Monday, June 25, 2018

Nature Reviews Cancer contents July 2018 Volume 18 Number 7

If you are unable to see the message below, click here to view.
Nature Reviews Cancer

Advance Your Cancer Research Through ATP Production Dynamics

Learn how the Agilent Seashore XF Real-Time ATP rate assay can be used to:
  • Understand metabolic mechanisms driving cancer cell behavior/function.
  • Quantify ATP production rates from glycolysis and mitochondrial respiration in live cells in real time.
  • Characterize fuel dependencies in cancer cells.
Download Poster.

July 2018 Volume 18, Issue 7

Research Highlights

Do you have a career question?

The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud. 

Listen today!


Register now for ESMO 2018: the most influential annual congress in Europe for oncology professionals.

A comprehensive educational programme combined with the latest in oncology science.

Early registration deadline 18 July 2018
Advertisement webcasts

Nature Research Custom Media presents a webcast on: Rspondin3 from stromal myofibroblasts orchestrates gastric epithelial stem cells2

Date: Wednesday, July 11, 2018 Join our webcast to learn how the RNAscope® Dual ISH technology was utilized to thoroughly characterize the gastric antral gland stem cell niche.

This webcast has been produced on behalf of the sponsor who retains sole responsibility for content

Register for FREE 

Sponsored by: ACD 



Early detection: a long road ahead    p401

Research Highlights


Lethally high ROS levels thwart resistance    p403
Sarah Seton-Rogers

Wang, Leite de Oliveira et al. show that BRAFV600E-mutant melanomas that are resistant to BRAF and MEK inhibitors are vulnerable to increased levels of reactive oxygen species and that this can be exploited therapeutically using a histone deacetylase inhibitor.


On the cutting edge    pp404 - 405
Ulrike Harjes

A recent study published in Science Translational Medicine generated a mouse model to study the link between surgical wounding and distant tumour growth, showing that the systemic wound healing response induced by surgery can promote tumour growth.


Organoid diversity    pp404 - 405
Anna Dart

Roerink et al. have used organoids derived from multiple single cells of colorectal cancers from three patients as well as from normal colorectal epithelium of the same patients to comprehensively study intratumoural heterogeneity.


Inverted architecture    p405
Sarah Seton-Rogers

Single-cell RNA sequencing analysis in paediatric diffuse midline gliomas with histone H3 lysine 27 to methionine mutations indicates that these aggressive tumours contain many stem-like cells and that lineage-based therapeutic targeting might be beneficial.


Nature Reviews Cancer
JOBS of the week
Hamad bin Khalifa University (HBKU)
Fellowship position-Zebrafish Models of Cancer
The University of Texas Health Science Center, San Antonio

Postdoctoral Researcher in Cancer Systems Biology and Bioinformatics
Postdoctoral Fellowships in Experimental Genetics, Epigenetics and Functional Screens
The University of Texas MD Anderson Cancer Center
More Science jobs from
Nature Reviews Cancer
2nd Global Cancer Meet and Expo
Rome, Italy
More science events from
Nature Milestone: Anticoagulants from Nature Reviews Cardiology 

This Milestone plots the history of anticoagulant drugs, used to prevent and treat thrombotic disorders in millions of patients worldwide. Fourteen Milestone articles are presented on an interactive timeline with associated multimedia.

Access free online 

Produced with support from Portola Pharmaceuticals, Inc



Organoids in cancer research    pp407 - 418
Jarno Drost & Hans Clevers

In this Review, Drost and Clevers discuss the recent advances in organoid models of cancer and how they can be exploited to drive the translation of basic cancer research into novel patient-specific treatment regimens in the clinic.


Advertisement webcasts

Nature Research Custom Media presents a webcast on: Rapid discovery of glioma-specific TCRs using Digital Cell Biology

Date: Tuesday, July 17, 2018

Join our webcast to learn about the advantages of automated cell cloning and methods for rapid cloning and validation of functional TCRs.

This webcast has been produced on behalf of the sponsor who retains sole responsibility for content 

Register for FREE 

Sponsored by: Berkeley Lights Inc 



Oncolytic viruses as engineering platforms for combination immunotherapy    pp419 - 432


In this Opinion article, Twumasi-Boateng et al. discuss the use of oncolytic viruses as multiplexed immune-modulating platforms with the potential to improve the effectiveness of immunotherapies through novel synergistic mechanisms promoting antitumour immune activity.


Mechanisms of cancer resistance in long-lived mammals    pp433 - 441
Andrei Seluanov, Vadim N. Gladyshev, Jan Vijg & Vera Gorbunova

In this Opinion article, Seluanov et al. discuss the diverse mechanisms of cancer resistance found in long-lived mammals and argue that studies of unconventional long-lived and cancer-resistant animal species could provide breakthroughs in cancer therapy and prevention.


Non-canonical functions of the RB protein in cancer    pp442 - 451
Frederick A. Dick, David W. Goodrich, Julien Sage & Nicholas J. Dyson

This Opinion discusses studies indicating a direct role of RB in chromatin regulation and DNA repair. The authors propose that a non-canonical RB pathway exists, which is independent of the function of RB in cell cycle regulation and which contributes to cancer progression.


Revisiting the role of ABC transporters in multidrug-resistant cancer    pp452 - 464
Robert W. Robey, Kristen M. Pluchino, Matthew D. Hall, Antonio T. Fojo, Susan E. Bates et al.

This Opinion argues for a new look at the role of ABC transporters in cancer multidrug resistance to push forward their clinical application as biomarkers and as targets in combination therapies in order to improve anticancer drug efficiency.


Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours.

Click here to sign up.
nature events
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.
Find the latest scientific conferences, courses, meetings and symposia on For event advertising opportunities across the Nature Publishing Group portfolio please contact
More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your account at:
(You will need to log in to be recognised as a registrant)

For further technical assistance, please contact our registration department

For print subscription enquiries, please contact our subscription department

For other enquiries, please contact our customer feedback department

Springer Nature | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA

Springer Nature's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne
San Diego - San Francisco - Washington - New York - Boston

Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW.

© 2018 Macmillan Publishers Limited, part of Springer Nature. All Rights Reserved.

Springer Nature

No comments: