The EDGE

Optical activation of endogenous metabotropic glutamate receptor 4 (mGlu₄) in the amygdala dynamically regulates symptoms associated with persistent inflammatory pain

C Zussy, X Gómez-Santacana, X Rovira, D De Bundel, S Ferrazzo, D Bosch, D Asede, F Malhaire, F Acher, J Giraldo, E Valjent, I Ehrlich, F Ferraguti, J-P Pin, A Llebaria and C Goudet

Mol Psychiatry 2018 23: 489; 10.1038/mp.2018.4

Letters to the Editor

The NF-κB signaling pathway: an important therapeutic target in psychiatric disorders

M A Altinoz, B Ince, C Tek, V H Srihari and S Guloksuz

Mol Psychiatry 2018 23: 490-491; advance online publication, November 15, 2016; 10.1038/mp.2016.207

Enrichment of factors regulating canonical Wnt signaling among autism risk genes

A Packer

Mol Psychiatry 2018 23: 492-493; advance online publication, December 13, 2016; 10.1038/mp.2016.228

Challenges in conducting genetic analyses based on data-driven classification of major depressive disorder

V-P Mäkinen

Mol Psychiatry 2018 23: 494; advance online publication, November 8, 2016; 10.1038/mp.2016.205

Problems with latent class analysis to detect data-driven subtypes of depression

H M van Loo, R B K Wanders, K J Wardenaar and E I Fried

Mol Psychiatry 2018 23: 495-496; advance online publication, November 8, 2016; 10.1038/mp.2016.202

Do not bury thirty years of avoidance findings

A Fernández-Teruel and A Tobeña

Mol Psychiatry 2018 23: 497-498; advance online publication, October 31, 2017; 10.1038/mp.2017.209

Original Articles

Characterization and transplantation of enteric neural crest cells from human induced pluripotent stem cells OPEN

W Li, L Huang, J Zeng, W Lin, K Li, J Sun, W Huang, J Chen, G Wang, Q Ke, J Duan, X Lai, R Chen, M Liu, Y Liu, T Wang, X Yang, Y Chen, H Xia and A P Xiang

Mol Psychiatry 2018 23: 499-508; advance online publication, October 25, 2016; 10.1038/mp.2016.191

Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4

C Zussy, X Gómez-Santacana, X Rovira, D De Bundel, S Ferrazzo, D Bosch, D Asede, F Malhaire, F Acher, J Giraldo, E Valjent, I Ehrlich, F Ferraguti, J-P Pin, A Llebaria and C Goudet

Mol Psychiatry 2018 23: 509-520; advance online publication, December 20, 2016; 10.1038/mp.2016.223

Evidence for newly generated interneurons in the basolateral amygdala of adult mice OPEN

D J Jhaveri, A Tedoldi, S Hunt, R Sullivan, N R Watts, J M Power, P F Bartlett and P Sah

Mol Psychiatry 2018 23: 521-532; advance online publication, August 15, 2017; 10.1038/mp.2017.134

Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood OPEN

N Dedic, M L Pöhlmann, J S Richter, D Mehta, D Czamara, M W Metzger, J Dine, B T Bedenk, J Hartmann, K V Wagner, A Jurik, L M Almli, A Lori, S Moosmang, F Hofmann, C T Wotjak, G Rammes, M Eder, A Chen, K J Ressler, W Wurst, M V Schmidt, E B Binder and J M Deussing

Mol Psychiatry 2018 23: 533-543; advance online publication, July 11, 2017; 10.1038/mp.2017.133

Male-specific deficits in natural reward learning in a mouse model of neurodevelopmental disorders OPEN

N M Grissom, S E McKee, H Schoch, N Bowman, R Havekes, W T O'Brien, E Mahrt, S Siegel, K Commons, C Portfors, T Nickl-Jockschat, T M Reyes and T Abel

Mol Psychiatry 2018 23: 544-555; advance online publication, October 17, 2017; 10.1038/mp.2017.184

Gene deficiency and pharmacological inhibition of caspase-1 confers resilience to chronic social defeat stress via regulating the stability of surface AMPARs OPEN

M-X Li, H-L Zheng, Y Luo, J-G He, W Wang, J Han, L Zhang, X Wang, L Ni, H-Y Zhou, Z-L Hu, P-F Wu, Y Jin, L-H Long, H Zhang, G Hu, J-G Chen and F Wang

Mol Psychiatry 2018 23: 556-568; advance online publication, April 18, 2017; 10.1038/mp.2017.76

Diazepam actions in the VTA enhance social dominance and mitochondrial function in the nucleus accumbens by activation of dopamine D1 receptors OPEN

M A van der Kooij, F Hollis, L Lozano, I Zalachoras, S Abad, O Zanoletti, J Grosse, I Guillot de Suduiraut, C Canto and C Sandi

Mol Psychiatry 2018 23: 569-578; advance online publication, July 20, 2017; 10.1038/mp.2017.135

The nucleus reuniens: a key node in the neurocircuitry of stress and depression

V Kafetzopoulos, N Kokras, I Sotiropoulos, J F Oliveira, H Leite-Almeida, A Vasalou, V M Sardinha, Z Papadopoulou-Daifoti, O F X Almeida, K Antoniou, N Sousa and C Dalla

Mol Psychiatry 2018 23: 579-586; advance online publication, April 11, 2017; 10.1038/mp.2017.55

Inducing a long-term potentiation in the dentate gyrus is sufficient to produce rapid antidepressant-like effects

A Kanzari, C Bourcier-Lucas, A Freyssin, D N Abrous, N Haddjeri and G Lucas

Mol Psychiatry 2018 23: 587-596; advance online publication, May 9, 2017; 10.1038/mp.2017.94

Uncoupling DAPK1 from NMDA receptor GluN2B subunit exerts rapid antidepressant-like effects OPEN

S-X Li, Y Han, L-Z Xu, K Yuan, R-X Zhang, C-Y Sun, D-F Xu, M Yuan, J-H Deng, S-Q Meng, X-J Gao, Q Wen, L-J Liu, W-L Zhu, Y-X Xue, M Zhao, J Shi and L Lu

Mol Psychiatry 2018 23: 597-608; advance online publication, April 25, 2017; 10.1038/mp.2017.85

Genetic contributions to self-reported tiredness OPEN

V Deary, S P Hagenaars, S E Harris, W D Hill, G Davies, D C M Liewald, International Consortium for Blood Pressure GWAS, CHARGE Consortium Aging and Longevity Group, CHARGE Consortium Inflammation Group, A M McIntosh, C R Gale and I J Deary

Mol Psychiatry 2018 23: 609-620; advance online publication, February 14, 2017; 10.1038/mp.2017.5

The Arf6 activator Efa6/PSD3 confers regional specificity and modulates ethanol consumption in Drosophila and humans

D A Gonzalez, T Jia, J H Pinzón, S F Acevedo, S A Ojelade, B Xu, N Tay, S Desrivières, J L Hernandez, T Banaschewski, C Büchel, A L W Bokde, P J Conrod, H Flor, V Frouin, J Gallinat, H Garavan, P A Gowland, A Heinz, B Ittermann, M Lathrop, J-L Martinot, T Paus, M N Smolka, the IMAGEN Consortium, A R Rodan, G Schumann and A Rothenfluh

Mol Psychiatry 2018 23: 621-628; advance online publication, June 13, 2017; 10.1038/mp.2017.112

A synthetic small-molecule Isoxazole-9 protects against methamphetamine relapse

M H Galinato, J W Lockner, M J Fannon-Pavlich, J C Sobieraj, M C Staples, S S Somkuwar, A Ghofranian, S Chaing, A I Navarro, A Joea, B W Luikart, K D Janda, C Heyser, G F Koob and C D Mandyam

Mol Psychiatry 2018 23: 629-638; advance online publication, March 28, 2017; 10.1038/mp.2017.46

A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder OPEN

M Ikeda, A Takahashi, Y Kamatani, Y Okahisa, H Kunugi, N Mori, T Sasaki, T Ohmori, Y Okamoto, H Kawasaki, S Shimodera, T Kato, H Yoneda, R Yoshimura, M Iyo, K Matsuda, M Akiyama, K Ashikawa, K Kashiwase, K Tokunaga, K Kondo, T Saito, A Shimasaki, K Kawase, T Kitajima, K Matsuo, M Itokawa, T Someya, T Inada, R Hashimoto, T Inoue, K Akiyama, H Tanii, H Arai, S Kanba, N Ozaki, I Kusumi, T Yoshikawa, M Kubo and N Iwata for the advanced Collaborative Study of Mood Disorder (COSMO) team

Mol Psychiatry 2018 23: 639-647; advance online publication, January 24, 2017; 10.1038/mp.2016.259

NRSF-dependent epigenetic mechanisms contribute to programming of stress-sensitive neurons by neonatal experience, promoting resilience OPEN

A Singh-Taylor, J Molet, S Jiang, A Korosi, J L Bolton, Y Noam, K Simeone, J Cope, Y Chen, A Mortazavi and T Z Baram

Mol Psychiatry 2018 23: 648-657; advance online publication, January 10, 2017; 10.1038/mp.2016.240

Estrogen-dependent association of HDAC4 with fear in female mice and women with PTSD OPEN

S A Maddox, V Kilaru, J Shin, T Jovanovic, L M Almli, B G Dias, S D Norrholm, N Fani, V Michopoulos, Z Ding, K N Conneely, E B Binder, K J Ressler and A K Smith

Mol Psychiatry 2018 23: 658-665; advance online publication, January 17, 2017; 10.1038/mp.2016.250

Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability OPEN

L E Duncan, A Ratanatharathorn, A E Aiello, L M Almli, A B Amstadter, A E Ashley-Koch, D G Baker, J C Beckham, L J Bierut, J Bisson, B Bradley, C-Y Chen, S Dalvie, L A Farrer, S Galea, M E Garrett, J E Gelernter, G Guffanti, M A Hauser, E O Johnson, R C Kessler, N A Kimbrel, A King, N Koen, H R Kranzler, M W Logue, A X Maihofer, A R Martin, M W Miller, R A Morey, N R Nugent, J P Rice, S Ripke, A L Roberts, N L Saccone, J W Smoller, D J Stein, M B Stein, J A Sumner, M Uddin, R J Ursano, D E Wildman, R Yehuda, H Zhao, M J Daly, I Liberzon, K J Ressler, C M Nievergelt and K C Koenen

Mol Psychiatry 2018 23: 666-673; advance online publication, April 25, 2017; 10.1038/mp.2017.77

Preventing intrusive memories after trauma via a brief intervention involving Tetris computer game play in the emergency department: a proof-of-concept randomized controlled trial OPEN

L Iyadurai, S E Blackwell, R Meiser-Stedman, P C Watson, M B Bonsall, J R Geddes, A C Nobre and E A Holmes

Mol Psychiatry 2018 23: 674-682; advance online publication, March 28, 2017; 10.1038/mp.2017.23

Neuroanatomic, epigenetic and genetic differences in monozygotic twins discordant for attention deficit hyperactivity disorder

Y-C Chen, G Sudre, W Sharp, F Donovan, S C Chandrasekharappa, N Hansen, L Elnitski and P Shaw

Mol Psychiatry 2018 23: 683-690; advance online publication, March 21, 2017; 10.1038/mp.2017.45

GluD1, linked to schizophrenia, controls the burst firing of dopamine neurons OPEN

N Benamer, F Marti, R Lujan, R Hepp, T G Aubier, A A M Dupin, G Frébourg, S Pons, U Maskos, P Faure, Y A Hay, B Lambolez and L Tricoire

Mol Psychiatry 2018 23: 691-700; advance online publication, July 11, 2017; 10.1038/mp.2017.137

Greater extracellular free-water in first-episode psychosis predicts better neurocognitive functioning

A E Lyall, O Pasternak, D G Robinson, D Newell, J W Trampush, J A Gallego, M Fava, A K Malhotra, K H Karlsgodt, M Kubicki and P R Szeszko

Mol Psychiatry 2018 23: 701-707; advance online publication, March 28, 2017; 10.1038/mp.2017.43

Comparative genomic evidence for the involvement of schizophrenia risk genes in antipsychotic effects

Y Kim, P Giusti-Rodriguez, J J Crowley, J Bryois, R J Nonneman, A K Ryan, C R Quackenbush, M D Iglesias-Ussel, P H Lee, W Sun, F P-M de Villena and P F Sullivan

Mol Psychiatry 2018 23: 708-712; advance online publication, May 30, 2017; 10.1038/mp.2017.111

A missense mutation in Katnal1 underlies behavioural, neurological and ciliary anomalies OPEN

G Banks, G Lassi, A Hoerder-Suabedissen, F Tinarelli, M M Simon, A Wilcox, P Lau, T N Lawson, S Johnson, A Rutman, M Sweeting, J E Chesham, A R Barnard, N Horner, H Westerberg, L B Smith, Z Molnár, M H Hastings, R A Hirst, V Tucci and P M Nolan

Mol Psychiatry 2018 23: 713-722; advance online publication, April 4, 2017; 10.1038/mp.2017.54

Neural progenitor fate decision defects, cortical hypoplasia and behavioral impairment in Celsr1-deficient mice OPEN

C Boucherie, C Boutin, Y Jossin, O Schakman, A M Goffinet, L Ris, P Gailly and F Tissir

Mol Psychiatry 2018 23: 723-734; advance online publication, December 19, 2017; 10.1038/mp.2017.236

Stem cell-derived neurons from autistic individuals with SHANK3 mutation show morphogenetic abnormalities during early development OPEN

A Kathuria, P Nowosiad, R Jagasia, S Aigner, R D Taylor, L C Andreae, N J F Gatford, W Lucchesi, D P Srivastava and J Price

Mol Psychiatry 2018 23: 735-746; advance online publication, September 26, 2017; 10.1038/mp.2017.185

Autism-associated Dyrk1a truncation mutants impair neuronal dendritic and spine growth and interfere with postnatal cortical development OPEN

T Dang, W Y Duan, B Yu, D L Tong, C Cheng, Y F Zhang, W Wu, K Ye, W X Zhang, M Wu, B B Wu, Y An, Z L Qiu and B L Wu

Mol Psychiatry 2018 23: 747-758; advance online publication, February 7, 2017; 10.1038/mp.2016.253

Prenatal fever and autism risk OPEN

M Hornig, M A Bresnahan, X Che, A F Schultz, J E Ukaigwe, M L Eddy, D Hirtz, N Gunnes, K K Lie, P Magnus, S Mjaaland, T Reichborn-Kjennerud, S Schjølberg, A-S Øyen, B Levin, E S Susser, C Stoltenberg and W I Lipkin

Mol Psychiatry 2018 23: 759-766; advance online publication, June 13, 2017; 10.1038/mp.2017.119

Reduced TRPC6 mRNA levels in the blood cells of patients with Alzheimer’s disease and mild cognitive impairment

R Lu, J Wang, R Tao, J Wang, T Zhu, W Guo, Y Sun, H Li, Y Gao, W Zhang, C J Fowler, Q Li, S Chen, Z Wu, C L Masters, C Zhong, N Jing, Y Wang and Y Wang

Mol Psychiatry 2018 23: 767-776; advance online publication, July 11, 2017; 10.1038/mp.2017.136

Treatment with a non-toxic, self-replicating anti-prion delays or prevents prion disease in vivo

R Diaz-Espinoza, R Morales, L Concha-Marambio, I Moreno-Gonzalez, F Moda and C Soto

Mol Psychiatry 2018 23: 777-788; advance online publication, June 20, 2017; 10.1038/mp.2017.84

Corrigendum

Genetic contributions to self-reported tiredness OPEN

V Deary, S P Hagenaars, S E Harris, W D Hill, G Davies, D C M Liewald, International Consortium for Blood Pressure GWAS, CHARGE consortium Aging and Longevity Group, CHARGE consortium Inflammation Group, A M McIntosh, C R Gale and I J Deary

Mol Psychiatry 2018 23: 789-790; advance online publication, March 21, 2017; 10.1038/mp.2017.70