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The Pharmacogenomics Journal - Table of Contents alert Volume 18 Issue 1

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The Pharmacogenomics Journal

Volume 18, Issue 1 (January 2018)

In this issue
Original Articles
Consensus Article

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Pharmacogenetic biomarkers of response in Crohn’s disease

T M Linares-Pineda, M Cañadas-Garre, A Sánchez-Pozo and M Á Calleja-Hernández

Pharmacogenomics J 2018 18: 1-13; advance online publication, June 20, 2017; 10.1038/tpj.2017.27

Abstract | Full Text

Predictive genetic markers in neoadjuvant chemoradiotherapy for locally advanced esophageal cancer: a long way to go. Review of the literature

M Gusella, E Pezzolo, Y Modena, C Barile, D Menon, G Crepaldi, F La Russa, A P Fraccon and F Pasini

Pharmacogenomics J 2018 18: 14-22; advance online publication, June 13, 2017; 10.1038/tpj.2017.25

Abstract | Full Text

Original Articles


Epigenomics alternations and dynamic transcriptional changes in responses to 5-fluorouracil stimulation reveal mechanisms of acquired drug resistance of colorectal cancer cells OPEN

Y Shen, M Tong, Q Liang, Y Guo, H Q Sun, W Zheng, L Ao, Z Guo and F She

Pharmacogenomics J 2018 18: 23-28; advance online publication, January 3, 2017; 10.1038/tpj.2016.91

Abstract | Full Text

Clinical relevance of EMT and stem-like gene expression in circulating tumor cells of metastatic colorectal cancer patients

Y Ning, W Zhang, D L Hanna, D Yang, S Okazaki, M D Berger, Y Miyamoto, M Suenaga, M Schirripa, A El-Khoueiry and H-J Lenz

Pharmacogenomics J 2018 18: 29-34; advance online publication, August 9, 2016; 10.1038/tpj.2016.62

Abstract | Full Text

ABC transporter polymorphisms are associated with irinotecan pharmacokinetics and neutropenia

M Li, E L Seiser, R M Baldwin, J Ramirez, M J Ratain, F Innocenti and D L Kroetz

Pharmacogenomics J 2018 18: 35-42; advance online publication, November 15, 2016; 10.1038/tpj.2016.75

Abstract | Full Text

A genetic variant in Rassf1a predicts outcome in mCRC patients treated with cetuximab plus chemotherapy: results from FIRE-3 and JACCRO 05 and 06 trials

A Sebio, S Stintzing, V Heinemann, Y Sunakawa, W Zhang, W Ichikawa, A Tsuji, T Takahashi, A Parek, D Yang, S Cao, Y Ning, S Stremitzer, S Matsusaka, S Okazaki, A Barzi, M D Berger and H-J Lenz

Pharmacogenomics J 2018 18: 43-48; advance online publication, October 4, 2016; 10.1038/tpj.2016.69

Abstract | Full Text

Genetic polymorphisms as predictive biomarker of survival in patients with gastrointestinal stromal tumors treated with sunitinib

J S L Kloth, M C Verboom, J J Swen, T van der Straaten, S Sleijfer, A K L Reyners, N Steeghs, H Gelderblom, H J Guchelaar and R H J Mathijssen

Pharmacogenomics J 2018 18: 49-55; advance online publication, January 24, 2017; 10.1038/tpj.2016.83

Abstract | Full Text

A systems biology approach to investigate the mechanism of action of trabectedin in a model of myelomonocytic leukemia OPEN

L Mannarino, L Paracchini, I Craparotta, M Romano, S Marchini, R Gatta, E Erba, L Clivio, C Romualdi, M D’Incalci, L Beltrame and L Pattini

Pharmacogenomics J 2018 18: 56-63; advance online publication, December 13, 2016; 10.1038/tpj.2016.76

Abstract | Full Text

Association of CTH variant with sinusoidal obstruction syndrome in children receiving intravenous busulfan and cyclophosphamide before hematopoietic stem cell transplantation OPEN

P Huezo-Diaz Curtis, C R S Uppugunduri, J Muthukumaran, M A Rezgui, C Peters, P Bader, M Duval, H Bittencourt, Maja Krajinovic and Marc Ansari on behalf of the Paediatric Disease Working Parties of the European Blood and Marrow Transplant group

Pharmacogenomics J 2018 18: 64-69; advance online publication, October 25, 2016; 10.1038/tpj.2016.65

Abstract | Full Text

New polymorphisms associated with response to anti-TNF drugs in patients with moderate-to-severe plaque psoriasis

R Prieto-Pérez, G Solano-López, T Cabaleiro, M Román, D Ochoa, M Talegón, O Baniandrés, J L López-Estebaranz, P de la Cueva, E Daudén and F Abad-Santos

Pharmacogenomics J 2018 18: 70-75; advance online publication, September 27, 2016; 10.1038/tpj.2016.64

Abstract | Full Text

IL17RA gene variants and anti-TNF response among psoriasis patients

A Batalla, E Coto, J Gómez, N Eirís, D González-Fernández, C Gómez-De Castro, E Daudén, M Llamas-Velasco, R Prieto-Perez, F Abad-Santos, G Carretero, F S García, Y B Godoy, L F Cardo, B Alonso, S Iglesias and P Coto-Segura

Pharmacogenomics J 2018 18: 76-80; advance online publication, September 27, 2016; 10.1038/tpj.2016.70

Abstract | Full Text

Confirmation of an IRAK3 polymorphism as a genetic marker predicting response to anti-TNF treatment in rheumatoid arthritis

J Sode, U Vogel, S Bank, P S Andersen, M L Hetland, H Locht, N H H Heegaard and V Andersen

Pharmacogenomics J 2018 18: 81-86; advance online publication, October 4, 2016; 10.1038/tpj.2016.66

Abstract | Full Text

Genetically determined high activity of IL-12 and IL-18 in ulcerative colitis and TLR5 in Crohns disease were associated with non-response to anti-TNF therapy

S Bank, P S Andersen, J Burisch, N Pedersen, S Roug, J Galsgaard, S Y Turino, J B Brodersen, S Rashid, B K Rasmussen, S Avlund, T B Olesen, H J Hoffmann, B A Nexø, J Sode, U Vogel and V Andersen

Pharmacogenomics J 2018 18: 87-97; advance online publication, January 31, 2017; 10.1038/tpj.2016.84

Abstract | Full Text

Genes differentially expressed by methylprednisolone in vivo in CD4 T lymphocytes from multiple sclerosis patients: potential biomarkers

C De Andres, M I García, H Goicoechea, M L Martínez-Ginés, J M García-Domínguez, M L Martín, F Romero-Delgado, A Benguría, M Sanjurjo and L A López-Fernández

Pharmacogenomics J 2018 18: 98-105; advance online publication, September 27, 2016; 10.1038/tpj.2016.71

Abstract | Full Text

Genome-wide association study identifies pharmacogenomic loci linked with specific antihypertensive drug treatment and new-onset diabetes

S-W Chang, C W McDonough, Y Gong, T A Johnson, T Tsunoda, E R Gamazon, M A Perera, A Takahashi, T Tanaka, M Kubo, C J Pepine, J A Johnson and R M Cooper-DeHoff

Pharmacogenomics J 2018 18: 106-112; advance online publication, September 27, 2016; 10.1038/tpj.2016.67

Abstract | Full Text

Cost-effectiveness of cytochrome P450 2C19 *2 genotype-guided selection of clopidogrel or ticagrelor in Chinese patients with acute coronary syndrome

Y Wang, B P Yan, D Liew and V W Y Lee

Pharmacogenomics J 2018 18: 113-120; advance online publication, January 24, 2017; 10.1038/tpj.2016.94

Abstract | Full Text

Increasing BMI is associated with reduced expression of P-glycoprotein (ABCB1 gene) in the human brain with a stronger association in African Americans than Caucasians OPEN

J Vendelbo, R H Olesen, J K Lauridsen, J Rungby, J E Kleinman, T M Hyde and A Larsen

Pharmacogenomics J 2018 18: 121-126; advance online publication, November 29, 2016; 10.1038/tpj.2016.74

Abstract | Full Text

Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group

J S Floyd, C M Sitlani, C L Avery, R Noordam, X Li, A V Smith, S M Gogarten, J Li, L Broer, D S Evans, S Trompet, J A Brody, J D Stewart, J D Eicher, A A Seyerle, J Roach, L A Lange, H J Lin, J A Kors, T B Harris, R Li-Gao, N Sattar, S R Cummings, K L Wiggins, M D Napier, T Stürmer, J C Bis, K F Kerr, A G Uitterlinden, K D Taylor, D J Stott, R de Mutsert, L J Launer, E L Busch, R Méndez-Giráldez, N Sotoodehnia, E Z Soliman, Y Li, Q Duan, F R Rosendaal, P E Slagboom, K C Wilhelmsen, A P Reiner, Y-DI Chen, S R Heckbert, R C Kaplan, K M Rice, J W Jukema, A D Johnson, Y Liu, D O Mook-Kanamori, V Gudnason, J G Wilson, J I Rotter, C C Laurie, B M Psaty, E A Whitsel, L A Cupples and B H Stricker

Pharmacogenomics J 2018 18: 127-135; advance online publication, December 13, 2016; 10.1038/tpj.2016.90

Abstract | Full Text

Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain

A M Teitelbaum, S E Murphy, G Akk, T B Baker, A Germann, L B von Weymarn, L J Bierut, A Goate, E D Kharasch and A J Bloom

Pharmacogenomics J 2018 18: 136-143; advance online publication, March 14, 2017; 10.1038/tpj.2016.92

Abstract | Full Text

Systems genetics analysis of pharmacogenomics variation during antidepressant treatment

M B Madsen, L J A Kogelman, H N Kadarmideen and H B Rasmussen

Pharmacogenomics J 2018 18: 144-152; advance online publication, October 18, 2016; 10.1038/tpj.2016.68

Abstract | Full Text

An integrated pharmacokinetic/pharmacogenomic analysis of ABCB1 and SLCO1B1 polymorphisms on edoxaban exposure OPEN

A G Vandell, J Lee, M Shi, I Rubets, K S Brown and J R Walker

Pharmacogenomics J 2018 18: 153-159; advance online publication, November 29, 2016; 10.1038/tpj.2016.82

Abstract | Full Text

The glutathione transferase Mu null genotype leads to lower 6-MMPR levels in patients treated with azathioprine but not with mercaptopurine

M M T J Broekman, D R Wong, G J A Wanten, H M Roelofs, C J van Marrewijk, O H Klungel, A L M Verbeek, P M Hooymans, H-J Guchelaar, H Scheffer, L J J Derijks, M J H Coenen and D J de Jong in collaboration with TOPIC Recruitment Team

Pharmacogenomics J 2018 18: 160-166; advance online publication, January 3, 2017; 10.1038/tpj.2016.87

Abstract | Full Text

Influence of IL6R gene polymorphisms in the effectiveness to treatment with tocilizumab in rheumatoid arthritis

M Maldonado-Montoro, M Cañadas-Garre, A González-Utrilla and M Ángel Calleja-Hernández

Pharmacogenomics J 2018 18: 167-172; advance online publication, December 13, 2016; 10.1038/tpj.2016.88

Abstract | Full Text

A polymorphism in the OPRM1 3′-untranslated region is associated with methadone efficacy in treating opioid dependence

R C Crist, G A Doyle, E C Nelson, L Degenhardt, N G Martin, G W Montgomery, A J Saxon, W Ling and W H Berrettini

Pharmacogenomics J 2018 18: 173-179; advance online publication, December 13, 2016; 10.1038/tpj.2016.89

Abstract | Full Text

Weight of ABCB1 and POR genes on oral tacrolimus exposure in CYP3A5 nonexpressor pediatric patients with stable kidney transplant

G N Almeida-Paulo, I Dapía García, R Lubomirov, A M Borobia, N L Alonso-Sánchez, L Espinosa and A J Carcas-Sansuán

Pharmacogenomics J 2018 18: 180-186; advance online publication, January 17, 2017; 10.1038/tpj.2016.93

Abstract | Full Text

The global spectrum of protein-coding pharmacogenomic diversity OPEN

G E B Wright, B Carleton, M R Hayden and C J D Ross

Pharmacogenomics J 2018 18: 187-195; advance online publication, October 25, 2016; 10.1038/tpj.2016.77

Abstract | Full Text

Consensus Article


Association between DRD2 and DRD3 gene polymorphisms and gastrointestinal symptoms induced by levodopa therapy in Parkinson’s disease

M Rieck, A F Schumacher-Schuh, V Altmann, S M Callegari-Jacques, C R M Rieder and M H Hutz

Pharmacogenomics J 2018 18: 196-200; advance online publication, October 25, 2016; 10.1038/tpj.2016.79

Abstract | Full Text

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