Nature Immunology Contents: May 2018 Volume 19 Issue 5

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Advertisement Read the latest science news from A*STAR, the Agency for Science, Technology and Research, Singapore's leading research organization Recent stories:  Immunology: Using a mouse to make an 'iMac'  Allergy: Clinging on to the memory  Infectious disease: Gut bacteria implicated in liver inflammation  Download the A*STAR Research App now!  TABLE OF CONTENTS May 2018 Volume 19, Issue 5 Comment News & Views Letters Articles   Advertisement Visualize and Quantify Cellular Interactions in the Tumor Microenvironment What would it mean to your research if you could accurately quantify cellular interactions in the tumor microenvironment? Download the eBook to learn how scientists are using the Phenoptics™ research solution to visualize, analyze, quantify and phenotype immune cells in situ, in FFPE tissue sections and TMAs. Download eBook    Advertisement Nature Roundtable: The Future of Medicine, 16 July, 2018 | Darmstadt, Germany In association with the Curious 2018 -Future Insight conference, Nature and Nature Medicine have invited outstanding researchers in academia and industry for a round table discussion of the most exciting scientific developments that are shaping the future of medicine. Discover more and apply for your free ticket.   Comment   Of mice, men and immunity: a case for evolutionary systems biology    pp421 - 425 Peter B. Ernst & Anne-Ruxandra Carvunis doi:10.1038/s41590-018-0084-4 Mice are generally the ‘go-to’ organism for modeling of the human immune system, but this often leads to inaccurate interpretations. Ernst and Carvunis argue in this Comment that taking into account the evolutionary and environmental context can generate better models of disease.   News & Views   Adaptive responses of innate lymphocytes    pp426 - 427 Carsten Watzl doi:10.1038/s41590-018-0088-0 Got my γδ17 T cells to keep me warm    pp427 - 429 Pedro H. Papotto & Bruno Silva-Santos doi:10.1038/s41590-018-0090-6 c-Maf in CD4+ T cells: it’s all about context    pp429 - 431 W. Nicholas Haining & Sarah A. Weiss doi:10.1038/s41590-018-0087-1 Traumatic meningeal injury and repair mechanisms    pp431 - 432 David J. Loane & Alan I. Faden doi:10.1038/s41590-018-0093-3 Hard-to-kill macrophages lead to chronic inflammation in HIV    pp433 - 434 Peter Kelleher & Xiao-Ning Xu doi:10.1038/s41590-018-0089-z Immunology JOBS of the week Malaria Pathogenesis and Immunity Postdoctoral Scientist National Institute of Allergy and Infectious Diseases Executive Director, Brown Center for Immunotherapy Indiana University School of Medicine University Professor of Immunogerontology University of Innsbruck Postdoctoral Position - Immune Oncology H. Lee Moffitt Cancer & Research Institute Scientist I / II, Immunology Bioverativ More Science jobs from Immunology EVENT Nutritional Immunology and the Microbiota: Rules of Engagement in Health and Disease 24.06.18 Leesburg, USA More science events from Advertisement Do you have a career question? The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.  Listen today!   Letters   Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling    pp1 - 7 Harald Lund, Melanie Pieber, Roham Parsa, David Grommisch, Ewoud Ewing et al. doi:10.1038/s41590-018-0091-5 Harris and colleagues show that the cytokine TGF-β is required for colonization of the microglial niche and maintenance of central nervous system integrity. Acute loss of TGF-β leads to proinflammatory responses and fatal demyelinating disease.   Advertisement nature.com webcasts Nature Research Custom presents a webcast on: Ultra-sensitive detection of interferon alpha protein in human disease by digital ELISA Date: Tuesday, May 15, 2018 Darragh Duffy, Institut Pasteur, will address how digital ELISA enables direct qualification of IFNa protein in human samples. This webcast has been produced on behalf of the sponsor who retains sole responsibility for content  Register for FREE Sponsored by: Quanterix   Articles   Distinct myeloid cell subsets promote meningeal remodeling and vascular repair after mild traumatic brain injury    pp442 - 452 Matthew V. Russo, Lawrence L. Latour & Dorian B. McGavern doi:10.1038/s41590-018-0086-2 Meningeal vascular damage accompanies mild traumatic brain injury, which persists in a fraction of patients. McGavern and colleagues report that distinct myeloid cell subsets are temporally recruited to the wound site during tissue repair; however, re-injury at early time points impairs recovery.   Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells    pp453 - 463 Quirin Hammer, Timo Rückert, Eva Maria Borst, Josefine Dunst, André Haubner et al. doi:10.1038/s41590-018-0082-6 NK cells constrain infection by cytomegalovirus. Romagnani and colleagues show that human NKG2C+ NK cells recognize distinct HCMV UL40 viral peptides, which can vary among viral isolates. NKG2C+ NK cells thereby demonstrate adaptive-like recognition that can discriminate between closely related viral strains.   γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis    pp464 - 474 Ayano C. Kohlgruber, Shani T. Gal-Oz, Nelson M. LaMarche, Moto Shimazaki, Danielle Duquette et al. doi:10.1038/s41590-018-0094-2 Lynch, Brenner and colleagues find that tissue-resident γδ T cells reside in adipose tissues in both mice and humans. These cells play essential roles in regulating thermogenesis and supporting age-dependent increases in adipose-tissue regulatory T cell populations.   Resistance of HIV-infected macrophages to CD8+ T lymphocyte–mediated killing drives activation of the immune system    pp475 - 486 Kiera L. Clayton, David R. Collins, Josh Lengieza, Musie Ghebremichael, Farokh Dotiwala et al. doi:10.1038/s41590-018-0085-3 Macrophages can be an important niche for chronic viral infection. Walker and colleagues demonstrate that macrophages are intrinsically resistant to CTL-mediated killing and can thereby contribute to the maintenance of HIV reservoirs and chronic inflammation.   Monomeric TCRs drive T cell antigen recognition    pp487 - 496 Mario Brameshuber, Florian Kellner, Benedikt K. Rossboth, Haisen Ta, Kevin Alge et al. doi:10.1038/s41590-018-0092-4 Higher-order TCRs have been postulated to maintain high antigen sensitivity and trigger signaling. Huppa and colleagues use various investigative techniques and find exclusively monomeric TCR–CD3 complexes that drive the recognition of antigenic pMHC.   c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells    pp497 - 507 Leona Gabryšová, Marisol Alvarez-Martinez, Raphaëlle Luisier, Luke S. Cox, Jan Sodenkamp et al. doi:10.1038/s41590-018-0083-5 The transcription factor c-Maf controls IL-10 production in T cells. O’Garra and colleagues use systems and in vivo functional analysis of T cell subsets to reveal distinct context-specific roles for c-Maf.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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