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Innovations In: The Biggest Questions in Science Read our new special report on the nature of spacetime, the origin of life, the source of consciousness, and other fundamental questions in science. Access free online Produced with support from: The Kavli Prize | | |
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TABLE OF CONTENTS
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June 2018 Volume 19, Issue 6 |
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| Comment Research Highlights Reviews | |
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Continued access to investigational brain implants pp317 - 318 doi:10.1038/s41583-018-0004-5 |
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Research Highlights | |
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| | The power of 3' UTRs p319 Natasha Bray doi:10.1038/s41583-018-0011-6 Different 3' untranslated regions of mRNA transcripts are associated with differences in mRNA localization, translation, stability and activity-dependent changes in expression. | | | | Time to get tough pp320 - 321 Natasha Bray doi:10.1038/s41583-018-0005-4 In mice, aggression is regulated by the circadian suprachiasmatic nucleus through at least two neural pathways. | | | | An expanding role pp320 - 321 Darran Yates doi:10.1038/s41583-018-0017-0 A new study suggests an evolutionary mechanism — involving abnormal spindle-like microcephaly-associated protein — that, in part, underlies cerebral cortical expansion. | | | | Creating a diversion p321 Sian Lewis doi:10.1038/s41583-018-0016-1 Elevated maternal IL-6 in the maternal circulation can enter the fetus via the maternal—placental—fetal route and alter neurodevelopmental processes, with potentially wide-ranging effects on brain function later in life. | | | | Pathways to contextual control p322 Katherine Whalley doi:10.1038/s41583-018-0009-0 Distinct output pathways of the nucleus accumbens mediate the opposing effects of context on relapse to alcohol seeking. | | | | Synaptic nibbling p322 Grant Otto doi:10.1038/s41583-018-0008-1 In the mouse postnatal hippocampus, microglia trim presynaptic structures by a partial phagocytic process termed trogocytosis and remodel postsynaptic structures. | | | | | |
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Reviews | |
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Intrinsic mechanisms of neuronal axon regeneration pp323 - 337 Marcus Mahar & Valeria Cavalli doi:10.1038/s41583-018-0001-8 Peripheral axon injury initiates a regenerative response that is absent in CNS axons. Mahar and Cavalli describe the mechanisms that initiate and coordinate the programme of transcriptional and epigenetic changes that enable axon regeneration in the peripheral nervous system. |
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The basal ganglia and the cerebellum: nodes in an integrated network pp338 - 350 Andreea C. Bostan & Peter L. Strick doi:10.1038/s41583-018-0002-7 The basal ganglia and the cerebellum were thought to communicate via the cerebral cortex. In this Review, Andreea Bostan and Peter Strick discuss findings indicating that these subcortical areas are in fact interconnected and, along with the cerebral cortex, form an integrated network. |
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Breathing matters pp351 - 367 Christopher A. Del Negro, Gregory D. Funk & Jack L. Feldman doi:10.1038/s41583-018-0003-6 Breathing is a crucial yet surprisingly complex behaviour. Del Negro, Funk and Feldman describe the neural mechanisms underlying different phases of the breathing cycle, and how breathing affects, and is affected by, emotion, cognition and other behaviours. |
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Rett syndrome: insights into genetic, molecular and circuit mechanisms pp368 - 382 Jacque P. K. Ip, Nikolaos Mellios & Mriganka Sur doi:10.1038/s41583-018-0006-3 The neurodevelopmental disorder Rett syndrome is caused by a deficiency in methyl-CpG-binding protein 2 (MeCP2). Ip, Mellios and Sur describe the many functions of MeCP2 and the effects of MeCP2 loss on gene expression, excitation–inhibition balance and activity-dependent plasticity. |
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