Nature Reviews Neuroscience contents April 2018 Volume 19 Number 4 pp 181-249

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TABLE OF CONTENTS
April 2018 Volume 19 Number 4		Advertisement
2016 2-year Impact Factor 28.880 Journal Metrics 2-year Median 23	In this issue Research Highlights Reviews   Also this month Article series: Food intake, metabolism and the brain  Featured article: Signalling from the periphery to the brain that regulates energy homeostasis Ki-Suk Kim, Randy J. Seeley & Darleen A. Sandoval	The first journal to bring together the findings of neuroscientists, psychologists, and education researchers to understand how the brain learns. The journal is now open for submissions.   Explore the benefits of submitting your next paper to npj Science of Learning.
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RESEARCH HIGHLIGHTS   Top Depression: Bursting with depression p181 | doi:10.1038/nrn.2018.28 Upregulated bursting activity in the lateral habenula is associated with depression-like behaviours in rats and mice, and depends on NMDA receptors, T-type voltage-sensitive calcium channels and the astrocytic inwardly rectifying potassium channel KIR4.1. PDF Emotion: 'Anxiety cells' drive avoidance p182 | doi:10.1038/nrn.2018.21 A population of 'anxiety cells' that encode anxiogenic information and drive avoidance behaviour is identified in the mouse hippocampus. PDF Neurodevelopmental disorders: A targeted rescue p182 | doi:10.1038/nrn.2018.29 Study employs DNA methylation editing to reactivate FMR1 expression and reverse phenotypic deficits in cells derived from individuals with fragile X syndrome. PDF Synaptic transmission: A hare as well as a tortoise p183 | doi:10.1038/nrn.2018.17 Axons of striatal dopaminergic neurons are shown to release dopamine in a RIM-dependent manner and with a high release probability from axonal active zone-like structures. PDF Neuronal plasticity: Upscale, downscale p184 | doi:10.1038/nrn.2018.30 Neurons exhibiting synaptic upscaling or downscaling in response to decreases or increases in activity, respectively, show changes in protein expression that depend on the duration and the polarity of the change. PDF   IN BRIEF Gene expression: Key codes | Spatial processing: Directional dilemmas | Cell biology of the neuron: Untangling the ubiquitin-proteasome system | Sleep: Ever-decreasing ripples PDF Nature Reviews Neuroscience JOBS of the week 18 PhD Positions Medical Neuroscience Medical University of Vienna Postdoctoral Position in NeuroImmunology and Behavioral Science Lewis Katz School of Medicine at Temple University Postdoctoral Fellow Positions in RNA Biology / Neurobiology Lab University of California, Riverside Assistant, Associate or Full Professor of Neuroscience NC State University College of Veterinary Medicine Faculty Positions- Neurovascular Center Thomas Jefferson University (TJU) More Science jobs from Nature Reviews Neuroscience EVENT Summer Program in Neuroscience, Excellence and Success 14.06.18 Wood Hole, USA More science events from
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Article series: Food intake, metabolism and the brain Signalling from the periphery to the brain that regulates energy homeostasis Ki-Suk Kim, Randy J. Seeley & Darleen A. Sandoval p185 | doi:10.1038/nrn.2018.8 Coordination between peripheral signals that reflect feeding status and central regulatory mechanisms are crucial for regulating body weight. In this Review, Sandoval and colleagues discuss how and where peripherally derived signals are integrated within the CNS to modulate feeding behaviour. Abstract | Full Text | PDF
Effects of adolescent alcohol consumption on the brain and behaviour Linda P. Spear p197 | doi:10.1038/nrn.2018.10 The prevalence of adolescent alcohol use in some countries is high and is associated with various changes in brain function and behaviour. In this Review, Linda Spear examines the contributors to and consequences of alcohol use during adolescence, covering findings in humans and rodent models of this developmental period. Abstract | Full Text | PDF
Dendritic structural plasticity and neuropsychiatric disease Marc P. Forrest, Euan Parnell & Peter Penzes p215 | doi:10.1038/nrn.2018.16 The morphology of dendrites and dendritic spines changes with development and as a result of activity-dependent plasticity mechanisms. Penzes and colleagues describe the altered dendritic structural plasticity that is associated with some neuropsychiatric disorders and consider the underlying molecular mechanisms, based on recent genetic discoveries. Abstract | Full Text | PDF | Supplementary information
Lactate in the brain: from metabolic end-product to signalling molecule Pierre J. Magistretti & Igor Allaman p235 | doi:10.1038/nrn.2018.19 Much research has shown that lactate produced by astrocytes serves as a neuronal energy substrate. In this Review, Magistretti and Allaman describe this model as well as recent evidence that lactate also modulates neuronal properties, including excitability and plasticity, thus helping to set the 'homeostatic tone' of the nervous system. Abstract | Full Text | PDF
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