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CALL FOR APPLICATIONS: The 2019 Vilcek Prizes for Creative Promise in Biomedical Science Three $50,000 cash awards for young immigrant biomedical scientists. Learn more about the prizes and apply at VILCEK.ORG. DEADLINE: June 11, 2018 | | |
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TABLE OF CONTENTS
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May 2018 Volume 24, Issue 5 |
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| Editorial News Feature News & Views Review Articles Brief Communications Letters Articles Resources | | Advertisement | | | | New Antibody Search Engine with Publication Data BenchSci extracts antibody usage data from publications with machine learning. Search over 3.7 million antibodies and 1.3 million published figures, and filter by your experimental context. It's fast, easy, and 100% free for academic scientists. Sign Up Now | | | |
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Nature Index 2018 Japan Some of Japan's smallest institutions are among the most efficient in the production of high quality scientific research, though the decline in Japan's high quality scientific research output continues. This supplement examines reform efforts in light of the country's aim to become a "super-smart" society. Read the full supplement | | |
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Editorial | |
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Redefining Medicine p527 doi:10.1038/s41591-018-0037-3 |
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News Feature | |
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The best Cas scenario pp528 - 530 Peter Andrey Smith doi:10.1038/s41591-018-0038-2 |
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Sleeper cells pp531 - 533 Shraddha Chakradhar doi:10.1038/s41591-018-0039-1 |
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Do you have a career question? The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud. Listen today! | | |
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News & Views | |
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Review Articles | |
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Understanding the tumor immune microenvironment (TIME) for effective therapy pp541 - 550 Mikhail Binnewies, Edward W. Roberts, Kelly Kersten, Vincent Chan, Douglas F. Fearon et al. doi:10.1038/s41591-018-0014-x The tumor immune microenvironment influences tumor progression and response to immunotherapy; its further characterization will improve therapeutic outcome. |
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Brief Communications | |
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MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency pp551 - 555 Karine Clément, Heike Biebermann, I. Sadaf Farooqi, Lex Van der Ploeg, Barbara Wolters et al. doi:10.1038/s41591-018-0015-9 Treatment with setmelanotide, a new-generation MC4R agonist, provides durable weight loss in hyperphagic, leptin receptor-deficient patients, suggesting a pharmacological avenue to treat patients with various MC4R pathway defects. |
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Letters | |
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ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade pp556 - 562 Jianfeng Shen, Zhenlin Ju, Wei Zhao, Lulu Wang, Yang Peng et al. doi:10.1038/s41591-018-0012-z Loss of mismatch-repair protein ARID1A in cancer correlates with high mutation load & checkpoint blockade response, complementing MSI-based prognosis. |
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Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia pp563 - 571 Joseph A. Fraietta, Simon F. Lacey, Elena J. Orlando, Iulian Pruteanu-Malinici, Mercy Gohil et al. doi:10.1038/s41591-018-0010-1 An IL-6/STAT3 signature and memory CD8 T cell subset in preinfusion chimeric antigen receptor–expressing T cells associate with response in patients with high-risk chronic lymphocytic leukemia. |
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Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M+ diffuse midline gliomas pp572 - 579 Christopher W. Mount, Robbie G. Majzner, Shree Sundaresh, Evan P. Arnold, Meena Kadapakkam et al. doi:10.1038/s41591-018-0006-x Lethal pediatric tumors bearing a particular histone H3 mutation upregulate the disialoganglioside GD2, thereby making these tumors susceptible to chimeric antigen receptor T cell–based immunotherapy. |
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Transcript-indexed ATAC-seq for precision immune profiling pp580 - 590 Ansuman T. Satpathy, Naresha Saligrama, Jason D. Buenrostro, Yuning Wei, Beijing Wu et al. doi:10.1038/s41591-018-0008-8 A new technique enabling single-cell analysis of T cell receptor identity and epigenomic state uncovers heterogeneity in normal and leukemic T cells. |
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Antidepressive effects of targeting ELK-1 signal transduction pp591 - 597 Kallia Apazoglou, Séverine Farley, Victor Gorgievski, Raoul Belzeaux, Juan Pablo Lopez et al. doi:10.1038/s41591-018-0011-0 The transcription factor ELK-1 is upregulated in patients with major depressive disorder, and selective inhibition of hippocampal ELK-1 produces rapid antidepressive effects in rodent models of depression. |
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PM20D1 is a�quantitative trait locus associated with Alzheimer's disease pp598 - 603 Jose V. Sanchez-Mut, Holger Heyn, Bianca A. Silva, Lucie Dixsaut, Paula Garcia-Esparcia et al. doi:10.1038/s41591-018-0013-y Expression of PM20D1 is regulated by long-range chromatin interactions with an Alzheimer's disease risk haplotype, and PM20D1 overexpression reduces AD-like pathology and cognitive impairment in a rodent model. |
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Clonal CD4+ T cells in the HIV-1 latent reservoir display a distinct gene profile upon reactivation pp604 - 609 Lillian B. Cohn, Israel T. da Silva, Renan Valieris, Amy S. Huang, Julio C. C. Lorenzi et al. doi:10.1038/s41591-018-0017-7 A shared gene expression program associated with silencing HIV-1 transcription may be critical for persistence of reactivated latent CD4+ T cells in patients with HIV. |
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Articles | |
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A single injection of crystallizable fragment domain-modified antibodies elicits durable protection from SHIV infection pp610 - 616 Rajeev Gautam, Yoshiaki Nishimura, Natalie Gaughan, Anna Gazumyan, Till Schoofs et al. doi:10.1038/s41591-018-0001-2 Long-lived antibodies that can prevent viral infection of monkeys for 6 months may be a future alternative to an HIV vaccine. |
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Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis pp617 - 627 Zhuzhen Zhang, Zhenzhen Zi, Eunice E. Lee, Jiawei Zhao, Diana C. Contreras et al. doi:10.1038/s41591-018-0003-0 Keratinocytes require glucose for injury- or inflammation-driven but not homeostatic proliferation, and glucose-transport blockade blocks psoriasis-like pathology in experimental models. |
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Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial pp628 - 637 Andrew Tutt, Holly Tovey, Maggie Chon U. Cheang, Sarah Kernaghan, Lucy Kilburn et al. doi:10.1038/s41591-018-0009-7 The phase 3 TNT Trial in subjects with triple-negative breast cancer supports the superiority of carboplatin over docetaxel in BRCA1/2-mutated tumors and a greater response to taxanes in the nonbasal subtype. |
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Mechanisms and clinical activity of an EGFR and HER2 exon 20-selective kinase inhibitor in non-small cell lung cancer pp638 - 646 Jacqulyne P. Robichaux, Yasir Y. Elamin, Zhi Tan, Brett W. Carter, Shuxing Zhang et al. doi:10.1038/s41591-018-0007-9 Poziotinib is a candidate inhibitor for a subset of EGFR or HER2 mutant non–small cell lung cancers that lack effective therapy. |
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Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector pp647 - 657 Chengzhong Wang, Ramsey Najm, Qin Xu, Dah-eun Jeong, David Walker et al. doi:10.1038/s41591-018-0004-z Human iPSC-derived neurons are generated from individuals with or without Alzheimer's disease carrying different APOE alleles and reveal a toxic, neuron-intrinsic gain of function of the ApoE4 variant that is a strong genetic risk factor for AD. |
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Stimulation of entorhinal cortex-dentate gyrus circuitry is antidepressive pp658 - 666 Sanghee Yun, Ryan P. Reynolds, Iraklis Petrof, Alicia White, Phillip D. Rivera et al. doi:10.1038/s41591-018-0002-1 In mouse models of stress-induced depression, molecular and chemogenetic stimulation of the entorhinal cortex induces the production of adult-born hippocampal neurons and generates antidepressive-like effects. |
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Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss pp667 - 678 Sarah Weske, Mithila Vaidya, Alina Reese, Karin von Wnuck Lipinski, Petra Keul et al. doi:10.1038/s41591-018-0005-y Promoting more bone growth is of keen interest in the treatment of osteoporosis, and preventing the degradation of S1P offers a new therapeutic avenue for this approach. |
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Resources | |
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Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes pp679 - 690 Bjoern Chapuy, Chip Stewart, Andrew J. Dunford, Jaegil Kim, Atanas Kamburov et al. doi:10.1038/s41591-018-0016-8 Comprehensive integration of mutational and structural alterations in clinically-annotated DLBCL patient samples provides a novel molecular classification of the disease. |
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NYU - Nature Conference on Chemical Biology August 13-14, New York This conference will provide a forum for discussing innovative strategies for research in chemical biology. It will cover the breadth of chemical biology ranging from the construction DNA as material and sensors, regulation of gene expression, synthesis and derivatization of proteins, synthetic biology and the human microbiome. | | |
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| | | | | | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com | | | | | | |
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