The EMBO Journal Table of Contents for 04 January 2018; Vol. 37, No. 1

04 January 2018 | Volume 37, Number 1 Submit Table of Contents Articles Resource Volume 37, Number 1 Articles Rab29 activation of the Parkinson's disease‐associated LRRK2 kinase Rab29 GTPase emerges as a master regulator of LRRK2, controlling its activation, Golgi localization and potentially biomarker phosphorylation. Elena Purlyte, Herschel S Dhekne, Adil R Sarhan, Rachel Gomez, Pawel Lis, Melanie Wightman, Terina N Martinez, Francesca Tonelli, Suzanne R Pfeffer and Dario R Alessi Published online 06.12.2017 The IKK‐related kinase TBK1 activates mTORC1 directly in response to growth factors and innate immune agonists Innate immune kinase TBK1‐dependent activation of mTORC1 occurs in response to pathogen recognition and EGF receptor activation and drives interferon production, thus highlighting the role of mTOR for innate immunity. Cagri Bodur, Dubek Kazyken, Kezhen Huang, Bilgen Ekim Ustunel, Kate A Siroky, Aaron Seth Tooley, Ian E Gonzalez, Daniel H Foley, Hugo A Acosta‐Jaquez, Tammy M Barnes, Gabrielle K Steinl, Kae‐Won Cho, Carey N Lumeng, Steven M Riddle, Martin G Myers, Jr and Diane C Fingar Published online 17.11.2017 Guanylyl cyclase‐G is an alarm pheromone receptor in mice Gain‐ and loss‐of‐function studies in mouse cells and knock‐out animals unequivocally define the transmembrane guanylyl cyclase GC‐G as the receptor binding to and mediating the stress‐associated effects of the alarm pheromone SBT. Ying‐Chi Chao, Joerg Fleischer and Ruey‐Bing Yang Published online 28.09.2017 DNA damage induced by topoisomerase inhibitors activates SAMHD1 and blocks HIV‐1 infection of macrophages Dephosphorylation of the viral restriction factor SAMHD1 via a p53/p21‐mediated pathway suggests that chemotherapeutic drugs could limit cellular HIV‐1 reservoirs at a post‐reverse transcription step. Petra Mlcochova, Sarah J Caswell, Ian A Taylor, Greg J Towers and Ravindra K Gupta Published online 30.10.2017 Selective base excision repair of DNA damage by the non‐base‐flipping DNA glycosylase AlkC DNA kinking by HEAT‐like repeats and an immunoglobulin‐like domain exemplify a new mechanism for bulky lesion exposure and excision in the absence of base‐flipping. Rongxin Shi, Elwood A Mullins, Xing‐Xing Shen, Kori T Lay, Philip K Yuen, Sheila S David, Antonis Rokas and Brandt F Eichman Published online 20.10.2017 Helix‐7 in Argonaute2 shapes the microRNA seed region for rapid target recognition Argonaute2, the key effector of microRNA‐mediated gene silencing, controls base‐pairing in the miRNA seed region to facilitate fast and accurate binding of target mRNAs. Shannon M Klum, Stanley D Chandradoss, Nicole T Schirle, Chirlmin Joo and Ian J MacRae Published online 22.09.2017 Sde2 is an intron‐specific pre‐mRNA splicing regulator activated by ubiquitin‐like processing Deubiquitinating enzymes‐mediated removal of an N‐terminal ubiquitin‐like domain in Sde2 serves as a checkpoint for incorporation in the spliceosome and ensures proper splicing for a subset of mRNAs in Schizosaccharomyces pombe. Poonam Thakran, Prashant Arun Pandit, Sumanjit Datta, Kiran Kumar Kolathur, Jeffrey A Pleiss and Shravan Kumar Mishra Published online 25.09.2017 WH2 and proline‐rich domains of WASP‐family proteins collaborate to accelerate actin filament elongation In addition to creating new actin filaments via the Arp2/3 complex, WASP‐family proteins promote actin filament growth by recruiting actin monomers and actin‐profilin complexes to membrane surfaces. Peter Bieling, Scott D Hansen, Orkun Akin, Tai‐De Li, Carl C Hayden, Daniel A Fletcher and R Dyche Mullins Published online 15.11.2017 Ca2+/calmodulin binding to PSD‐95 mediates homeostatic synaptic scaling down Structure‐based abrogation of calmodulin/PSD‐95 interaction reveals how activity‐induced calcium influx couples to AMPA receptor displacement and reduction in synaptic strength. Dhrubajyoti Chowdhury, Matthew Turner, Tommaso Patriarchi, Anne C Hergarden, David Anderson, Yonghong Zhang, Junqing Sun, Chao‐Yin Chen, James B Ames and Johannes W Hell Published online 08.11.2017 Resource Glyoxal as an alternative fixative to formaldehyde in immunostaining and super‐resolution microscopy Enhanced fixation speed and better preservation of cytosolic nanostructures and membrane‐bound antigens make the small dialdehyde glyoxal a promising substitute for the commonly used paraformaldehyde. Katharina N Richter, Natalia H Revelo, Katharina J Seitz, Martin S Helm, Deblina Sarkar, Rebecca S Saleeb, Elisa D'Este, Jessica Eberle, Eva Wagner, Christian Vogl, Diana F Lazaro, Frank Richter, Javier Coy‐Vergara, Giovanna Coceano, Edward S Boyden, Rory R Duncan, Stefan W Hell, Marcel A Lauterbach, Stephan E Lehnart, Tobias Moser, Tiago F Outeiro, Peter Rehling, Blanche Schwappach, Ilaria Testa, Bolek Zapiec and Silvio O Rizzoli Published online 16.11.2017   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 973 University Avenue * Los Gatos, CA 95032 * U.S.A. Copyright © 2017 by the European Molecular Biology Organisation.