Nature Biotechnology Contents: Volume 36 pp 373 - 476

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Advertisement Do you have a career question? The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.  Listen today! TABLE OF CONTENTS May 2018 Volume 36, Issue 5 Editorial News Bioentrepreneur Opinion and Comment Features News and Views Research Careers and Recruitment   Advertisement NYU - Nature Conference on Chemical Biology August 13-14, New York This conference will provide a forum for discussing innovative strategies for research in chemical biology. It will cover the breadth of chemical biology ranging from the construction DNA as material and sensors, regulation of gene expression, synthesis and derivatization of proteins, synthetic biology and the human microbiome.   Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Advertisement KACST Impact KACST Impact is a new online publication highlighting the latest cutting edge scientific research conducted at King Abdulaziz City for Science and Technology (KACST) that features various stories ranging from exciting new scientific finds to the commercialization of innovative discoveries.  Learn more »   Advertisement First Rounders Podcast   Nature Biotechnology's First Rounders podcast is a series of conversations with founders, financers and developers from biotech's past, present and future. Register now Sponsored by: Johns Hopkins University   Editorial Top Unleashing biotech's crouching tiger   p373 doi:10.1038/nbt.4149 With a massive expansion in healthcare coverage, biotech's next big boom could occur in India. But this revolution will not be globalized[mdash]it will be about serving national needs.   News Top Allogene and Celularity move CAR-T therapy off the shelf   pp375 - 377 Cormac Sheridan doi:10.1038/nbt0518-375   Cytokine resurrection: engineered IL-2 ramps up immuno-oncology responses   pp378 - 379 Ken Garber doi:10.1038/nbt0518-378   2020 African American genomes   p380 doi:10.1038/nbt0518-380a   Indian biotech sector readies for liftoff   pp380 - 381 Killugudi Jayaraman doi:10.1038/nbt0518-380b   Patent challenges to antibody and gene-therapy firms on the rise   pp382 - 383 Charlotte Harrison doi:10.1038/nbt0518-382   Trump threatens then signs, a win for FDA, NIH   p383 doi:10.1038/nbt0518-383   To keep biotechs trading at home, China pilots new stock market rules   p384 Shannon Ellis doi:10.1038/nbt0518-384   Around the world in a month   p385 doi:10.1038/nbt0518-385     Top Drug pipeline: 1Q18   p386 Laura DeFrancesco doi:10.1038/nbt.4142   Advertisement Searching for a new career? At Nature Research we frequently recruit talented individuals to join our editorial and publishing teams. If you have a PhD and a passion for science this may be the perfect career for you. Visit our research editorial and publishing careers website to discover more about what we do    Bioentrepreneur Top Building a Business A rich resource   pp387 - 390 Ahmet-Hamdi Cavusoglu, Elizabeth Beerman and Orin Herskowitz doi:10.1038/nbt.4130   Opinion and Comment Top Correspondence Alternative models for sharing confidential biomedical data   pp391 - 392 Justin Guinney and Julio Saez-Rodriguez doi:10.1038/nbt.4128   Features Top Bringing up baby   pp393 - 401 Brady Huggett doi:10.1038/nbt.4135 More investors are building companies from scratch, with more money than any time in biotech's history.   Podcast First rounders: John Maraganore   p401 John Maraganore doi:10.1038/nbt.4145     Top Advertisement Nominations now open!  Who are the future leading women in science? The Nature Research Awards for Inspiring Science and Innovating Science are now open for nominations.  Find out more about these awards and nominate your inspiration >>  In partnership with The Estée Lauder Companies.   Patentability of antibodies for therapeutic use in Europe   pp402 - 405 Claudio Germinario, Sara Bertoli, Patrizia Rampinelli and Maurizio Cini doi:10.1038/nbt.4134 General guidelines are presented on the types of patent protection available for inventions arising from research in the field of monoclonal antibodies, using concepts drawn from European case law and expert practice.   Feature Top Patents Recent patents in biomedical imaging   p406 doi:10.1038/nbt.4146   News and Views Top Brain organoids get vascularized   pp407 - 408 Madeline A Lancaster doi:10.1038/nbt.4133 Transplantation of cerebral organoids into the mouse brain overcomes some limitations of in vitro systems. See also: Research by Mansour et al. Boosting the power of single-cell analysis   pp408 - 409 Lu Wen and Fuchou Tang doi:10.1038/nbt.4131 Data sets from different single-cell RNA-seq experiments are combined with reduced technical error. See also: Research by Butler et al. | Research by Haghverdi et al. All the skin that's fit to print   p410 Irene Jarchum doi:10.1038/nbt.4129   Research Highlights   p410 doi:10.1038/nbt.4139   Biotechnology EVENT Medical Biotechnology 24.05.18 Gent, Belgium More science events from Research Top Analysis Integrating single-cell transcriptomic data across different conditions, technologies, and species   pp411 - 420 Andrew Butler, Paul Hoffman, Peter Smibert, Efthymia Papalexi and Rahul Satija doi:10.1038/nbt.4096 A new computational approach enables integrative analysis of disparate single-cell RNA-sequencing data sets by identifying shared patterns of variation between cell subpopulations. See also: News and Views by Wen & Tang Batch effects in single-cell RNA-sequencing data are corrected by matching mutual nearest neighbors   pp421 - 427 Laleh Haghverdi, Aaron T L Lun, Michael D Morgan and John C Marioni doi:10.1038/nbt.4091 Differences in gene expression between individual cells of the same type are measured across batches and used to correct technical artifacts in single-cell RNA-sequencing data. See also: News and Views by Wen & Tang Brief Communications Highly scalable generation of DNA methylation profiles in single cells   pp428 - 431 Ryan M Mulqueen, Dmitry Pokholok, Steven J Norberg, Kristof A Torkenczy, Andrew J Fields et al. doi:10.1038/nbt.4112 Methylation profiling of single cells in high throughput achieves read-alignment rates approaching bulk cell population studies.   Articles An in vivo model of functional and vascularized human brain organoids   pp432 - 441 Abed AlFatah Mansour, J Tiago Goncalves, Cooper W Bloyd, Hao Li, Sarah Fernandes et al. doi:10.1038/nbt.4127 Human cerebral organoids undergo vascularization and maturation in the mouse brain. See also: News and Views by Lancaster Simultaneous single-cell profiling of lineages and cell types in the vertebrate brain   pp442 - 450 Bushra Raj, Daniel E Wagner, Aaron McKenna, Shristi Pandey, Allon M Klein et al. doi:10.1038/nbt.4103 scGESTALT enables large-scale characterization of cell types and lineage relationships during vertebrate brain development.   Fast, long-term, super-resolution imaging with Hessian structured illumination microscopy   pp451 - 459 Xiaoshuai Huang, Junchao Fan, Liuju Li, Haosen Liu, Runlong Wu et al. doi:10.1038/nbt.4115 An improved image reconstruction algorithm increases time resolution and maximal imaging time for super-resolution microscopy.   Deep learning massively accelerates super-resolution localization microscopy   pp460 - 468 Wei Ouyang, Andrey Aristov, Mickael Lelek, Xian Hao and Christophe Zimmer doi:10.1038/nbt.4106 Accelerating PALM/STORM microscopy with deep learning allows super-resolution imaging of >1,000 cells in a few hours.   Letter Simultaneous lineage tracing and cell-type identification using CRISPR-Cas9-induced genetic scars   pp469 - 473 Bastiaan Spanjaard, Bo Hu, Nina Mitic, Pedro Olivares-Chauvet, Sharan Janjuha et al. doi:10.1038/nbt.4124 LINNAEUS reconstructs developmental lineages using RNA sequencing data and lineage markers from the same single cells.   Careers and Recruitment Top First-quarter biotech job picture   p475 Michael Francisco doi:10.1038/nbt.4141   People People   p476 doi:10.1038/nbt.4144   Top Advertisement nature.com webcasts Nature Research Custom presents a webcast on: Highly multiplexed transcriptome and protein immune profiling in single cells with CITE-seq Date: Wednesday, May 23, 2018 Peter Smibert, Ph.D. from New York Genome Center, will present an overview of CITE-seq and Cell Hashing and discuss methods compatible with 10x Genomics single cell platforms sample multiplexing. 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