Nature Structural & Molecular Biology Contents: 2018 Volume #25 pp 357 - 434

If you are unable to see the message below, click here to view.

Advertisement nature.com webcasts Nature Research Custom presents a webcast on: MicroRNAs in CSF as prodromal biomarkers for Huntington?s disease Date: Tuesday, May 29, 2018 Join our webcast to learn about the fundamental characteristics of microRNAs and why Huntington?s disease may serve as a disease model for the assessment of biomarkers. This webcast has been produced on behalf of the sponsor who retains sole responsibility for content  Register for FREE Sponsored by: HTG Molecular  TABLE OF CONTENTS May 2018 Volume 25, Issue 5 Review Articles Articles Technical Reports   Advertisement nature.com webcasts Nature Research Custom presents a webcast on: Highly multiplexed transcriptome and protein immune profiling in single cells with CITE-seq Date: Wednesday, May 23, 2018 Peter Smibert, Ph.D. from New York Genome Center, will present an overview of CITE-seq and Cell Hashing and discuss methods compatible with 10x Genomics single cell platforms for enhanced cellular phenotyping and sample multiplexing. This webcast has been produced on behalf of the sponsor who retains sole responsibility for content  Register for FREE Sponsored by: 10x Genomics    Review Articles   Tapping the RNA world for therapeutics    pp357 - 364 Judy Lieberman doi:10.1038/s41594-018-0054-4 Developments in basic RNA biology have spawned RNA-based strategies to generate new types of therapeutics. Judy Lieberman reviews RNA-based drug design and discusses barriers to more widespread applications and possible ways to overcome them.   Articles   Short cryptic exons mediate recursive splicing in Drosophila     pp365 - 371 Brian Joseph, Shu Kondo & Eric C. Lai doi:10.1038/s41594-018-0052-6 Selective disruption of adjacent splice acceptor and donor sites identifies cryptic exons involved in recursive splicing in Drosophila, thus unifying the mechanism of recursive splicing in flies and mammals.   Iron homeostasis regulates facultative heterochromatin assembly in adaptive genome control    pp372 - 383 Pamela S. Gallagher, Madeline Larkin, Gobi Thillainadesan, Jothy Dhakshnamoorthy, Vanivilasini Balachandran et al. doi:10.1038/s41594-018-0056-2 Genome-wide analyses in fission yeast reveal that iron homeostasis influences facultative heterochromatin assembly to modulate gene expression in response to changes in growth temperature.   Structural & Molecular Biology JOBS of the week More Science jobs from Structural & Molecular Biology EVENT 6th Annual Congress on Biology and Medicine of Molecules 17.09.18 Abu Dhabi, UAE More science events from Mapping interactions with the chaperone network reveals factors that protect against tau aggregation    pp384 - 393 Sue-Ann Mok, Carlo Condello, Rebecca Freilich, Anne Gillies, Taylor Arhar et al. doi:10.1038/s41594-018-0057-1 The effects of chaperones on the aggregation of different tau variants are examined in a large-scale study. Among other findings, the work reveals that DnaJA2 can inhibit tau aggregation, a role that is supported by analysis of samples from human brains.   Defective germline reprogramming rewires the spermatogonial transcriptome    pp394 - 404 Lina Vasiliauskaitė, Rebecca V. Berrens, Ivayla Ivanova, Claudia Carrieri, Wolf Reik et al. doi:10.1038/s41594-018-0058-0 Deficits in de novo DNA methylation and the piRNA pathway in the mouse germline cause spermatogonial dysfunction because derepressed transposons deregulate gene expression.   Conformational plasticity in the selectivity filter of the TRPV2 ion channel    pp405 - 415 Lejla Zubcevic, Son Le, Huanghe Yang & Seok-Yong Lee doi:10.1038/s41594-018-0059-z Crystal structures capture the TRPV2 channel in a two-fold symmetric conformation, with the selectivity filter open wide enough to permeate large organic cations.   Structural basis for membrane anchoring and fusion regulation of the herpes simplex virus fusogen gB    pp416 - 424 doi:10.1038/s41594-018-0060-6 Structure of HSV-1 fusogen gB reveals the ectodomain sitting atop a trimeric platform that restrains gB in its prefusion conformation.   Advertisement Searching for a new career? At Nature Research we frequently recruit talented individuals to join our editorial and publishing teams. If you have a PhD and a passion for science this may be the perfect career for you. Visit our research editorial and publishing careers website to discover more about what we do   Technical Reports   High-performance virtual screening by targeting a high-resolution RNA dynamic ensemble    pp425 - 434 Laura R. Ganser, Janghyun Lee, Atul Rangadurai, Dawn K. Merriman, Megan L. Kelly et al. doi:10.1038/s41594-018-0062-4 A new way to virtually screen HIV-1 TAR RNA using dynamic ensembles better identifies small molecules targeting RNA secondary structures for development.   Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. Click here to sign up.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant) For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our customer feedback department Springer Nature | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA Springer Nature's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW. © 2018 Macmillan Publishers Limited, part of Springer Nature. All Rights Reserved.