Nature Reviews Molecular Cell Biology contents May 2018 Volume 19 Number 5 pp 275-341

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TABLE OF CONTENTS
May 2018 Volume 19 Number 5		Advertisement
2016 2-year Impact Factor 46.602 Journal Metrics 2-year Median 28.5	In this issue Comment Research Highlights Reviews   Also this month  Featured article: Understanding the diversity of membrane lipid composition Takeshi Harayama & Howard Riezman	Nominations now open! Who are the future leading women in science? The Nature Research Awards for Inspiring Science and Innovating Science are now open for nominations. Find out more about these awards and nominate your inspiration In partnership with The Estée Lauder Companies.
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Nature Outlook: Cancer immunotherapy  Drugs that mobilize our immune systems against cancer are dramatically improving care for many people, and research is rapidly moving ahead in the lab and the clinic.  Access this Outlook free online for more  Produced with support from  F. Hoffmann-La Roche Ltd   Medimmune  Produced with support of a grant from Merck & Co., Inc.
Comment: The future of CRISPR technologies in agriculture Caixia Gao p275 | doi:10.1038/nrm.2018.2 Conventional plant breeding is unlikely to meet increasing food demands and other environmental challenges. By contrast, CRISPR technology is erasing barriers to genome editing and could revolutionize plant breeding. However, to fully benefit from the CRISPR revolution, we should focus on resolving its technical and regulatory uncertainties. Caixia Gao outlines the technical, regulatory and public opinion hurdles for the future use of CRISPR technologies in plant breeding. Full Text | PDF
RESEARCH HIGHLIGHTS   Top Regeneration: Mending broken hearts p277 | doi:10.1038/nrm.2018.18 The polyploidy of mammalian cardiomyocytes is a barrier to heart regeneration, but modification of the cardiomyocyte cell cycle can boost their regenerative potential. PDF Reprogramming: Methylation patterns in primordial germ cells p278 | doi:10.1038/nrm.2018.20 This study describes the molecular mechanisms underlying epigenetic reprogramming in primordial germ cells. PDF Mechanotransduction: Kindlin' the fate of mesenchymal stem cells p278 | doi:10.1038/nrm.2018.21 Kindlin-2 controls mesenchymal stem cell differentiation in repsonse to matrix stiffness by regulting the levels and activity of YAP and TAZ. PDF Cell signalling: DNA damage puts p38 under the UV light p279 | doi:10.1038/nrm.2018.22 Ultraviolet radiation induces p38-MK2-dependent phosphorylation of NELFE, which causes its dissociation from chromatin and promotes transcription of damage-response genes. PDF   Nature Reviews Molecular Cell Biology JOBS of the week Research group leader (2 positions) Centre of New Technologies, University of Warsaw Postdoctoral fellow Institute of Oncology Research (IOR) - An Institute affiliated to USI - Universit� della Svizzera italiana Post-doctoral Associate Yale University School of Medicine Senior Project Manager University of Glasgow Post-Doctoral Fellow Johns Hopkins University More Science jobs from Nature Reviews Molecular Cell Biology EVENT Single Cell Technologies and Analysis 21.07.18 Hinxton, UK More science events from
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Nature Index 2018 Japan Some of Japan's smallest institutions are among the most efficient in the production of high quality scientific research, though the decline in Japan's high quality scientific research output continues. This supplement examines reform efforts in light of the country's aim to become a "super-smart" society. Read the full supplement
REVIEWS		Top
Understanding the diversity of membrane lipid composition Takeshi Harayama & Howard Riezman p281 | doi:10.1038/nrm.2017.138 Membrane lipids exhibit a remarkable diversity — they vary in structure and chemical properties, and their distribution between different membranes and their subcompartments is highly heterogeneous. Recent progress in studies of membrane lipids has broadened our understanding of how this diversity affects membrane properties and membrane-associated processes. Abstract | Full Text | PDF | Supplementary information
Once and only once: mechanisms of centriole duplication and their deregulation in disease Erich A. Nigg & Andrew J. Holland p297 | doi:10.1038/nrm.2017.127 Most eukaryotic cells contain a single centrosome with a pair of centrioles, which duplicate before mitosis. Defects in duplication lead to aberrant numbers of centrioles and centrosomes. Recent insights into mechanisms of centriole biogenesis and centriole number control are helping us to better understand the links between aberrant centrosome number and human disease. Abstract | Full Text | PDF
Mechanisms of clathrin-mediated endocytosis Marko Kaksonen & Aurélien Roux p313 | doi:10.1038/nrm.2017.132 Clathrin-mediated endocytosis is the main mechanism for internalization of cell-surface molecules and surface-bound cargoes. Although the machineries that drive the formation of endocytic vesicle are intricate, an understanding of endocytosis is being unravelled at the molecular level. Abstract | Full Text | PDF
A brave new world of RNA-binding proteins Matthias W. Hentze, Alfredo Castello, Thomas Schwarzl & Thomas Preiss p327 | doi:10.1038/nrm.2017.130 Recent proteome-wide studies have uncovered hundreds of RNA-binding proteins (RBPs) that lack conventional RNA-binding domains. These RBPs instead use intrinsically disordered regions, protein-protein interaction interfaces and enzymatic cores to bind RNA. Interestingly, some RBPs are regulated by RNA rather than regulate RNA. Abstract | Full Text | PDF | Supplementary information
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