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Bioprocessing Technologies in Stem Cell Research: Perspectives on Process Design, Scale-Up, and Product Safety
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TABLE OF CONTENTS |
February 2018 Volume 36, Issue 2 |
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| Editorials News Opinion and Comment Features News and Views Research Careers and Recruitment
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Editorials | |
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A less than ideal Deal p117 doi:10.1038/nbt.4084 The UK government's strategic plan for the life sciences is short on ambition and capital.
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No research in Correspondence p117 doi:10.1038/nbt.4085 Nature Biotechnology will no longer publish research in its Correspondence section.
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News | |
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FDA warns public of dangers of DIY gene therapy pp119 - 120 Eric Smalley doi:10.1038/nbt0218-119
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Gut bacteria link to immunotherapy sparks interest pp121 - 123 Brian Owens doi:10.1038/nbt0218-121
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Spark's gene therapy price tag: $850,000 p122 doi:10.1038/nbt0218-122
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Roche pays $1.7 billion to target tumors' genetic signatures p123 doi:10.1038/nbt0218-123
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Approval of first tumor gene panel sends shockwaves through labs pp124 - 125 Mark Ratner doi:10.1038/nbt0218-124
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California voters and CIRM—will lightning strike twice? pp126 - 127 Laura DeFrancesco doi:10.1038/nbt0218-126
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Around the world in a month p127 doi:10.1038/nbt0218-127
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US tax reform may jeopardize orphans p128 Chris Morrison doi:10.1038/nbt0218-128
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Data Page |
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2017—venture funding goes into overdrive p129 Laura DeFrancesco doi:10.1038/nbt.4081
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Drug pipeline: 4Q17 p130 Laura DeFrancesco doi:10.1038/nbt.4073
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News Feature |
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Fresh from the biotech pipeline—2017 pp131 - 136 Chris Morrison doi:10.1038/nbt.4068 A positive regulatory environment, combined with a raft of drug approvals that included the first US gene therapy, buoyed the sector in 2017. The FDA's flexibility and focus on marketplace competition is likely to galvanize innovators in the coming year. Chris Morrison reports.
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Opinion and Comment | |
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Correspondence |
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Rationalizing governance of genetically modified products in developing countries pp137 - 139 Ademola A Adenle, E Jane Morris, Denis J Murphy, Peter W B Phillips, Eduardo Trigo et al. doi:10.1038/nbt.4069
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An alternative proposal to the destruction of abandoned human embryos pp139 - 141 Norbert Gleicher and Arthur L Caplan doi:10.1038/nbt.4070
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Faster, Simpler Biological LC-MS/MS Analysis
Shimadzu's Clinical Laboratory Automation Module, a fully integrated sample pretreatment module for LC-MS/MS, automatically performs all of the processes necessary for analyzing blood and other biological samples, providing more precise results by reducing human error and improving laboratory safety and efficiency. Learn more. | | |
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Features | |
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Patents |
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Tertiary patenting on drug-device combination products in the United States pp142 - 145 Reed F Beall and Aaron S Kesselheim doi:10.1038/nbt.4078 Drug-device combination products are becoming increasingly prevalent, with many lasting years beyond the expiration date of primary and secondary patents on the drug itself.
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Recent patents in neoantigens and neoepitopes p146 doi:10.1038/nbt.4083
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News and Views | |
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Research | |
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Brief Communications |
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Functional interrogation and mining of natively paired human VH:VL antibody repertoires pp152 - 155 Bo Wang, Brandon J DeKosky, Morgan R Timm, Jiwon Lee, Erica Normandin et al. doi:10.1038/nbt.4052 Libraries of natively paired human VH:VL chains enable screening of the human B-cell repertoire in yeast.
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Labeling and identifying cell-specific proteomes in the mouse brain pp156 - 159 Toke P Krogager, Russell J Ernst, Thomas S Elliott, Laura Calo, Vaclav Beranek et al. doi:10.1038/nbt.4056 Labeling of cell-type-specific proteomes in the brains of live mice is enabled by an orthogonal-amino-acid approach.
See also: News and Views by Wilson & Nairn
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Articles |
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Scaffolds that mimic antigen-presenting cells enable ex vivo expansion of primary T cells pp160 - 169 Alexander S Cheung, David K Y Zhang, Sandeep T Koshy and David J Mooney doi:10.1038/nbt.4047 T cells are readily expanded in culture using a system that presents membrane-bound and soluble cues in a natural context.
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Dual gene activation and knockout screen reveals directional dependencies in genetic networks pp170 - 178 Michael Boettcher, Ruilin Tian, James A Blau, Evan Markegard, Ryan T Wagner et al. doi:10.1038/nbt.4062 Combining gene activation and knockout of different genes in the same cell using two different Cas9 enzymes enables the reconstruction of directional dependency.
See also: News and Views by Zhou & Wei
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Orthologous CRISPR-Cas9 enzymes for combinatorial genetic screens pp179 - 189 Fadi J Najm, Christine Strand, Katherine F Donovan, Mudra Hegde, Kendall R Sanson et al. doi:10.1038/nbt.4048 Combinatorial CRISPR screens are improved by using Cas9 enzymes from two different organisms.
See also: News and Views by Zhou & Wei
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Letter |
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Retrieval of a million high-quality, full-length microbial 16S and 18S rRNA gene sequences without primer bias pp190 - 195 Soren M Karst, Morten S Dueholm, Simon J McIlroy, Rasmus H Kirkegaard, Per H Nielsen et al. doi:10.1038/nbt.4045 More of the diversity present in any microbiome is revealed by a method to sequence 16S rRNA that avoids primer bias.
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Corrigenda |
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Corrigendum: Minimum information about a single amplified genome (MISAG) and a metagenome-assembled genome (MIMAG) of bacteria and archaea p196 Robert M Bowers, Nikos C Kyrpides, Ramunas Stepanauskas, Miranda Harmon-Smith, Devin Doud et al. doi:10.1038/nbt0218-196a
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Corrigendum: Assisted reproductive technologies to prevent human mitochondrial disease transmission p196 Andy Greenfield, Peter Braude, Frances Flinter, Robin Lovell-Badge, Caroline Ogilvie et al. doi:10.1038/nbt0218-196b
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Corrigendum: Reproducing with DNA p196 Malorye Allison Branca doi:10.1038/nbt0218-196c
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Erratum |
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Erratum: Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells p196 Trung Van Chu, Timm Weber, Benedikt Wefers, Wolfgang Wurst, Sandrine Sander et al. doi:10.1038/nbt0218-196d
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Careers and Recruitment | |
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Visualizing detailed postdoctoral employment trends using a new career outcome taxonomy pp197 - 202 Hong Xu, Richard S T Gilliam, Shyamal D Peddada, Gregory M Buchold and Tammy R L Collins doi:10.1038/nbt.4059 A standard taxonomy and visualization methods can provide postdoctoral scholars with tools to critically evaluate their career prospects.
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People |
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People p204 doi:10.1038/nbt.4082
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