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Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding. | | | | | Latest Articles | View all Articles | | | A supramolecular lanthanide separation approach based on multivalent cooperative enhancement of metal ion selectivity OPEN | | Xiao-Zhen Li, Li-Peng Zhou, Liang-Liang Yan, Ya-Min Dong, Zhuan-Ling Bai, Xiao-Qi Sun, Juan Diwu, Shuao Wang, Jean-Claude Bünzli & Qing-Fu Sun | | | Lanthanide ions possess similar chemical properties, making their separation from one another challenging. Here the authors show that a tris-tridentate ligand causes high-precision metal ion self-sorting, leading to the selective assembly of tetrahedral M4L4 cages across the lanthanide series. | | 07 February 2018 | doi: 10.1038/s41467-018-02940-7 | | Coordination chemistry Inorganic chemistry Nuclear waste Self-assembly | Inhibition of overactive TGF-β attenuates progression of heterotopic ossification in mice OPEN | | Xiao Wang, Fengfeng Li, Liang Xie, Janet Crane, Gehua Zhen, Yuji Mishina, Ruoxian Deng, Bo Gao, Hao Chen, Shen Liu, Ping Yang, Manman Gao, Manli Tu, Yiguo Wang, Mei Wan, Cunyi Fan & Xu Cao | | | Heterotopic ossification (HO) is a painful disease of unknown etiology characterized by extraskeletal bone formation after injury. Here the authors show that TGF-β is increased in HO lesions, where it promotes the early stages of HO pathology, and demonstrate that TGF-β inhibition ameliorates HO in mice. | | 07 February 2018 | doi: 10.1038/s41467-018-02988-5 | | Bone Mesenchymal stem cells Transforming growth factor beta | α-cell glucokinase suppresses glucose-regulated glucagon secretion OPEN | | Davide Basco, Quan Zhang, Albert Salehi, Andrei Tarasov, Wanda Dolci, Pedro Herrera, Ioannis Spiliotis, Xavier Berney, David Tarussio, Patrik Rorsman & Bernard Thorens | | | Glucagon secretion is promoted during hypoglycemia and inhibited by increased glucose levels. Here, Basco et al. show that glucokinase suppresses glucose-regulated glucagon secretion by modulating the intracellular ATP/ADP ratio and the closure of KATP channels in α-cells. | | 07 February 2018 | doi: 10.1038/s41467-018-03034-0 | | Islets of Langerhans Nutrient signalling Pre-diabetes | Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner OPEN | | Yun-Qian Wang, Hao-Lian Wang, Jie Xu, Juan Tan, Lin-Na Fu, Ji-Lin Wang, Tian-Hui Zou, Dan-Feng Sun, Qin-Yan Gao, Ying-Xuan Chen & Jing-Yuan Fang | | | Tumour metabolism can be controlled through post-translational modifications. Here the authors show that Sirtuin5 promotes glutaminolysis in colorectal cancer cells via glutamate dehydrogenase-1, a critical regulator of glutaminolysis, inducing its deglutarylation and functional activation. | | 07 February 2018 | doi: 10.1038/s41467-018-02951-4 | | Cancer metabolism Colorectal cancer Post-translational modifications | AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle OPEN | | Young-Chae Kim, Sunmi Seok, Sangwon Byun, Bo Kong, Yang Zhang, Grace Guo, Wen Xie, Jian Ma, Byron Kemper & Jongsook Kim Kemper | | | Methyl metabolites in the one-carbon cycle, such as phosphatidylcholines and S-adenosylmethionine, play a role in hepatic triglyceride regulation. Here Kim et al. show that AhR and SHP are both involved in the expression of several key enzymes of one-carbon metabolism, with the former regulating them early after feeding and the latter inhibiting AhR at later stages. | | 07 February 2018 | doi: 10.1038/s41467-018-03060-y | | Fat metabolism Non-alcoholic fatty liver disease Transcriptional regulatory elements | BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage OPEN | | Kajal Biswas, Subha Philip, Aditya Yadav, Betty K. Martin, Sandra Burkett, Vaibhav Singh, Anav Babbar, Susan Lynn North, Suhwan Chang & Shyam K. Sharan | | | Loss of BRCA2 leads to cancer formation. Here, the authors use an insertional mutagenesis approach and identify a multiprotein complex consisting of BRE, USP7 and CDC25A that can support the survival of BRCA2-deficient cells. | | 07 February 2018 | doi: 10.1038/s41467-018-03020-6 | | Breast cancer Checkpoints | A general soft-enveloping strategy in the templating synthesis of mesoporous metal nanostructures OPEN | | Jixiang Fang, Lingling Zhang, Jiang Li, Lu Lu, Chuansheng Ma, Shaodong Cheng, Zhiyuan Li, Qihua Xiong & Hongjun You | | | Metal species are highly mobile within mesoporous silica, making it difficult to template growth of metallic nanocrystals inside the channels. Here, the authors introduce a solid-liquid-solution interfacial strategy to suppress migration of the metal species, achieving control over a variety of mesostructured nanomaterials. | | 06 February 2018 | doi: 10.1038/s41467-018-02930-9 | | Nanoparticles Porous materials Synthesis and processing | Bacterial capture efficiency in fluid bloodstream improved by bendable nanowires OPEN | | Lizhi Liu, Sheng Chen, Zhenjie Xue, Zhen Zhang, Xuezhi Qiao, Zongxiu Nie, Dong Han, Jianlong Wang & Tie Wang | | | Bacteria and other pathogens entering the blood stream can have serious consequences, which can even lead to death. Here, the authors developed a sieve containing nano-sized claws that capture and hold these intruders, thus aiding their removal from patient’s blood | | 06 February 2018 | doi: 10.1038/s41467-018-02879-9 | | Mechanical properties Nanostructures Nanowires | Cryo-EM structure of 5-HT3A receptor in its resting conformation OPEN | | Sandip Basak, Yvonne Gicheru, Amrita Samanta, Sudheer Kumar Molugu, Wei Huang, Maria la de Fuente, Taylor Hughes, Derek J. Taylor, Marvin T. Nieman, Vera Moiseenkova-Bell & Sudha Chakrapani | | | Serotonin receptor (5-HT3AR), a pentameric ligand-gated ion channel, regulates numerous gastrointestinal functions. Here the authors provide a cryo-electron microscopic structure from the full-length 5-HT3AR in the apo-state which corresponds to a resting conformation of the channel. | | 06 February 2018 | doi: 10.1038/s41467-018-02997-4 | | Cryoelectron microscopy Ion transport | A microengineered vascularized bleeding model that integrates the principal components of hemostasis OPEN | | Yumiko Sakurai, Elaissa T. Hardy, Byungwook Ahn, Reginald Tran, Meredith E. Fay, Jordan C. Ciciliano, Robert G. Mannino, David R. Myers, Yongzhi Qiu, Marcus A. Carden, W. Hunter Baldwin, Shannon L. Meeks, Gary E. Gilbert, Shawn M. Jobe & Wilbur A. Lam | | | Hemostasis is a complex ensemble of events, but current bleeding assays only analyze single components like coagulation or platelet function. Here the authors present a comprehensive vascularized microfluidic mechanical injury bleeding model that addresses different aspects of the hemostatic process. | | 06 February 2018 | doi: 10.1038/s41467-018-02990-x | | Biomedical engineering Haematological diseases Lab-on-a-chip | A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense OPEN | | Dennis Wolf, Nathaly Anto-Michel, Hermann Blankenbach, Ansgar Wiedemann, Konrad Buscher, Jan David Hohmann, Bock Lim, Marina Bäuml, Alex Marki, Maximilian Mauler, Daniel Duerschmied, Zhichao Fan, Holger Winkels, Daniel Sidler, Philipp Diehl, Dirk M Zajonc, Ingo Hilgendorf, Peter Stachon, Timoteo Marchini, Florian Willecke et al. | | | Integrin-based therapeutics could block inflammatory processes but they also impair host defence, limiting their usefulness. Here the authors report an anti-Mac1 antibody that blocks its interaction with pro-inflammatory ligand CD40L but not other ligands, and show that it can protect against sepsis in mice. | | 06 February 2018 | doi: 10.1038/s41467-018-02896-8 | | Molecular medicine Sepsis Translational immunology Translational research | Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis OPEN | | Fu-Long Li, Jin-Ping Liu, Ruo-Xuan Bao, GuoQuan Yan, Xu Feng, Yan-Ping Xu, Yi-Ping Sun, Weili Yan, Zhi-Qiang Ling, Yue Xiong, Kun-Liang Guan & Hai-Xin Yuan | | | Enhanced glycolysis in cancer cells has been associated with protection from DNA damage. Here the authors show that DNA damaging signals induce acetylation of PFKFB3 at lysine K472 and promote its cytosolic accumulation, which enhances glycolysis, resulting in protection from cisplatin-induced cell death. | | 06 February 2018 | doi: 10.1038/s41467-018-02950-5 | | Acetylation Cancer metabolism | Samarium hexaboride is a trivial surface conductor OPEN | | P. Hlawenka, K. Siemensmeyer, E. Weschke, A. Varykhalov, J. Sánchez-Barriga, N. Y. Shitsevalova, A. V. Dukhnenko, V. B. Filipov, S. Gabáni, K. Flachbart, O. Rader & E. D. L. Rienks | | | Samarium hexahoride is argued to be a topological Kondo insulator, but this claim remains under debate. Here, Hlawenka et al. provide a topologically trivial explanation for the conducting states at the (100) surface of samarium hexaboride; an explanation based on Rashba splitting and a surface shift of the Kondo resonance. | | 06 February 2018 | doi: 10.1038/s41467-018-02908-7 | | Electronic properties and materials Surfaces, interfaces and thin films Topological insulators | Ultrafast current imaging by Bayesian inversion OPEN | | S. Somnath, K. J. H. Law, A. N. Morozovska, P. Maksymovych, Y. Kim, X. Lu, M. Alexe, R. Archibald, S. V. Kalinin, S. Jesse & R. K. Vasudevan | | | Scanning probe microscopy is widely used to characterize material properties with atomic resolution, yet electronic property mapping is normally constrained by slow data acquisition. Somnath et al. show a current–voltage method, which enables fast electronic spectroscopy mapping over micrometer-sized areas. | | 06 February 2018 | doi: 10.1038/s41467-017-02455-7 | | Electronic properties and materials Scanning probe microscopy | Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding OPEN | | Hou-Fu Guo, Chi-Lin Tsai, Masahiko Terajima, Xiaochao Tan, Priyam Banerjee, Mitchell D. Miller, Xin Liu, Jiang Yu, Jovita Byemerwa, Sarah Alvarado, Tamer S. Kaoud, Kevin N. Dalby, Neus Bota-Rabassedas, Yulong Chen, Mitsuo Yamauchi, John A. Tainer, George N. Phillips Jr. & Jonathan M. Kurie | | | Collagen lysyl hydroxylases promote cancer progression. Here the authors present the crystal structure of the lysyl hydroxylase domain of L230 from Acanthamoeba polyphaga mimivirus, which is of interest for LH inhibitor development, and show that ectopic expression of L230 in tumors promotes collagen cross-linking and metastasis. | | 06 February 2018 | doi: 10.1038/s41467-018-02859-z | | Cancer microenvironment X-ray crystallography | Creation of a long-acting nanoformulated dolutegravir OPEN | | Brady Sillman, Aditya N. Bade, Prasanta K. Dash, Biju Bhargavan, Ted Kocher, Saumi Mathews, Hang Su, Georgette D. Kanmogne, Larisa Y. Poluektova, Santhi Gorantla, JoEllyn McMillan, Nagsen Gautam, Yazen Alnouti, Benson Edagwa & Howard E. Gendelman | | | Current ART for treatment of HIV-1 infection requires a strict daily regimen adherence. Herein, the authors report the manufacture and characterization of a nanoformulated dolutegravir prodrug with improved cell and tissue penetration, a remarkable apparent half-life and the potential for bimonthly drug administration. | | 06 February 2018 | doi: 10.1038/s41467-018-02885-x | | Chemical modification Drug delivery HIV infections Pharmacodynamics Pharmacokinetics | Sensory deprivation in Staphylococcus aureus OPEN | | Maite Villanueva, Begoña García, Jaione Valle, Beatriz Rapún, Igor Ruiz de los Mozos, Cristina Solano, Miguel Martí, José R. Penadés, Alejandro Toledo-Arana & Iñigo Lasa | | | Bacteria use two-component systems (TCSs) to sense and respond to environmental changes. Here, the authors show that Staphylococcus aureus can survive in the absence of all its 16 TCSs under growth arrest conditions, and each TCS seems to be sufficient to sense and respond to specific environmental clues. | | 06 February 2018 | doi: 10.1038/s41467-018-02949-y | | Bacteria Bacterial genetics Cell signalling | Afforestation neutralizes soil pH OPEN | | Songbai Hong, Shilong Piao, Anping Chen, Yongwen Liu, Lingli Liu, Shushi Peng, Jordi Sardans, Yan Sun, Josep Peñuelas & Hui Zeng | | | Afforestation is often used to increase terrestrial carbon sequestration and restore ecosystem services. Here, the authors show that afforestation can also neutralize soil pH by lowering pH in alkaline soil but raising pH in acid soil, thus further promoting the restoration of ecosystem functions. | | 06 February 2018 | doi: 10.1038/s41467-018-02970-1 | | Carbon cycle Element cycles Forest ecology | Closed-loop stimulation of temporal cortex rescues functional networks and improves memory OPEN | | Youssef Ezzyat, Paul A. Wanda, Deborah F. Levy, Allison Kadel, Ada Aka, Isaac Pedisich, Michael R. Sperling, Ashwini D. Sharan, Bradley C. Lega, Alexis Burks, Robert E. Gross, Cory S. Inman, Barbara C. Jobst, Mark A. Gorenstein, Kathryn A. Davis, Gregory A. Worrell, Michal T. Kucewicz, Joel M. Stein, Richard Gorniak, Sandhitsu R. Das et al. | | | Memory lapses can occur due to ineffective encoding, but it is unclear if targeted brain stimulation can improve memory performance. Here, authors use a closed-loop system to decode and stimulate periods of ineffective encoding, showing that stimulation of lateral temporal cortex can enhance memory. | | 06 February 2018 | doi: 10.1038/s41467-017-02753-0 | | Cognitive neuroscience Human behaviour Long-term memory | Cell fate in antiviral response arises in the crosstalk of IRF, NF-κB and JAK/STAT pathways OPEN | | Maciej Czerkies, Zbigniew Korwek, Wiktor Prus, Marek Kochańczyk, Joanna Jaruszewicz-Błońska, Karolina Tudelska, Sławomir Błoński, Marek Kimmel, Allan R. Brasier & Tomasz Lipniacki | | | Innate immunity combines intra- and intercellular signalling to develop responses that limit pathogen spread. Here the authors analyse feedback and feedforward loops connecting IRF3, NF-κB and STAT pathways, and suggest they allow coordinating cell fate decisions in cellular populations in response to the virus-mimicking agent poly(I:C). | | 05 February 2018 | doi: 10.1038/s41467-017-02640-8 | | Cellular signalling networks Innate immunity Regulatory networks Stochastic modelling | BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1 OPEN | | Sen Zhu, Dongyu Zhao, Lin Yan, Weihua Jiang, Jung-Sun Kim, Bingnan Gu, Qipeng Liu, Rui Wang, Bo Xia, Jonathan C. Zhao, Gang Song, Wenyi Mi, Rong-Fu Wang, Xiaobing Shi, Hung-Ming Lam, Xuesen Dong, Jindan Yu, Kaifu Chen & Qi Cao | | | The polycomb group protein BMI1 is highly expressed in prostate cancer. Here, the authors demonstrate that BMI1 directly interacts with AR leading to increased AR signaling independently of PRC1 complex and that targeting BMI1 inhibits tumor growth of castration-resistant prostate cancer tumors. | | 05 February 2018 | doi: 10.1038/s41467-018-02863-3 | | Epigenetics Prostate cancer | Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes OPEN | | Jasper Edgar Neggers, Bert Kwanten, Tim Dierckx, Hiroki Noguchi, Arnout Voet, Lotte Bral, Kristien Minner, Bob Massant, Nicolas Kint, Michel Delforge, Thomas Vercruysse, Erkan Baloglu, William Senapedis, Maarten Jacquemyn & Dirk Daelemans | | | Cancer therapy drugs are designed to target genetic vulnerabilities, but loss-of-function screens often fail to identify essential genes in drug mechanism studies. Here the authors demonstrate CRISPRres, which exploits in-frame variation generated by indel formation to discover gene-drug interactions. | | 05 February 2018 | doi: 10.1038/s41467-017-02349-8 | | CRISPR-Cas9 genome editing Target identification Target validation | Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis OPEN | | Do-Hyun Kim, Hong-Jai Park, Sangho Lim, Ja-Hyun Koo, Hong-Gyun Lee, Jin Ouk Choi, Ji Hoon Oh, Sang-Jun Ha, Min-Jong Kang, Chang-Min Lee, Chun Geun Lee, Jack A. Elias & Je-Min Choi | | | Chitinase-3-like-1 (Chi3l1) has been involved in inflammation and pulmonary metastasis. Here the authors show that Chi3l1 inhibits the T cell response by negatively regulating their activation and that, in a mouse model of melanoma, T cell-targeted silencing of Chi3l1 results in reduced lung metastasis. | | 05 February 2018 | doi: 10.1038/s41467-017-02731-6 | | Cancer immunotherapy Drug delivery RNAi therapy Tumour immunology | A NIN-LIKE PROTEIN mediates nitrate-induced control of root nodule symbiosis in Lotus japonicus OPEN | | Hanna Nishida, Sachiko Tanaka, Yoshihiro Handa, Momoyo Ito, Yuki Sakamoto, Sachihiro Matsunaga, Shigeyuki Betsuyaku, Kenji Miura, Takashi Soyano, Masayoshi Kawaguchi & Takuya Suzaki | | | Leguminous plants host nitrogen-fixing bacteria in root nodules, but cease symbiosis when sufficient nitrogen is available. Here, the authors show that the Lotus japonicus transcription factor NRSYM1 activates the production of CLE-RS2 in nitrogen-sufficient conditions to prevent nodulation | | 05 February 2018 | doi: 10.1038/s41467-018-02831-x | | Plant development Rhizobial symbiosis | Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva OPEN | | John B. Lees-Shepard, Masakazu Yamamoto, Arpita A. Biswas, Sean J. Stoessel, Sarah-Anne E. Nicholas, Cathy A. Cogswell, Parvathi M. Devarakonda, Michael J. Schneider Jr., Samantha M. Cummins, Nicholas P. Legendre, Shoko Yamamoto, Vesa Kaartinen, Jeffrey W. Hunter & David J. Goldhamer | | | Fibrodysplasia ossificans progressiva is a severe disorder characterized by heterotopic ossification, and is caused by mutations in ACVR1. Here, the authors show that expression of mutant ACVR1 in fibro/adipogenic progenitors recapitulates disease progression, and that this can be halted by systemic inhibition of activin A in mice. | | 02 February 2018 | doi: 10.1038/s41467-018-02872-2 | | Antibody therapy Bone Disease model Muscle stem cells | Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer OPEN | | Tesa M. Severson, Yongsoo Kim, Stacey E. P. Joosten, Karianne Schuurman, Petra van der Groep, Cathy B. Moelans, Natalie D. ter Hoeve, Quirine F. Manson, John W. Martens, Carolien H. M. van Deurzen, Ellis Barbe, Ingrid Hedenfalk, Peter Bult, Vincent T. H. B. M. Smit, Sabine C. Linn, Paul J. van Diest, Lodewyk Wessels & Wilbert Zwart | | | Male breast cancer (MBC) is rare and largely hormonally driven. Here, the authors examine the action of steroid hormone receptors in male and female breast cancers and find gender selective hormone receptor action that associates with the survival of MBC patients. | | 02 February 2018 | doi: 10.1038/s41467-018-02856-2 | | Breast cancer Cancer genomics Prognostic markers | Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice OPEN | | Jun Wang, Georgia E. Hodes, Hongxing Zhang, Song Zhang, Wei Zhao, Sam A. Golden, Weina Bi, Caroline Menard, Veronika Kana, Marylene Leboeuf, Marc Xie, Dana Bregman, Madeline L. Pfau, Meghan E. Flanigan, Adelaida Esteban-Fernández, Shrishailam Yemul, Ali Sharma, Lap Ho, Richard Dixon, Miriam Merad et al. | | | Polyphenols have partial antidepressant effect without known mechanism. Here, the authors identify two phytochemicals from bioactive dietary polyphenols, show their antidepressant effect in a rodent model of depression, and that this effect is mediated by epigenetic and anti-inflammatory mechanisms. | | 02 February 2018 | doi: 10.1038/s41467-017-02794-5 | | Epigenetics and plasticity Neuroimmunology Stress and resilience | Replication confers β cell immaturity OPEN | | Sapna Puri, Nilotpal Roy, Holger A. Russ, Laura Leonhardt, Esra K. French, Ritu Roy, Henrik Bengtsson, Donald K. Scott, Andrew F. Stewart & Matthias Hebrok | | | Adult beta cells, which are highly specialised insulin-secreting cells, rarely replicate. Puri et al. demonstrate that beta cell proliferative capacity is inversely correlated with their functionality and differentiation state, by inducing proliferation of adult cells with ectopic overexpression of the cell cycle regulator c-Myc. | | 02 February 2018 | doi: 10.1038/s41467-018-02939-0 | | Cell division Cell proliferation Differentiation Islets of Langerhans | Revealing hole trapping in zinc oxide nanoparticles by time-resolved X-ray spectroscopy OPEN | | Thomas J. Penfold, Jakub Szlachetko, Fabio G. Santomauro, Alexander Britz, Wojciech Gawelda, Gilles Doumy, Anne Marie March, Stephen H. Southworth, Jochen Rittmann, Rafael Abela, Majed Chergui & Christopher J. Milne | | | Metal-oxide nanostructures are used in a range of light-driven applications, yet the fundamentals behind their properties are poorly understood. Here the authors probe photoexcited zinc oxide nanoparticles using time-resolved X-ray spectroscopy, identifying photocatalytically-active hole traps as oxygen vacancies in the lattice. | | 02 February 2018 | doi: 10.1038/s41467-018-02870-4 | | Nanoparticles Optical materials X-rays | Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation OPEN | | Yiyan Zheng, Ritika Sethi, Lingegowda S. Mangala, Charlotte Taylor, Juliet Goldsmith, Ming Wang, Kenta Masuda, Mohammad Karaminejadranjbar, David Mannion, Fabrizio Miranda, Sandra Herrero-Gonzalez, Karin Hellner, Fiona Chen, Abdulkhaliq Alsaadi, Ashwag Albukhari, Donatien Chedom Fotso, Christopher Yau, Dahai Jiang, Sunila Pradeep, Cristian Rodriguez-Aguayo et al. | | | Some anticancer drugs target cell microtubules inhibiting mitosis and cell division. Here, the authors show that CRMP2 induces microtubule bundling and that this activity is regulated by the FER kinase, thus providing a rationale for targeting FER in combination with microtubule-targeting drugs. | | 02 February 2018 | doi: 10.1038/s41467-017-02811-7 | | Kinases Ovarian cancer | Evolving affinity between Coulombic reversibility and hysteretic phase transformations in nano-structured silicon-based lithium-ion batteries OPEN | | K. Ogata, S. Jeon, D.-S. Ko, I. S. Jung, J. H. Kim, K. Ito, Y. Kubo, K. Takei, S. Saito, Y.-H. Cho, H. Park, J. Jang, H.-G. Kim, J.-H. Kim, Y. S. Kim, W. Choi, M. Koh, K. Uosaki, S. G. Doo, Y. Hwang et al. | | | Using silicon electrodes could improve lithium ion battery storage capacities, but irreversible side reactions during cycling rapidly degrade current batteries. Here, the authors studied silicon-rich electrode phase transitions and how such transitions may benefit the rechargeable cell systems. | | 02 February 2018 | doi: 10.1038/s41467-018-02824-w | | Batteries | Discordant congenital Zika syndrome twins show differential in vitro viral susceptibility of neural progenitor cells OPEN | | Luiz Carlos Caires-Júnior, Ernesto Goulart, Uirá Souto Melo, Bruno Silva Henrique Araujo, Lucas Alvizi, Alessandra Soares-Schanoski, Danyllo Felipe de Oliveira, Gerson Shigeru Kobayashi, Karina Griesi-Oliveira, Camila Manso Musso, Murilo Sena Amaral, Lucas Ferreira daSilva, Renato Mancini Astray, Sandra Fernanda Suárez-Patiño, Daniella Cristina Ventini, Sérgio Gomes da Silva, Guilherme Lopes Yamamoto, Suzana Ezquina, Michel Satya Naslavsky, Kayque Alves Telles-Silva et al. | | | Zika virus (ZIKV) infection can cause congenital Zika syndrome (CZS), but the underlying mechanisms are poorly understood. Here, the authors generate neural progenitor cells from dizygotic twins with a discordant phenotype regarding CZS and study their response to ZIKV infection. | | 02 February 2018 | doi: 10.1038/s41467-017-02790-9 | | Neural stem cells Viral host response | Direct effects of transcranial electric stimulation on brain circuits in rats and humans OPEN | | Mihály Vöröslakos, Yuichi Takeuchi, Kitti Brinyiczki, Tamás Zombori, Azahara Oliva, Antonio Fernández-Ruiz, Gábor Kozák, Zsigmond Tamás Kincses, Béla Iványi, György Buzsáki & Antal Berényi | | | Though transcranial electric stimulation has been used to influence brain activity, it is debated whether neuronal spiking activity is directly affected by commonly-used protocols. Here, the authors quantify the voltage gradients necessary to instantaneously affect neuronal spiking and show that they are higher than commonly-used protocols. | | 02 February 2018 | doi: 10.1038/s41467-018-02928-3 | | Neurology Neuroscience | Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression OPEN | | Chungyong Han, Su-Jung Sim, Seon-Hee Kim, Rohit Singh, Sunhee Hwang, Yu I. Kim, Sang H. Park, Kwang H. Kim, Don G. Lee, Ho S. Oh, Sangeun Lee, Young H. Kim, Beom K. Choi & Byoung S. Kwon | | | Engineered T cells with chimeric antigen receptor (CAR) are emerging as an effective cancer therapy. Here the authors show that CAR T cells recognizing self-MHC can be ‘tuned’ ex vivo via CAR downregulation and CAR T cell death to generate a CAR T pool specifically targeting tumor cells with high MHC expression. | | 01 February 2018 | doi: 10.1038/s41467-018-02912-x | | Cancer immunotherapy Clonal selection Lymphocyte activation Peripheral tolerance | | | | | | | | Advertisement | | | | | Advertisement | | | | | | | | | | | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com | | | | | | | | You have been sent this Table of Contents Alert because you have opted in to receive it. 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