Nature Reviews Genetics Contents April 2018 Volume 19 Number 4 pp 187-246

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TABLE OF CONTENTS
April 2018 Volume 19 Number 4
2016 2-year Impact Factor 40.282 Journal Metrics 2-year Median 28.5	In this issue Research Highlights Reviews Perspectives   Also this month Article series: Computational tools  Featured article: Cloud computing for genomic data analysis and collaboration Ben Langmead & Abhinav Nellore
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Genomic Epidemiology of Malaria (11-13 June 2018) This meeting focusses on understanding the clinical and biological consequences of genome variation in malaria-exposed populations, transmission models and migration patterns, and the implications for policies to eradicate malaria. Deadlines: Early bird: 20 Mar/ Bursaries: 3 Apr / Abstracts: 17 Apr / Registration: 15 May
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RESEARCH HIGHLIGHTS   Top Gene expression: Developmental enhancers in action p187 | doi:10.1038/nrg.2018.13 PDF RNA: Follow the SINE for nuclear localization p188 | doi:10.1038/nrg.2018.10 PDF Genetic variation: Putting causal variants on the map p188 | doi:10.1038/nrg.2018.11 PDF Comparative genomics: Blood, guts and vampire bats p189 | doi:10.1038/nrg.2018.14 PDF   Genetics JOBS of the week New Postdoctoral Positions The University of Texas MD Anderson Cancer Center, Department of Genertics Postdoctoral Research Scholar UT Southwestern Medical Center Postdoctoral Fellow / Pediatrics - 180000006J The University of Tennessee Health Science Center (UTHSC) Post-doctoral fellow Washington University School of Medicine, St. Louis Postdoctoral Fellow Positions in RNA Biology / Neurobiology Lab University of California, Riverside More Science jobs from Genetics EVENT Machines on Genes 24.06.18 Snowmass Village, USA More science events from
REVIEWS		Top
A change of view: homologous recombination at single-molecule resolution Kyle Kaniecki, Luisina De Tullio & Eric C. Greene p191 | doi:10.1038/nrg.2017.92 In this Review, Kaniecki et al. discuss how the use of single-molecule optical microscopy and super-resolution optical microscopy methods has benefited our understanding of homologous recombination by generating detailed insights into the molecules and processes involved. Abstract | Full Text | PDF
Article series: Computational tools Cloud computing for genomic data analysis and collaboration Ben Langmead & Abhinav Nellore p208 | doi:10.1038/nrg.2017.113 Next-generation sequencing technologies have fuelled a rapid rise in data, which require vast computational resources to store and analyse. This Review discusses the role of cloud computing in genomics research to facilitate data sharing and new analyses of archived sequencing data, as well as large-scale international collaborations. Abstract | Full Text | PDF | Supplementary information
Runs of homozygosity: windows into population history and trait architecture Francisco C. Ceballos, Peter K. Joshi, David W. Clark, Michèle Ramsay & James F. Wilson p220 | doi:10.1038/nrg.2017.109 Runs of homozygosity (ROH) are genomic regions of homozygosity where the identical maternal and paternal haplotypes are descended from a shared common ancestor, and they are well known to occur as a result of inbreeding. This article discusses strategies for detecting ROH, their underappreciated prevalence across diverse outbred populations and implications for complex traits and human disease. Abstract | Full Text | PDF
PERSPECTIVES		Top
SCIENCE AND SOCIETY Cost-effectiveness analyses of genetic and genomic diagnostic tests Katherine Payne, Sean P. Gavan, Stuart J. Wright & Alexander J. Thompson p235 | doi:10.1038/nrg.2017.108 Next-generation sequencing is fuelling a rise in the number of genomic diagnostic tests, which compete with existing interventions for limited health-care budgets. This Perspective presents key approaches and challenges that must be considered by decision-makers assessing the relative cost-effectiveness of new genomic tests. Abstract | Full Text | PDF | Supplementary information
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