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March 2018 Volume 16 Number 3 | Advertisement | ||||||||||||||||||||||||||||||||||||||||||||||
| In this issue Research Highlights News and Analysis Reviews
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NEWS AND ANALYSIS | Top | ||||||||||||||||||||||||||||||||||||||||||||||
Genome watch: Keeping tally in the microbiome Alexandre Almeida & Yan Shao p124 | doi:10.1038/nrmicro.2018.13 This month's Genome Watch highlights how the development of new approaches for quantifying the human microbiome may pave the way for better understanding microbial shifts in the context of human health and disease. | |||||||||||||||||||||||||||||||||||||||||||||||
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REVIEWS | Top | ||||||||||||||||||||||||||||||||||||||||||||||
Rewiring cellular networks by members of the Flaviviridae family Christopher J. Neufeldt, Mirko Cortese, Eliana G. Acosta & Ralf Bartenschlager p125 | doi:10.1038/nrmicro.2017.170 In this Review, Bartenschlager and colleagues discuss how Flaviviridae viruses rewire cellular pathways and co-opt organelles. They compare strategies employed by flaviviruses with those employed by hepaciviruses and discuss the importance of these virus-host interactions in the context of viral replication and antiviral therapies. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||||||||||||
Article series: Microbiome The human skin microbiome Allyson L. Byrd, Yasmine Belkaid & Julia A. Segre p143 | doi:10.1038/nrmicro.2017.157 Our skin is home to millions of bacteria, fungi and viruses that comprise the skin microbiota. In this Review, Byrd and colleagues discuss recent insights into skin microbial communities, including their composition in health and disease, dynamics between species and interactions with the immune system. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||||||||||||
Article series: Antimicrobial resistance Drug resistance in Plasmodium Kasturi Haldar, Souvik Bhattacharjee & Innocent Safeukui p156 | doi:10.1038/nrmicro.2017.161 Haldar and colleagues discuss markers and mechanisms of resistance to artemisinins and artemisinin-based combination therapies. They describe the identification of Plasmodium falciparum Kelch 13 as the primary and, to date, sole causative marker of artemisinin resistance in P. falciparum and explore two proposed resistance mechanisms. They emphasize continuing challenges to improve detection strategies and new drug development strategies. Abstract | Full Text | PDF | Supplementary information | |||||||||||||||||||||||||||||||||||||||||||||||
Article series: Microbiome Microbial modulation of cardiovascular disease J. Mark Brown & Stanley L. Hazen p171 | doi:10.1038/nrmicro.2017.149 The interplay between nutrient intake, gut microbial metabolism and microorganism-driven engagement of host receptors contributes to the pathogenesis of cardiovascular disease. In this Review, Brown and Hazen discuss the gut microbial mechanisms that drive cardiovascular disease, with special emphasis on therapeutic interventions. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||||||||||||
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