listen today! | | | |
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nature.com webcasts Nature Research Custom Media presents a webcast on: Rspondin3 from stromal myofibroblasts orchestrates gastric epithelial stem cells2 Date: Wednesday, July 11, 2018 Join our webcast to learn how the RNAscope® Dual ISH technology was utilized to thoroughly characterize the gastric antral gland stem cell niche. This webcast has been produced on behalf of the sponsor who retains sole responsibility for content Register for FREE Sponsored by: ACD | |
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Editorial | |
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Early detection: a long road ahead p401 doi:10.1038/s41568-018-0021-8 |
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Research Highlights | |
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| | Lethally high ROS levels thwart resistance p403 Sarah Seton-Rogers doi:10.1038/s41568-018-0031-6 Wang, Leite de Oliveira et al. show that BRAFV600E-mutant melanomas that are resistant to BRAF and MEK inhibitors are vulnerable to increased levels of reactive oxygen species and that this can be exploited therapeutically using a histone deacetylase inhibitor. | | | | On the cutting edge pp404 - 405 Ulrike Harjes doi:10.1038/s41568-018-0017-4 A recent study published in Science Translational Medicine generated a mouse model to study the link between surgical wounding and distant tumour growth, showing that the systemic wound healing response induced by surgery can promote tumour growth. | | | | Organoid diversity pp404 - 405 Anna Dart doi:10.1038/s41568-018-0018-3 Roerink et al. have used organoids derived from multiple single cells of colorectal cancers from three patients as well as from normal colorectal epithelium of the same patients to comprehensively study intratumoural heterogeneity. | | | | Inverted architecture p405 Sarah Seton-Rogers doi:10.1038/s41568-018-0025-4 Single-cell RNA sequencing analysis in paediatric diffuse midline gliomas with histone H3 lysine 27 to methionine mutations indicates that these aggressive tumours contain many stem-like cells and that lineage-based therapeutic targeting might be beneficial. | | | | | |
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Reviews | |
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Organoids in cancer research pp407 - 418 Jarno Drost & Hans Clevers doi:10.1038/s41568-018-0007-6 In this Review, Drost and Clevers discuss the recent advances in organoid models of cancer and how they can be exploited to drive the translation of basic cancer research into novel patient-specific treatment regimens in the clinic. |
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nature.com webcasts Nature Research Custom Media presents a webcast on: Rapid discovery of glioma-specific TCRs using Digital Cell Biology Date: Tuesday, July 17, 2018 Join our webcast to learn about the advantages of automated cell cloning and methods for rapid cloning and validation of functional TCRs. This webcast has been produced on behalf of the sponsor who retains sole responsibility for content Register for FREE Sponsored by: Berkeley Lights Inc | |
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Perspectives | |
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Oncolytic viruses as engineering platforms for combination immunotherapy pp419 - 432 doi:10.1038/s41568-018-0009-4 In this Opinion article, Twumasi-Boateng et al. discuss the use of oncolytic viruses as multiplexed immune-modulating platforms with the potential to improve the effectiveness of immunotherapies through novel synergistic mechanisms promoting antitumour immune activity. |
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Mechanisms of cancer resistance in long-lived mammals pp433 - 441 Andrei Seluanov, Vadim N. Gladyshev, Jan Vijg & Vera Gorbunova doi:10.1038/s41568-018-0004-9 In this Opinion article, Seluanov et al. discuss the diverse mechanisms of cancer resistance found in long-lived mammals and argue that studies of unconventional long-lived and cancer-resistant animal species could provide breakthroughs in cancer therapy and prevention. |
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Non-canonical functions of the RB protein in cancer pp442 - 451 Frederick A. Dick, David W. Goodrich, Julien Sage & Nicholas J. Dyson doi:10.1038/s41568-018-0008-5 This Opinion discusses studies indicating a direct role of RB in chromatin regulation and DNA repair. The authors propose that a non-canonical RB pathway exists, which is independent of the function of RB in cell cycle regulation and which contributes to cancer progression. |
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Revisiting the role of ABC transporters in multidrug-resistant cancer pp452 - 464 Robert W. Robey, Kristen M. Pluchino, Matthew D. Hall, Antonio T. Fojo, Susan E. Bates et al. doi:10.1038/s41568-018-0005-8 This Opinion argues for a new look at the role of ABC transporters in cancer multidrug resistance to push forward their clinical application as biomarkers and as targets in combination therapies in order to improve anticancer drug efficiency. |
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