Friday, February 23, 2018

Nature Reviews Cancer contents March 2018 Volume 18 Number 3 135-201

If you are unable to see the message below, click here to view.
Nature Reviews Cancer
 

Advertisement
Visualize, Analyze, and Phenotype Immune Cells in the Tumor Microenvironment

Gain a deeper understanding of the complex interactions in the tumor microenvironment and assess cancer biomarkers with seven-color multispectral imaging of FFPE tissue sections and TMAs in situ on the Vectra Polaris™ quantitative pathology imaging system. 

Download Application Note 
 
TABLE OF CONTENTS
 
March 2018 Volume 18 Number 3 Advertisement
 
Nature Reviews Cancer cover
2016 2-year Impact Factor 37.147 Journal Metrics 2-year Median 28
In this issue
Research Highlights
Reviews
Perspectives
 
Also this month
 Featured article:
Impact of oncogenic pathways on evasion of antitumour immune responses
Stefani Spranger & Thomas F. Gajewski

 
 

SensiFAST™ Real-Time PCR Kits
  • qPCR
  • 1-Step RT-qPCR
  • Genotyping
  • cDNA Synthesis
  • Probe & SYBR®
  • Lyo-Ready
 

 
Subscribe
 
Facebook
 
RSS
 
Recommend to library
 
Twitter
   
Advertisement
 
Featuring keynote speaker Lewis Cantley (Weill Cornell Medical College), this symposium will highlight mechanisms of tumor metabolism and signaling and explore current strategies to design safe and effective, metabolism-targeted cancer therapies.
Abstract deadline March 23rd.
 
 
Advertisement
Animation on CRISPR: Gene editing and beyond 

The CRISPR-Cas9 system has revolutionised gene editing, but cutting DNA isn't all it can do.

This Animation, from Nature Methods, explores where CRISPR might be headed next. 

Watch the Animation >> 

Produced with support from: 
Dharmacon 
 
Advertisement
 
npj Breast Cancer is an online-only, open access, multidisciplinary journal dedicated to publishing high-quality original research articles, reviews, editorials, commentaries, and hypothesis generating observations on all areas of breast cancer research. All content from the journal is now included in PubMed Central and PubMed. Part of the Nature Partner Journal series, npj Breast Cancer is published in partnership with the Breast Cancer Research Foundation. 
 
 
RESEARCH HIGHLIGHTS
 
Top

Immunotherapy: Viral reprogramming
p135 | doi:10.1038/nrc.2018.12
Two studies have shown that oncolytic virus treatment prior to surgery can prime the tumour immune microenvironment for subsequent immune checkpoint inhibition and lead to better outcomes in preclinical models of breast and brain cancers.
PDF


Breast cancer: Staying silent
p136 | doi:10.1038/nrc.2018.17
Mitogen- and stress-activated kinase 1 (MSK1) has been identified as an epigenetic modulator of luminal gene expression in breast cancer, maintaining latency of bone micrometastases.
PDF


Tumour microenvironment: Fibroblast subtype provides niche for cancer stem cells
p136 | doi:10.1038/nrc.2018.18
A subset of cancer-associated firboblasts, defined by the presence of the cell surface markers CD10 and GPR77, promotes tumour formation and chemoresistance by providing a niche for cancer stem cells.
PDF


Genomic instability: The sting of metastasis
p137 | doi:10.1038/nrc.2018.16
Data presented by Bakhoum, Ngo et al. suggest that chromosomal instability can promote metastasis through a cGAS-STING-dependent response to cytosolic DNA.
PDF


 

Nature Reviews Cancer
JOBS of the week
Postdoctoral Scientist (m / f) Cancer Research
Boehringer Ingelheim
Research Fellow in Cancer Biology
University of Michigan
Post-doc Positions in Translational Leukemia
NYU Langone School of Medicine
Post Doctoral Associate - Gene Therapy Center - 30273
University of Massachusetts
Postdoctoral Position in Cancer Biology: Yale University
Yale University
More Science jobs from
Nature Reviews Cancer
EVENT
Cancer and Metabolism
25.06.18
Cambridge, UK
More science events from
Advertisement
Poster on: CAR T cells in cancer therapy 

Nature Reviews Drug Discovery present this Poster which provides an overview of the different ways to design and produce CAR T cells and the journey that has driven these CAR T cells to FDA approval in 2017. 

Download free today 

Produced with support from: 
Lonza Bioscience Solutions
 
 
 
REVIEWS
 
Top
Impact of oncogenic pathways on evasion of antitumour immune responses
Stefani Spranger & Thomas F. Gajewski

p139 | doi:10.1038/nrc.2017.117
This Review describes tumour cell-intrinsic oncogenic pathways implicated in tumour immune evasion and highlights the potential for targeting these pathways to overcome resistance to immunotherapy in various cancer types.
Abstract | Full Text | PDF

 
Targeting B cell receptor signalling in cancer: preclinical and clinical advances
Jan A. Burger & Adrian Wiestner

p148 | doi:10.1038/nrc.2017.121
In this Review, Burger and Wiestner describe the latest insights into B cell receptor (BCR) signalling with respect to its contribution to B cell malignancies and discuss how inhibitors that target kinases downstream of the BCR are changing treatment outcomes for patients with B cell neoplasms.
Abstract | Full Text | PDF

 
Fanconi anaemia and cancer: an intricate relationship
Grzegorz Nalepa & D. Wade Clapp

p168 | doi:10.1038/nrc.2017.116
Fanconi anaemia (FA) is a genetic disorder associated with bone marrow failure, congenital abnormalities and an increased risk of developing cancer. In this Review, Nalepa and Clapp describe the roles of FA proteins in maintaining genome homeostasis and explain how dysregulation of the FA pathway through mutations in the FA genes might lead to carcinogenesis.
Abstract | Full Text | PDF

 
Advertisement
Do you have a career question?

The Naturejobs podcast features one-on-one Q&As, panel discussions and other exclusive content to help scientists with their careers. Hosted on the Naturejobs blog, the podcast is also available on iTunes and Soundcloud. 

Listen today!
 
 
PERSPECTIVES
 
Top
OPINION
A matter of life and death: stem cell survival in tissue regeneration and tumour formation
Despina Soteriou & Yaron Fuchs

p187 | doi:10.1038/nrc.2017.122
Stem cells are long-lived and possess unique mechanisms related to quiescence, DNA damage response and apoptosis that protect them throughout their lifespan and during tissue repair. These mechanisms may also have a role in cancer stem cells and tumorigenesis.
Abstract | Full Text | PDF

 
Advertisement
npj Genomic Medicine is an open access journal dedicated to publishing the most important scientific advances in all aspects of genomics and its application in the practice of medicine. Part of the Nature Partner Journals series, the journal is published in partnership with the Center of Excellence in Genomic Medicine Research. All content from the journal is now included in PubMed Central and PubMed.
 
 
nature events
Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here.

Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com
More Nature Events

You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount
(You will need to log in to be recognised as a nature.com registrant).

For further technical assistance, please contact our registration department

For print subscription enquiries, please contact our subscription department

For other enquiries, please contact our feedback department

Springer Nature | One New York Plaza, Suite 4500 | New York | NY 10004-1562 | USA

Springer Nature's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne
San Diego - San Francisco - Washington - New York - Boston

Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at The Campus, 4 Crinan Street, London, N1 9XW.

© 2018 Macmillan Publishers Limited, part of Springer Nature. All Rights Reserved.

Springer Nature

7 comments:

SCOAN ADMIN said...

Good morning my dear brothers and sisters
My name is sister Angela from Switzerland last
month i desperately wanted to visit the SCOAN
in Lagos Nigeria to get the new morning water to
help my sick mom but i was not sent invitation
after many times of trying ...i was so sad until i
searched for friends from Lagos on Facebook
where i communicated with one sister from the
church sister Helen who finally sent me the new
morning water through DHL and i used it for my
mom and she became well i now know that TB
Joshua is a true Man of God to save this
generation through Jesus Christ God bless scoan
God bless T B Joshua God bless Nigeria. .
if you need an urgent invitation from scoan, or
you do not have the money to visit scoan
yourself, i can connect you to a trusted sister
from Lagos Nigeria who will help you with what
ever you need . Email her on
sisterhelene4christ@gmail.com

Unknown said...

TB JOSHUA SCOAN HQ LAGOS NIGERIA wish to inform the General Public that the Current distribution of the NEW ANOINTING WATER AND STICKERS is still on and you can only get the NEW ANOINTING MORNING WATER, FAITH BRACELETS AND STICKERS , DVD's Of Prophet TB Joshua and The Mirror Books by ordering for it. To make an order send the following DETAILs to TB Joshua Official Email Address:



TbjoshuaScoanWater1@yahoo.com



ScoanMorningWaterSupply@yahoo.com


WHATSAPP: +2348112139676


Full Name:.............................

Full Home Address..............

Country.................................

City…………………………

Age.........................................

Phone Number....................

Occupation...........................

This is to enable us for further processing. We will reach you on the cost of courier Delivery charges to send your Package to your Country through DHL Courier Delivery service. GOD BLESS YOU

EMMANUEL.


Unknown said...


MY TESTIMONY TO THE WORLD

HOW I WAS HEALED BY PROPHET TB JOSHUA HE SEND ME HIS ANOINTING WATER HE INSTRUCTED ME ON HOW TO GO ABOUT IT AND I DID SO THERE IS NOTHING GOD CANNOT DO I THOUGHT I WILL REMAIN SICK FOREVER BEFORE ALMIGHTY GOD SAVE ME AND WIPE MY TEARS

I'M KATE ANSLEY GEORGE I lives in Texas United State the greatest testimony i have ever seen in my life. i want to use this great opportunity to thank prophet Tb Joshua the man of God.firstly..I was having a breast cancer over 5 months,secondly, my only SON who sudied LAW and graduated in readind university (UK) Developed habit of DRINKING & SMOKING, He became acting foolish and speak in slangs, everyone around me run away from me even my husband who i think he loves me so much told me is over i cried and cried no body could help me out i went to the best hospital in Here In United State of America USA no solution, all hope was lost, on one faithful day as i was going online i saw a testimony of this great man of God Tb Joshua
that people sharing about him how he has been helping people i never believed that this will work out but not withstanding there is nothing God can not do, so i decided to contact his Email: tbjoshuascoanwater1@yahoo.com i explain all my problems to him he told me not to worry about if really i believe in God the most high i shall be healed. he told me what to do i quickly follow up with his instruction i never let money be my problem. within the next 2days my illness and pains were healed, my brothers and sisters there is nothing God can not do if you have not given your life to Christ please try and do so once again his email: tbjoshuascoanwater1@yahoo.com if you have any problem similar to this you can contact him and your problem shall be solve, i will not stop sharing his name as a testimony because he brings me joy and happiness now i am happy my husband is back.if you also have any problem regarding as follow you can contact him God almighty is great
(1) If you want your ex back.
(2) if you always have bad dreams.
(3) You want to be promoted in your office.
(4) You want women/men to run after you.
(5) If you want a child.
(6) You want to tie your husband/wife to be yours forever.
(7)If you need financial breakthrough.
(8)if you need God intervention in all your endeavors.
(9)if you want to be a fertile woman
(10)if you want to be the head and never the tail.
(11)if you want God to bless the fruit of your Labor.
(12)if you want to be untouchable by the hands of your enemies.
(13)if you need unity and co-operation. in your family.
(14)if you need breakthrough.
(15)if you want your Broken Marriage to be Restored
(16) If you are having any Spiritual problems in your Life
(17)if you are Sick from any Illness
(18)f you want your home to be restored with God intervention
(19)If you need your life partner/Husband ..
(20)if you want to be successful in all works of life.and lots more just contact him
tbjoshuascoanwater1@yahoo.com


Unknown said...

HELLO BETHREN TB JOSHUA SCOAN HQ LAGOS NIGERIA wish to inform the General Public that the Current distribution of the NEW ANOINTING WATER AND STICKERS is still on and you can only get the NEW ANOINTING MORNING WATER, FAITH BRACELETS AND STICKERS , DVD's Of Prophet TB Joshua and The Mirror Books by ordering for it. To make an order send the following DETAILs to TB Joshua Official Email Address
[emmanueltv466@gmail.com]
emmanueltv466@gmail.com
Full Name:.............................

Full Home Address..............

Country.................................

City…………………………

Age.........................................

Phone Number....................

Occupation...........................

This is to enable us for further processing. We will reach you on the cost of courier Delivery charges to send your Package to your Country through DHL Courier Delivery service. GOD BLESS YOU

EMMANUEL.

Unknown said...

GET PROPHET TB JOSHUA MORNING WATER HERE!

Hello Brethren in the Lord,
May the peace and unity of the holy spirit fall upon you and your entire family as you read this splendid message from the synagogue church of all nations (SCOAN).

Remember that our Lord Jesus Christ is still saying something as He is the deliverer, the healer and the same yesterday today and forever. God has used prophet TB Joshua morning water to work miracles and i know yours will not be a different in Jesus name!!!!

The God of prophet TB Joshua is a wonder working God. God have used the medium of the morning water to heal thousand of diseases, ranging from HIV AIDS, CANCER, BRAIN TURMOIL, TYPE 2 DIABETES, FINANCIAL BREAKTHROUGHS, FREEDOM FROM POVERTY, BUSINESS BREAKTHROUGH ETC. If you need the morning water, and you do not have the time or money to visit the synagogue church of all nations, you can get one by contacting our email.

Send an E-mail directly to ( scoan.org109@gmail.com ) specifying what you need.

The morning water is totally free, we do not sell it. (free shipping inclusive)

E-mail: scoan.org109@gmail.com

SCOAN ADMIN said...

GET PROPHET TB JOSHUA MORNING WATER HERE!

Hello Brethren in the Lord,
May the peace and unity of the holy spirit fall upon you and your entire family as you read this splendid message from the synagogue church of all nations (SCOAN).

Remember that our Lord Jesus Christ is still saying something as He is the deliverer, the healer and the same yesterday today and forever. God has used prophet TB Joshua morning water to work miracles and i know yours will not be a different in Jesus name!!!!

The God of prophet TB Joshua is a wonder working God. God have used the medium of the morning water to heal thousand of diseases, ranging from HIV AIDS, CANCER, BRAIN TURMOIL, TYPE 2 DIABETES, FINANCIAL BREAKTHROUGHS, FREEDOM FROM POVERTY, BUSINESS BREAKTHROUGH ETC. If you need the morning water, and you do not have the time or money to visit the synagogue church of all nations, you can get one by contacting our email.

Send an E-mail directly to ( emmanuelscoan01@gmail.com ) specifying what you need.

The morning water is totally free, we do not sell it. (free shipping inclusive)

E-mail: emmanuelscoan01@gmail.com

SCOAN ADMIN said...

SCOAN NEW MORNING WATER 2020

Hello Brethren in the Lord,
May the peace and unity of the holy spirit fall upon you and your entire family as you read this splendid message from the synagogue church of all nations (SCOAN).

We have started the distribution of the New Morning Water to all our members of the church. If you need the New Morning Water. All you have to do is to contact us on the email and specify what you need, and the morning water will be sent to you.

The God of prophet TB Joshua is a wonder working God. God have used the medium of the morning water to heal thousand of diseases, ranging from Hiv Aids, Cancer, Brain Turmoil, Type 2 diabetes, Financial breakthroughs, Freedom from Poverty, Business breakthrough etc... If you need the morning water, and you do not have the time or money to visit the synagogue church of all nations, you can get one by contacting the email of the church store:( scoanonlinesales@gmail.com )

The morning water is totally free, we do not sell it. But please when you receive the items from the church do not sell them. Use them to pray and believe that Jesus will be glorified in your life. To place an order. Email us: ( scoanonlinesales@gmail.com )

Visit our website to get more info: www.scoanmorningwater.com

Thank you all. Remain blessed