Nature Reviews Genetics Contents June 2018 Volume 19 Number 6

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Advertisement Do you have a career question?  The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.  Listen today!  TABLE OF CONTENTS June 2018 Volume 19, Issue 6 Research Highlights Reviews   Advertisement   Harness the Power of Machine Learning to Find Antibodies BenchSci has decoded millions of scientific papers and extracted published figures with their antibody usage information. You can view 3,161,807 figures from publications, vendors, and independent organizations. It's free for academic researchers. Sign up now!    Research Highlights   Tracing cell-lineage histories    p327 Darren J. Burgess doi:10.1038/s41576-018-0015-0 Three new studies in Nature and Nature Biotechnology report methods for dissecting transcriptomic cell phenotypes and lineage history simultaneously by combining single-cell RNA sequencing (scRNA-seq) with CRISPR-based lineage tracing.   Linking tissues to disease    p328 Ross Cloney doi:10.1038/s41576-018-0009-y A recent analysis in Nature Genetics combines genome-wide association study summary statistics with gene expression data to identify the contribution of different cell types and tissues to disease.   Taking aim at transcriptional regulator targets    p328 Linda Koch doi:10.1038/s41576-018-0010-5 A paper in Science reports a strategy that combines rapid chemical-genetic perturbation with measurements of immediate gene expression changes to identify targets of transcriptional regulators.   Genetics JOBS of the week Postdoctoral Fellow / Genetics, Genomics and Informatics - 18000000JP The University of Tennessee Health Science Center (UTHSC) Genomics Project Leaders AstraZeneca Staff Scientist VA Boston Healthcare System Faculty Positions in Statistical Genetics and Computational Genomics Genome Institute of Singapore (GIS) Principal Scientist - Human Genetics, Early Target Discovery Takeda More Science jobs from Genetics EVENT The Genetics of Neuropathic Pain and its Comorbidities 09.09.18 Bar Harbor, USA More science events from Reviews   Piercing the dark matter: bioinformatics of long-range sequencing and mapping    pp329 - 346 Fritz J. Sedlazeck, Hayan Lee, Charlotte A. Darby & Michael C. Schatz doi:10.1038/s41576-018-0003-4 Various genomics-related fields are increasingly taking advantage of long-read sequencing and long-range mapping technologies, but making sense of the data requires new analysis strategies. This Review discusses bioinformatics tools that have been devised to handle the numerous characteristic features of these long-range data types, with applications in genome assembly, genetic variant detection, haplotype phasing, transcriptomics and epigenomics.   The genetics of fruit flavour preferences    pp347 - 356 Harry J. Klee & Denise M. Tieman doi:10.1038/s41576-018-0002-5 Fruit flavour is a complex phenotype that has been adversely affected by human intervention. Recent progress in defining the chemistry of consumer preferences and the availability of high-quality genome sequences are providing a foundation for defining the genetics underlying this trait and could be used for flavour improvement.   High-throughput mouse phenomics for characterizing mammalian gene function    pp357 - 370 Steve D. M. Brown, Chris C. Holmes, Ann-Marie Mallon, Terrence F. Meehan, Damian Smedley & Sara Wells doi:10.1038/s41576-018-0005-2 DNA methylation-based biomarkers and the epigenetic clock theory of ageing    pp371 - 384 Steve Horvath & Kenneth Raj doi:10.1038/s41576-018-0004-3 Biomarkers of ageing based on DNA methylation data enable accurate age estimates for any tissue across the entire life course. Horvath and Raj review the development of these 'epigenetic clocks' and how they link to biological ageing.   Molecular mechanisms driving transcriptional stress responses    pp385 - 397 Anniina Vihervaara, Fabiana M. Duarte & John T. Lis doi:10.1038/s41576-018-0001-6 Recent studies have revealed the genome-wide reprogramming of gene expression upon exposure to stress, such as acute heat stress. Here, the authors review the molecular mechanisms that underlie stress-induced changes at promoters, enhancers and untranscribed loci.   Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. Click here to sign up.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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