| | | Brief Communications Arising | | | | A coherent spin–photon interface in silicon
A single spin in silicon is strongly coupled to a microwave-frequency photon and coherent single-spin dynamics are observed using circuit quantum electrodynamics.
X. Mi, M. Benito, S. Putz et al. | Planning chemical syntheses with deep neural networks and symbolic AI
Deep neural networks and Monte Carlo tree search can plan chemical syntheses by training models on a huge database of published reactions; their predicted synthetic routes cannot be distinguished from those a human chemist would design.
Marwin H. S. Segler, Mike Preuss, Mark P. Waller | De novo mutations in regulatory elements in neurodevelopmental disorders
Analysis of rare de novo mutations in gene regulatory elements suggests that 1–3% of patients with neurodevelopmental disorders carry such mutations in elements that are active in the fetal brain.
Patrick J. Short, Jeremy F. McRae, Giuseppe Gallone et al. | Encoding of danger by parabrachial CGRP neurons
Single-cell recordings show that CGRP-expressing neurons in the parabrachial nucleus in mice respond to both noxious stimuli and signals of feeding satiety.
Carlos A. Campos, Anna J. Bowen, Carolyn W. Roman et al. | Extensive impact of non-antibiotic drugs on human gut bacteria
A screen of more than 1,000 drugs shows that about a quarter of the non-antibiotic drugs inhibit the growth of at least one commensal bacterial strain in vitro.
Lisa Maier, Mihaela Pruteanu, Michael Kuhn et al. | | A galaxy lacking dark matter
Galaxies normally have far more dark matter than normal matter, but the dynamics of objects within the ultra-diffuse galaxy NGC1052–DF2 suggest that it has a very little dark matter component.
Pieter van Dokkum, Shany Danieli, Yotam Cohen et al. | A programmable two-qubit quantum processor in silicon
A two-qubit quantum processor in a silicon device is demonstrated, which can perform the Deutsch–Josza algorithm and the Grover search algorithm.
T. F. Watson, S. G. J. Philips, E. Kawakami et al. | Massive Dirac fermions in a ferromagnetic kagome metal
Fe3Sn2 hosts massive Dirac fermions, owing to the underlying symmetry properties of the bilayer kagome lattice in the ferromagnetic state and the atomic spin–orbit coupling.
Linda Ye, Mingu Kang, Junwei Liu et al. | Timing of oceans on Mars from shoreline deformation
Ancient shorelines on Mars must have formed before and during the emplacement of the Tharsis volcanic province, instead of afterwards as previously assumed, suggesting that oceans on Mars formed early.
Robert I. Citron, Michael Manga, Douglas J. Hemingway | Insulin resistance in cavefish as an adaptation to a nutrient-limited environment
Cavefish populations of the Mexican tetra, Astyanax mexicanus, carry a mutation in the insulin receptor gene that renders them insulin- and starvation-resistant relative to surface populations of the same species.
Misty R. Riddle, Ariel C. Aspiras, Karin Gaudenz et al. | Reconstructing the genetic history of late Neanderthals
Genetic similarity among late Neanderthals is predicted well by their geographical location, and although some of these Neanderthals were contemporaneous with early modern humans, their genomes show no evidence of recent gene flow from modern humans.
Mateja Hajdinjak, Qiaomei Fu, Alexander Hübner et al. | Moving magnetoencephalography towards real-world applications with a wearable system
A new magnetoencephalography system allows high-spatiotemporal-resolution imaging of human brain function in moving subjects.
Elena Boto, Niall Holmes, James Leggett et al. | A TRP channel trio mediates acute noxious heat sensing
Three transient receptor potential channels (TRPA1, TRPV1 and TRPM3) mediate sensitivity to acute noxious heat in mice in a redundant system; mice lacking all three show severe deficits in heat sensing, whereas double-knockout mice do not.
Ine Vandewauw, Katrien De Clercq, Marie Mulier et al. | Electromechanical vortex filaments during cardiac fibrillation
Using optical mapping and 3D ultrasound, the dynamics and interactions between electrical and mechanical phase singularities were analysed by simultaneously measuring the membrane potential, intracellular calcium concentration and mechanical contractions of the heart during normal rhythm and fibrillation.
J. Christoph, M. Chebbok, C. Richter et al. | Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance
Hepatocytes secrete DPP4, which promotes adipose tissue inflammation and insulin resistance in obese mice, suggesting a new specific target for treatment of metabolic disorders.
Devram S. Ghorpade, Lale Ozcan, Ze Zheng et al. | The protein histidine phosphatase LHPP is a tumour suppressor
Decreased expression of histidine phosphatase LHPP, a novel tumour suppressor, results in increased global histidine phosphorylation and hepatocellular carcinoma.
Sravanth K. Hindupur, Marco Colombi, Stephen R. Fuhs et al. | Optogenetic regulation of engineered cellular metabolism for microbial chemical production
Finely tuned optogenetic control of engineered Saccharomyces cerevisiae enhances the biosynthesis of valuable products such as isobutanol in laboratory-scale fermenters.
Evan M. Zhao, Yanfei Zhang, Justin Mehl et al. | | | | |
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