Tuesday, February 6, 2018

Nature Biotechnology Contents: Volume 36 pp 117 - 204

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Nature Biotechnology

Bioprocessing Technologies in Stem Cell Research:
Perspectives on Process Design, Scale-Up, and Product Safety

The 2nd Stem Cell Community Day brings together experts from industry and academia to discuss recent achievements, challenges, and chances in stem cell bioprocessing for research and commercial manufacturing. Register now and submit your abstract! 

February 2018 Volume 36, Issue 2

Opinion and Comment
News and Views
Careers and Recruitment

Discover a new path to your success via Human Data Science. IMS Health and Quintiles are now IQVIA™ - created to advance your pursuits of human science by unleashing the power of data science and human ingenuity. We are here to help you find solutions to drive healthcare forward.

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A*STAR Research - Highlighting the latest breakthroughs at the Agency for Science, Technology and Research (A*STAR), Singapore's premier research organization

Recent Highlights 

Nanomedicine: Taking a stab at microbes | Oncology: All in a molecule of water for effective cancer therapy | Microcapsules: Getting functional proteins from A to B  

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BIOPHARMA DEALMAKERSCompany Profiles and Partnering Opportunities


Nature Outlook: Cancer immunotherapy 

Drugs that mobilize our immune systems against cancer are dramatically improving care for many people, and research is rapidly moving ahead in the lab and the clinic. 

Access this Outlook free >> 

Produced with support from 
F. Hoffmann-La Roche Ltd  
Produced with support of a grant from Merck & Co., Inc.


A less than ideal Deal   p117
The UK government's strategic plan for the life sciences is short on ambition and capital.

No research in Correspondence   p117
Nature Biotechnology will no longer publish research in its Correspondence section.


FDA warns public of dangers of DIY gene therapy   pp119 - 120
Eric Smalley

Gut bacteria link to immunotherapy sparks interest   pp121 - 123
Brian Owens

Spark's gene therapy price tag: $850,000   p122

Roche pays $1.7 billion to target tumors' genetic signatures   p123

Approval of first tumor gene panel sends shockwaves through labs   pp124 - 125
Mark Ratner

California voters and CIRM—will lightning strike twice?   pp126 - 127
Laura DeFrancesco

Around the world in a month   p127

US tax reform may jeopardize orphans   p128
Chris Morrison

Data Page

2017—venture funding goes into overdrive   p129
Laura DeFrancesco

Drug pipeline: 4Q17   p130
Laura DeFrancesco

News Feature

Fresh from the biotech pipeline—2017   pp131 - 136
Chris Morrison
A positive regulatory environment, combined with a raft of drug approvals that included the first US gene therapy, buoyed the sector in 2017. The FDA's flexibility and focus on marketplace competition is likely to galvanize innovators in the coming year. Chris Morrison reports.

Opinion and Comment


Rationalizing governance of genetically modified products in developing countries   pp137 - 139
Ademola A Adenle, E Jane Morris, Denis J Murphy, Peter W B Phillips, Eduardo Trigo et al.

An alternative proposal to the destruction of abandoned human embryos   pp139 - 141
Norbert Gleicher and Arthur L Caplan

Faster, Simpler Biological LC-MS/MS Analysis 

Shimadzu's Clinical Laboratory Automation Module, a fully integrated sample pretreatment module for LC-MS/MS, automatically performs all of the processes necessary for analyzing blood and other biological samples, providing more precise results by reducing human error and improving laboratory safety and efficiency. Learn more.



Tertiary patenting on drug-device combination products in the United States   pp142 - 145
Reed F Beall and Aaron S Kesselheim
Drug-device combination products are becoming increasingly prevalent, with many lasting years beyond the expiration date of primary and secondary patents on the drug itself.

Recent patents in neoantigens and neoepitopes   p146

Naturejobs Career Guide China 2018 

China's scientific landscape is shifting fast. Where can you fit in? Read the latest issue of our career guide to see what opportunities await you. 

Read more online >> 

News and Views

PrePAIRing Cas9s for screening success   pp147 - 148
Zhuo Zhou and Wensheng Wei
Orthogonal CRISPR-Cas9 nucleases enable more efficient high-throughput screens for deciphering genetic interactions.

See also: Research by Boettcher et al. | Research by Najm et al.

Making brain proteomics true to type   pp149 - 150
Rashaun S Wilson and Angus C Nairn
Two independent but related strategies use unnatural amino acid incorporation to enable in vivo cell-type-specific proteomics in the mouse brain.

See also: Research by Krogager et al.

Research Highlights   p150

Putting a number on neoepitope quality   p151
Irene Jarchum

JOBS of the week
Postdoctoral Fellow
University of Pennsylvania - Perelman School of Medicine
Postdoctoral Fellow
University Health Network (Toronto)
Bioinformatician / Computational Biologist (PhD)
University of Helsinki
PhD Students and Postdoctoral Scientists
University Medical Center Freiburg
University of Virginia
More Science jobs from
International Conference on Biotechnology & Environmental Science
March 18, 2018
New Delhi, India
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Brief Communications

Functional interrogation and mining of natively paired human VH:VL antibody repertoires   pp152 - 155
Bo Wang, Brandon J DeKosky, Morgan R Timm, Jiwon Lee, Erica Normandin et al.
Libraries of natively paired human VH:VL chains enable screening of the human B-cell repertoire in yeast.

Labeling and identifying cell-specific proteomes in the mouse brain   pp156 - 159
Toke P Krogager, Russell J Ernst, Thomas S Elliott, Laura Calo, Vaclav Beranek et al.
Labeling of cell-type-specific proteomes in the brains of live mice is enabled by an orthogonal-amino-acid approach.

See also: News and Views by Wilson & Nairn


Scaffolds that mimic antigen-presenting cells enable ex vivo expansion of primary T cells   pp160 - 169
Alexander S Cheung, David K Y Zhang, Sandeep T Koshy and David J Mooney
T cells are readily expanded in culture using a system that presents membrane-bound and soluble cues in a natural context.

Dual gene activation and knockout screen reveals directional dependencies in genetic networks   pp170 - 178
Michael Boettcher, Ruilin Tian, James A Blau, Evan Markegard, Ryan T Wagner et al.
Combining gene activation and knockout of different genes in the same cell using two different Cas9 enzymes enables the reconstruction of directional dependency.

See also: News and Views by Zhou & Wei

Orthologous CRISPR-Cas9 enzymes for combinatorial genetic screens   pp179 - 189
Fadi J Najm, Christine Strand, Katherine F Donovan, Mudra Hegde, Kendall R Sanson et al.
Combinatorial CRISPR screens are improved by using Cas9 enzymes from two different organisms.

See also: News and Views by Zhou & Wei


Retrieval of a million high-quality, full-length microbial 16S and 18S rRNA gene sequences without primer bias   pp190 - 195
Soren M Karst, Morten S Dueholm, Simon J McIlroy, Rasmus H Kirkegaard, Per H Nielsen et al.
More of the diversity present in any microbiome is revealed by a method to sequence 16S rRNA that avoids primer bias.


Corrigendum: Minimum information about a single amplified genome (MISAG) and a metagenome-assembled genome (MIMAG) of bacteria and archaea   p196
Robert M Bowers, Nikos C Kyrpides, Ramunas Stepanauskas, Miranda Harmon-Smith, Devin Doud et al.

Corrigendum: Assisted reproductive technologies to prevent human mitochondrial disease transmission   p196
Andy Greenfield, Peter Braude, Frances Flinter, Robin Lovell-Badge, Caroline Ogilvie et al.

Corrigendum: Reproducing with DNA   p196
Malorye Allison Branca


Erratum: Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells   p196
Trung Van Chu, Timm Weber, Benedikt Wefers, Wolfgang Wurst, Sandrine Sander et al.

Careers and Recruitment

Visualizing detailed postdoctoral employment trends using a new career outcome taxonomy   pp197 - 202
Hong Xu, Richard S T Gilliam, Shyamal D Peddada, Gregory M Buchold and Tammy R L Collins
A standard taxonomy and visualization methods can provide postdoctoral scholars with tools to critically evaluate their career prospects.


People   p204

Nature Mentoring Collection 

Offering advice and support to scientist mentors and their mentees 

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