| | | Brief Communications Arising | | | | Unconventional superconductivity in magic-angle graphene superlattices
A superlattice consisting of two graphene sheets twisted relative to each other by a specific amount exhibits superconductivity when doped electrostatically, with a relatively high critical temperature.
Yuan Cao, Valla Fatemi, Shiang Fang et al. | The logic of single-cell projections from visual cortex
Tracing of projection neuron axons from the primary visual cortex to their targets shows that these neurons often project to multiple cortical areas of the mouse brain.
Yunyun Han, Justus M. Kebschull, Robert A. A. Campbell et al. | Evolved Cas9 variants with broad PAM compatibility and high DNA specificity
Phage-assisted continuous evolution of Cas9 variants with broad PAM compatibility and high DNA specificity that can be used for transcriptional activation, gene disruption and base editing.
Johnny H. Hu, Shannon M. Miller, Maarten H. Geurts et al. | Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes
Cryo-electron microscopy and biochemical analyses of the GATOR1 protein complex reveal that two binding modes underpin its ability to regulate Rag GTPases as a GTPase-activating protein for RAGA.
Kuang Shen, Rick K. Huang, Edward J. Brignole et al. | | A density cusp of quiescent X-ray binaries in the central parsec of the Galaxy
Observations of 12 X-ray binaries that contain black holes within the central parsec of the Galaxy suggest the existence of hundreds more, and even more isolated black holes.
Charles J. Hailey, Kaya Mori, Franz E. Bauer et al. | Quantized Majorana conductance
In a step towards topological quantum computation, a quantized Majorana conductance has been demonstrated for a semiconducting nanowire coupled to a superconductor.
Hao Zhang, Chun-Xiao Liu, Sasa Gazibegovic et al. | Correlated insulator behaviour at half-filling in magic-angle graphene superlattices
When the two graphene sheets in a van der Waals heterostructure are twisted relative to each other by a specific amount, Mott-like insulating phases are observed at half-filling.
Yuan Cao, Valla Fatemi, Ahmet Demir et al. | Room-temperature nine-µm-wavelength photodetectors and GHz-frequency heterodyne receivers
Quantum-well photodetectors fabricated from photonic metamaterials show enhanced room-temperature sensitivity to long-wavelength infrared radiation and produce gigahertz-frequency heterodyne signals when pumped with quantum cascade lasers.
Daniele Palaferri, Yanko Todorov, Azzurra Bigioli et al. | Molecular nucleation mechanisms and control strategies for crystal polymorph selection
Cryo-transmission electron microscopy reveals the initiation of glucose isomerase crystals and their growth into different crystalline or gel polymorphs, and shows that mutating specific amino acids controls which polymorph grows.
Alexander E. S. Van Driessche, Nani Van Gerven, Paul H. H. Bomans et al. | Climatic control of Mississippi River flood hazard amplified by river engineering
A suite of river discharge, tree-ring, sedimentary and climate data shows that the Mississippi’s flood magnitude has risen by about twenty per cent over the past half-century, largely owing to engineering works.
Samuel E. Munoz, Liviu Giosan, Matthew D. Therrell et al. | Shifts in tree functional composition amplify the response of forest biomass to climate
Forest inventory data from the 1980s and 2000s show the response of eastern USA forests to climate variability; direct effects of climate on forest biomass are amplified by changes in tree species composition.
Tao Zhang, Ülo Niinemets, Justin Sheffield et al. | A new class of synthetic retinoid antibiotics effective against bacterial persisters
Synthetic retinoid compounds can kill both growing and persister MRSA cells by disrupting the membrane lipid bilayer, and are effective in a mouse model of chronic MRSA infection.
Wooseong Kim, Wenpeng Zhu, Gabriel Lambert Hendricks et al. | Whole-organism clone tracing using single-cell sequencing
A single-cell sequencing method is developed that uses transcriptomics and CRISPR–Cas9 technology to investigate clonal relationships in cells present in different zebrafish tissues.
Anna Alemany, Maria Florescu, Chloé S. Baron et al. | Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
Treatment of lipopolysaccharide-activated macrophages with the cell-permeable itaconate derivative 4-octyl itaconate activates the anti-inflammatory transcription factor Nrf2 by alkylating key cysteine residues on the KEAP1 protein.
Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag et al. | Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis
Evolutionary coupling-enabled molecular replacement determination of the structure of Thermus thermophilus RodA reveals a highly conserved cavity in its transmembrane domain, and mutagenesis experiments in Bacillus subtilis and Escherichia coli show that perturbation of this cavity abolishes RodA function.
Megan Sjodt, Kelly Brock, Genevieve Dobihal et al. | Structure of the insulin receptor–insulin complex by single-particle cryo-EM analysis
Cryo-electron microscopy structures of insulin in a complex with the insulin receptor define the S2 binding site on the receptor and suggest a mechanism for downstream propagation of insulin signalling.
Giovanna Scapin, Venkata P. Dandey, Zhening Zhang et al. | Modular assembly of the nucleolar pre-60S ribosomal subunit
Cryo-electron microscopy structures of multiple states along the assembly pathway of the nucleolar pre-60S ribosomal subunit suggest that folding of the pre-ribosomal RNA and sequential binding of transient assembly factors are regulated by steric hindrance among these factors.
Zahra Assur Sanghai, Linamarie Miller, Kelly R. Molloy et al. | Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel
Structures of the voltage-gated and phosphatidylinositol 3,5-bisphosphate-activated mouse two-pore channel TPC1 in apo and ligand-bound states provide insights into the selectivity and gating mechanisms of mammalian two-pore channels.
Ji She, Jiangtao Guo, Qingfeng Chen et al. | | | | |
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