Nature Reviews Immunology Contents May 2018 Volume 18 Number 5 pp 289-356

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Advertisement Real time detection of neutrophil activation Discover a new method to assess neutrophil activation and oxidative burst with Agilent Seahorse XF technology. Simultaneous glycolytic (PER) and oxygen consumption (OCR) rate detection can dissect the interdependency of the two pathways that are required for neutrophil activation. Download the app note to learn more. TABLE OF CONTENTS May 2018 Volume 18, Issue 5 Comment Research Highlights Reviews   Advertisement nature.com webcasts Nature Research Custom presents a webcast on: Ultra-sensitive detection of interferon alpha protein in human disease by digital ELISA   Date: Tuesday, May 15, 2018   Darragh Duffy, Institut Pasteur, will address how digital ELISA enables direct qualification of IFNa protein in human samples. This webcast has been produced on behalf of the sponsor who retains sole responsibility for content   Register for FREE     Sponsored by: Quanterix   Advertisement Nature Roundtable: The Future of Medicine, 16 July, 2018 | Darmstadt, Germany In association with the Curious2018 - Future Insight Conference, Nature and Nature Medicine have invited outstanding researchers in academia and industry for a round table discussion of the most exciting scientific developments that are shaping the future of medicine. Discover more and apply for your free ticket.   Advertisement Do you have a career question? The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.  Listen today!   Comment   Discovering transcriptional signatures of disease for diagnosis versus mechanism    pp289 - 290 Julie G. Burel & Bjoern Peters doi:10.1038/nri.2018.26 Research Highlights   Mucosal immunology: Glucose not good for the gut    p291 Kirsty Minton doi:10.1038/nri.2018.22 Hyperglycaemia directly mediates dysfunction of the intestinal epithelial barrier in obesity, leading to increased translocation of microbial products. Germinal centres: An exit strategy for B cells    pp292 - 293 Kirsty Minton doi:10.1038/nri.2018.24 The ubiquitin ligase activity of CBL proteins controls the exit of B cells from the germinal centre to become plasma cells. Macrophages: Running on empty    pp292 - 293 Yvonne Bordon doi:10.1038/nri.2018.25 NRP1-deficient macrophages show impaired fatty acid oxidation. Allergy: An alarmin cut    p293 Lucy Bird doi:10.1038/nri.2018.23 Proteolytic cleavage of IL-33 by environmental allergens induces rapid induction of allergic type 2 inflammation. Immunometabolism: Itaconate helps KEAP1's cool    pp294 - 295 Grant Otto doi:10.1038/nri.2018.27 Itaconate alkylates KEAP1 to regulate NRF2 activity and induce an anti-inflammatory response in macrophages Journal Club Adaptive immunity by convergent evolution    p294 Jean-Laurent Casanova doi:10.1038/nri.2018.28 Jean-Laurent Casanova describes three papers by Max Cooper and colleagues that described the convergent evolution of adaptive immunity in jawless vertebrates. Influenza virus: Choose your enemies wisely    pp294 - 295 Yvonne Bordon doi:10.1038/nri.2018.30 Natural influenza virus infection in humans induces protective neuraminidase-reactive antibodies that are not induced by current influenza vaccines. Immunometabolism: Old drug, new trick    p295 Yvonne Bordon doi:10.1038/nri.2018.29 The immunomodulatory drug dimethyl fumarate blocks GAPDH and aerobic glycolysis in activated immune cells. Nature Reviews Immunology JOBS of the week Malaria Pathogenesis and Immunity Postdoctoral Scientist National Institute of Allergy and Infectious Diseases Executive Director, Brown Center for Immunotherapy Indiana University School of Medicine University Professor of Immunogerontology University of Innsbruck Postdoctoral Position - Immune Oncology H. Lee Moffitt Cancer & Research Institute Scientist I / II, Immunology Bioverativ More Science jobs from Nature Reviews Immunology EVENT Nutritional Immunology and the Microbiota: Rules of Engagement in Health and Disease 24.06.18 Leesburg, USA More science events from Reviews   Passive immunotherapy of viral infections: 'super-antibodies' enter the fray    pp297 - 308 Laura M. Walker & Dennis R. Burton doi:10.1038/nri.2017.148 So-called super-antibodies are highly potent, broadly reactive antiviral antibodies that offer promise for the treatment of various chronic and emerging viruses. This Review describes how recent technological advances led to their isolation from rare, infected individuals and their development for the prevention and treatment of various viral infections. NF-κB, inflammation, immunity and cancer: coming of age    pp309 - 324 Koji Taniguchi & Michael Karin doi:10.1038/nri.2017.142 Here, Koji Taniguchi and Michael Karin discuss the key roles of the nuclear factor-κB (NF-κB) transcription factor in cancer-related inflammation and consider the potential of targeting NF-κB in different types of cancer. HLA variation and disease    pp325 - 339 Calliope A. Dendrou, Jan Petersen, Jamie Rossjohn & Lars Fugger doi:10.1038/nri.2017.143 Technological advances have given valuable insight into the molecular mechanisms that underpin the association between HLA genetics and disease. Dendrou and colleagues review mechanisms of HLA–peptide–T cell receptor binding in health and disease and discuss how this knowledge may be translated into clinical benefit. Epigenetic control of CD8+ T cell differentiation    pp340 - 356 Amanda N. Henning, Rahul Roychoudhuri & Nicholas P. Restifo doi:10.1038/nri.2017.146 CD8+ T cell differentiation and function are regulated by epigenetic changes mainly including DNA methylation, histone modification and modification of chromatin architecture. As described here, a detailed understanding of these epigenetic mechanisms can be harnessed to improve T cell-based immunotherapies. Advertisement Searching for a new career?  At Nature Research we frequently recruit talented individuals to join our editorial and publishing teams. If you have a PhD and a passion for science this may be the perfect career for you. Visit our research editorial and publishing careers website to discover more about what we do    Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. 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