EMBO reports Table of Contents for May 2018; Vol. 19, No. 5

May 2018 | Volume 19, Number 5 Submit Table of Contents Opinion Science & Society Review Scientific Report Articles Volume 19, Number 5 Opinion Ticking time bomb? High time for chronobiological research The 2017 Nobel prize for elucidating the mechanisms of chronobiology highlights the urgent need to better understand our internal clockwork and its effects on health and disease. Philip Lewis, Russell G Foster and Thomas C Erren Published online 03.04.2018 Put science first and formatting later Scientists spend considerable efforts with reformatting their research articles before each new submission. A widely adopted format‐free submission process would save them valuable time to do research instead. Aziz Khan, Alejandro Montenegro‐Montero and Anthony Mathelier Published online 12.04.2018 Science & Society Improving animal research reporting standards: HARRP, the first step of a unified approach by ICLAS to improve animal research reporting standards worldwide The HAARP guidelines aim to set a global minimum standard for reporting results from and details of research experiments using animals. Their adoption would contribute to more transparency in research and improve reproducibility. Nikki Osborne, Marc T Avey, Lida Anestidou, Merel Ritskes‐Hoitinga and Gilly Griffin Published online 17.04.2018 Synthetic gene drive: between continuity and novelty: Crucial differences between gene drive and genetically modified organisms require an adapted risk assessment for their use Gene drive organisms differ from “classical” genetically modified organisms in several crucial aspects. It would require new approaches for risk assessment to gauge their potential impact on the environment. Samson Simon, Mathias Otto and Margret Engelhard Published online 12.04.2018 Science, politics and ideologies: Global political developments towards isolationism, ideology or disregard of facts have scientists concerned about the free exchange of ideas and people In light of Brexit, US policies on research or the Turkish government's crackdown after the 2017 coup, scientists worry about larger political developments that could harm international science. Philip Hunter Published online 16.04.2018 Review Mitochondria and the dynamic control of stem cell homeostasis Dissecting the roles of mitochondria in stem cell homeostasis and differentiation is essential to understand stem cell dynamics and fate. This review discusses how mitochondria are implicated in the acquisition, maintenance and loss of stemness. Pawel Lisowski, Preethi Kannan, Barbara Mlody and Alessandro Prigione Published online 16.04.2018 Scientific Report Disentangling the molecular determinants for Cenp‐F localization to nuclear pores and kinetochores Cenp‐F contributes to multiple processes throughout the cell cycle. Here, key residues required for Cenp‐F recruitment to nuclear pores or kinetochores are identified using in silico structural modelling, yeast two‐hybrid assays and localization studies. Alessandro Berto, Jinchao Yu, Stéphanie Morchoisne‐Bolhy, Chiara Bertipaglia, Richard Vallee, Julien Dumont, Francoise Ochsenbein, Raphael Guerois and Valérie Doye Published online 09.04.2018 Articles Cross‐talk between monocyte invasion and astrocyte proliferation regulates scarring in brain injury Astrocytes resume proliferation specifically at the vascular wall after brain injury. Genetic increase of astrocyte proliferation reduces monocyte invasion at the injury site, while lack of monocyte invasion promotes astrocyte proliferation and reduces the GFAP+ scar. Jesica Frik, Juliane Merl‐Pham, Nikolaus Plesnila, Nicola Mattugini, Jacob Kjell, Jonas Kraska, Ricardo M Gómez, Stefanie M Hauck, Swetlana Sirko and Magdalena Götz Published online 09.04.2018 CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis Complete loss of mitochondrial CLPP protease protects mice from diet‐induced obesity and insulin‐resistance but impairs cold‐induced thermogenesis due to a decline in brown adipocyte function. Christina Becker, Alexandra Kukat, Karolina Szczepanowska, Steffen Hermans, Katharina Senft, Christoph Paul Brandscheid, Priyanka Maiti and Aleksandra Trifunovic Published online 27.03.2018 Alpha‐synuclein aggregates activate calcium pump SERCA leading to calcium dysregulation Aggregated α‐synuclein stimulates the calcium pump SERCA thereby reducing cytosolic Ca2+ and contributing to neurodegeneration. Pharmacological SERCA inhibition protects against α‐synuclein aggregate stress with potential therapeutic implications. Cristine Betzer, Louise Berkhoudt Lassen, Anders Olsen, Rikke Hahn Kofoed, Lasse Reimer, Emil Gregersen, Jin Zheng, Tito Calì, Wei‐Ping Gai, Tong Chen, Arne Moeller, Marisa Brini, Yuhong Fu, Glenda Halliday, Tomasz Brudek, Susana Aznar, Bente Pakkenberg, Jens Peter Andersen and Poul Henning Jensen Published online 29.03.2018 Stress granules counteract senescence by sequestration of PAI‐1 Stress granules counteract senescence by sequestration of PAI‐1, which activates the cyclin D1/Rb pathway and promotes cell proliferation. Amr Omer, Devang Patel, Xian Jin Lian, Jason Sadek, Sergio Di Marco, Arnim Pause, Myriam Gorospe and Imed Eddine Gallouzi Published online 28.03.2018 Quorum‐sensing regulator RhlR but not its autoinducer RhlI enables Pseudomonas to evade opsonization Tep4‐mediated opsonization blocks rhlR but not rhlI quorum‐sensing mutants during intestinal Pseudomonas infection in flies. In contrast, Tep4 is detrimental to host defense upon septic injury, highlighting the importance of the infection route. Samantha Haller, Adrien Franchet, Abdul Hakkim, Jing Chen, Eliana Drenkard, Shen Yu, Stefanie Schirmeier, Zi Li, Nelson Martins, Frederick M Ausubel, Samuel Liégeois and Dominique Ferrandon Published online 09.03.2018 EphrinB2/EphB4 signaling regulates non‐sprouting angiogenesis by VEGF EphrinB2/EphB4 signalling between pericytes and endothelium regulates the switch from normal to aberrant angiogenesis caused by increasing VEGF doses. Pharmacologic stimulation of EphB4 ensures exclusively physiological vessel growth under therapeutically relevant conditions of VEGF gene delivery. Elena Groppa, Sime Brkic, Andrea Uccelli, Galina Wirth, Petra Korpisalo‐Pirinen, Maria Filippova, Boris Dasen, Veronica Sacchi, Manuele Giuseppe Muraro, Marianna Trani, Silvia Reginato, Roberto Gianni‐Barrera, Seppo Ylä‐Herttuala and Andrea Banfi Published online 11.04.2018 SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer This study reveals a role for SIRT5 in regulating peroxisomal H2O2 and ROS homeostasis and indicates its potential function in liver protection and hepatocellular carcinoma suppression. Xiu‐Fei Chen, Meng‐Xin Tian, Ren‐Qiang Sun, Meng‐Li Zhang, Li‐Sha Zhou, Lei Jin, Lei‐Lei Chen, Wen‐Jie Zhou, Kun‐Long Duan, Yu‐Jia Chen, Chao Gao, Zhou‐Li Cheng, Fang Wang, Jin‐Ye Zhang, Yi‐Ping Sun, Hong‐Xiu Yu, Yu‐Zheng Zhao, Yi Yang, Wei‐Ren Liu, Ying‐Hong Shi, Yue Xiong, Kun‐Liang Guan and Dan Ye Published online 28.02.2018 Oncoprotein CIP2A promotes the disassembly of primary cilia and inhibits glycolytic metabolism Cancerous inhibitor of protein phosphatase 2A (CIP2A) is located at the cilia transition zone and inhibits cilia assembly and the glycolytic pathway. CIP2A depletion increases ciliated cells and cilia length and enhances the glycolytic pathway. Ae Lee Jeong, Hye In Ka, Sora Han, Sunyi Lee, Eun‐Woo Lee, Su Jung Soh, Hyun Jeong Joo, Buyanravjkh Sumiyasuren, Ji Young Park, Jong‐Seok Lim, Jong Hoon Park, Myung Sok Lee and Young Yang Published online 28.02.2018 RNase H eliminates R‐loops that disrupt DNA replication but is nonessential for efficient DSB repair Yeast cells lacking RNases H1 and H2 accumulate RNA–DNA hybrids that trigger replication fork collapse, but RNases H1/H2 are not generally required for efficient double‐strand break repair. Hongchang Zhao, Min Zhu, Oliver Limbo and Paul Russell Published online 05.04.2018 MARCH6 and TRC8 facilitate the quality control of cytosolic and tail‐anchored proteins Using near‐haploid and CRISPR‐Cas9 mutagenesis screens, this study identifies overlapping functions for the ER‐resident E3 ligases, MARCH6 and TRC8, in the quality control of selected soluble and tail‐anchored proteins at the cytosolic face of the ER. Sandra Stefanovic‐Barrett, Anna S Dickson, Stephen P Burr, James C Williamson, Ian T Lobb, Dick JH van den Boomen, Paul J Lehner and James A Nathan Published online 08.03.2018   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.