Tuesday, February 20, 2018

Nature Reviews Molecular Cell Biology contents March 2018 Volume 19 Number 3 pp 137-206

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Nature Reviews Molecular Cell Biology

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Nature Reviews Molecular Cell Biology cover
2016 2-year Impact Factor 46.602 Journal Metrics 2-year Median 28.5
In this issue
Research Highlights
Also this month
Article series:
Translation and protein quality control
 Featured article:
The functions and unique features of long intergenic non-coding RNA
Julia D. Ransohoff, Yuning Wei & Paul A. Khavari


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Comment: The comeback of hand drawing in modern life sciences
Renaud Chabrier & Carsten Janke

p137 | doi:10.1038/nrm.2017.126
Images are an integral part of reporting scientific data and conveying concepts in science. Janke and Chabrier argue for the importance of hand drawing — the original form of representation in science — as a complementary medium to photographs and schematics used in science publications today.
Abstract | Full Text | PDF


Chromosome biology: A stairway to mitotic chromosome assembly
p139 | doi:10.1038/nrm.2018.13
Condensin complexes drive mitotic chromosome formation by structuring chromatin into nested loops and organizing them along a central, helical scaffold.

RNA metabolism: Interfering with interferon by RNA editing
p140 | doi:10.1038/nrm.2018.12
By editing of endogenous mRNAs, the RNA editing enzyme ADAR1 prevents interferon-induced translation shutdown and cell death, and virus-independent interferon induction in neuronal cells.

Mechanisms of disease: Consequences of mitoribosome overload
p140 | doi:10.1038/nrm.2018.8
The exonuclease EXD2 prevents the overload of the mitochondrial 28S ribosome subunit with mitochondrial mRNAs, and is important for development and lifespan regulation

Stem cells: A balancing act of lipids
p141 | doi:10.1038/nrm.2018.10
Perturbation of phospholipid composition in intestinal stem cells (ISCs) results in increased cholesterol biosynthesis; excess cholesterol is a driver of ISC hyperproliferation, and consequently of intestinal hypertrophy and cancer.

Cytoskeleton in high resolution

p142 | doi:10.1038/nrm.2018.1
Eva Nogales looks back at the early days of structure determination of cytoskeletal components.

Gene expression: AMPK relieves PRC2-mediated silencing
p142 | doi:10.1038/nrm.2018.6
AMPK phosphorylates EZH2 — the catalytic subunit of the Polycomb repressive complex 2, thereby inhibiting its gene suppression function and counteracting its tumorigenic effects.


Nature Reviews Molecular Cell Biology
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Live Webinar on Life Science Applications in UV/VIS Spectroscopy
Join METTLER TOLEDO's Live Webinar with Nature on Life Science Applications in UV/VIS Spectroscopy. The webinar reviews the most relevant applications that can be performed with a UV/VIS spectrophotometer with the focus on the life science market. Typical samples and applications will be highlighted with many tips and hints for optimizing measurement accuracy.
The functions and unique features of long intergenic non-coding RNA
Julia D. Ransohoff, Yuning Wei & Paul A. Khavari

p143 | doi:10.1038/nrm.2017.104
Long intergenic non-coding RNAs (lincRNAs) do not overlap protein-coding genes, although some lincRNA genes have minimal coding potential and can include small open reading frames that encode functional peptides. lincRNA functions include RNA stabilization and transcription regulation and the remodelling of chromatin and genome architecture. Recent insights suggest that lincRNAs broadly serve to fine-tune the expression of neighbouring genes with remarkable tissue specificity.
Abstract | Full Text | PDF

Article series: Translation and protein quality control
Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them
Kathrin Leppek, Rhiju Das & Maria Barna

p158 | doi:10.1038/nrm.2017.103
Structures in 5′ untranslated regions of eukaryotic mRNAs contribute to gene regulation by controlling cap-dependent and cap-independent translation initiation through diverse mechanisms. New structure probing technologies coupled with techniques such as compensatory mutagenesis will likely identify new structured RNA elements and help elucidate their function.
Abstract | Full Text | PDF | Supplementary information

Sphingolipids and their metabolism in physiology and disease
Yusuf A. Hannun & Lina M. Obeid

p175 | doi:10.1038/nrm.2017.107
Sphingolipids are a major class of lipids, comprising various species with diverse functions. In addition to being structural elements of membranes, many sphingolipids are bioactive and regulate a myriad of cellular processes. Recent advances have shed new light on the complexity of sphingolipid metabolism and their various roles in physiology and disease.
Abstract | Full Text | PDF | Supplementary information

Emerging roles of linker histones in regulating chromatin structure and function
Dmitry V. Fyodorov, Bing-Rui Zhou, Arthur I. Skoultchi & Yawen Bai

p192 | doi:10.1038/nrm.2017.94
Linker histones bind to nucleosomes and have been traditionally perceived as structural units of chromatin. Recent advances indicate that these histones have an active role in the control of chromatin architecture and function, participating in the regulation of gene expression, DNA replication and DNA repair.
Abstract | Full Text | PDF

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