| | Advertisement | | nature.com webcasts Nature Research Custom presents a webcast on: Multicolour Digital PCR for ctDNA detection in breast cancer Date: 12 June 2018 Dr. Isaac Garcia-Murillas from ICR will address the technical challenges for clinical utility of liquid biopsy and ctDNA as a biomarker in breast cancer. This webcast has been produced on behalf of the sponsor who retains sole responsibility for content Register for FREE Sponsored by: Stilla Technologies | | | | | | | | | | Advertisement | | Nature Index 2018 Japan Some of Japan's smallest institutions are among the most efficient in the production of high quality scientific research, though the decline in Japan's high quality scientific research output continues. This supplement examines reform efforts in light of the country's aim to become a "super-smart" society. Read the full supplement | | | | | | | | | Latest Articles | View all Articles | | | Coherent transfer of electron spin correlations assisted by dephasing noise OPEN | | Takashi Nakajima, Matthieu R. Delbecq, Tomohiro Otsuka, Shinichi Amaha, Jun Yoneda, Akito Noiri, Kenta Takeda, Giles Allison, Arne Ludwig, Andreas D. Wieck, Xuedong Hu, Franco Nori & Seigo Tarucha | | Methods for coherently transferring quantum states are needed in order to develop larger scale quantum devices. Here the authors implement an adiabatic transfer protocol in a triple quantum dot and show that dephasing noise can accelerate the process while maintaining the coherence of the transferred state. | | 30 May 2018 | doi: 10.1038/s41467-018-04544-7 | | Quantum dots Quantum information Qubits | Crystal step edges can trap electrons on the surfaces of n-type organic semiconductors OPEN | | Tao He, Yanfei Wu, Gabriele D’Avino, Elliot Schmidt, Matthias Stolte, Jérôme Cornil, David Beljonne, P. Paul Ruden, Frank Würthner & C. Daniel Frisbie | | The microstructure of organic semiconductors affects their transport properties, but directly probing this relationship is challenging. He et al. show that step edges act as electron traps on the surfaces of n-type single crystals, resulting in a field effect transistor mobility that depends on step density. | | 30 May 2018 | doi: 10.1038/s41467-018-04479-z | | Electronic and spintronic devices Electronic devices Scanning probe microscopy | Molecular polarizability anisotropy of liquid water revealed by terahertz-induced transient orientation OPEN | | Peter Zalden, Liwei Song, Xiaojun Wu, Haoyu Huang, Frederike Ahr, Oliver D. Mücke, Joscha Reichert, Michael Thorwart, Pankaj Kr. Mishra, Ralph Welsch, Robin Santra, Franz X. Kärtner & Christian Bressler | | The intermolecular dynamics of liquid water impact most biological processes. Here, the authors use intense terahertz electromagnetic pulses to generate a transient, out-of-equilibrium state of the water network to show that the molecules become oriented and probe the polarizability of this anisotropic state. | | 30 May 2018 | doi: 10.1038/s41467-018-04481-5 | | Chemical physics Electronic properties and materials Terahertz optics | High pCO2-induced exopolysaccharide-rich ballasted aggregates of planktonic cyanobacteria could explain Paleoproterozoic carbon burial OPEN | | Nina A. Kamennaya, Marcin Zemla, Laura Mahoney, Liang Chen, Elizabeth Holman, Hoi-Ying Holman, Manfred Auer, Caroline M. Ajo-Franklin & Christer Jansson | | A Paleoproterozoic carbon isotope anomaly is likely linked to burial of oceanic cyanobacteria, but it is not clear how burial occurred. Here, the authors find that, under Paleoproterozoic pCO2 conditions, planktonic cyanobacteria increase exopolysaccharide production and mineralization, leading to aggregation and faster sinking. | | 29 May 2018 | doi: 10.1038/s41467-018-04588-9 | | Bacterial physiology Carbon cycle Microbial biooceanography | Intravital imaging by simultaneous label-free autofluorescence-multiharmonic microscopy OPEN | | Sixian You, Haohua Tu, Eric J. Chaney, Yi Sun, Youbo Zhao, Andrew J. Bower, Yuan-Zhi Liu, Marina Marjanovic, Saurabh Sinha, Yang Pu & Stephen A. Boppart | | Label-free and real-time visualization of the tumor microenvironment is attractive but challenging. Here the authors present an approach for simultaneous autofluorescence functional imaging and second/third harmonic generation imaging of structural features, using a single excitation source. | | 29 May 2018 | doi: 10.1038/s41467-018-04470-8 | | Cancer imaging Optical imaging | Increased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving l-2-hydroxyglutarate OPEN | | Manman Zhang, Chao Gao, Xiaoting Guo, Shiting Guo, Zhaoqi Kang, Dan Xiao, Jinxin Yan, Fei Tao, Wen Zhang, Wenyue Dong, Pan Liu, Chen Yang, Cuiqing Ma & Ping Xu | | It is known that the five carbon platform chemical glutarate can be catabolized by the glutaryl-CoA dehydrogenation pathway. Here, the authors discover an additional glutarate catabolic pathway involving l-2-hydroxyglutarate and show increased glutarate production by blocking both catabolic pathways. | | 29 May 2018 | doi: 10.1038/s41467-018-04513-0 | | Bacteria Metabolic engineering Metabolic pathways | In situ redox reactions facilitate the assembly of a mixed-valence metal-organic nanocapsule OPEN | | Asanka S. Rathnayake, Hector W. L. Fraser, Euan K. Brechin, Scott J. Dalgarno, Jakob E. Baumeister, Joshua White, Pokpong Rungthanaphatsophon, Justin R. Walensky, Charles L. Barnes, Simon J. Teat & Jerry L. Atwood | | New approaches are required to access metal-organic assemblies with unusual structural properties. Here, the authors use an in situ redox reaction to obtain a mixed-valence, Mn(II)/Mn(III)-containing metal-organic nanocapsule with an odd number of metal ions. | | 29 May 2018 | doi: 10.1038/s41467-018-04541-w | | Molecular capsules Self-assembly | Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function OPEN | | Gail Davies , Max Lam, Sarah E. Harris, Joey W. Trampush, Michelle Luciano, W. David Hill, Saskia P. Hagenaars, Stuart J. Ritchie, Riccardo E. Marioni, Chloe Fawns-Ritchie, David C. M. Liewald, Judith A. Okely, Ari V. Ahola-Olli, Catriona L. K. Barnes, Lars Bertram, Joshua C. Bis, Katherine E. Burdick, Andrea Christoforou, Pamela DeRosse, Srdjan Djurovic et al. | | Cognitive function is associated with health and important life outcomes. Here, the authors perform a genome-wide association study for general cognitive function in 300,486 individuals and identify genetic loci that implicate neural and cell developmental pathways in this trait. | | 29 May 2018 | doi: 10.1038/s41467-018-04362-x | | Cognitive neuroscience Genetics of the nervous system Genome-wide association studies Quantitative trait | Chemically activating MoS2 via spontaneous atomic palladium interfacial doping towards efficient hydrogen evolution OPEN | | Zhaoyan Luo, Yixin Ouyang, Hao Zhang, Meiling Xiao, Junjie Ge, Zheng Jiang, Jinlan Wang, Daiming Tang, Xinzhong Cao, Changpeng Liu & Wei Xing | | While water reduction may provide a carbon-neutral means to produce hydrogen gas, there is a scarcity of efficient, earth-abundant electrocatalysts. Here, the authors add palladium into MoS2 materials to activate and stabilize the conductive basal plane to improve the electrocatalytic activity. | | 29 May 2018 | doi: 10.1038/s41467-018-04501-4 | | Catalyst synthesis Electrocatalysis Two-dimensional materials | Uranium(III)-carbon multiple bonding supported by arene δ-bonding in mixed-valence hexauranium nanometre-scale rings OPEN | | Ashley J. Wooles, David P. Mills, Floriana Tuna, Eric J. L. McInnes, Gareth T. W. Law, Adam J. Fuller, Felipe Kremer, Mark Ridgway, William Lewis, Laura Gagliardi, Bess Vlaisavljevich & Stephen T. Liddle | | Owing to the propensity for uranium(III) compounds to undergo disproportionation, uranium-element multiple bonds involving uranium(III) oxidation states remain rare. Here the authors report hexauranium-methanediide rings that formally contain uranium(III)- and uranium(IV)-methanediides supported by alternating halide and arene bridges. | | 29 May 2018 | doi: 10.1038/s41467-018-04560-7 | | Chemical bonding Coordination chemistry Inorganic chemistry | The RPAP3-Cterminal domain identifies R2TP-like quaternary chaperones OPEN | | Chloé Maurizy , Marc Quinternet, Yoann Abel, Céline Verheggen, Paulo E. Santo, Maxime Bourguet, Ana C.F. Paiva, Benoît Bragantini, Marie-Eve Chagot, Marie-Cécile Robert, Claire Abeza, Philippe Fabre, Philippe Fort, Franck Vandermoere, Pedro M.F. Sousa, Jean-Christophe Rain, Bruno Charpentier, Sarah Cianférani, Tiago M. Bandeiras, Bérengère Pradet-Balade et al. | | R2TP is an HSP90 co-chaperone composed of an RPAP3-PIH1D1 heterodimer, which binds two essential AAA+ ATPases RUVBL1/RUVBL2. Here authors use a structural approach to study RPAP3 and find an RPAP3-like protein (SPAG1) which also forms a co-chaperone complex with PIH1D2 and RUVBL1/2 enriched in testis. | | 29 May 2018 | doi: 10.1038/s41467-018-04431-1 | | Biochemistry Cell biology Molecular biology Structural biology | Dominant-negative STAT5B mutations cause growth hormone insensitivity with short stature and mild immune dysregulation OPEN | | Jürgen Klammt, David Neumann, Evelien F. Gevers, Shayne F. Andrew, I. David Schwartz, Denise Rockstroh, Roberto Colombo, Marco A. Sanchez, Doris Vokurkova, Julia Kowalczyk, Louise A. Metherell, Ron G. Rosenfeld, Roland Pfäffle, Mehul T. Dattani, Andrew Dauber & Vivian Hwa | | Severe growth hormone insensitivity syndrome (GHIS) with immunodeficiency is caused by autosomal recessive mutations in STAT5B. Here the authors report heterozygous STAT5B mutations with dominant-negative effects, causing mild GHIS without immune defects. | | 29 May 2018 | doi: 10.1038/s41467-018-04521-0 | | Genetics research Growth disorders Growth factor signalling | The Holocene retreat dynamics and stability of Petermann Glacier in northwest Greenland OPEN | | Martin Jakobsson, Kelly A. Hogan, Larry A. Mayer, Alan Mix, Anne Jennings, Joe Stoner, Björn Eriksson, Kevin Jerram, Rezwan Mohammad, Christof Pearce, Brendan Reilly & Christian Stranne | | Submarine glacial landforms are used to reconstruct the Holocene retreat dynamics and stability of Petermann Glacier in northwest Greenland. Here, a large grounding-zone wedge at the mouth of Petermann fjord indicates a period of glacier stability, with final retreat likely driven by marine ice cliff instability. | | 29 May 2018 | doi: 10.1038/s41467-018-04573-2 | | Cryospheric science Geomorphology | Nonlinear optical components for all-optical probabilistic graphical model OPEN | | Masoud Babaeian, Pierre-A. Blanche, Robert A. Norwood, Tommi Kaplas, Patrick Keiffer, Yuri Svirko, Taylor G. Allen, Vincent W. Chen, San-Hui Chi, Joseph W. Perry, Seth R. Marder, Mark A. Neifeld & N. Peyghambarian | | To circumvent the limitations of electronic computers, moving to hybrid optical-electronic or all-optical devices may be useful. Here, Babaeian et al. present an all-optical implementation of the probabilistic graphical model using nonlinear optics in thin films to implement mathematical functions. | | 29 May 2018 | doi: 10.1038/s41467-018-04578-x | | Integrated optics Optoelectronic devices and components | The hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages OPEN | | Daejin Lim, Kwang Soo Kim, Jae-Ho Jeong, Oriana Marques, Hyun-Ju kim, Miryoung Song, Tae-Hoon Lee, Jae Il Kim, Hueng-Sik Choi, Jung-Joon Min, Dirk Bumann, Martina U. Muckenthaler & Hyon E. Choy | | The effects of iron on vacuole-resident Salmonella in macrophages are unclear. Here the authors show that the bacteria are not subject to nutritional inhibition by iron deprivation, but that iron depletion in the vacuole, via the hepcidin-ferroportin axis, inhibits the bactericidal effect of oxidative burst. | | 29 May 2018 | doi: 10.1038/s41467-018-04446-8 | | Infection Pathogens | The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity OPEN | | Julien Bricambert, Marie-Clotilde Alves-Guerra, Pauline Esteves, Carina Prip-Buus, Justine Bertrand-Michel, Hervé Guillou, Christopher J. Chang, Mark N. Vander Wal, François Canonne-Hergaux, Philippe Mathurin, Violeta Raverdy, François Pattou, Jean Girard, Catherine Postic & Renaud Dentin | | Steatosis is characterized by initial accumulation of lipids, followed by inflammation and ultimately fibrosis. Here the authors show that the histone demethylase Plant Homeodomain Finger 2 protects liver form steatosis progression by acting as a co-activator of ChREBP, thus, favouring lipid accumulation without inflammation. | | 29 May 2018 | doi: 10.1038/s41467-018-04361-y | | Epigenetics Liver fibrosis Metabolic syndrome Methylation Non-alcoholic fatty liver disease | Induction of anergic or regulatory tumor-specific CD4+ T cells in the tumor-draining lymph node OPEN | | Ruby Alonso, Héloïse Flament, Sébastien Lemoine, Christine Sedlik, Emanuel Bottasso, Isabel Péguillet, Virginie Prémel, Jordan Denizeau, Marion Salou, Aurélie Darbois, Nicolás Gonzalo Núñez, Benoit Salomon, David Gross, Eliane Piaggio & Olivier Lantz | | Tumor neoantigens can be drained to the lymph nodes, but the nature and the significance of the induced immune responses are still unclear. Here the authors use a mouse genetic tumor model to show that tumor-specific CD4 T cells can become anergic or suppressive in the draining lymph node to modulate tumor immunity. | | 29 May 2018 | doi: 10.1038/s41467-018-04524-x | | Lymph node Lymphocyte activation Regulatory T cells Tumour immunology | Pharmacologic inhibition of protein phosphatase-2A achieves durable immune-mediated antitumor activity when combined with PD-1 blockade OPEN | | Winson S. Ho, Herui Wang, Dominic Maggio, John S. Kovach, Qi Zhang, Qi Song, Francesco M. Marincola, John D. Heiss, Mark R. Gilbert, Rongze Lu & Zhengping Zhuang | | Protein phosphatase 2A (PP2A) has been proposed as a target for cancer immunotherapy. Here the authors show that pharmacological inhibition of PP2A with a clinically-relevant inhibitor enhances response to immune checkpoint blockade in pre-clinical models of cancer, resulting in long lasting immunity. | | 29 May 2018 | doi: 10.1038/s41467-018-04425-z | | Cancer immunotherapy Tumour immunology | Male germ cells support long-term propagation of Zika virus OPEN | | Christopher L. Robinson , Angie C. N. Chong, Alison W. Ashbrook, Ginnie Jeng, Julia Jin, Haiqi Chen, Elizabeth I. Tang, Laura A. Martin, Rosa S. Kim, Reyn M. Kenyon, Eileen Do, Joseph M. Luna, Mohsan Saeed, Lori Zeltser, Harold Ralph, Vanessa L. Dudley, Marc Goldstein, Charles M. Rice, C. Yan Cheng, Marco Seandel et al. | | Zika virus (ZIKV) can persist for months in semen and sperm. Here, the authors show that germ cells, compared to other cell types in the reproductive tract, are most susceptible to ZIKV and produce high levels of progeny virus, which coincides with decreased expression of the interferon-stimulated gene Ifi44l. | | 29 May 2018 | doi: 10.1038/s41467-018-04444-w | | Drug discovery Germ cells Viral reservoirs Virus–host interactions | Tumour-associated missense mutations in the dMi-2 ATPase alters nucleosome remodelling properties in a mutation-specific manner OPEN | | Kristina Kovač, Anja Sauer, Igor Mačinković, Stephan Awe, Florian Finkernagel, Helen Hoffmeister, Andreas Fuchs, Rolf Müller, Christina Rathke, Gernot Längst & Alexander Brehm | | ATP-dependent chromatin remodelers are often found mutated in human cancers. Here, the authors characterize the nucleosome remodelling properties of cancer-associated mutants of the Drosophila Chd4 homolog dMi-2. | | 29 May 2018 | doi: 10.1038/s41467-018-04503-2 | | Chromatin remodelling Enzyme mechanisms | STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap OPEN | | Anna Woroniuk, Andrew Porter, Gavin White, Daniel T. Newman, Zoi Diamantopoulou, Thomas Waring, Claire Rooney, Douglas Strathdee, Daniel J. Marston, Klaus M. Hahn, Owen J. Sansom, Tobias Zech & Angeliki Malliri | | The perinuclear actin cap determines nuclear morphology but its regulation is currently poorly understood. Here, the authors find that an activator of the Rac1 GTPase, STEF/TIAM2, localises to the nuclear envelope and contributes to perinuclear actin and myosin tension, which in turn regulates the actin cap. | | 29 May 2018 | doi: 10.1038/s41467-018-04404-4 | | Cell polarity Nuclear envelope RHO signalling | Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines OPEN | | Chunshuai Huang, Chunfang Yang, Wenjun Zhang, Liping Zhang, Bidhan Chandra De, Yiguang Zhu, Xiaodong Jiang, Chunyan Fang, Qingbo Zhang, Cheng-Shan Yuan, Hung-wen Liu & Changsheng Zhang | | Benzofluorene-containing angucyclines, bacterial natural compounds with potential use as therapeutics/antibiotics, occur as dimers. Here, the authors elucidated the dimerization mechanism which turned out to work spontaneously, without enzymatic catalysis. | | 25 May 2018 | doi: 10.1038/s41467-018-04487-z | | Biosynthesis Hydrolases | Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells OPEN | | Ashish Misra, Zhonghui Feng, Rachana R. Chandran, Inamul Kabir, Noemi Rotllan, Binod Aryal, Abdul Q. Sheikh, Ling Ding, Lingfeng Qin, Carlos Fernández-Hernando, George Tellides & Daniel M. Greif | | Smooth muscle cells (SMCs) invade atherosclerotic lesions and expand, contributing to plaque progression. Here Misra et al. show that SMC-derived plaque cells come from a single SMC and integrin β3 in SMCs and macrophages regulate the fate, expansion and migration of SMCs during plaque formation. | | 25 May 2018 | doi: 10.1038/s41467-018-04447-7 | | Atherosclerosis Cell lineage Integrin signalling | Testosterone is an endogenous regulator of BAFF and splenic B cell number OPEN | | Anna S. Wilhelmson , Marta Lantero Rodriguez, Alexandra Stubelius, Per Fogelstrand, Inger Johansson, Matthew B. Buechler, Steve Lianoglou, Varun N. Kapoor, Maria E. Johansson, Johan B. Fagman, Amanda Duhlin, Prabhanshu Tripathi, Alessandro Camponeschi, Bo T. Porse, Antonius G. Rolink, Hans Nissbrandt, Shannon J. Turley, Hans Carlsten, Inga-Lill Mårtensson, Mikael C. I. Karlsson et al. | | Testosterone deficiency is associated with autoimmunity and increased B cell numbers, but the underlying mechanism is unclear. Here the authors show that testosterone may modulate the production of B cell survival factor BAFF by fibroblastic reticular cells via regulation of splenic neurotransmitter levels. | | 25 May 2018 | doi: 10.1038/s41467-018-04408-0 | | Autoimmune diseases B-2 cells Endocrinology Neuroimmunology | Fossilized skin reveals coevolution with feathers and metabolism in feathered dinosaurs and early birds OPEN | | Maria E. McNamara, Fucheng Zhang, Stuart L. Kearns, Patrick J. Orr, André Toulouse, Tara Foley, David W. E. Hone, Chris S. Rogers, Michael J. Benton, Diane Johnson, Xing Xu & Zhonghe Zhou | | In addition to the evolutionary innovation of feathers, bird skin has complex adaptations. Here, McNamara and colleagues examine exceptionally preserved skin from feathered dinosaurs and ancient birds from the Cretaceous and show the early acquisition of many skin attributes seen in modern species. | | 25 May 2018 | doi: 10.1038/s41467-018-04443-x | | Palaeontology | The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma OPEN | | Bill H. Diplas , Xujun He, Jacqueline A. Brosnan-Cashman, Heng Liu, Lee H. Chen, Zhaohui Wang, Casey J. Moure, Patrick J. Killela, Daniel B. Loriaux, Eric S. Lipp, Paula K. Greer, Rui Yang, Anthony J. Rizzo, Fausto J. Rodriguez, Allan H. Friedman, Henry S. Friedman, Sizhen Wang, Yiping He, Roger E. McLendon, Darell D. Bigner et al. | | Glioblastoma can be classified based on IDH and TERT promoter mutations, but ~20% of glioblastoma do not have these mutations (TERTpWT-IDHWT glioblastoma). Here, the authors present a genetic landscape of TERTpWT-IDHWT glioblastoma, identifying a telomerase-positive subgroup driven by TERT-structural rearrangements and an ALT-positive subgroup with mutations in ATRX or SMARCAL1. | | 25 May 2018 | doi: 10.1038/s41467-018-04448-6 | | Cancer genomics CNS cancer Telomeres Tumour biomarkers Tumour-suppressor proteins | Robust nonfullerene solar cells approaching unity external quantum efficiency enabled by suppression of geminate recombination OPEN | | Derya Baran, Nicola Gasparini, Andrew Wadsworth, Ching Hong Tan, Nimer Wehbe, Xin Song, Zeinab Hamid, Weimin Zhang, Marios Neophytou, Thomas Kirchartz, Christoph J. Brabec, James R. Durrant & Iain McCulloch | | The nonfullerene-based small molecules start to attract more attention for solar cell research than the fullerene acceptors due to their wider tunability. Here Baran et al. demonstrate nonfullerene-based solar cells with high power conversion efficiency of 12% and quantum efficiencies approaching 100%. | | 25 May 2018 | doi: 10.1038/s41467-018-04502-3 | | Electronic devices Solar cells | Live-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation OPEN | | Roubina Tatavosian, Huy Nguyen Duc, Thao Ngoc Huynh, Dong Fang, Benjamin Schmitt, Xiaodong Shi, Yiming Deng, Christopher Phiel, Tingting Yao, Zhiguo Zhang, Haobin Wang & Xiaojun Ren | | Diffuse intrinsic pontine gliomas exhibit a characteristic mutation of lysine 27 to methionine (K27M) in genes encoding histone H3.3. Here the authors show that the H3.3K27M mutation imposes a specific pattern of H3.3K27 methylation by altering the target search dynamics of PcG proteins. | | 25 May 2018 | doi: 10.1038/s41467-018-04455-7 | | Histone post-translational modifications Histone variants Paediatric cancer Single-molecule biophysics | Demonstration of Ru as the 4th ferromagnetic element at room temperature OPEN | | P. Quarterman, Congli Sun, Javier Garcia-Barriocanal, Mahendra DC, Yang Lv, Sasikanth Manipatruni, Dmitri E. Nikonov, Ian A. Young, Paul M. Voyles & Jian-Ping Wang | | Until now, there have been three choices for a room temperature (RT) single element ferromagnetic material in fundamental studies and applications. Here the authors achieved body-centered tetragonal phase ruthenium thin films by epitaxial growth, which is the 4th RT ferromagnetic single element material. | | 25 May 2018 | doi: 10.1038/s41467-018-04512-1 | | Ferromagnetism Magnetic properties and materials Surfaces, interfaces and thin films | Identification of rare de novo epigenetic variations in congenital disorders OPEN | | Mafalda Barbosa , Ricky S. Joshi, Paras Garg, Alejandro Martin-Trujillo, Nihir Patel, Bharati Jadhav, Corey T. Watson, William Gibson, Kelsey Chetnik, Chloe Tessereau, Hui Mei, Silvia De Rubeis, Jennifer Reichert, Fatima Lopes, Lisenka E. L. M. Vissers, Tjitske Kleefstra, Dorothy E. Grice, Lisa Edelmann, Gabriela Soares, Patricia Maciel et al. | | A proportion of neurodevelopmental disorder and congenital anomaly cases remain without a genetic diagnosis. Here, the authors study aberrations of DNA methylation in such cases and find that epivariations might provide an explanation for some of these undiagnosed patients. | | 25 May 2018 | doi: 10.1038/s41467-018-04540-x | | DNA methylation Epigenomics Medical genomics Mutation | High temperature deformability of ductile flash-sintered ceramics via in-situ compression OPEN | | Jaehun Cho, Qiang Li, Han Wang, Zhe Fan, Jin Li, Sichuang Xue, K. S. N. Vikrant, Haiyan Wang, Troy B. Holland, Amiya K. Mukherjee, R. Edwin García & Xinghang Zhang | | Flash sintering allows for rapid ceramic processing, but the mechanical behavior of such ceramics remains poorly understood. Here, the authors compress micropillars of yttria stabilized zirconia to show flash sintering promotes outstanding plasticity. | | 25 May 2018 | doi: 10.1038/s41467-018-04333-2 | | Ceramics Mechanical engineering Mechanical properties | In vivo reprogramming drives Kras-induced cancer development OPEN | | Hirofumi Shibata, Shingo Komura, Yosuke Yamada, Nao Sankoda, Akito Tanaka, Tomoyo Ukai, Mio Kabata, Satoko Sakurai, Bunya Kuze, Knut Woltjen, Hironori Haga, Yatsuji Ito, Yoshiya Kawaguchi, Takuya Yamamoto & Yasuhiro Yamada | | Cellular reprogramming and cancer development share properties. Here, the authors examine the impact of in vivo reprogramming on Kras-induced cancer and show reprogramming-mediated repression of somatic cell enhancers in conjunction with Kras mutation results in rapid PDAC development. | | 25 May 2018 | doi: 10.1038/s41467-018-04449-5 | | Cancer models Induced pluripotent stem cells | Whole-genome sequencing reveals genomic signatures associated with the inflammatory microenvironments in Chinese NSCLC patients OPEN | | Cheng Wang , Rong Yin, Juncheng Dai, Yayun Gu, Shaohua Cui, Hongxia Ma, Zhihong Zhang, Jiaqi Huang, Na Qin, Tao Jiang, Liguo Geng, Meng Zhu, Zhening Pu, Fangzhi Du, Yuzhuo Wang, Jianshui Yang, Liang Chen, Qianghu Wang, Yue Jiang, Lili Dong et al. | | The distinct genomic and epidemiological features of Chinese lung cancer patients suggest the presence of alternative causal mechanisms. Here, the authors present the genomic landscape of 149 Chinese NSCLC patients and reveal distinct mutational signatures associated with inflammatory microenvironments. | | 24 May 2018 | doi: 10.1038/s41467-018-04492-2 | | Cancer genomics Cancer microenvironment Non-small-cell lung cancer | Dual origin of relapses in retinoic-acid resistant acute promyelocytic leukemia OPEN | | Jacqueline Lehmann-Che, Cécile Bally, Eric Letouzé, Caroline Berthier, Hao Yuan, Florence Jollivet, Lionel Ades, Bruno Cassinat, Pierre Hirsch, Arnaud Pigneux, Marie-Joelle Mozziconacci, Scott Kogan, Pierre Fenaux & Hugues de Thé | | Historical acute promyelocytic leukemia patients treated with retinoic acid and chemotherapy sometimes did relapse. Here the authors performed exome sequencing on 64 patient's samples from diagnosis/relapse/remission and show relapse associates either with cooperating oncogenes at diagnosis, or with unexpected persistence of ancestral pre-leukemic clones. | | 24 May 2018 | doi: 10.1038/s41467-018-04384-5 | | Cancer genetics Cancer genomics | Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation OPEN | | Masaki Tsuchiya , Yuji Hara, Masaki Okuda, Karin Itoh, Ryotaro Nishioka, Akifumi Shiomi, Kohjiro Nagao, Masayuki Mori, Yasuo Mori, Junichi Ikenouchi, Ryo Suzuki, Motomu Tanaka, Tomohiko Ohwada, Junken Aoki, Motoi Kanagawa, Tatsushi Toda, Yosuke Nagata, Ryoichi Matsuda, Yasunori Takayama, Makoto Tominaga et al. | | Myotube formation by fusion of myoblasts is essential for skeletal muscle formation, but which molecules regulate this process remains elusive. Here authors identify the mechanosensitive PIEZO1 channel as a key element, whose activity is regulated by phosphatidylserine during myotube formation. | | 24 May 2018 | doi: 10.1038/s41467-018-04436-w | | Calcium signalling Phospholipids | An antibacterial platform based on capacitive carbon-doped TiO2 nanotubes after direct or alternating current charging OPEN | | Guomin Wang, Hongqing Feng, Liangsheng Hu, Weihong Jin, Qi Hao, Ang Gao, Xiang Peng, Wan Li, Kwok-Yin Wong, Huaiyu Wang, Zhou Li & Paul K. Chu | | Bacteria are known to be sensitive to electrical interactions with the environment. Here, the authors report on a study into how the antibacterial properties of carbon-doped titania nanotubes are affected by capacitance after charging with direct and alternating currents. | | 24 May 2018 | doi: 10.1038/s41467-018-04317-2 | | Bacteria Bioinspired materials Biomedical materials Nanoscale materials | | | | | Latest Author Corrections | | | | Author Correction: Oxidative rearrangement of (+)-sesamin by CYP92B14 co-generates twin dietary lignans in sesame OPEN | | Jun Murata, Eiichiro Ono, Seigo Yoroizuka, Hiromi Toyonaga, Akira Shiraishi, Shoko Mori, Masayuki Tera, Toshiaki Azuma, Atsushi J. Nagano, Masaru Nakayasu, Masaharu Mizutani, Tatsuya Wakasugi, Masayuki P. Yamamoto & Manabu Horikawa | | 25 May 2018 | doi: 10.1038/s41467-018-04596-9 | | Enzyme mechanisms Oxidoreductases Secondary metabolism | Author Correction: Smac mimetics and oncolytic viruses synergize in driving anticancer T-cell responses through complementary mechanisms OPEN | | Dae-Sun Kim, Himika Dastidar, Chunfen Zhang, Franz J. Zemp, Keith Lau, Matthias Ernst, Andrea Rakic, Saif Sikdar, Jahanara Rajwani, Victor Naumenko, Dale R. Balce, Ben W. Ewanchuk, Pankaj Tailor, Robin M. Yates, Craig Jenne, Chris Gafuik & Douglas J. Mahoney | | 24 May 2018 | doi: 10.1038/s41467-018-04597-8 | | Cancer immunotherapy Tumour immunology | | | | | Latest Publisher Correction | | | | Publisher Correction: Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes OPEN | | Sílvia Bonàs-Guarch , Marta Guindo-Martínez, Irene Miguel-Escalada, Niels Grarup, David Sebastian, Elias Rodriguez-Fos, Friman Sánchez, Mercè Planas-Fèlix, Paula Cortes-Sánchez, Santi González, Pascal Timshel, Tune H. Pers, Claire C. Morgan, Ignasi Moran, Goutham Atla, Juan R. González, Montserrat Puiggros, Jonathan Martí, Ehm A. Andersson, Carlos Díaz et al. | | 30 May 2018 | doi: 10.1038/s41467-018-04170-3 | | Diabetes Genome-wide association studies | | | | | Advertisement | | nature.com webcasts Nature Research Custom presents a webcast on: Saving an Enzymatic HTS Assay with Sound Date: Wednesday, June 13, 2018 Labcyte and Servier will present a recent experiment about Echo technology. 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