Nature Biotechnology Contents: Volume 36 pp 205 - 286

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Advertisement Do you have a career question? The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud.  Listen today! TABLE OF CONTENTS March 2018 Volume 36, Issue 3 Editorial News Correction Bioentrepreneur Opinion and Comment Feature News and Views Research Careers and Recruitment Advertisement Nature Spotlight on Nano Carbon Technology in Japan - Catching up with carbon - Japan's historical leadership in the field of nanocarbon research is being challenged.  Access free online >> Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Advertisement Poster on: The expanding CRISPR toolbox The CRISPR-Cas9 system can do a lot more than gene editing. This Poster, from Nature Methods, explores the newest possibilities of CRISPR.  Available to download free online >>  Produced with support from:  Dharmacon    Advertisement nature.com webcasts Springer Nature presents a custom webcast on: Sequencing Structural Variants for Disease Gene Discovery and Population Genetics Date: Thursday, March 8, 2018 Register for FREE Sponsored by: PacBio   Editorial Amazon's cloud on the healthcare horizon   p205 doi:10.1038/nbt.4107 A new venture from Amazon, JP Morgans and Berkshire Hathaway has US healthcare in its crosshairs. It may also offer opportunities for innovators in health IT and digital medicine. News Migraine drug race turns its final corner, FDA decisions in sight   pp207 - 208 Elie Dolgin doi:10.1038/nbt0318-207 EPO revokes Broad's CRISPR patent   p209 Charlotte Harrison doi:10.1038/nbt0318-209b Jury out on liquid biopsies for cancer   pp209 - 210 Mark Ratner doi:10.1038/nbt0318-209a Preprint wipes millions off CRISPR companies' stocks   p211 Eva von Schaper doi:10.1038/nbt0318-211 FDA makes drug data public   p212 doi:10.1038/nbt0318-212b First off-the-shelf mesenchymal stem cell therapy nears European approval   pp212 - 214 Cormac Sheridan doi:10.1038/nbt0318-212a Correction Correction   p214 doi:10.1038/nbt0318-214a News Around the world in a month   p214 doi:10.1038/nbt0318-214b News Feature Driving T-cell immunotherapy to solid tumors   pp215 - 219 Ken Garber doi:10.1038/nbt.4090 T cell receptor (TCR) gene therapy can target the immune system to solid tumors in ways CAR-T cells can't match, but the field is still looking for a clear success. Ken Garber reports. Benchtop Linear MALDI-TOF Mass Spec Providing a dependable, robust, and easy-to-maintain platform, Shimadzu's new benchtop MALDI-8020 delivers sensitive detection and accurate mass determination by MALDI-TOF MS for a variety of analytes. Intuitive software simplifies operation and enables 21 CFR Part 11 compliance. Learn more. Bioentrepreneur Building a Business The alphabet soup of agreements   pp220 - 224 Sadhana Chitale, Colm Lawler and Scott Macfarlane doi:10.1038/nbt.4088 Podcast First Rounders podcast: Jeffrey Leiden   p224 doi:10.1038/nbt.4087 Countering Antimicrobial Resistance This conference will highlight work on understanding the ecology and spread of infectious agents and innovations in screening, therapeutic modalities and new countermeasures to address the spread of organisms resistant to carbapenem or vancomycin as well as multidrug-resistant Mycobacterium tuberculosis. May 28-29, 2018 | Beijing, China   Opinion and Comment Correspondence The NIEHS TaRGET II Consortium and environmental epigenomics   pp225 - 227 Ting Wang, Erica C Pehrsson, Deepak Purushotham, Daofeng Li, Xiaoyu Zhuo et al. doi:10.1038/nbt.4099 Commentary The evidence gap   pp228 - 232 Vicki Seyfert-Margolis doi:10.1038/nbt.4097 Why digitally powered real-world evidence is the fix needed for our broken clinical trials system. Feature Patents Recent patents in DNA sequencing   p233 doi:10.1038/nbt.4105 News and Views Smart cancer therapy with DNA origami   pp234 - 235 Ennio Tasciotti doi:10.1038/nbt.4095 Tumor infarction is achieved through targeted delivery of thrombin by DNA nanorobots. See also: Research by Li et al. An archive written in DNA   pp236 - 237 Reinhard Heckel doi:10.1038/nbt.4093 New research sets a world record in the volume of data stored in and retrieved from DNA. See also: Research by Organick et al. Research Highlights   p237 doi:10.1038/nbt.4092 All MiNDS on the brain   p238 Irene Jarchum doi:10.1038/nbt.4094 Biotechnology JOBS of the week Dean of the Faculty of Science The Chinese University of Hong Kong Associate Research Scientist Columbia University Postdoctoral Fellow Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. Postdoctoral Research Associates – Computational Biology St. Jude Children's Research Hospital (SJCRH) Computational Scientist Celgene CITRE More Science jobs from Biotechnology EVENT International Biotechnology Conference April 25, 2018 Rome, Italy More science events from Research Brief Communications Deep learning improves prediction of CRISPR-Cpf1 guide RNA activity   pp239 - 241 Hui Kwon Kim, Seonwoo Min, Myungjae Song, Soobin Jung, Jae Woo Choi et al. doi:10.1038/nbt.4061 Using deep learning to combine target sequence and chromatin accessibility data boosts the accuracy of CRISPR-Cpf1 guide RNA activity Articles Random access in large-scale DNA data storage   pp242 - 248 Lee Organick, Siena Dumas Ang, Yuan-Jyue Chen, Randolph Lopez, Sergey Yekhanin et al. doi:10.1038/nbt.4079 200 MB of digital data is stored in DNA, randomly accessed and recovered using an error-free approach. See also: News and Views by Heckel Sugar release and growth of biofuel crops are improved by downregulation of pectin biosynthesis   pp249 - 257 Ajaya K Biswal, Melani A Atmodjo, Mi Li, Holly L Baxter, Chang Geun Yoo et al. doi:10.1038/nbt.4067 Engineered switchgrass and poplar are better feedstocks for biofuel synthesis and yield more biomass in multi-year field trials. Letters A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo    pp258 - 264 Suping Li, Qiao Jiang, Shaoli Liu, Yinlong Zhang, Yanhua Tian et al. doi:10.1038/nbt.4071 DNA origami-based nanorobot presents thrombin to cause tumor infarction after specific recognition of a tumor vessel marker. See also: News and Views by Tasciotti A highly specific SpCas9 variant is identified by in vivo screening in yeast   pp265 - 271 Antonio Casini, Michele Olivieri, Gianluca Petris, Claudia Montagna, Giordano Reginato et al. doi:10.1038/nbt.4066 Evolved SpCas9 variant evoCas9 has improved specificity and retains near wild-type on-target activity. Resources Recon3D enables a three-dimensional view of gene variation in human metabolism   pp272 - 281 Elizabeth Brunk, Swagatika Sahoo, Daniel C Zielinski, Ali Altunkaya, Andreas Drager et al. doi:10.1038/nbt.4072 Large-scale integration of metabolite and protein structural data with existing networks of human metabolism provides insights into gene function and how drugs affect metabolic response. Careers and Recruitment Evidence for a mental health crisis in graduate education   pp282 - 284 Teresa M Evans, Lindsay Bira, Jazmin Beltran Gastelum, L Todd Weiss and Nathan L Vanderford doi:10.1038/nbt.4089 With mental illness a growing concern within graduate education, data from a new survey should prompt both academia and policy makers to consider intervention strategies. People People   p286 doi:10.1038/nbt.4100 Advertisement nature.com webcasts Springer Nature presents a custom webcast on: Precision over Bulk: Opportunities for Single-Cell DNA Analysis in Oncology Date: Tuesday, March 13, 2018 Register for the webcast and live Q&A session Sponsored by: Mission Bio   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. 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