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| | 25 April 2018 | | | | Advertisement | nature.com webcasts Nature Research Custom presents a webcast on: Ultra-sensitive detection of interferon alpha protein in human disease by digital ELISA Date: Tuesday, May 15, 2018 Darragh Duffy, Institut Pasteur, will address how digital ELISA enables direct qualification of IFNa protein in human samples. This webcast has been produced on behalf of the sponsor who retains sole responsibility for content Register for FREE Sponsored by: Quanterix | | | | | | | Advertisement | | Nature Neuroscience: Poster on Cerebral Organoids Emerging three-dimensional culture methods enable differentiated human stem cells to form into brain organoids or assembloids, which can be used to study evolution, development, and disease. Available to download free online Produced with support from STEMCELL Technologies | | | | | | Latest Editorial | | | | Vaccines work OPEN | | 24 April 2018 | doi: 10.1038/s41467-018-04085-z | | | | | | | Latest Articles | View all Articles | | | Crystalline polymer nanofibers with ultra-high strength and thermal conductivity OPEN | | Ramesh Shrestha, Pengfei Li, Bikramjit Chatterjee, Teng Zheng, Xufei Wu, Zeyu Liu, Tengfei Luo, Sukwon Choi, Kedar Hippalgaonkar, Maarten P. de Boer & Sheng Shen | | Polymers compared to structural materials usually have low strength and thermal conductivity. Here the authors show a fabrication method to form bio-compatible crystalline polyethylene nanofibers that exhibit ultra-high strength, thermal conductivity and electrical insulation. | | 25 April 2018 | doi: 10.1038/s41467-018-03978-3 | | Nanowires Polymers | Structural basis for GPR40 allosteric agonism and incretin stimulation OPEN | | Joseph D. Ho , Betty Chau, Logan Rodgers, Frances Lu, Kelly L. Wilbur, Keith A. Otto, Yanyun Chen, Min Song, Jonathan P. Riley, Hsiu-Chiung Yang, Nichole A. Reynolds, Steven D. Kahl, Anjana Patel Lewis, Christopher Groshong, Russell E. Madsen, Kris Conners, Jayana P. Lineswala, Tarun Gheyi, Melbert-Brian Decipulo Saflor, Matthew R. Lee et al. | | GPR40 is a G-protein coupled receptor that binds to free fatty acids, mediating insulin and incretin secretion. Here, the authors present the crystal structure of human GPR40 with an agonist bound to an allosteric site located near the lipid-rich region that suggests a mechanism for biased agonism. | | 25 April 2018 | doi: 10.1038/s41467-017-01240-w | | Receptor pharmacology Type 2 diabetes X-ray crystallography | The multiple myeloma risk allele at 5q15 lowers ELL2 expression and increases ribosomal gene expression OPEN | | Mina Ali, Ram Ajore, Anna-Karin Wihlborg, Abhishek Niroula, Bhairavi Swaminathan, Ellinor Johnsson, Owen W Stephens, Gareth Morgan, Tobias Meissner, Ingemar Turesson, Hartmut Goldschmidt, Ulf-Henrik Mellqvist, Urban Gullberg, Markus Hansson, Kari Hemminki, Hareth Nahi, Anders Waage, Niels Weinhold & Björn Nilsson | | ELL2 was recently discovered as a susceptibility gene for multiple myeloma (MM). Here, they show that the MM risk allele lowers ELL2 expression in plasma cells, that it also upregulates gene sets related to ribosome biogenesis, and that one of the linked variants reduces binding of MAFF/G/K family transcription factors. | | 25 April 2018 | doi: 10.1038/s41467-018-04082-2 | | Cancer genetics Clinical genetics Myeloma Risk factors | Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment OPEN | | Claudia M. Wunderlich, P. Justus Ackermann, Anna Lena Ostermann, Petra Adams-Quack, Merly C. Vogt, My-Ly Tran, Alexei Nikolajev, Ari Waisman, Christoph Garbers, Sebastian Theurich, Jan Mauer, Nadine Hövelmeyer & F. Thomas Wunderlich | | Inflammation can be induced by obesity, and has been linked with onset of colorectal cancer (CAC). Here the authors show in mouse models that obesity-induced interleukin-6 alters macrophage function to enhance CCL-20/CCR-6-mediated recruitment of B cells and γδ T cells, thereby promoting gut inflammation and CAC progression. | | 25 April 2018 | doi: 10.1038/s41467-018-03773-0 | | Cancer microenvironment Chemokines Interleukins Tumour immunology | Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies OPEN | | Mette Boyd , Malte Thodberg, Morana Vitezic, Jette Bornholdt, Kristoffer Vitting-Seerup, Yun Chen, Mehmet Coskun, Yuan Li, Bobby Zhao Sheng Lo, Pia Klausen, Pawel Jan Schweiger, Anders Gorm Pedersen, Nicolas Rapin, Kerstin Skovgaard, Katja Dahlgaard, Robin Andersson, Thilde Bagger Terkelsen, Berit Lilje, Jesper Thorvald Troelsen, Andreas Munk Petersen et al. | | Many SNPs associated with inflammatory bowel disease are located in non-coding genomic regions. Here, the authors perform CAGE-sequencing on descending colon biopsies of Crohn’s disease and ulcerative colitis patients to map transcription start sites and enhancer activity for analysis of regulatory regions. | | 25 April 2018 | doi: 10.1038/s41467-018-03766-z | | Disease genetics Inflammatory bowel disease Transcriptional regulatory elements Transcriptomics | Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity OPEN | | Tanguy Le Marchand, Matteo de Rosa, Nicola Salvi, Benedetta Maria Sala, Loren B. Andreas, Emeline Barbet-Massin, Pietro Sormanni, Alberto Barbiroli, Riccardo Porcari, Cristiano Sousa Mota, Daniele de Sanctis, Martino Bolognesi, Lyndon Emsley, Vittorio Bellotti, Martin Blackledge, Carlo Camilloni, Guido Pintacuda & Stefano Ricagno | | The aggregation prone D76N beta-2 microglobulin mutant causes systemic amyloidosis. Here the authors combine crystallography, solid-state NMR, and computational studies and show that the D76N mutation increases protein dynamics and destabilizes the outer strands, which leads to an exposure of amyloidogenic parts explaining its aggregation propensity. | | 25 April 2018 | doi: 10.1038/s41467-018-04078-y | | Molecular modelling NMR spectroscopy Protein aggregation X-ray crystallography | Correlation of the Dzyaloshinskii–Moriya interaction with Heisenberg exchange and orbital asphericity OPEN | | Sanghoon Kim, Kohei Ueda, Gyungchoon Go, Peong-Hwa Jang, Kyung-Jin Lee, Abderrezak Belabbes, Aurelien Manchon, Motohiro Suzuki, Yoshinori Kotani, Tetsuya Nakamura, Kohji Nakamura, Tomohiro Koyama, Daichi Chiba, Kihiro. T. Yamada, Duck-Ho Kim, Takahiro Moriyama, Kab-Jin Kim & Teruo Ono | | Dzyaloshinskii–Moriya interaction (DMI) is one of the key factors to control the chiral spin textures in spintronic applications. Here the authors demonstrate the correlation of the DMI with the anisotropy of the orbital magnetic moment and magnetic dipole moment in Pt/Co/MgO ultrathin trilayers. | | 25 April 2018 | doi: 10.1038/s41467-018-04017-x | | Ferromagnetism Spintronics | Exercise induces new cardiomyocyte generation in the adult mammalian heart OPEN | | Ana Vujic, Carolin Lerchenmüller, Ting-Di Wu, Christelle Guillermier, Charles P. Rabolli, Emilia Gonzalez, Samuel E. Senyo, Xiaojun Liu, Jean-Luc Guerquin-Kern, Matthew L. Steinhauser, Richard T. Lee & Anthony Rosenzweig | | The adult mammalian heart has a limited cardiomyogenic capacity. Here the authors show that intensive exercise leads to a 4.6-fold increase in murine cardiomyocyte proliferation requiring the expression of miR-222, and that exercise induces an extended cardiomyogenic response in the murine heart after infarction. | | 25 April 2018 | doi: 10.1038/s41467-018-04083-1 | | Cardiac regeneration Cell division | A phase transformable ultrastable titanium-carboxylate framework for photoconduction OPEN | | Sujing Wang, Takashi Kitao, Nathalie Guillou, Mohammad Wahiduzzaman, Charlotte Martineau-Corcos, Farid Nouar, Antoine Tissot, Laurent Binet, Naseem Ramsahye, Sabine Devautour-Vinot, Susumu Kitagawa, Shu Seki, Yusuke Tsutsui, Valérie Briois, Nathalie Steunou, Guillaume Maurin, Takashi Uemura & Christian Serre | | Porous TiO2 materials are attractive for energy-related applications owing to their accessible active sites, but suffer from poor stability. Here the authors synthesize a highly stable and porous metal–organic framework containing polymeric 1D Ti–O subunits, which displays a high condensation degree and high photoconductivity. | | 25 April 2018 | doi: 10.1038/s41467-018-04034-w | | Electronic devices Metal–organic frameworks Nanowires Porous materials | Demographic causes of adult sex ratio variation and their consequences for parental cooperation OPEN | | Luke J. Eberhart-Phillips, Clemens Küpper, María Cristina Carmona-Isunza, Orsolya Vincze, Sama Zefania, Medardo Cruz-López, András Kosztolányi, Tom E. X. Miller, Zoltán Barta, Innes C. Cuthill, Terry Burke, Tamás Székely, Joseph I. Hoffman & Oliver Krüger | | Biases in adult sex ratio (ASR) are common, yet their causes and consequences are not well understood. Here, the authors analyse data from >6000 individuals of five shorebird species, showing that sex differences in juvenile survival drive ASR variation and biased ASR is associated with uniparental care. | | 25 April 2018 | doi: 10.1038/s41467-018-03833-5 | | Behavioural ecology Population dynamics Sexual selection | Dissociation of two-dimensional excitons in monolayer WSe2 OPEN | | Mathieu Massicotte, Fabien Vialla, Peter Schmidt, Mark B. Lundeberg, Simone Latini, Sten Haastrup, Mark Danovich, Diana Davydovskaya, Kenji Watanabe, Takashi Taniguchi, Vladimir I. Fal’ko, Kristian S. Thygesen, Thomas G. Pedersen & Frank H. L. Koppens | | In two-dimensional semiconductors excitons are strongly bound, suppressing the creation of free carriers. Here, the authors investigate the main exciton dissociation pathway in p-n junctions of monolayer WSe2 by means of time and spectrally resolved photocurrent measurements. | | 24 April 2018 | doi: 10.1038/s41467-018-03864-y | | Optical properties and devices Two-dimensional materials | Control of mechanical pain hypersensitivity in mice through ligand-targeted photoablation of TrkB-positive sensory neurons OPEN | | Rahul Dhandapani, Cynthia Mary Arokiaraj, Francisco J. Taberner, Paola Pacifico, Sruthi Raja, Linda Nocchi, Carla Portulano, Federica Franciosa, Mariano Maffei, Ahmad Fawzi Hussain, Fernanda de Castro Reis, Luc Reymond, Emerald Perlas, Simone Garcovich, Stefan Barth, Kai Johnsson, Stefan G. Lechner & Paul A. Heppenstall | | There are several classes of sensory neuron that contribute to pain states. Here, the authors demonstrate that TrkB+ sensory neurons detect light touch under normal conditions in mice but contribute to hypersensitivity in models of chronic pain, and that ligand-guided laser ablation of TrkB+ sensory neurons in the mouse skin attenuates this hypersensitivity. | | 24 April 2018 | doi: 10.1038/s41467-018-04049-3 | | Chronic pain Sensory processing | Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease OPEN | | Connor A. Emdin , Amit V. Khera, Mark Chaffin, Derek Klarin, Pradeep Natarajan, Krishna Aragam, Mary Haas, Alexander Bick, Seyedeh M. Zekavat, Akihiro Nomura, Diego Ardissino, James G. Wilson, Heribert Schunkert, Ruth McPherson, Hugh Watkins, Roberto Elosua, Matthew J. Bown, Nilesh J. Samani, Usman Baber, Jeanette Erdmann et al. | | Examination of predicted loss-of-function (pLOF) genetic variants allows direct identification of genes with therapeutic potential. Here, Emdin et al. perform association analysis for 3759 pLOF variants with 24 traits and highlight protective variants against cardiometabolic and immune phenotypes. | | 24 April 2018 | doi: 10.1038/s41467-018-03911-8 | | Genetic association study Genetic predisposition to disease Medical genomics Rare variants | A serum microRNA signature predicts trastuzumab benefit in HER2-positive metastatic breast cancer patients OPEN | | Huiping Li, Jiang Liu, Jianing Chen, Huiyun Wang, Linbin Yang, Fei Chen, Siting Fan, Jing Wang, Bin Shao, Dong Yin, Musheng Zeng, Mengfeng Li, Jun Li, Fengxi Su, Qiang Liu, Herui Yao, Shicheng Su & Erwei Song | | Resistance to therapy is a significant issue for patients with metastatic breast cancer (MBC). Here the authors analyze total miRNA from serum samples of 386 MBC patients before treatment with a follow up of 31 months and define a four miRNA signature that predicts the therapeutic benefit of trastuzumab. | | 24 April 2018 | doi: 10.1038/s41467-018-03537-w | | Breast cancer Cancer therapeutic resistance Tumour biomarkers | Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques OPEN | | Diogo M. Magnani , Thomas F. Rogers, Nicholas J. Maness, Nathan D. Grubaugh, Nathan Beutler, Varian K. Bailey, Lucas Gonzalez-Nieto, Martin J. Gutman, Núria Pedreño-Lopez, Jaclyn M. Kwal, Michael J. Ricciardi, Tereance A. Myers, Justin G. Julander, Rudolf P. Bohm, Margaret H. Gilbert, Faith Schiro, Pyone P. Aye, Robert V. Blair, Mauricio A. Martins, Kathrine P. Falkenstein et al. | | Zika virus (ZIKV) infection in pregnant women has been associated with fetal developmental defects. Here, the authors show that a Brazilian ZIKV isolate causes fetal demise in non-human primates and that antibody treatment at time of peak viremia is insufficient to clear ZIKV replication from amniotic fluid. | | 24 April 2018 | doi: 10.1038/s41467-018-04056-4 | | Antibody therapy Viral infection Viral pathogenesis | Epigenetic landscape influences the liver cancer genome architecture OPEN | | Natsuko Hama, Yasushi Totoki, Fumihito Miura, Kenji Tatsuno, Mihoko Saito-Adachi, Hiromi Nakamura, Yasuhito Arai, Fumie Hosoda, Tomoko Urushidate, Shoko Ohashi, Wakako Mukai, Nobuyoshi Hiraoka, Hiroyuki Aburatani, Takashi Ito & Tatsuhiro Shibata | | Genomic aberrations contribute to the development of cancer; however, their interdependence remains poorly understood. Here the authors analyze liver cancer samples to find correlation between epigenetic features and genetic aberrations including somatic substitutions, mutation signatures, and HBV integration sites. | | 24 April 2018 | doi: 10.1038/s41467-018-03999-y | | Cancer genomics Hepatocellular carcinoma | Galectin-3 deficiency drives lupus-like disease by promoting spontaneous germinal centers formation via IFN-γ OPEN | | Cristian Gabriel Beccaria, María Carolina Amezcua Vesely, Facundo Fiocca Vernengo, Ricardo Carlos Gehrau, María Cecilia Ramello, Jimena Tosello Boari, Melisa Gorosito Serrán, Juan Mucci, Eliane Piaggio, Oscar Campetella, Eva Virginia Acosta Rodríguez, Carolina Lucía Montes & Adriana Gruppi | | Germinal center (GC) is where B cells interact with other immune cells for optimal induction of antibody responses. Here the authors show that galectin-3 regulates GC development by modulating interferon-γ and B cell-intrinsic signaling, such that galectin-3 deficiency mice exhibit lupus-like autoimmune symptoms. | | 24 April 2018 | doi: 10.1038/s41467-018-04063-5 | | Autoimmunity Follicular B cells Germinal centres Interferons | Precisely printable and biocompatible silk fibroin bioink for digital light processing 3D printing OPEN | | Soon Hee Kim, Yeung Kyu Yeon, Jung Min Lee, Janet Ren Chao, Young Jin Lee, Ye Been Seo, Md. Tipu Sultan, Ok Joo Lee, Ji Seung Lee, Sung-il Yoon, In-Sun Hong, Gilson Khang, Sang Jin Lee, James J. Yoo & Chan Hum Park | | Although 3D bioprinting technology has gained much attention in the field of tissue engineering, there are still several significant challenges that need to be overcome. Here, the authors present silk fibroin bioink with printability and biocompatibility suited for digital light processing 3D printing. | | 24 April 2018 | doi: 10.1038/s41467-018-03759-y | | Biomaterials – cells Tissue engineering | Molecular doping enabled scalable blading of efficient hole-transport-layer-free perovskite solar cells OPEN | | Wu-Qiang Wu, Qi Wang, Yanjun Fang, Yuchuan Shao, Shi Tang, Yehao Deng, Haidong Lu, Ye Liu, Tao Li, Zhibin Yang, Alexei Gruverman & Jinsong Huang | | The existing hole-transporting materials cause problems in the cost and scalability of the perovskite solar cells. Here Wu et al. fabricate high efficiency cells by molecularly doping the perovskite layer without using hole-transporting layers, thus simplify the device architecture and processing steps. | | 24 April 2018 | doi: 10.1038/s41467-018-04028-8 | | Devices for energy harvesting Electrical and electronic engineering Electronic devices | Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of Japanese OPEN | | Yukinori Okada, Yukihide Momozawa, Saori Sakaue, Masahiro Kanai, Kazuyoshi Ishigaki, Masato Akiyama, Toshihiro Kishikawa, Yasumichi Arai, Takashi Sasaki, Kenjiro Kosaki, Makoto Suematsu, Koichi Matsuda, Kazuhiko Yamamoto, Michiaki Kubo, Nobuyoshi Hirose & Yoichiro Kamatani | | Recent natural selection left signals in human genomes. Here, Okada et al. generate high-depth whole-genome sequence (WGS) data (25.9×) from 2,234 Japanese people of the BioBank Japan Project (BBJ), and identify signals of recent natural selection which overlap variants associated with human traits. | | 24 April 2018 | doi: 10.1038/s41467-018-03274-0 | | Evolutionary biology Next-generation sequencing Population genetics | The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia OPEN | | Akihiko Numata, Hui Si Kwok, Akira Kawasaki, Jia Li, Qi-Ling Zhou, Jon Kerry, Touati Benoukraf, Deepak Bararia, Feng Li, Erica Ballabio, Marta Tapia, Aniruddha J. Deshpande, Robert S. Welner, Ruud Delwel, Henry Yang, Thomas A. Milne, Reshma Taneja & Daniel G. Tenen | | Gene fusions involving MLL and different partner genes define unique subgroups of acute myelogenous leukemia, but the mechanisms underlying specific subgroups are not fully clear. Here the authors elucidate the mechanisms of MLL-AF6 induced transformation, providing a distinct pathway that involves SHARP1 as a critical target. | | 24 April 2018 | doi: 10.1038/s41467-018-03854-0 | | Acute myeloid leukaemia Cancer stem cells | Medical relevance of protein-truncating variants across 337,205 individuals in the UK Biobank study OPEN | | Christopher DeBoever, Yosuke Tanigawa, Malene E. Lindholm, Greg McInnes, Adam Lavertu, Erik Ingelsson, Chris Chang, Euan A. Ashley, Carlos D. Bustamante, Mark J. Daly & Manuel A. Rivas | | Protein-truncating variants (PTVs) are predicted to significantly affect a gene’s function and, thus, human traits. Here, DeBoever et al. systematically analyze PTVs in more than 300,000 individuals across 135 phenotypes and identify 27 associations between PTVs and medical conditions. | | 24 April 2018 | doi: 10.1038/s41467-018-03910-9 | | Genetic predisposition to disease Genome-wide association studies Medical genomics Rare variants | Feed-forward alpha particle radiotherapy ablates androgen receptor-addicted prostate cancer OPEN | | Michael R. McDevitt, Daniel L. J. Thorek, Takeshi Hashimoto, Tatsuo Gondo, Darren R. Veach, Sai Kiran Sharma, Teja Muralidhar Kalidindi, Diane S. Abou, Philip A. Watson, Bradley J. Beattie, Oskar Vilhemsson Timmermand, Sven-Erik Strand, Jason S. Lewis, Peter T. Scardino, Howard I. Scher, Hans Lilja, Steven M. Larson & David Ulmert | | Radionuclides that emit alpha particles (charged helium nuclei) are currently used clinically to treat cancers including prostate cancer. Here, the authors combine a humanized antibody to an alpha particle emitter, specifically to target a downstream effector of the androgen receptor and create a feed forward loop that increases the therapeutic efficacy. | | 24 April 2018 | doi: 10.1038/s41467-018-04107-w | | Cancer Prostate cancer Radiotherapy Targeted therapies | The Gastrodia elata genome provides insights into plant adaptation to heterotrophy OPEN | | Yuan Yuan , Xiaohua Jin, Juan Liu, Xing Zhao, Junhui Zhou, Xin Wang, Deyi Wang, Changjiangsheng Lai, Wei Xu, Jingwen Huang, Liangping Zha, Dahui Liu, Xiao Ma, Li Wang, Menyan Zhou, Zhi Jiang, Hubiao Meng, Huasheng Peng, Yuting Liang, Ruiqiang Li et al. | | Gastrodia elata is an obligate mycoheterotrophic plant with highly reduced leaves and bracts in scape. Here, Yuan et al sequence and analyze its 1.06 Gb genome which provides insights in adaptation to a lifestyle of heterotrophy. | | 24 April 2018 | doi: 10.1038/s41467-018-03423-5 | | Genome Genomic analysis Plant symbiosis | Vibrio vulnificus quorum-sensing molecule cyclo(Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity OPEN | | Wooseong Lee, Seung-Hoon Lee, Minwoo Kim, Jae-Su Moon, Geon-Woo Kim, Hae-Gwang Jung, In Hwang Kim, Ji Eun Oh, Hi Eun Jung, Heung Kyu Lee, Keun Bon Ku, Dae-Gyun Ahn, Seong-Jun Kim, Kun-Soo Kim & Jong-Won Oh | | Quorum sensing signaling molecules are known to be critical determinants in bacterial pathogenesis. Here the authors show the quorum sensing molecule cFP from Vibrio vulnificus inhibits the RIG-I mediated antiviral interferon response and enhances susceptibility to viral infection. | | 23 April 2018 | doi: 10.1038/s41467-018-04075-1 | | Bacterial host response Hepatitis C virus Molecular medicine Viral host response | The IL-33-PIN1-IRAK-M axis is critical for type 2 immunity in IL-33-induced allergic airway inflammation OPEN | | Morris Nechama, Jeahoo Kwon, Shuo Wei, Adrian Tun Kyi, Robert S. Welner, Iddo Z. Ben-Dov, Mohamed S. Arredouani, John M. Asara, Chun-Hau Chen, Cheng-Yu Tsai, Kyle F. Nelson, Koichi S Kobayashi, Elliot Israel, Xiao Zhen Zhou, Linda K. Nicholson & Kun Ping Lu | | IL-33 orchestrates type 2 immunity in allergic asthma. Here the authors show, using biochemical, structural and patient data, that upon IL-33 or allergic challenge, the isomerase Pin1 modifies IRAK-M to control the production of pro-inflammatory cytokines in the setting of airway inflammation. | | 23 April 2018 | doi: 10.1038/s41467-018-03886-6 | | Antibodies Chronic inflammation Inflammatory diseases Interleukins | High spectral resolution of gamma-rays at room temperature by perovskite CsPbBr3 single crystals OPEN | | Yihui He, Liviu Matei, Hee Joon Jung, Kyle M. McCall, Michelle Chen, Constantinos C. Stoumpos, Zhifu Liu, John A. Peters, Duck Young Chung, Bruce W. Wessels, Michael R. Wasielewski, Vinayak P. Dravid, Arnold Burger & Mercouri G. Kanatzidis | | Detection and spectroscopic measurements of gamma-ray used to rely on expensive materials such as CdZnTe crystals. Here He et al. develop a melt method to grow large size CsPbBr3 perovskite crystals and the devices achieve low cost, high energy resolving capabilities and stability. | | 23 April 2018 | doi: 10.1038/s41467-018-04073-3 | | Engineering Materials science Optics and photonics | A mobile endocytic network connects clathrin-independent receptor endocytosis to recycling and promotes T cell activation OPEN | | Ewoud B. Compeer, Felix Kraus, Manuela Ecker, Gregory Redpath, Mayan Amiezer, Nils Rother, Philip R. Nicovich, Natasha Kapoor-Kaushik, Qiji Deng, Guerric P. B. Samson, Zhengmin Yang, Jieqiong Lou, Michael Carnell, Haig Vartoukian, Katharina Gaus & Jérémie Rossy | | Endocytosis of T cell receptors (TCR) and their polarized recycling back to the plasma membrane is crucial for T cell activation; however, the underlying mechanisms remain unclear. Here the authors follow TCR and show that a mobile endocytic network connects clathrin-independent receptor endocytosis to recycling which is required for T cell activation. | | 23 April 2018 | doi: 10.1038/s41467-018-04088-w | | Cell signalling Endosomes Imaging the immune system | Evidence for prevalent Z=6 magic number in neutron-rich carbon isotopes OPEN | | D. T. Tran , H. J. Ong, G. Hagen, T. D. Morris, N. Aoi, T. Suzuki, Y. Kanada-En’yo, L. S. Geng, S. Terashima, I. Tanihata, T. T. Nguyen, Y. Ayyad, P. Y. Chan, M. Fukuda, H. Geissel, M. N. Harakeh, T. Hashimoto, T. H. Hoang, E. Ideguchi, A. Inoue et al. | | Magic numbers are associated with the stability of atomic nuclei. Here, the authors analyse the proton radii, binding energies and electric quadrupole transition rates of neutron-rich carbon isotopes at proton number six and use nuclear structure models to support the magic number Z = 6. | | 23 April 2018 | doi: 10.1038/s41467-018-04024-y | | Experimental nuclear physics Theoretical nuclear physics | Perovskite seeding growth of formamidinium-lead-iodide-based perovskites for efficient and stable solar cells OPEN | | Yicheng Zhao, Hairen Tan, Haifeng Yuan, Zhenyu Yang, James Z. Fan, Junghwan Kim, Oleksandr Voznyy, Xiwen Gong, Li Na Quan, Chih Shan Tan, Johan Hofkens, Dapeng Yu, Qing Zhao & Edward H. Sargent | | Formamidinium-lead-iodide-based perovskites have a preferred bandgap below 1.55 eV for solar cell applications but suffer from operational instability. Here, Zhao et al. improve the film quality using cesium-containing seeded growth to show high stabilized efficiency and more than 100 h lifetime under simulated sunlight. | | 23 April 2018 | doi: 10.1038/s41467-018-04029-7 | | Energy Solar cells | Targeting GLP-1 receptor trafficking to improve agonist efficacy OPEN | | Ben Jones , Teresa Buenaventura, Nisha Kanda, Pauline Chabosseau, Bryn M. Owen, Rebecca Scott, Robert Goldin, Napat Angkathunyakul, Ivan R. Corrêa Jr, Domenico Bosco, Paul R. Johnson, Lorenzo Piemonti, Piero Marchetti, A. M. James Shapiro, Blake J. Cochran, Aylin C. Hanyaloglu, Asuka Inoue, Tricia Tan, Guy A. Rutter, Alejandra Tomas et al. | | Glucagon-like peptide-1 receptor (GLP-1R) promotes insulin secretion from pancreatic beta cells and undergoes agonist-mediated endocytosis. Here, authors study GLP-1R endocytosis caused by different agonists and show that a longer plasma membrane retention time of GLP-1R results in greater long-term insulin release. | | 23 April 2018 | doi: 10.1038/s41467-018-03941-2 | | Membrane trafficking Receptor pharmacology | Tamoxifen-resistant breast cancer cells are resistant to DNA-damaging chemotherapy because of upregulated BARD1 and BRCA1 OPEN | | Yinghua Zhu, Yujie Liu, Chao Zhang, Junjun Chu, Yanqing Wu, Yudong Li, Jieqiong Liu, Qian Li, Shunying Li, Qianfeng Shi, Liang Jin, Jianli Zhao, Dong Yin, Sol Efroni, Fengxi Su, Herui Yao, Erwei Song & Qiang Liu | | Most breast cancer patients are estrogen receptor positive and thus benefit from treatments that inhibit estrogen production; however, one third of tamoxifen-treated patients develops resistance and relapse. Here the authors show that tamoxifen resistant cells are resistant to chemotherapy because of BARD1 and BRCA1 upregulation. | | 23 April 2018 | doi: 10.1038/s41467-018-03951-0 | | Biological sciences Breast cancer Cancer therapeutic resistance | High-order coherent communications using mode-locked dark-pulse Kerr combs from microresonators OPEN | | Attila Fülöp, Mikael Mazur, Abel Lorences-Riesgo, Óskar B. Helgason, Pei-Hsun Wang, Yi Xuan, Dan E. Leaird, Minghao Qi, Peter A. Andrekson, Andrew M. Weiner & Victor Torres-Company | | Dark-pulse combs may be useful for coherent communications since they display high power conversion efficiency. Here, the authors report the first demonstration of coherent wavelength division multiplexing using dark pulse microresonator combs high signal-to-noise while maintaining a low on-chip pump power. | | 23 April 2018 | doi: 10.1038/s41467-018-04046-6 | | Fibre optics and optical communications Frequency combs Microresonators Nonlinear optics | Mechanically interlocked functionalization of monoclonal antibodies OPEN | | Krzysztof P. Bzymek, James W. Puckett, Cindy Zer, Jun Xie, Yuelong Ma, Jeremy D. King, Leah H. Goodstein, Kendra N. Avery, David Colcher, Gagandeep Singh, David A. Horne & John C. Williams | | Meditope-Fab is a peptide-antibody complex potentially useful for drug delivery and diagnostic, but a short half-life prevents its use in vivo. Here the authors engineer the complex to improve its stability, create functionalized antibodies by click chemistry and use them for in vivo tumor imaging. | | 20 April 2018 | doi: 10.1038/s41467-018-03976-5 | | Biotechnology Chemical biology | Improving wood properties for wood utilization through multi-omics integration in lignin biosynthesis OPEN | | Jack P. Wang , Megan L. Matthews, Cranos M. Williams, Rui Shi, Chenmin Yang, Sermsawat Tunlaya-Anukit, Hsi-Chuan Chen, Quanzi Li, Jie Liu, Chien-Yuan Lin, Punith Naik, Ying-Hsuan Sun, Philip L. Loziuk, Ting-Feng Yeh, Hoon Kim, Erica Gjersing, Todd Shollenberger, Christopher M. Shuford, Jina Song, Zachary Miller et al. | | A systematic analysis of lignin biosynthetic genes to quantitatively understand their effect on wood properties is still lacking. Here, the authors integrate transcriptomic, proteomic, fluxomic and phenomic data to quantify the impact of perturbations of transcript abundance on lignin biosynthesis and wood properties. | | 20 April 2018 | doi: 10.1038/s41467-018-03863-z | | Genetic engineering Molecular engineering in plants Secondary metabolism | Inducing skyrmions in ultrathin Fe films by hydrogen exposure OPEN | | Pin-Jui Hsu, Levente Rózsa, Aurore Finco, Lorenz Schmidt, Krisztián Palotás, Elena Vedmedenko, László Udvardi, László Szunyogh, André Kubetzka, Kirsten von Bergmann & Roland Wiesendanger | | Stabilization of skyrmions is one of the key issues in skyrmion-based spintronics. Here the authors demonstrate that hydrogenation can induce the formation of skyrmions in iron thin films, which provides an alternative way to tailor skyrmion states in low-dimensional magnetic materials. | | 20 April 2018 | doi: 10.1038/s41467-018-04015-z | | Materials science Nanoscience and technology Physics | The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma OPEN | | Zhe Li, Jiwei Zhang, Xinyang Liu, Shengli Li, Qifeng Wang, Di Chen, Zhixiang Hu, Tao Yu, Jie Ding, Jinjun Li, Ming Yao, Jia Fan, Shenglin Huang, Qiang Gao, Yingjun Zhao & Xianghuo He | | Long intergenic non-coding RNAs have been linked to cancer development. Here the authors, using RNA-seq and genomic amplification data, identify lincRNAs deregulated in hepatocellular carcinoma and propose that Linc01138 is stabilized by IGF2BP1/3 in the cytoplasm, and binds and stabilizes the methyltransferase PRMT5 by preventing the association of PRMT5 to the E3 ubiquitin ligase CHIP. | | 20 April 2018 | doi: 10.1038/s41467-018-04006-0 | | Oncogenes Tumour biomarkers | Culturing of female bladder bacteria reveals an interconnected urogenital microbiota OPEN | | Krystal Thomas-White, Samuel C. Forster, Nitin Kumar, Michelle Van Kuiken, Catherine Putonti, Mark D. Stares, Evann E. Hilt, Travis K. Price, Alan J. Wolfe & Trevor D. Lawley | | The female bladder seems to harbor a poorly characterized indigenous microbiota. Here, the authors isolate and genome-sequence 149 bacterial strains from catheterized urine of 77 women, generating a culture collection representing two thirds of the bacterial diversity within the samples. | | 19 April 2018 | doi: 10.1038/s41467-018-03968-5 | | Bacterial genetics Bladder Metagenomics Microbiome | Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target OPEN | | Olli Dufva , Matti Kankainen, Tiina Kelkka, Nodoka Sekiguchi, Shady Adnan Awad, Samuli Eldfors, Bhagwan Yadav, Heikki Kuusanmäki, Disha Malani, Emma I Andersson, Paavo Pietarinen, Leena Saikko, Panu E. Kovanen, Teija Ojala, Dean A. Lee, Thomas P. Loughran Jr., Hideyuki Nakazawa, Junji Suzumiya, Ritsuro Suzuki, Young Hyeh Ko et al. | | Aggressive natural killer-cell leukemia (ANKL) has few targeted therapies. Here ANKL patients are reported to harbor STAT3, RAS-MAPK pathway, DDX3X and epigenetic modifier mutations; and drug sensitivity profiling uncovers the importance of the JAK-STAT pathway, revealing potential ANKL therapeutic targets. | | 19 April 2018 | doi: 10.1038/s41467-018-03987-2 | | Cancer genomics High-throughput screening Leukaemia | A proteomics landscape of circadian clock in mouse liver OPEN | | Yunzhi Wang, Lei Song, Mingwei Liu, Rui Ge, Quan Zhou, Wanlin Liu, Ruiyang Li, Jingbo Qie, Bei Zhen, Yi Wang, Fuchu He, Jun Qin & Chen Ding | | As a circadian organ, liver functions are regulated by circadian clock. Here, the authors present a comprehensive proteomics landscape of the mouse liver, including transcription factor binding profiles, phosphorylation and ubiquitylation patterns, nuclear and whole proteome, and the transcriptome. | | 19 April 2018 | doi: 10.1038/s41467-018-03898-2 | | Physiology Post-translational modifications Proteomics Transcriptomics | Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival OPEN | | Megumi Shiota , Masayuki Naya, Takehiro Yamamoto, Takako Hishiki, Takeharu Tani, Hiroyuki Takahashi, Akiko Kubo, Daisuke Koike, Mai Itoh, Mitsuyo Ohmura, Yasuaki Kabe, Yuki Sugiura, Nobuyoshi Hiraoka, Takayuki Morikawa, Keiyo Takubo, Kentaro Suina, Hideaki Nagashima, Oltea Sampetrean, Osamu Nagano, Hideyuki Saya et al. | | Surface-enhanced Raman spectroscopy (SERS) visualizes fingerprints of intermolecular vibrations of many metabolites. Here the authors report a SERS imaging technique that enables the visualization of metabolites distribution and automated extraction of tumour boundaries in frozen tissues. | | 19 April 2018 | doi: 10.1038/s41467-018-03899-1 | | Cancer metabolism Molecular medicine | Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch OPEN | | Yohei Abe, Yosuke Fujiwara, Hiroki Takahashi, Yoshihiro Matsumura, Tomonobu Sawada, Shuying Jiang, Ryo Nakaki, Aoi Uchida, Noriko Nagao, Makoto Naito, Shingo Kajimura, Hiroshi Kimura, Timothy F. Osborne, Hiroyuki Aburatani, Tatsuhiko Kodama, Takeshi Inagaki & Juro Sakai | | JMJD1A is essential for thermogenic gene induction in brown adipose tissue. Here the authors show that white adipose tissue beige-ing requires both β-adrenergic-dependent phosphorylation of S265 and demethylation activity of JMJD1A while brown adipose tissue-driven thermogenesis requires β-adrenergic dependent phosphorylation of S265 but is independent of H3K9me2 demethylation. | | 19 April 2018 | doi: 10.1038/s41467-018-03868-8 | | Fat metabolism Phosphorylation | Reduced oxidative capacity in macrophages results in systemic insulin resistance OPEN | | Saet-Byel Jung, Min Jeong Choi, Dongryeol Ryu, Hyon-Seung Yi, Seong Eun Lee, Joon Young Chang, Hyo Kyun Chung, Yong Kyung Kim, Seul Gi Kang, Ju Hee Lee, Koon Soon Kim, Hyun Jin Kim, Cuk-Seong Kim, Chul-Ho Lee, Robert W. Williams, Hail Kim, Heung Kyu Lee, Johan Auwerx & Minho Shong | | M1-like polarization of macrophages is thought to control adipose inflammation and associated insulin resistance and metabolic syndrome. Here the authors show that macrophage-specific deletion of the OxPhos-related gene Crif1 results in an M1-like phenotype in mice, and that the effects can be reversed by recombinant GDF15. | | 19 April 2018 | doi: 10.1038/s41467-018-03998-z | | Chronic inflammation Metabolic syndrome Obesity Type 2 diabetes | How high energy fluxes may affect Rayleigh–Taylor instability growth in young supernova remnants OPEN | | C. C. Kuranz , H.-S. Park, C. M. Huntington, A. R. Miles, B. A. Remington, T. Plewa, M. R. Trantham, H. F. Robey, D. Shvarts, A. Shimony, K. Raman, S. MacLaren, W. C. Wan, F. W. Doss, J. Kline, K. A. Flippo, G. Malamud, T. A. Handy, S. Prisbrey, C. M. Krauland et al. | | Radiation and conduction are generally considered as the main energy transport mechanisms for the evolution of early supernova remnants. Here the authors experimentally show the role of electron heat transfer on the growth of Rayleigh–Taylor instability in young supernova remnants. | | 19 April 2018 | doi: 10.1038/s41467-018-03548-7 | | Astronomy and planetary science Laser-produced plasmas | Evolutionary plasticity of the NHL domain underlies distinct solutions to RNA recognition OPEN | | Pooja Kumari, Florian Aeschimann, Dimos Gaidatzis, Jeremy J. Keusch, Pritha Ghosh, Anca Neagu, Katarzyna Pachulska-Wieczorek, Janusz M. Bujnicki, Heinz Gut, Helge Großhans & Rafal Ciosk | | The C. elegans LIN-41 and its homologs, including human TRIM71/LIN41, contain the RNA binding NHL domain. Here the authors combine computational analysis, structural biology and in vivo studies, to explain how these proteins bind RNA and how rapid evolution of NHL domains resulted in different solutions to RNA recognition. | | 19 April 2018 | doi: 10.1038/s41467-018-03920-7 | | Computational biology and bioinformatics RNA X-ray crystallography | | | | | | Latest Author Correction | | | | | | | | Latest Publisher Corrections | | | | Publisher Correction: Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning OPEN | | Matthias Weider , Laura Julia Starost, Katharina Groll, Melanie Küspert, Elisabeth Sock, Miriam Wedel, Franziska Fröb, Christian Schmitt, Tina Baroti, Anna C. Hartwig, Simone Hillgärtner, Sandra Piefke, Tanja Fadler, Marc Ehrlich, Corinna Ehlert, Martin Stehling, Stefanie Albrecht, Ammar Jabali, Hans R. Schöler, Jürgen Winkler et al. | | 23 April 2018 | doi: 10.1038/s41467-018-03871-z | | Differentiation Oligodendrocyte | | | | | Advertisement | | Adolescence Collection Exploring the science of adolescence and its far-reaching implications for societal challenges Access the Collection online | | | | | | | | | | | | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com | | | | | | | | You have been sent this Table of Contents Alert because you have opted in to receive it. 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