Nature Reviews Cancer contents June 2018 Volume 18 Number 6

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Advertisement Visualize and Quantify Cellular Interactions in the Tumor Microenvironment What would it mean to your research if you could accurately quantify cellular interactions in the tumor microenvironment? Download the eBook to learn how scientists are using the Phenoptics™ research solution to visualize, analyze, quantify and phenotype immune cells in situ, in FFPE tissue sections and TMAs. Download eBook TABLE OF CONTENTS June 2018 Volume 18, Issue 6 Research Highlights Reviews Perspectives   Advertisement   Do you have a career question? The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.  Listen today!   Advertisement New Whitepapers: How 3D Models Facilitate Studying Hypoxia in Cancer Model systems are critical to elucidating molecular pathways underscoring cellular responses to hypoxia. Compared to monolayer cultures, 3D models better replicate the in vivo tumor conditions but which model is best suited for your experiment? Learn more about Cellular Adaptations and Experimental Models   Advertisement Nominations now open!  Who are the future leading women in science? The Nature Research Awards for Inspiring Science and Innovating Science are now open for nominations.  Find out more about these awards and nominate your inspiration >>  In partnership with The Estée Lauder Companies.   Research Highlights   Take a left here    p337 Anna Dart doi:10.1038/s41568-018-0011-x Whether lymph node metastases can be a source of cancer cells for distant metastases has been debated. Now, two studies have used mouse models to show that tumour cells can colonize distant organs by invading lymph node blood vessels.   Pap seeking new challenges    pp338 - 339 Ulrike Harjes doi:10.1038/s41568-018-0013-8 Wang et al. have developed a diagnostic tool (based on the widely used Papanicolaou (Pap) test) to detect endometrial and ovarian cancer in patients by using PCR-based analyses of genetic mutations and aneuploidy.   Stop the shedding    pp338 - 339 Sarah Seton-Rogers doi:10.1038/s41568-018-0012-9 Ferrari de Andrade et al. find that monoclonal antibodies that prevent shedding of MICA and MICB from tumour cells can restore antitumour immunity by natural killer cells.   Cell genesis    p339 Anna Dart doi:10.1038/s41568-018-0014-7 Han et al. have identified a new tumour-induced immune cell population in the spleen that can promote tumour growth through production of the neurotrophic factor artemin.   Nature Reviews Cancer JOBS of the week Academic Position in Cancer Research Cedars Sinai Medical Center Postdoctoral Research Associate-Stem Cell and Cancer Biology University of North Texas Health Science Center Executive Director, Cancer Research Peter MacCallum Cancer Centre Junior Health and Research Officer ECPC - European Cancer Patient Coalition PhD Student German Cancer Research Center (DKFZ). More Science jobs from Nature Reviews Cancer EVENT Origins of Cancer 2018: Genetic and Epigenetic Alterations in Pediatric Cancers 20.07.18 Grand Rapids, USA More science events from Reviews   Known and novel roles of the MET oncogene in cancer: a coherent approach to targeted therapy    pp341 - 358 Paolo M. Comoglio, Livio Trusolino & Carla Boccaccio doi:10.1038/s41568-018-0002-y The MET oncogene encodes a receptor tyrosine kinase with pleiotropic functions. In this Review, Comoglio et al. describe the known and novel MET-mediated biological responses in cancer and discuss how clinical trials testing anti-MET therapies should be designed with careful consideration of these oncogenic functions of MET.   Advertisement nature.com webcasts Nature Research Custom presents a webcast on: Multicolour Digital PCR for ctDNA detection in breast cancer Date: 12 June 2018 Dr. Isaac Garcia-Murillas from ICR will address the technical challenges for clinical utility of liquid biopsy and ctDNA as a biomarker in breast cancer. This webcast has been produced on behalf of the sponsor who retains sole responsibility for content  Register for FREE  Sponsored by: Stilla Technologies    Perspectives   A history of exploring cancer in context    pp359 - 376 Shelly Maman & Isaac P. Witz doi:10.1038/s41568-018-0006-7 In this Timeline article, Maman and Witz describe how much progress has been made in understanding how the tumour microenvironment influences tumour progression since its initial description, highlighting the controversies in the field and the potential of targeting components of the microenvironment for cancer therapy.   Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance    pp377 - 388 John A. Katzenellenbogen, Christopher G. Mayne, Benita S. Katzenellenbogen, Geoffrey L. Greene & Sarat Chandarlapaty doi:10.1038/s41568-018-0001-z This Opinion article highlights how activating mutations in the gene encoding oestrogen receptor-α (ERα), a major driver in breast cancer, undermine structural features of wild-type ERα that maintain the ‘off-state’ in the absence of oestrogens, thus making ERα constitutively active and endocrine-therapy resistant.   Too many targets, not enough patients: rethinking neuroblastoma clinical trials    pp389 - 400 Jamie I. Fletcher, David S. Ziegler, Toby N. Trahair, Glenn M. Marshall, Michelle Haber et al. doi:10.1038/s41568-018-0003-x This Perspective provides an update on targeted therapy development for neuroblastoma and proposes that clinical trial design needs to be rethought in order to provide rigorous, evidence-based assessment of these new therapies in this rare and often deadly paediatric tumour.   Advertisement Nature Briefing is an essential round-up of science news, opinion and analysis, free in your inbox every weekday. With Nature Briefing, we'll keep you updated on the latest research, so you can focus on yours. Click here to sign up.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. 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