Nature Reviews Molecular Cell Biology contents February 2018 Volume 19 Number 2 pp 71-135

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TABLE OF CONTENTS
February 2018 Volume 19 Number 2
2016 2-year Impact Factor 46.602 Journal Metrics 2-year Median 28.5	In this issue Comment Research Highlights Focus on: Mitochondria Reviews   Also this month  Focus: Mitochondria Article series: Metabolic signalling  Featured article: Building and decoding ubiquitin chains for mitophagy J. Wade Harper, Alban Ordureau & Jin-Mi Heo
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Comment: Progress in mitochondrial replacement therapies Mary Herbert & Doug Turnbull p71 | doi:10.1038/nrm.2018.3 Mary Herbert and Doug Turnbull discuss how the transmission of pathogenic mutations in mitochondrial DNA may be prevented by reproductive techniques designed to replace the mitochondria in eggs from affected women. Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS   Top Stress responses: Reversible sequestration over irreversible aggregation p73 | doi:10.1038/nrm.2018.5 In stress conditions the intrinsically disordered region of the prion and translation factor Sup35 promotes reversible protein phase separation instead of the more stable fibrillar aggregation. PDF Ageing: Pol III inhibition: new promise of longevity p74 | doi:10.1038/nrm.2017.131 Inhibition of polymerase III in the gut is shown to promote animal lifespan downstream of the TOR complex 1. PDF Unfolded protein response: Pro-survival clock sUPRession p74 | doi:10.1038/nrm.2017.137 Activation of the unfolded protein response suppresses circadian clock genes, which contributes to translation repression and increased cell survival. PDF Gene expression: The yin and yang of enhancer-promoter interactions p75 | doi:10.1038/nrm.2017.136 The transcription factor YY1 structurally mediates enhancer-promoter looping interactions and controls gene expression. PDF JOURNAL CLUB Mitochondria: back to the future p76 | doi:10.1038/nrm.2017.133 Navdeep Chandel highlights a study published in 1996 that [mdash] by showing that mitochondria can release cytochrome c to initiate apoptosis [mdash] changed his view of the role of mitochondria in physiology. PDF Mitochondria: The needless PINK1 p76 | doi:10.1038/nrm.2018.4 Basal mitophagy can occur independently of the kinase PINK1 in mammalian organisms, calling for further studies to elucidate the mechanisms of mitophagy in vivo. PDF   ** Molecular Cell Biology JOBS of the week Tenure Track Faculty Position in Molecular Biology University of Wyoming Postdoctral Fellow Boston University School of Medicine, BUMC Postdoctoral Fellow Northwestern University Feinberg School of Medicine, Chicago Postdoctoral fellow Karolinska Institutet (KI) Post-doc for molecular biology Rutgers New Jersey Medical School More Science jobs from Molecular Cell Biology EVENT 2nd Global Conference on Plant Science and Molecular Biology 20.09.18 Rome, Italy More science events from
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Focus on: Mitochondria REVIEWS Top Mitochondrial diseases: the contribution of organelle stress responses to pathology Anu Suomalainen & Brendan J. Battersby p77 | doi:10.1038/nrm.2017.66 Mitochondrial disorders encompass a broad range of pathologies, which manifest in different tissues, with variable age of onset and symptoms. Recent findings suggest that mitochondrial stress responses, which are activated by defects in mitochondrial genome maintenance and expression, contribute to cell and systemic dysfunction, and could explain the phenotypic variability of mitochondrial disorders. Abstract | Full Text | PDF | Supplementary information   Building and decoding ubiquitin chains for mitophagy J. Wade Harper, Alban Ordureau & Jin-Mi Heo p93 | doi:10.1038/nrm.2017.129 Recent studies that combine cell biology, structural and proteomic approaches have unravelled how ubiquitin is conjugated to damaged mitochondria through the PINK1-parkin pathway to promote mitophagy. The findings have revealed links between PINK1-parkin, antigen presentation and neuronal survival and have implications for the understanding of neurological disorders. Abstract | Full Text | PDF   The mitochondrial UPR: mechanisms, physiological functions and implications in ageing Tomer Shpilka & Cole M. Haynes p109 | doi:10.1038/nrm.2017.110 Cells activate a transcriptional response known as the mitochondrial unfolded protein response (UPRmt) when mitochondrial integrity and function are impaired to promote their recovery. Recent insights into the regulation, mechanisms and functions of the UPRmt have uncovered important links to ageing and ageing-associated diseases. Abstract | Full Text | PDF   Article series: Metabolic signalling AMPK: guardian of metabolism and mitochondrial homeostasis Sebastien Herzig & Reuben J. Shaw p121 | doi:10.1038/nrm.2017.95 AMP-activated protein kinase (AMPK) senses cellular energy levels and phosphorylates a variety of cellular substrates to inhibit or stimulate anabolic and catabolic processes, adjusting metabolism to energy needs. Recent studies have uncovered a crucial role of AMPK in the regulation of mitochondrial dynamics and mitophagy, further expanding its role in the control of cellular metabolism. Abstract | Full Text | PDF
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