Nature Reviews Molecular Cell Biology contents June 2018 Volume 19 Number 6

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Advertisement nature.com webcasts Nature Research Custom presents a webcast on: Structural Tools In Your MS Tool Box Date: Wednesday, June 27, 2018 Dr. David Schriemer will provide some insights on how data from electron microscopy, H/D exchange and crosslinking mass spectrometry can be used together to solve complex structure-function problems. This webcast has been produced on behalf of the sponsor who retains sole responsibility for content  Register for FREE  Sponsored by: Thermo Fisher Scientific  TABLE OF CONTENTS June 2018 Volume 19, Issue 6 Comment Research Highlights Reviews   Comment   Choose your yeast strain carefully: the RAD5 gene matters    pp343 - 344 Menattallah Elserafy & Sherif F. El-Khamisy doi:10.1038/s41580-018-0005-2 Research Highlights   Smooth translation to maintain a healthy skin    p345 Kim Baumann doi:10.1038/s41580-018-0025-y Loss of the ribosome rescue factor Pelota causes epidermal defects in mice, indicating a link between translation and tissue homeostasis.   Proteins clog neural stem cell activation    pp346 - 347 Paulina Strzyz doi:10.1038/s41580-018-0012-3 The lysosomal degradation of protein aggregates declines with ageing in mammalian neural stem cells, reducing their capacity to transition from a quiescent to an active state.   Shieldin the ends for 53BP1    pp346 - 347 Eytan Zlotorynski doi:10.1038/s41580-018-0019-9 Shieldin is a newly characterized protein complex that functions downstream of 53BP1 in promoting NHEJ   Silencing drops    p347 Anne Mirabella doi:10.1038/s41580-018-0014-1 The microRNA-induced silencing complex undergoes phase separation, which promotes the sequestration and deadenylation of target mRNAs.   Nature Reviews Molecular Cell Biology JOBS of the week Post-Doctoral Associate St. Jude Children's Research Hospital (SJCRH), Department of Surgery Postdoctoral Associate Yale Cancer Center and Yale School of Medicine Postdoctoral Fellowship in Stem Cells Emory University Faculty for the College of Health and Life Sciences at all levels Hamad bin Khalifa University (HBKU) Post-doc Rutgers University-New Jersey Medical School More Science jobs from Nature Reviews Molecular Cell Biology EVENT Physiology: Modern Cell Biology Using Microscopic, Biochemical & Computational Approaches 10.06.18 Woods Hole, USA More science events from Advertisement Do you have a career question? The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.  Listen today!    Reviews   Mechanism and medical implications of mammalian autophagy    pp349 - 364 Ivan Dikic & Zvulun Elazar doi:10.1038/s41580-018-0003-4 Autophagy is a process of cellular self-consumption that promotes cell survival in response to stress. Various human pathologies, including cancer, neurodegeneration and inflammation, have been associated with aberrant autophagy, and recent studies of the mechanisms and regulation of autophagy in higher eukaryotes have suggested new therapeutic possibilities.   The coming of age of chaperone-mediated autophagy    pp365 - 381 Susmita Kaushik & Ana Maria Cuervo doi:10.1038/s41580-018-0001-6 The selective degradation of cellular components via chaperone-mediated autophagy (CMA) functions to regulate a wide range of cellular processes, from metabolism to DNA repair and cellular reprogramming. Recent in vivo studies have enabled to dissect key roles of CMA in ageing and ageing-associated disorders such as cancer and neurodegeneration.   The cytoplasmic dynein transport machinery and its many cargoes    pp382 - 398 Samara L. Reck-Peterson, William B. Redwine, Ronald D. Vale & Andrew P. Carter doi:10.1038/s41580-018-0004-3 Cytoplasmic dynein is a minus-end-directed microtubule-based motor that transports a wide range of cargoes, including organelles, RNAs, protein complexes and viruses. How a single motor can interact with and traffic such different cargoes has been unclear. Recent studies indicate how adaptor proteins, which can both activate dynein and link it to cargo, play an important role in this process.   Single-cell transcriptional profiling: a window into embryonic cell-type specification    pp399 - 412 Blanca Pijuan-Sala, Carolina Guibentif & Berthold Göttgens doi:10.1038/s41580-018-0002-5 Single-cell technologies are transforming our understanding of pre-implantation and early post-implantation development and of in vitro pluripotency. Specifically, single-cell transcriptomics and imaging and the accompanying bioinformatics methods have enabled precision interrogation of cell fate choices and cell lineage diversification, which occur at the level of the individual cell.   Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. Click here to sign up.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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