| Strong disk winds traced throughout outbursts in black-hole X-ray binaries Analysis of the light curves of outbursts in black-hole X-ray binaries suggests that throughout the accretion process mass is lost from the accretion disks through strong, magnetically driven disk winds. B. E. Tetarenko, J.-P. Lasota, C. O. Heinke et al. | A large oxygen-dominated core from the seismic cartography of a pulsating white dwarf Asteroseismic ‘sounding’ reveals the internal chemical stratification of the white dwarf KIC08626021, which has a central homogeneous core—composed of 86 per cent oxygen—that has a mass of 0.45 solar masses. N. Giammichele, S. Charpinet, G. Fontaine et al. | Centimetre-scale electron diffusion in photoactive organic heterostructures For a suitably designed organic multilayer structure, optically or electrically generated electrons confined to a thin fullerene channel can diffuse over surprisingly long distances of several centimetres. Quinn Burlingame, Caleb Coburn, Xiaozhou Che et al. | Small-scale soft-bodied robot with multimodal locomotion A tiny soft-bodied robot is described that can be magnetically actuated to swim, climb, roll, walk and jump, while carrying a load. Wenqi Hu, Guo Zhan Lum, Massimo Mastrangeli et al. | Generating carbyne equivalents with photoredox catalysis A photocatalytic strategy is described that generates diazomethyl radicals as direct equivalents of carbynes, which are often too reactive to use, enabling the functionalization of a range of medically useful compounds. Zhaofeng Wang, Ana G. Herraiz, Ana M. del Hoyo et al. | Reconciling divergent trends and millennial variations in Holocene temperatures Analysis of pollen records from North America and Europe reveals a warming trend over the Holocene, consistent with climate-model simulations. Jeremiah Marsicek, Bryan N. Shuman, Patrick J. Bartlein et al. | Early Middle Palaeolithic culture in India around 385–172 ka reframes Out of Africa models Lithic assemblages from the archaeological site of Attirampakkam, India, document processes of transition from Acheulian to Middle Palaeolithic cultures and substantial behavioural changes around 385,000 years ago and thereafter. Kumar Akhilesh, Shanti Pappu, Haresh M. Rajapara et al. | The honeycomb maze provides a novel test to study hippocampal-dependent spatial navigation A newly designed honeycomb maze presents several advantages over current spatial navigation assays that include greater control over the rat’s choices throughout the task and the collection of electrophysiological data during navigation. Ruth A. Wood, Marius Bauza, Julija Krupic et al. | Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells Analysis of transplantation of single haematopoietic stem cells in mice defines stable lineage-restricted fates in long-term self-renewing multipotent stem cells, including a class of multipotent stem cells that exclusively replenishes the megakaryocyte/platelet lineage. Joana Carrelha, Yiran Meng, Laura M. Kettyle et al. | Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders Mutations associated with Treacher Collins syndrome perturb the subnuclear localization of an RNA helicase involved in ribosome biogenesis through activation of p53 protein, illustrating how disruption in general regulators that compromise nucleolar homeostasis can result in tissue-selective malformations. Eliezer Calo, Bo Gu, Margot E. Bowen et al. | A major lineage of non-tailed dsDNA viruses as unrecognized killers of marine bacteria Members of a family of marine dsDNA non-tailed bacterial viruses have short, 10-kb genomes, infect a broader range of hosts than tailed viruses and belong to the double jelly roll capsid lineage of viruses, which are associated with diverse bacterial and archaeal hosts. Kathryn M. Kauffman, Fatima A. Hussain, Joy Yang et al. | Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation A report of RNA 5-methylcytosine oxidation by mammalian Tet2, showing that Tet2 promotes infection-induced myelopoiesis in mice via a mechanism involving the repression of Socs3 mRNA, a previously unknown regulatory role of Tet2 at the epitranscriptomic level. Qicong Shen, Qian Zhang, Yang Shi et al. | Mitochondrial translation requires folate-dependent tRNA methylation Mammalian mitochondria use folate-bound one-carbon units generated by the enzyme SHMT2 to methylate tRNA, and this modification is required for mitochondrial translation and thus oxidative phosphorylation. Raphael J. Morscher, Gregory S. Ducker, Sophia Hsin-Jung Li et al. | | | | |
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