Nature Reviews Molecular Cell Biology contents March 2018 Volume 19 Number 3 pp 137-206

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TABLE OF CONTENTS
March 2018 Volume 19 Number 3		Advertisement
2016 2-year Impact Factor 46.602 Journal Metrics 2-year Median 28.5	In this issue Comment Research Highlights Reviews   Also this month Article series: Translation and protein quality control  Featured article: The functions and unique features of long intergenic non-coding RNA Julia D. Ransohoff, Yuning Wei & Paul A. Khavari	The first journal to bring together the findings of neuroscientists, psychologists, and education researchers to understand how the brain learns. The journal is now open for submissions.   Explore the benefits of submitting your next paper to npj Science of Learning.
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Comment: The comeback of hand drawing in modern life sciences Renaud Chabrier & Carsten Janke p137 | doi:10.1038/nrm.2017.126 Images are an integral part of reporting scientific data and conveying concepts in science. Janke and Chabrier argue for the importance of hand drawing — the original form of representation in science — as a complementary medium to photographs and schematics used in science publications today. Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS   Top Chromosome biology: A stairway to mitotic chromosome assembly p139 | doi:10.1038/nrm.2018.13 Condensin complexes drive mitotic chromosome formation by structuring chromatin into nested loops and organizing them along a central, helical scaffold. PDF RNA metabolism: Interfering with interferon by RNA editing p140 | doi:10.1038/nrm.2018.12 By editing of endogenous mRNAs, the RNA editing enzyme ADAR1 prevents interferon-induced translation shutdown and cell death, and virus-independent interferon induction in neuronal cells. PDF Mechanisms of disease: Consequences of mitoribosome overload p140 | doi:10.1038/nrm.2018.8 The exonuclease EXD2 prevents the overload of the mitochondrial 28S ribosome subunit with mitochondrial mRNAs, and is important for development and lifespan regulation PDF Stem cells: A balancing act of lipids p141 | doi:10.1038/nrm.2018.10 Perturbation of phospholipid composition in intestinal stem cells (ISCs) results in increased cholesterol biosynthesis; excess cholesterol is a driver of ISC hyperproliferation, and consequently of intestinal hypertrophy and cancer. PDF JOURNAL CLUB Cytoskeleton in high resolution p142 | doi:10.1038/nrm.2018.1 Eva Nogales looks back at the early days of structure determination of cytoskeletal components. PDF Gene expression: AMPK relieves PRC2-mediated silencing p142 | doi:10.1038/nrm.2018.6 AMPK phosphorylates EZH2 — the catalytic subunit of the Polycomb repressive complex 2, thereby inhibiting its gene suppression function and counteracting its tumorigenic effects. PDF   Nature Reviews Molecular Cell Biology JOBS of the week Postdoctoral Fellow / Pediatrics - 180000003W The University of Tennessee Health Science Center (UTHSC) Postdoctoral Associate University of Minnesota - College of Pharmacy Postdoctoral Fellow Opportunity - Cold Spring Harbor Laboratory Cold Spring Harbor Laboratory (CSHL) Postdoctoral candidate (m / f) Helmholtz Zentrum M�nchen - German Research Center for Environmental Health - HMGU - Helmholtz Association Postdoctoral Position in Cancer Biology: Yale University Yale University More Science jobs from Nature Reviews Molecular Cell Biology EVENT EMBO Practical Course: Molecular Geobiology 26.08.18 Heidelberg, Germany More science events from
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The functions and unique features of long intergenic non-coding RNA Julia D. Ransohoff, Yuning Wei & Paul A. Khavari p143 | doi:10.1038/nrm.2017.104 Long intergenic non-coding RNAs (lincRNAs) do not overlap protein-coding genes, although some lincRNA genes have minimal coding potential and can include small open reading frames that encode functional peptides. lincRNA functions include RNA stabilization and transcription regulation and the remodelling of chromatin and genome architecture. Recent insights suggest that lincRNAs broadly serve to fine-tune the expression of neighbouring genes with remarkable tissue specificity. Abstract | Full Text | PDF
Article series: Translation and protein quality control Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them Kathrin Leppek, Rhiju Das & Maria Barna p158 | doi:10.1038/nrm.2017.103 Structures in 5′ untranslated regions of eukaryotic mRNAs contribute to gene regulation by controlling cap-dependent and cap-independent translation initiation through diverse mechanisms. New structure probing technologies coupled with techniques such as compensatory mutagenesis will likely identify new structured RNA elements and help elucidate their function. Abstract | Full Text | PDF | Supplementary information
Sphingolipids and their metabolism in physiology and disease Yusuf A. Hannun & Lina M. Obeid p175 | doi:10.1038/nrm.2017.107 Sphingolipids are a major class of lipids, comprising various species with diverse functions. In addition to being structural elements of membranes, many sphingolipids are bioactive and regulate a myriad of cellular processes. Recent advances have shed new light on the complexity of sphingolipid metabolism and their various roles in physiology and disease. Abstract | Full Text | PDF | Supplementary information
Emerging roles of linker histones in regulating chromatin structure and function Dmitry V. Fyodorov, Bing-Rui Zhou, Arthur I. Skoultchi & Yawen Bai p192 | doi:10.1038/nrm.2017.94 Linker histones bind to nucleosomes and have been traditionally perceived as structural units of chromatin. Recent advances indicate that these histones have an active role in the control of chromatin architecture and function, participating in the regulation of gene expression, DNA replication and DNA repair. Abstract | Full Text | PDF
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